• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Dme-031576
Ensembl Protein ID FBpp0089115
UniProt Accession P16371; A4V3F6; Q0KI08; Q7KRZ4; Q9V3F7; GROU_DROME
Genbank Protein ID AAA28512.1; AAF56557.1; AAN14068.1; AAN14069.1; AAS65218.1; AAD38670.1
Protein Name Protein groucho; Enhancer of split m9/10 protein
Genbank Nucleotide ID M20571; AE014297; AE014297; AE014297; AE014297; AF145695
Gene Name gro; E(spl)m9/m10; CG8384
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0001139 FBtr0084962 FBpp0084336
FBgn0001139 FBtr0302952 FBpp0292078
FBgn0001139 FBtr0337057 FBpp0307986
FBgn0001139 FBtr0305047 FBpp0293584
FBgn0001139 FBtr0339900 FBpp0308932
FBgn0001139 FBtr0084966 FBpp0089115
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
Post-translational Modifications (PTMs)
CPLMdbPAFdbPTMPhospho.ELM
UniProtPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 2.80e-22 77.9 574 612
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           gHtd+ +c++  +d  +l++G+ D+t++ WDlr+g++l+
   Q: 574  GHTDGASCIDIsPDgSRLWTGGLDNTVRSWDLREGRQLQ 612
           8***********9999********************998 PP
   
Organism Drosophila melanogaster
Functional Description
(View)

Functional Description


     Transcriptional corepressor that regulates transcription when recruited to specific target DNA by hairy-related bHLH proteins. Maternally required for neurogenesis; in the segregation of the neuroectoderm. Directly or indirectly interacts with Notch and Delta.
 Transcriptional corepressor that regulates transcription when recruited to specific target DNA by hairy-related bHLH proteins. Maternally required for neurogenesis; in the segregation of the neuroectoderm. Directly or indirectly interacts with Notch and Delta.
Protein Sequence
(Fasta)
MYPSPVRHPA AGGPPPQGPI KFTIADTLER IKEEFNFLQA QYHSIKLECE KLSNEKTEMQ 60
RHYVMYYEMS YGLNVEMHKQ TEIAKRLNTL INQLLPFLQA DHQQQVLQAV ERAKQVTMQE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Dme-031576|E3,WD_repeat|Drosophila melanogaster
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACACATCGAT AGGCGATAGC GCAAATTGCA TACCTGAGAC CGACGCGGTC TGTGTGTCGC 60
GGATAGGAAA ATAGGAAATT ATAAATAGAA ACGGGCCGTG CCGATGCCCC AAAAGCCACC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Dme-031576|E3,WD_repeat|Drosophila melanogaster
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0524--Neurogenesis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0853--WD repeat
KW-0879--Wnt signaling pathway
Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR005617--Groucho/TLE_N
IPR009146--Groucho_enhance
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF03920--TLE_N
PF00400--WD40
PRINTS

PR01850--GROUCHOFAMLY
SMART

SM00320--WD40
Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0043234--C:protein complex
GO:0071906--F:CRD domain binding
GO:0071837--F:HMG box domain binding
GO:0070491--F:repressing transcription factor binding
GO:0001106--F:RNA polymerase II transcription corepressor activity
GO:0003714--F:transcription corepressor activity
GO:0008134--F:transcription factor binding
GO:0007015--P:actin filament organization
GO:0048813--P:dendrite morphogenesis
GO:0046331--P:lateral inhibition
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0045879--P:negative regulation of smoothened signaling pathway
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0030178--P:negative regulation of Wnt signaling pathway
GO:0007399--P:nervous system development
GO:0006355--P:regulation of transcription, DNA-templated
GO:0007541--P:sex determination, primary response to X:A ratio
GO:0006351--P:transcription, DNA-templated
GO:0016055--P:Wnt signaling pathway
KEGG dme:Dmel_CG8384
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001359 Ailuropoda melanoleuca 86.03 0.00e+00 662.00
IUUC-Apl-003594 Anas platyrhynchos 86.03 0.00e+00 657.00
IUUC-Aca-005279 Anolis carolinensis 86.31 0.00e+00 664.00
IUUC-Ame-010724 Astyanax mexicanus 85.47 0.00e+00 660.00
IUUC-Bta-012646 Bos taurus 86.03 0.00e+00 664.00
IUUC-Cel-018361 Caenorhabditis elegans 56.34 4.00e-116 410.00
IUUC-Cja-019079 Callithrix jacchus 86.03 0.00e+00 664.00
IUUC-Cfa-020987 Canis familiaris 86.03 0.00e+00 663.00
IUUC-Cpo-021606 Cavia porcellus 86.03 0.00e+00 663.00
IUUC-Csa-023445 Chlorocebus sabaeus 86.03 0.00e+00 662.00
IUUC-Cho-024590 Choloepus hoffmanni 89.94 0.00e+00 641.00
IUUC-Cin-025767 Ciona intestinalis 76.79 2.00e-158 551.00
IUUC-Csv-026174 Ciona savignyi 76.19 6.00e-152 530.00
IUUC-Dre-028326 Danio rerio 84.92 0.00e+00 652.00
IUUC-Dno-029011 Dasypus novemcinctus 85.75 0.00e+00 656.00
IUUC-Dor-030533 Dipodomys ordii 85.75 0.00e+00 657.00
IUUC-Ete-032533 Echinops telfairi 86.29 0.00e+00 646.00
IUUC-Eca-034397 Equus caballus 86.03 0.00e+00 663.00
IUUC-Eeu-034666 Erinaceus europaeus 85.47 0.00e+00 654.00
IUUC-Fca-036030 Felis catus 86.03 0.00e+00 664.00
IUUC-Fal-037460 Ficedula albicollis 86.31 0.00e+00 664.00
IUUC-Gmo-038805 Gadus morhua 86.11 0.00e+00 658.00
IUUC-Gga-040416 Gallus gallus 86.31 0.00e+00 664.00
IUUC-Gac-042392 Gasterosteus aculeatus 86.03 0.00e+00 665.00
IUUC-Ggo-045633 Gorilla gorilla 86.03 0.00e+00 662.00
IUUC-Hsa-046461 Homo sapiens 86.03 0.00e+00 662.00
IUUC-Itr-048974 Ictidomys tridecemlineatus 86.03 0.00e+00 662.00
IUUC-Lch-049943 Latimeria chalumnae 86.87 0.00e+00 666.00
IUUC-Loc-052835 Lepisosteus oculatus 86.59 0.00e+00 664.00
IUUC-Laf-053425 Loxodonta africana 86.03 0.00e+00 663.00
IUUC-Mcc-055766 Macaca mulatta 86.03 0.00e+00 662.00
IUUC-Meu-056209 Macropus eugenii 85.75 0.00e+00 655.00
IUUC-Mga-059792 Meleagris gallopavo 83.90 7.00e-170 589.00
IUUC-Mmr-061317 Microcebus murinus 86.03 0.00e+00 662.00
IUUC-Mdo-061897 Monodelphis domestica 84.92 0.00e+00 657.00
IUUC-Mmu-063576 Mus musculus 86.03 0.00e+00 662.00
IUUC-Mpu-066410 Mustela putorius furo 86.03 0.00e+00 662.00
IUUC-Mlu-067456 Myotis lucifugus 86.03 0.00e+00 665.00
IUUC-Nle-069495 Nomascus leucogenys 86.03 0.00e+00 662.00
IUUC-Opr-070645 Ochotona princeps 86.03 0.00e+00 661.00
IUUC-Ont-071419 Oreochromis niloticus 86.31 0.00e+00 666.00
IUUC-Oan-072842 Ornithorhynchus anatinus 81.79 0.00e+00 654.00
IUUC-Ocu-074453 Oryctolagus cuniculus 86.03 0.00e+00 662.00
IUUC-Ola-087267 Oryzias latipes 86.35 0.00e+00 660.00
IUUC-Oga-087939 Otolemur garnettii 86.03 0.00e+00 663.00
IUUC-Oar-090347 Ovis aries 86.03 0.00e+00 662.00
IUUC-Ptr-091048 Pan troglodytes 86.03 0.00e+00 662.00
IUUC-Pan-091973 Papio anubis 86.03 0.00e+00 662.00
IUUC-Psi-093586 Pelodiscus sinensis 86.31 0.00e+00 663.00
IUUC-Pma-094546 Petromyzon marinus 84.96 0.00e+00 662.00
IUUC-Pfo-097518 Poecilia formosa 86.59 0.00e+00 667.00
IUUC-Pab-097539 Pongo abelii 86.03 0.00e+00 661.00
IUUC-Pca-101137 Procavia capensis 85.75 0.00e+00 658.00
IUUC-Pva-103037 Pteropus vampyrus 86.03 0.00e+00 664.00
IUUC-Rno-104864 Rattus norvegicus 84.92 0.00e+00 657.00
IUUC-Sha-106486 Sarcophilus harrisii 86.03 0.00e+00 660.00
IUUC-Sar-113414 Sorex araneus 82.82 2.00e-163 568.00
IUUC-Ssc-116408 Sus scrofa 86.03 0.00e+00 664.00
IUUC-Tgu-117068 Taeniopygia guttata 86.31 0.00e+00 665.00
IUUC-Tru-118424 Takifugu rubripes 85.75 0.00e+00 662.00
IUUC-Tsy-118884 Tarsius syrichta 86.03 0.00e+00 657.00
IUUC-Tni-120823 Tetraodon nigroviridis 86.03 0.00e+00 666.00
IUUC-Tbe-127881 Tupaia belangeri 85.47 0.00e+00 654.00
IUUC-Ttr-129285 Tursiops truncatus 86.03 0.00e+00 664.00
IUUC-Vpa-130577 Vicugna pacos 92.50 3.00e-90 325.00
IUUC-Xtr-132974 Xenopus tropicalis 85.60 0.00e+00 655.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved