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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046073
UUCD1 version UUC-HoS-00595
Ensembl Protein ID ENSP00000364885.2
UniProt Accession Q13105; A0AV07; B4DXB4; B7ZLQ9; F5H411; Q15932; Q5JYB2; Q9NUC9; ZBT17_HUMAN
Genbank Protein ID CAA70889.1; BAG63326.1; CAB85445.1; CAI19524.1; AAI26164.1; AAI43966.1; AAA61327.1; AAC50256.1
Protein Name Zinc finger and BTB domain-containing protein 17; Myc-interacting zinc finger protein 1; Zinc finger protein 151; Zinc finger protein 60
Genbank Nucleotide ID Y09723; AK301896; AL034555; AL034555; AL355994; BC143965; M88369; U20647
Gene Name ZBTB17; MIZ1; ZNF151; ZNF60
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000116809.11 ENST00000440560.5 ENSP00000400827.1
ENSG00000116809.11 ENST00000375743.8 ENSP00000364895.4
ENSG00000116809.11 ENST00000537142.5 ENSP00000438529.1
ENSG00000116809.11 ENST00000444358.1 ENSP00000408483.1
ENSG00000116809.11 ENST00000375733.6 ENSP00000364885.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsiteCircNetmiRTarBase
microRNATRANSFACRepTarmiRNAMap
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
GWASdbGWAS CentralOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtBioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB 3.50e-12 48.2 24 85
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_Other: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklden 68
           +D+++vv+g++f+ahk+vLaa+S++F+ lf     +  +k+ v+++   +  + ++l+F+Yt kl+++
   Q: 24   CDCTFVVDGVHFKAHKAVLAACSEYFKMLFV----D--QKDVVHLDISNAAGLGQVLEFMYTAKLSLS 85
           9*****************************2....2..26788888678999************9875 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. Represses RB1 transcription; this repression can be blocked by interaction with ZBTB49 isoform 3/ZNF509S1 (PubMed:25245946).
 Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. Represses RB1 transcription; this repression can be blocked by interaction with ZBTB49 isoform 3/ZNF509S1 (PubMed:25245946).
Protein Sequence
(Fasta)
MDFPQHSQHV LEQLNQQRQL GLLCDCTFVV DGVHFKAHKA VLAACSEYFK MLFVDQKDVV 60
HLDISNAAGL GQVLEFMYTA KLSLSPENVD DVLAVATFLQ MQDIITACHA LKSLAEPATS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046073|E3,BTB_Other|Homo sapiens
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Nucleotide Sequence
(Fasta)
ATGCGCCGGA AGTTGCAGCC GGGAAGCCTG CGAGGTCGGT TCCGCCCGAC TCTAACATGG 60
CGGCGCCCTT TGTCTGCTCT GGAGTGCCGT CCCCGGCCTT CTCGCGGCCG TGATGCACCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046073|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR000210--BTB/POZ_dom
IPR023413--GFP-like
IPR000877--Prot_inh_BBI
IPR004039--Rubredoxin-type_fold
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2
Pfam

PF00651--BTB
SMART

SM00225--BTB
SM00355--ZnF_C2H2
Gene Ontology

GO:0005654--C:nucleoplasm
GO:0046872--F:metal ion binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0007398--P:ectoderm development
GO:0001702--P:gastrulation with mouth forming second
GO:0036498--P:IRE1-mediated unfolded protein response
GO:0045786--P:negative regulation of cell cycle
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:1903146--P:regulation of mitophagy
KEGG hsa:7709
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002207 Ailuropoda melanoleuca 82.46 0.00e+00 685.00
IUUC-Apl-003789 Anas platyrhynchos 72.86 0.00e+00 1016.00
IUUC-Ame-010978 Astyanax mexicanus 78.49 0.00e+00 829.00
IUUC-Bta-012571 Bos taurus 85.50 0.00e+00 1244.00
IUUC-Cja-018730 Callithrix jacchus 95.71 0.00e+00 1421.00
IUUC-Cfa-020463 Canis familiaris 88.62 0.00e+00 1240.00
IUUC-Cpo-022120 Cavia porcellus 89.59 0.00e+00 1309.00
IUUC-Csa-024263 Chlorocebus sabaeus 95.65 2.00e-99 355.00
IUUC-Dre-027469 Danio rerio 76.45 0.00e+00 823.00
IUUC-Dno-029237 Dasypus novemcinctus 90.40 0.00e+00 1282.00
IUUC-Ete-033053 Echinops telfairi 84.58 0.00e+00 1229.00
IUUC-Eca-033861 Equus caballus 89.90 0.00e+00 1306.00
IUUC-Fca-036528 Felis catus 79.38 8.00e-132 464.00
IUUC-Fal-037166 Ficedula albicollis 89.34 0.00e+00 897.00
IUUC-Gmo-038904 Gadus morhua 74.90 0.00e+00 810.00
IUUC-Gga-040721 Gallus gallus 86.74 0.00e+00 913.00
IUUC-Gac-041298 Gasterosteus aculeatus 71.59 0.00e+00 789.00
IUUC-Ggo-045394 Gorilla gorilla 99.01 0.00e+00 1446.00
IUUC-Itr-048299 Ictidomys tridecemlineatus 91.73 0.00e+00 1366.00
IUUC-Lch-050218 Latimeria chalumnae 72.79 0.00e+00 725.00
IUUC-Loc-052153 Lepisosteus oculatus 73.90 0.00e+00 785.00
IUUC-Laf-053829 Loxodonta africana 90.98 0.00e+00 1348.00
IUUC-Mcc-055270 Macaca mulatta 83.70 0.00e+00 1191.00
IUUC-Meu-056271 Macropus eugenii 92.50 0.00e+00 993.00
IUUC-Mga-059305 Meleagris gallopavo 69.00 0.00e+00 982.00
IUUC-Mmr-060760 Microcebus murinus 92.68 0.00e+00 1361.00
IUUC-Mdo-062280 Monodelphis domestica 77.02 0.00e+00 1186.00
IUUC-Mmu-064100 Mus musculus 89.63 0.00e+00 1375.00
IUUC-Mpu-066286 Mustela putorius furo 77.89 2.00e-173 602.00
IUUC-Mlu-067394 Myotis lucifugus 90.74 0.00e+00 1299.00
IUUC-Nle-069713 Nomascus leucogenys 94.65 0.00e+00 1248.00
IUUC-Opr-071195 Ochotona princeps 88.21 0.00e+00 1252.00
IUUC-Ont-071808 Oreochromis niloticus 75.88 0.00e+00 817.00
IUUC-Oan-072892 Ornithorhynchus anatinus 90.38 0.00e+00 918.00
IUUC-Ocu-074812 Oryctolagus cuniculus 92.10 0.00e+00 1340.00
IUUC-Oga-088345 Otolemur garnettii 92.05 0.00e+00 1379.00
IUUC-Oar-089992 Ovis aries 93.83 4.00e-112 399.00
IUUC-Ptr-091414 Pan troglodytes 97.78 0.00e+00 1459.00
IUUC-Pan-091888 Papio anubis 97.04 0.00e+00 1459.00
IUUC-Psi-094055 Pelodiscus sinensis 83.79 0.00e+00 866.00
IUUC-Pfo-096787 Poecilia formosa 77.14 0.00e+00 793.00
IUUC-Pab-098341 Pongo abelii 98.52 0.00e+00 1443.00
IUUC-Pca-100832 Procavia capensis 91.82 0.00e+00 1243.00
IUUC-Pva-102905 Pteropus vampyrus 93.06 0.00e+00 1283.00
IUUC-Rno-105884 Rattus norvegicus 88.74 0.00e+00 1353.00
IUUC-Sha-107460 Sarcophilus harrisii 63.65 0.00e+00 907.00
IUUC-Sar-113442 Sorex araneus 86.59 0.00e+00 1141.00
IUUC-Ssc-115342 Sus scrofa 83.33 0.00e+00 1161.00
IUUC-Tgu-117348 Taeniopygia guttata 90.40 0.00e+00 835.00
IUUC-Tru-118668 Takifugu rubripes 73.80 0.00e+00 805.00
IUUC-Tni-120159 Tetraodon nigroviridis 73.02 0.00e+00 795.00
IUUC-Tbe-127424 Tupaia belangeri 69.14 2.00e-178 619.00
IUUC-Ttr-128620 Tursiops truncatus 91.70 0.00e+00 1118.00
Created Date 25-Jun-2017

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