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Basic Information Integrated Annotations

Tag Content
UUCD2 ID IUUC-Dme-031745
UUCD1 version UUC-DrM-00192
Ensembl Protein ID FBpp0086379
UniProt Accession A0A0B4K812; A0A0B4K812_DROME
Genbank Protein ID AFH08114.1
Protein Name Lissencephaly-1 homolog
Genbank Nucleotide ID AE013599
Gene Name Lis-1; CG8440; Dmel_CG8440
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0015754 FBtr0087240 FBpp0086379
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNARAID2
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 8.00e-58 189.8 337 375
UBD/Beta-Prp 3.80e-86 289.0 107 411
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
    gH ++v++laf ++ ++lvs+sdD+ti+vWDlr ++ k
   Q: 337 GHDNWVRGLAFhPGgKYLVSASDDKTIRVWDLRNKRCMK 375
    8***********999******************999987 PP
   


   UBD/Beta-Prp

   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdls.tgkcvhtlkghedsvlslsfsps 105
    h + it v f+p l++++s+d+ti++wd++tg + rsl+gh++ v++v f+ +gk+l+++s D ik+wd++ +++c+ t++gh+++v s++f p
   Q: 107 HRASITRVIFHPIFALMVSASEDATIRIWDFETGEYERSLKGHTDSVQDVAFDAQGKLLASCSADLSIKLWDFQqSYECIKTMHGHDHNVSSVAFVPA 204
    6678999******************************************************************9789********************* PP
   S: 106 gdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsng........... 192
    gd+++s+s+drti++w++ tg+c++ t +gh+++v++v+vh +g++++++s+D+t+r+W +++++ +l+ h++ v+++++ ++
   Q: 205 GDYVLSASRDRTIKMWEVATGYCVK-TYTGHREWVRMVRVHIEGSIFATCSNDQTIRVWLTNSKDCKVELRD-HEHTVECIAWAPEAaasaineaaga 300
    *************************.*********************************************8.*********9999999999999999 PP
   S: 193 .........kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvisvavlsfgdnvlv 281
    ++l+sgs+d+t+++wd++ g c+ tl gh+++v+ ++f+p +++lvs+s+D++ir+Wdlr++ ++ktl h++ +s+++ + +++++
   Q: 301 dnkkghhqgPFLASGSRDKTIRIWDVSVGLCLLTLSGHDNWVRGLAFHPGGKYLVSASDDKTIRVWDLRNKRCMKTLYAHQHFCTSIDF-HKAHPYVI 397
    999999999********************************************************************************.999***** PP
   S: 282 lgsedskvniwklk 295
    +gs d++v++w+++
   Q: 398 SGSVDQTVKVWECR 411
    ***********985 PP
   

Organism Drosophila melanogaster
Functional Description
(View)

Functional Description



     Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes.
Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes.
Protein Sequence
(Fasta)
MKMVLSQRQR EELNQAIADY LGSNGYADSL ETFRKEADLS TEVEKKFGGL LEKKWTSVIR 60
LQKKVMELEA KLTEAEKEVI EGAPTKNKRT PGEWIPRPPE KFSLTGHRAS ITRVIFHPIF 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Dme-031745|E3,WD_repeat;UBD,Beta-Prp|Drosophila melanogaster
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CCACTGCGGT CACACTAATC GAAGCATTTT CGTCCGCTCG TCACTTTTCT GCGTAATTCT 60
TTTCGTATAT TTCGATTAAA CATAAATAAA TAAGCGTAAT TATAAATATA TGAAATACTA 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Dme-031745|E3,WD_repeat;UBD,Beta-Prp|Drosophila melanogaster
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0378--Hydrolase
KW-0493--Microtubule
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08513--LisH
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00667--LisH
SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:0005815--C:microtubule organizing center
GO:0016787--F:hydrolase activity
GO:0051301--P:cell division
GO:0000132--P:establishment of mitotic spindle orientation
GO:0007067--P:mitotic nuclear division
GO:0006810--P:transport

KEGG dme:Dmel_CG8440
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001589 Ailuropoda melanoleuca 69.50 3.00e-173 600.00
IUUC-Apl-004024 Anas platyrhynchos 69.83 5.00e-179 619.00
IUUC-Aca-004564 Anolis carolinensis 69.59 4.00e-177 613.00
IUUC-Ago-007862 Ashbya gossypii 28.70 2.00e-39 155.00
IUUC-Acl-008360 Aspergillus clavatus 45.45 7.00e-99 353.00
IUUC-Afl-008502 Aspergillus flavus 44.91 1.00e-90 325.00
IUUC-Afu-008848 Aspergillus fumigatus 45.02 5.00e-100 357.00
IUUC-Ani-009173 Aspergillus nidulans 43.75 2.00e-86 311.00
IUUC-Ang-009873 Aspergillus niger 43.47 9.00e-87 313.00
IUUC-Aor-009973 Aspergillus oryzae 43.61 3.00e-89 321.00
IUUC-Ate-010523 Aspergillus terreus 42.86 3.00e-86 311.00
IUUC-Ame-010969 Astyanax mexicanus 70.56 0.00e+00 627.00
IUUC-Bgr-011972 Blumeria graminis 44.72 1.00e-97 349.00
IUUC-Bta-013106 Bos taurus 70.07 3.00e-179 620.00
IUUC-Bci-013615 Botrytis cinerea 45.70 1.00e-95 342.00
IUUC-Cel-018459 Caenorhabditis elegans 56.72 2.00e-145 507.00
IUUC-Cja-018755 Callithrix jacchus 67.88 6.00e-174 602.00
IUUC-Cfa-020749 Canis familiaris 70.07 3.00e-179 620.00
IUUC-Cpo-022371 Cavia porcellus 70.07 3.00e-179 620.00
IUUC-Cre-022578 Chlamydomonas reinhardtii 35.42 5.00e-49 186.00
IUUC-Csa-023524 Chlorocebus sabaeus 69.65 5.00e-151 526.00
IUUC-Cho-024764 Choloepus hoffmanni 63.24 3.00e-141 493.00
IUUC-Cin-025753 Ciona intestinalis 63.11 7.00e-163 565.00
IUUC-Csv-025817 Ciona savignyi 65.04 1.00e-168 585.00
IUUC-Cgl-026529 Colletotrichum gloeosporioides 45.23 8.00e-91 326.00
IUUC-Cne-027087 Cryptococcus neoformans 50.26 1.00e-100 358.00
IUUC-Dre-028314 Danio rerio 70.56 0.00e+00 628.00
IUUC-Dno-029050 Dasypus novemcinctus 69.83 4.00e-179 619.00
IUUC-Dor-030222 Dipodomys ordii 64.48 4.00e-160 556.00
IUUC-Dse-031164 Dothistroma septosporum 44.04 7.00e-97 346.00
IUUC-Ete-032508 Echinops telfairi 58.88 4.00e-140 490.00
IUUC-Eca-034288 Equus caballus 69.00 4.00e-172 596.00
IUUC-Eeu-034984 Erinaceus europaeus 64.23 6.00e-159 552.00
IUUC-Fca-036498 Felis catus 70.07 3.00e-179 620.00
IUUC-Fal-036920 Ficedula albicollis 69.83 5.00e-179 619.00
IUUC-Fox-037996 Fusarium oxysporum 46.34 8.00e-97 346.00
IUUC-Fso-038160 Fusarium solani 43.90 5.00e-94 337.00
IUUC-Gmo-038983 Gadus morhua 71.29 0.00e+00 633.00
IUUC-Ggr-040051 Gaeumannomyces graminis 44.39 6.00e-92 330.00
IUUC-Gga-040623 Gallus gallus 69.83 5.00e-179 619.00
IUUC-Gac-041613 Gasterosteus aculeatus 71.05 0.00e+00 632.00
IUUC-Ggo-045410 Gorilla gorilla 62.81 2.00e-147 514.00
IUUC-Hsa-046358 Homo sapiens 70.07 5.00e-179 619.00
IUUC-Itr-047890 Ictidomys tridecemlineatus 70.07 3.00e-179 620.00
IUUC-Kpa-049351 Komagataella pastoris 28.60 9.00e-42 163.00
IUUC-Lch-049936 Latimeria chalumnae 69.83 5.00e-179 619.00
IUUC-Loc-052476 Lepisosteus oculatus 69.75 4.00e-174 603.00
IUUC-Lma-053170 Leptosphaeria maculans 46.42 5.00e-95 340.00
IUUC-Laf-053713 Loxodonta africana 68.54 2.00e-174 604.00
IUUC-Mcc-054628 Macaca mulatta 69.83 1.00e-178 617.00
IUUC-Meu-055927 Macropus eugenii 60.43 9.00e-98 348.00
IUUC-Mor-056962 Magnaporthe oryzae 43.31 1.00e-90 325.00
IUUC-Mpo-057583 Magnaporthe poae 44.15 2.00e-91 328.00
IUUC-Mla-058819 Melampsora laricipopulina 47.54 4.00e-109 387.00
IUUC-Mga-059945 Meleagris gallopavo 70.07 2.00e-179 620.00
IUUC-Mvi-060403 Microbotryum violaceum 47.20 2.00e-118 417.00
IUUC-Mmr-061289 Microcebus murinus 69.50 3.00e-173 600.00
IUUC-Mdo-061912 Monodelphis domestica 69.59 5.00e-178 615.00
IUUC-Mmu-063253 Mus musculus 70.07 3.00e-179 620.00
IUUC-Mpu-066638 Mustela putorius furo 70.07 3.00e-179 620.00
IUUC-Mlu-067267 Myotis lucifugus 68.22 2.00e-174 604.00
IUUC-Nfi-068571 Neosartorya fischeri 43.68 3.00e-92 331.00
IUUC-Ncr-068895 Neurospora crassa 48.66 2.00e-99 354.00
IUUC-Nle-069087 Nomascus leucogenys 69.25 5.00e-141 493.00
IUUC-Opr-070579 Ochotona princeps 69.83 4.00e-179 619.00
IUUC-Ont-071905 Oreochromis niloticus 71.29 0.00e+00 629.00
IUUC-Oan-073072 Ornithorhynchus anatinus 70.07 3.00e-179 620.00
IUUC-Ocu-074180 Oryctolagus cuniculus 69.83 4.00e-179 619.00
IUUC-Ola-086815 Oryzias latipes 71.05 0.00e+00 630.00
IUUC-Oga-088219 Otolemur garnettii 68.05 6.00e-174 602.00
IUUC-Oar-090394 Ovis aries 70.07 3.00e-179 620.00
IUUC-Ptr-091517 Pan troglodytes 70.07 3.00e-179 620.00
IUUC-Pan-092421 Papio anubis 69.83 1.00e-178 617.00
IUUC-Psi-093370 Pelodiscus sinensis 69.59 2.00e-178 617.00
IUUC-Pma-094319 Petromyzon marinus 67.71 1.00e-145 508.00
IUUC-Pno-094815 Phaeosphaeria nodorum 47.42 4.00e-100 357.00
IUUC-Pfo-096228 Poecilia formosa 70.32 0.00e+00 625.00
IUUC-Pab-098421 Pongo abelii 70.07 3.00e-179 620.00
IUUC-Pca-100120 Procavia capensis 50.62 7.00e-111 392.00
IUUC-Pva-102960 Pteropus vampyrus 69.83 7.00e-178 615.00
IUUC-Pgr-103538 Puccinia graminis 46.22 1.00e-109 389.00
IUUC-Ptt-103990 Puccinia triticina 41.77 7.00e-44 171.00
IUUC-Pte-104261 Pyrenophora teres 47.91 4.00e-101 360.00
IUUC-Pyt-104780 Pyrenophora triticirepentis 48.16 1.00e-101 362.00
IUUC-Rno-105123 Rattus norvegicus 70.07 3.00e-179 620.00
IUUC-Sha-107010 Sarcophilus harrisii 69.83 2.00e-178 617.00
IUUC-Sja-107899 Schizosaccharomyces japonicus 33.56 3.00e-61 228.00
IUUC-Ssl-108571 Sclerotinia sclerotiorum 45.45 2.00e-95 342.00
IUUC-Sar-113309 Sorex araneus 68.75 2.00e-170 590.00
IUUC-Sre-115003 Sporisorium reilianum 51.52 1.00e-118 419.00
IUUC-Ssc-116148 Sus scrofa 70.07 3.00e-179 620.00
IUUC-Tgu-117299 Taeniopygia guttata 69.83 6.00e-179 619.00
IUUC-Tru-118179 Takifugu rubripes 71.05 0.00e+00 627.00
IUUC-Tsy-119493 Tarsius syrichta 69.59 5.00e-177 612.00
IUUC-Tni-120355 Tetraodon nigroviridis 70.32 4.00e-177 613.00
IUUC-Tre-121977 Trichoderma reesei 40.34 5.00e-91 327.00
IUUC-Tvi-122661 Trichoderma virens 40.77 3.00e-90 324.00
IUUC-Tme-127031 Tuber melanosporum 47.39 3.00e-97 348.00
IUUC-Tbe-127492 Tupaia belangeri 46.45 2.00e-88 318.00
IUUC-Ttr-128929 Tursiops truncatus 70.07 6.00e-179 619.00
IUUC-Uma-129347 Ustilago maydis 46.58 2.00e-116 411.00
IUUC-Vda-129837 Verticillium dahliae 44.99 9.00e-94 336.00
IUUC-Vpa-130532 Vicugna pacos 59.17 2.00e-132 464.00
IUUC-Xtr-131985 Xenopus tropicalis 69.59 3.00e-180 623.00
IUUC-Xma-133469 Xiphophorus maculatus 70.56 0.00e+00 625.00
IUUC-Yli-134403 Yarrowia lipolytica 39.73 2.00e-72 265.00
Created Date 25-Jun-2017

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