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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046751
Ensembl Protein ID ENSP00000363117.3
UniProt Accession P09769; D3DPL7; Q9UIQ3; FGR_HUMAN
Genbank Protein ID AAA52451.1; CAB62998.1; EAX07748.1; EAX07749.1; EAX07750.1; AAH64382.1; CAA36457.2; CAA36457.2; AAA52762.1; AAA52762.1; AAA52762.1; AAA52762.1; AAA52762.1; AAA52762.1
Protein Name Tyrosine-protein kinase Fgr; Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog; Proto-oncogene c-Fgr; p55-Fgr; p58-Fgr; p58c-Fgr
Genbank Nucleotide ID M19722; AL031729; CH471059; CH471059; CH471059; BC064382; X52207; X52208; M12724; M12719; M12720; M12721; M12722; M12723
Gene Name FGR; SRC2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000000938.12 ENST00000374005.7 ENSP00000363117.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
microRNATRANSFACTargetScanRepTar
SomamiRmiRcodeRAID2LncRNADisease
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
GWASdbGWAS CentralOMIM
Drug and target
TTDGRAC
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMHPRD
Phospho.ELMUniProtPHOSIDABioGRID
mUbiSiDa
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 9.00e-16 59.2 81 137
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           ++++lydyea ++d+Lt++kG++ +++  ++++++W+++ +  +gk G +P+n+v+ ++
   Q: 81   LFIALYDYEARTEDDLTFTKGEKFHIL--NNTEGDWWEARSLSSGKTGCIPSNYVAPVD 137
           5789***********************..8999**********************9987 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1.
 Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1.
Protein Sequence
(Fasta)
MGCVFCKKLE PVATAKEDAG LEGDFRSYGA ADHYGPDPTK ARPASSFAHI PNYSNFSSQA 60
INPGFLDSGT IRGVSGIGVT LFIALYDYEA RTEDDLTFTK GEKFHILNNT EGDWWEARSL 120
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Protein Fasta Sequence


>IUUC-Hsa-046751|UBD,SH3|Homo sapiens
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Nucleotide Sequence
(Fasta)
GGCTTGGGGC TAGGGCGTGA CTGTCTCCCT GCCACCATCA CCGCCCGCCG GCCGTGACTG 60
CAATAAGAGA AGTCCGAGGC GGCTTCCTCC TCCCTGCCCA GCAGGGGCGG CGGTCAGAGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046751|UBD,SH3|Homo sapiens
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Sequence Source Ensembl
Keyword

KW-0067--ATP-binding
KW-1003--Cell membrane
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0391--Immunity
KW-0399--Innate immunity
KW-0418--Kinase
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0496--Mitochondrion
KW-0999--Mitochondrion inner membrane
KW-0519--Myristate
KW-0547--Nucleotide-binding
KW-0564--Palmitate
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase
KW-0832--Ubl conjugation
Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom
PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3
Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1
PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE
SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc
Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0016235--C:aggresome
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005576--C:extracellular region
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005743--C:mitochondrial inner membrane
GO:0005758--C:mitochondrial intermembrane space
GO:0005886--C:plasma membrane
GO:0032587--C:ruffle membrane
GO:0034774--C:secretory granule lumen
GO:0005524--F:ATP binding
GO:0034988--F:Fc-gamma receptor I complex binding
GO:0034987--F:immunoglobulin receptor binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0001784--F:phosphotyrosine binding
GO:0019901--F:protein kinase binding
GO:0004713--F:protein tyrosine kinase activity
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0050830--P:defense response to Gram-positive bacterium
GO:0038096--P:Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0002768--P:immune response-regulating cell surface receptor signaling pathway
GO:0045087--P:innate immune response
GO:0007229--P:integrin-mediated signaling pathway
GO:0043312--P:neutrophil degranulation
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0018108--P:peptidyl-tyrosine phosphorylation
GO:0030335--P:positive regulation of cell migration
GO:0050715--P:positive regulation of cytokine secretion
GO:0043306--P:positive regulation of mast cell degranulation
GO:0043552--P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0046777--P:protein autophosphorylation
GO:0006468--P:protein phosphorylation
GO:0042127--P:regulation of cell proliferation
GO:0008360--P:regulation of cell shape
GO:0045088--P:regulation of innate immune response
GO:0050764--P:regulation of phagocytosis
GO:0045859--P:regulation of protein kinase activity
GO:0009615--P:response to virus
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG hsa:2268
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001938 Ailuropoda melanoleuca 89.22 0.00e+00 989.00
IUUC-Bta-012607 Bos taurus 89.98 0.00e+00 1003.00
IUUC-Cja-018914 Callithrix jacchus 91.30 0.00e+00 1007.00
IUUC-Cfa-020165 Canis familiaris 89.04 0.00e+00 988.00
IUUC-Cpo-021476 Cavia porcellus 88.85 0.00e+00 967.00
IUUC-Csa-023692 Chlorocebus sabaeus 96.98 0.00e+00 1076.00
IUUC-Dno-028920 Dasypus novemcinctus 86.77 0.00e+00 962.00
IUUC-Eca-033581 Equus caballus 90.74 0.00e+00 1010.00
IUUC-Fca-036499 Felis catus 89.22 0.00e+00 998.00
IUUC-Ggo-044640 Gorilla gorilla 99.81 0.00e+00 1105.00
IUUC-Itr-048218 Ictidomys tridecemlineatus 89.79 0.00e+00 985.00
IUUC-Laf-054128 Loxodonta africana 87.15 0.00e+00 978.00
IUUC-Mcc-054715 Macaca mulatta 97.54 0.00e+00 1083.00
IUUC-Meu-056155 Macropus eugenii 82.30 0.00e+00 779.00
IUUC-Mmr-060615 Microcebus murinus 90.24 0.00e+00 985.00
IUUC-Mmu-063286 Mus musculus 84.12 0.00e+00 930.00
IUUC-Mpu-066641 Mustela putorius furo 88.85 0.00e+00 989.00
IUUC-Oan-073486 Ornithorhynchus anatinus 76.94 0.00e+00 857.00
IUUC-Ocu-074552 Oryctolagus cuniculus 88.83 0.00e+00 962.00
IUUC-Oga-088731 Otolemur garnettii 90.74 0.00e+00 1008.00
IUUC-Oar-090207 Ovis aries 89.98 0.00e+00 996.00
IUUC-Ptr-090979 Pan troglodytes 99.62 0.00e+00 1103.00
IUUC-Pan-092188 Papio anubis 97.73 0.00e+00 1087.00
IUUC-Pab-098617 Pongo abelii 98.87 0.00e+00 1096.00
IUUC-Pca-100834 Procavia capensis 78.83 0.00e+00 842.00
IUUC-Rno-104945 Rattus norvegicus 85.07 0.00e+00 924.00
Created Date 25-Jun-2017

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