iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
miRTarBase	microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	5.40e-06	26.9	369	409

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC e  kd  ++ pCgH+ ++ Cl  w    ++ s  + CP Cr
   Q: 369  CKICAENDKD-IRIEPCGHLLCTPCLTSW----QVDSEGQGCPFCR 409
           99********.******************....88888999****8 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MATRGSGTRV QSQPKIFPSL LSKLHGAISE ACVSQRLSTD KKTLEKTWKL MDKVVKLCQQ 60
PKMNLKNSPP FILDILPDTY QRLRLIYSKN EDQMHLLHAN EHFNVFINNL MRKCKQAIKL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTACTGGCGT TGCGGCCGCG GTCATACCGA GATTTCATTG AAAAAGTCGA AAATATTGTG 60
TGGGTTTAAA AAACGCAAAC GTCGCCGAAA CGCGTAGCCC CAAATGCACA CGCCAGGTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-1185--Reference proteome

Interpro

IPR024162--Adaptor_Cbl
IPR014741--Adaptor_Cbl_EF_hand-like
IPR003153--Adaptor_Cbl_N_hlx
IPR014742--Adaptor_Cbl_SH2-like
IPR024159--Cbl_PTB
IPR011992--EF-hand-dom_pair
IPR000980--SH2
IPR015940--UBA
IPR009060--UBA-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51506--CBL_PTB
PS50030--UBA
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF02262--Cbl_N
PF02761--Cbl_N2
PF02762--Cbl_N3

SMART

SM00184--RING
SM00165--UBA

Gene Ontology

GO:0005938--C:cell cortex
GO:0005737--C:cytoplasm
GO:0045121--C:membrane raft
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005509--F:calcium ion binding
GO:0016874--F:ligase activity
GO:0001784--F:phosphotyrosine binding
GO:0030971--F:receptor tyrosine kinase binding
GO:0017124--F:SH3 domain binding
GO:0004871--F:signal transducer activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007298--P:border follicle cell migration
GO:0009950--P:dorsal/ventral axis specification
GO:0008069--P:dorsal/ventral axis specification, ovarian follicular epithelium
GO:0006897--P:endocytosis
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0001754--P:eye photoreceptor cell differentiation
GO:0048134--P:germ-line cyst formation
GO:0007476--P:imaginal disc-derived wing morphogenesis
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:0032353--P:negative regulation of hormone biosynthetic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0006508--P:proteolysis
GO:0007465--P:R7 cell fate commitment
GO:0006109--P:regulation of carbohydrate metabolic process
GO:0010941--P:regulation of cell death
GO:0042127--P:regulation of cell proliferation

KEGG

dme:Dmel_CG7037

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001412	Ailuropoda melanoleuca	72.43	0.00e+00	642.00
IUUC-Apl-004148	Anas platyrhynchos	73.35	0.00e+00	644.00
IUUC-Aca-005204	Anolis carolinensis	73.23	0.00e+00	642.00
IUUC-Ame-011919	Astyanax mexicanus	67.42	1.00e-169	589.00
IUUC-Bta-012759	Bos taurus	74.81	0.00e+00	646.00
IUUC-Cel-018674	Caenorhabditis elegans	57.33	1.00e-138	485.00
IUUC-Cja-019207	Callithrix jacchus	74.81	0.00e+00	647.00
IUUC-Cfa-020897	Canis familiaris	75.26	0.00e+00	647.00
IUUC-Cpo-022514	Cavia porcellus	71.93	0.00e+00	636.00
IUUC-Csa-023136	Chlorocebus sabaeus	74.81	0.00e+00	647.00
IUUC-Cho-024282	Choloepus hoffmanni	62.47	5.00e-146	511.00
IUUC-Cin-025574	Ciona intestinalis	69.97	7.00e-176	608.00
IUUC-Csv-025938	Ciona savignyi	67.58	3.00e-172	596.00
IUUC-Dre-027644	Danio rerio	74.29	0.00e+00	650.00
IUUC-Dno-028923	Dasypus novemcinctus	71.93	0.00e+00	638.00
IUUC-Dor-031040	Dipodomys ordii	62.66	1.00e-151	529.00
IUUC-Ete-032406	Echinops telfairi	73.09	1.00e-175	609.00
IUUC-Eca-033849	Equus caballus	72.43	0.00e+00	642.00
IUUC-Eeu-035142	Erinaceus europaeus	63.81	2.00e-144	505.00
IUUC-Fca-035455	Felis catus	74.81	0.00e+00	645.00
IUUC-Fal-037182	Ficedula albicollis	74.55	0.00e+00	644.00
IUUC-Gmo-038698	Gadus morhua	73.40	0.00e+00	635.00
IUUC-Gga-040438	Gallus gallus	74.55	0.00e+00	645.00
IUUC-Gac-042166	Gasterosteus aculeatus	74.36	0.00e+00	640.00
IUUC-Ggo-045618	Gorilla gorilla	74.81	0.00e+00	647.00
IUUC-Hsa-046177	Homo sapiens	74.81	0.00e+00	647.00
IUUC-Itr-048795	Ictidomys tridecemlineatus	77.59	5.00e-148	516.00
IUUC-Lch-050095	Latimeria chalumnae	74.29	0.00e+00	645.00
IUUC-Loc-052570	Lepisosteus oculatus	74.55	0.00e+00	652.00
IUUC-Laf-054008	Loxodonta africana	74.55	0.00e+00	642.00
IUUC-Mcc-054676	Macaca mulatta	74.81	0.00e+00	647.00
IUUC-Meu-056045	Macropus eugenii	57.64	3.00e-136	478.00
IUUC-Mga-059239	Meleagris gallopavo	74.55	0.00e+00	646.00
IUUC-Mmr-060907	Microcebus murinus	74.81	0.00e+00	646.00
IUUC-Mdo-062020	Monodelphis domestica	72.43	0.00e+00	642.00
IUUC-Mmu-063725	Mus musculus	74.55	0.00e+00	648.00
IUUC-Mpu-066771	Mustela putorius furo	74.55	0.00e+00	645.00
IUUC-Mlu-067145	Myotis lucifugus	72.43	0.00e+00	642.00
IUUC-Nle-069285	Nomascus leucogenys	74.81	0.00e+00	645.00
IUUC-Opr-071026	Ochotona princeps	75.07	9.00e-180	623.00
IUUC-Ont-071954	Oreochromis niloticus	74.17	0.00e+00	643.00
IUUC-Oan-073165	Ornithorhynchus anatinus	72.43	0.00e+00	644.00
IUUC-Ocu-074723	Oryctolagus cuniculus	72.43	0.00e+00	642.00
IUUC-Ola-087165	Oryzias latipes	72.82	0.00e+00	643.00
IUUC-Oga-088198	Otolemur garnettii	74.81	0.00e+00	643.00
IUUC-Oar-089809	Ovis aries	72.43	0.00e+00	641.00
IUUC-Ptr-090710	Pan troglodytes	74.81	0.00e+00	647.00
IUUC-Pan-092785	Papio anubis	74.81	0.00e+00	647.00
IUUC-Psi-093317	Pelodiscus sinensis	71.93	0.00e+00	644.00
IUUC-Pma-094249	Petromyzon marinus	65.48	6.00e-111	392.00
IUUC-Pfo-096049	Poecilia formosa	73.71	0.00e+00	639.00
IUUC-Pab-098526	Pongo abelii	74.81	0.00e+00	647.00
IUUC-Pca-100844	Procavia capensis	57.14	3.00e-129	455.00
IUUC-Pva-103216	Pteropus vampyrus	72.68	0.00e+00	642.00
IUUC-Pgr-103631	Puccinia graminis	34.62	4.00e-06	43.90
IUUC-Rno-105876	Rattus norvegicus	74.55	0.00e+00	647.00
IUUC-Sha-107574	Sarcophilus harrisii	72.43	0.00e+00	642.00
IUUC-Sar-112959	Sorex araneus	75.07	7.00e-180	623.00
IUUC-Ssc-115261	Sus scrofa	74.81	0.00e+00	646.00
IUUC-Tgu-116580	Taeniopygia guttata	74.55	0.00e+00	646.00
IUUC-Tru-118731	Takifugu rubripes	74.17	0.00e+00	642.00
IUUC-Tsy-119167	Tarsius syrichta	74.28	7.00e-145	507.00
IUUC-Tni-119861	Tetraodon nigroviridis	72.75	0.00e+00	635.00
IUUC-Tbe-128018	Tupaia belangeri	75.34	4.00e-180	624.00
IUUC-Ttr-128927	Tursiops truncatus	74.81	0.00e+00	647.00
IUUC-Vpa-130713	Vicugna pacos	72.43	0.00e+00	640.00
IUUC-Xtr-132474	Xenopus tropicalis	73.60	0.00e+00	643.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence