iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000197122.11	ENST00000373578.6	ENSP00000362680.2
ENSG00000197122.11	ENST00000373558.2	ENSP00000362659.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	miRWalk
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
ClinVar	GWASdb	OMIM
Drug and target
TTD	KPID	GRAC	PDTD
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	HPRD
Phospho.ELM	UniProt	PHOSIDA	BioGRID
mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	5.90e-12	47.0	88	148

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlvi....ekeeqdegWlkgvkelegkrGlfPenFvek 61
           ++ +lydye+ ++ +L++kkG+ ++++    + +  +++W+ + +  +g+ G +P+n+v+ 
   Q: 88   TFVALYDYESRTETDLSFKKGERLQIVnntrKVDVREGDWWLAHSLSTGQTGYIPSNYVAP 148
           5789***********************64444455689********************975 PP

Organism

Homo sapiens

Functional Description
(View)

Functional Description

Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates such as AFAP1. Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1 and to localize to actin filaments. Cytoskeletal reorganization is also controlled through the phosphorylation of cortactin (CTTN). When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN). In addition to phosphorylating focal adhesion proteins, SRC is also active at the sites of cell-cell contact adherens junctions and phosphorylates substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1), and plakoglobin (JUP). Another type of cell-cell junction, the gap junction, is also a target for SRC, which phosphorylates connexin-43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing and phosphorylates RNA-binding proteins such as KHDRBS1. Also plays a role in PDGF-mediated tyrosine phosphorylation of both STAT1 and STAT3, leading to increased DNA binding activity of these transcription factors. Involved in the RAS pathway through phosphorylation of RASA1 and RASGRF1. Plays a role in EGF-mediated calcium-activated chloride channel activation. Required for epidermal growth factor receptor (EGFR) internalization through phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at 'Tyr-1477'. Involved in beta-arrestin (ARRB1 and ARRB2) desensitization through phosphorylation and activation of GRK2, leading to beta-arrestin phosphorylation and internalization. Has a critical role in the stimulation of the CDK20/MAPK3 mitogen-activated protein kinase cascade by epidermal growth factor. Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus. Plays an important role in osteoclastic bone resorption in conjunction with PTK2B/PYK2. Both the formation of a SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for this function. Recruited to activated integrins by PTK2B/PYK2, thereby phosphorylating CBL, which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase. Phosphorylates DDR2 on tyrosine residues, thereby promoting its subsequent autophosphorylation. Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731'. Enhances DDX58/RIG-I-elicited antiviral signaling. Phosphorylates PDPK1 at 'Tyr-9', 'Tyr-373' and 'Tyr-376'. Phosphorylates BCAR1 at 'Tyr-128'. Phosphorylates CBLC at multiple tyrosine residues, phosphorylation at 'Tyr-341' activates CBLC E3 activity. Required for podosome formation (By similarity).

Protein Sequence
(Fasta)

MGSNKSKPKD ASQRRRSLEP AENVHGAGGG AFPASQTPSK PASADGHRGP SAAFAPAAAE 60
PKLFGGFNSS DTVTSPQRAG PLAGGVTTFV ALYDYESRTE TDLSFKKGER LQIVNNTRKV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAAACAAGTG CGGCCATTTC ACCAGCCCAG GCTGGCTTCT GCTGTTGACT GGCTGTGGCA 60
CCTCAAGCAG CCCCTTTCCC CTCTAGCCTC AGTTTATCAC CGCAAGAGCT ACCATTCATC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0130--Cell adhesion
KW-0131--Cell cycle
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0225--Disease mutation
KW-0945--Host-virus interaction
KW-0391--Immunity
KW-0418--Kinase
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0496--Mitochondrion
KW-0999--Mitochondrion inner membrane
KW-0519--Myristate
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase
KW-0832--Ubl conjugation

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005884--C:actin filament
GO:0005901--C:caveola
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005770--C:late endosome
GO:0005764--C:lysosome
GO:0005743--C:mitochondrial inner membrane
GO:0005739--C:mitochondrion
GO:0043005--C:neuron projection
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0002102--C:podosome
GO:0014069--C:postsynaptic density
GO:0032587--C:ruffle membrane
GO:0005524--F:ATP binding
GO:0045296--F:cadherin binding
GO:0019899--F:enzyme binding
GO:0046875--F:ephrin receptor binding
GO:0070851--F:growth factor receptor binding
GO:0020037--F:heme binding
GO:0051427--F:hormone receptor binding
GO:0005178--F:integrin binding
GO:0044325--F:ion channel binding
GO:0016301--F:kinase activity
GO:0019900--F:kinase binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0051219--F:phosphoprotein binding
GO:0004672--F:protein kinase activity
GO:0004713--F:protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0097110--F:scaffold protein binding
GO:0042169--F:SH2 domain binding
GO:0005070--F:SH3/SH2 adaptor activity
GO:0032148--P:activation of protein kinase B activity
GO:0034332--P:adherens junction organization
GO:0086098--P:angiotensin-activated signaling pathway involved in heart process
GO:0007411--P:axon guidance
GO:0045453--P:bone resorption
GO:0060444--P:branching involved in mammary gland duct morphogenesis
GO:0007049--P:cell cycle
GO:0008283--P:cell proliferation
GO:0071398--P:cellular response to fatty acid
GO:0071498--P:cellular response to fluid shear stress
GO:0071456--P:cellular response to hypoxia
GO:0032869--P:cellular response to insulin stimulus
GO:0071222--P:cellular response to lipopolysaccharide
GO:0071375--P:cellular response to peptide hormone stimulus
GO:0036120--P:cellular response to platelet-derived growth factor stimulus
GO:0071393--P:cellular response to progesterone stimulus
GO:0034614--P:cellular response to reactive oxygen species
GO:0007417--P:central nervous system development
GO:0035635--P:entry of bacterium into host cell
GO:0048013--P:ephrin receptor signaling pathway
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0038128--P:ERBB2 signaling pathway
GO:0038096--P:Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0030900--P:forebrain development
GO:0045087--P:innate immune response
GO:0007229--P:integrin-mediated signaling pathway
GO:0030520--P:intracellular estrogen receptor signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0050900--P:leukocyte migration
GO:2000811--P:negative regulation of anoikis
GO:0043066--P:negative regulation of apoptotic process
GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:0051895--P:negative regulation of focal adhesion assembly
GO:2001243--P:negative regulation of intrinsic apoptotic signaling pathway
GO:0051902--P:negative regulation of mitochondrial depolarization
GO:0032463--P:negative regulation of protein homooligomerization
GO:0051974--P:negative regulation of telomerase activity
GO:0032211--P:negative regulation of telomere maintenance via telomerase
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0048011--P:neurotrophin TRK receptor signaling pathway
GO:0048477--P:oogenesis
GO:0036035--P:osteoclast development
GO:0018105--P:peptidyl-serine phosphorylation
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0018108--P:peptidyl-tyrosine phosphorylation
GO:0030168--P:platelet activation
GO:0048008--P:platelet-derived growth factor receptor signaling pathway
GO:0043065--P:positive regulation of apoptotic process
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0045737--P:positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0050715--P:positive regulation of cytokine secretion
GO:2000573--P:positive regulation of DNA biosynthetic process
GO:0010634--P:positive regulation of epithelial cell migration
GO:0070374--P:positive regulation of ERK1 and ERK2 cascade
GO:0010907--P:positive regulation of glucose metabolic process
GO:0046628--P:positive regulation of insulin receptor signaling pathway
GO:0033625--P:positive regulation of integrin activation
GO:2000394--P:positive regulation of lamellipodium morphogenesis
GO:0043406--P:positive regulation of MAP kinase activity
GO:0050731--P:positive regulation of peptidyl-tyrosine phosphorylation
GO:0043552--P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0010641--P:positive regulation of platelet-derived growth factor receptor signaling pathway
GO:0071803--P:positive regulation of podosome assembly
GO:0031954--P:positive regulation of protein autophosphorylation
GO:0051897--P:positive regulation of protein kinase B signaling
GO:1900182--P:positive regulation of protein localization to nucleus
GO:0010954--P:positive regulation of protein processing
GO:0071902--P:positive regulation of protein serine/threonine kinase activity
GO:0051057--P:positive regulation of small GTPase mediated signal transduction
GO:0014911--P:positive regulation of smooth muscle cell migration
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0050847--P:progesterone receptor signaling pathway
GO:0046777--P:protein autophosphorylation
GO:0031648--P:protein destabilization
GO:0045124--P:regulation of bone resorption
GO:2001286--P:regulation of caveolin-mediated endocytosis
GO:0051726--P:regulation of cell cycle
GO:0060491--P:regulation of cell projection assembly
GO:0042127--P:regulation of cell proliferation
GO:0022407--P:regulation of cell-cell adhesion
GO:2000641--P:regulation of early endosome to late endosome transport
GO:0010632--P:regulation of epithelial cell migration
GO:0033146--P:regulation of intracellular estrogen receptor signaling pathway
GO:0071801--P:regulation of podosome assembly
GO:0043393--P:regulation of protein binding
GO:0043114--P:regulation of vascular permeability
GO:0010447--P:response to acidic pH
GO:0042493--P:response to drug
GO:0051602--P:response to electrical stimulus
GO:0042542--P:response to hydrogen peroxide
GO:0070555--P:response to interleukin-1
GO:0009612--P:response to mechanical stimulus
GO:0051385--P:response to mineralocorticoid
GO:0031667--P:response to nutrient levels
GO:0009615--P:response to virus
GO:0007172--P:signal complex assembly
GO:0007165--P:signal transduction
GO:0016337--P:single organismal cell-cell adhesion
GO:0002223--P:stimulatory C-type lectin receptor signaling pathway
GO:0043149--P:stress fiber assembly
GO:0034446--P:substrate adhesion-dependent cell spreading
GO:0031295--P:T cell costimulation
GO:0045056--P:transcytosis
GO:0007179--P:transforming growth factor beta receptor signaling pathway
GO:0060065--P:uterus development
GO:0048010--P:vascular endothelial growth factor receptor signaling pathway

KEGG

hsa:6714

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001713	Ailuropoda melanoleuca	97.79	0.00e+00	1090.00
IUUC-Aca-004237	Anolis carolinensis	91.14	0.00e+00	1018.00
IUUC-Ame-011887	Astyanax mexicanus	78.28	0.00e+00	874.00
IUUC-Bta-012982	Bos taurus	95.99	0.00e+00	1063.00
IUUC-Bdi-014324	Brachypodium distachyon	35.11	5.00e-23	103.00
IUUC-Cja-019995	Callithrix jacchus	99.63	0.00e+00	1110.00
IUUC-Cfa-020060	Canis familiaris	97.79	0.00e+00	1089.00
IUUC-Cpo-021557	Cavia porcellus	94.46	0.00e+00	1049.00
IUUC-Csa-023711	Chlorocebus sabaeus	99.82	0.00e+00	1111.00
IUUC-Cin-025390	Ciona intestinalis	69.94	0.00e+00	664.00
IUUC-Dre-028491	Danio rerio	82.14	0.00e+00	879.00
IUUC-Dno-029651	Dasypus novemcinctus	93.84	0.00e+00	1052.00
IUUC-Ete-033170	Echinops telfairi	97.60	0.00e+00	930.00
IUUC-Eca-033970	Equus caballus	92.10	0.00e+00	992.00
IUUC-Fca-036113	Felis catus	97.79	0.00e+00	1089.00
IUUC-Fal-036785	Ficedula albicollis	94.46	0.00e+00	1056.00
IUUC-Gga-040899	Gallus gallus	92.62	0.00e+00	1033.00
IUUC-Gac-042332	Gasterosteus aculeatus	80.59	0.00e+00	885.00
IUUC-Ggo-044829	Gorilla gorilla	85.98	0.00e+00	917.00
IUUC-Hvu-047855	Hordeum vulgare	30.71	3.00e-22	100.00
IUUC-Itr-049014	Ictidomys tridecemlineatus	98.71	0.00e+00	1087.00
IUUC-Lch-049892	Latimeria chalumnae	85.71	0.00e+00	954.00
IUUC-Loc-052812	Lepisosteus oculatus	81.42	0.00e+00	887.00
IUUC-Laf-053977	Loxodonta africana	98.52	0.00e+00	1117.00
IUUC-Mcc-055159	Macaca mulatta	97.83	0.00e+00	1100.00
IUUC-Mga-060135	Meleagris gallopavo	94.28	0.00e+00	1056.00
IUUC-Mmr-061168	Microcebus murinus	96.38	0.00e+00	1087.00
IUUC-Mdo-063030	Monodelphis domestica	91.68	0.00e+00	1041.00
IUUC-Mmu-063893	Mus musculus	98.89	0.00e+00	1102.00
IUUC-Mpu-066411	Mustela putorius furo	97.79	0.00e+00	1089.00
IUUC-Mlu-068139	Myotis lucifugus	97.79	0.00e+00	1083.00
IUUC-Nle-070178	Nomascus leucogenys	96.49	0.00e+00	1041.00
IUUC-Ont-072130	Oreochromis niloticus	81.16	0.00e+00	910.00
IUUC-Ocu-074403	Oryctolagus cuniculus	96.32	0.00e+00	1061.00
IUUC-Ogu-078962	Oryza glumaepatula	34.25	1.00e-23	105.00
IUUC-Oin-079172	Oryza indica	34.25	1.00e-23	105.00
IUUC-Olo-080286	Oryza longistaminata	34.25	1.00e-23	105.00
IUUC-Ome-081400	Oryza meridionalis	34.25	8.00e-24	105.00
IUUC-Oni-082734	Oryza nivara	34.25	2.00e-23	104.00
IUUC-Oru-084741	Oryza rufipogon	34.25	1.00e-23	105.00
IUUC-Osa-085779	Oryza sativa	35.16	2.00e-23	105.00
IUUC-Ola-086527	Oryzias latipes	80.80	0.00e+00	912.00
IUUC-Oga-088493	Otolemur garnettii	98.71	0.00e+00	1100.00
IUUC-Oar-090279	Ovis aries	96.34	0.00e+00	1065.00
IUUC-Ptr-091050	Pan troglodytes	100.00	0.00e+00	1113.00
IUUC-Pan-091862	Papio anubis	98.71	0.00e+00	1091.00
IUUC-Psi-093071	Pelodiscus sinensis	92.99	0.00e+00	1038.00
IUUC-Pfo-096578	Poecilia formosa	81.49	0.00e+00	921.00
IUUC-Pab-097902	Pongo abelii	97.83	0.00e+00	1100.00
IUUC-Ppe-102072	Prunus persica	34.89	3.00e-26	114.00
IUUC-Pva-103176	Pteropus vampyrus	83.95	0.00e+00	909.00
IUUC-Rno-105847	Rattus norvegicus	98.90	0.00e+00	1098.00
IUUC-Sha-107539	Sarcophilus harrisii	92.80	0.00e+00	1035.00
IUUC-Stu-112331	Solanum tuberosum	32.00	2.00e-22	101.00
IUUC-Sbi-114480	Sorghum bicolor	35.78	1.00e-23	105.00
IUUC-Ssc-115762	Sus scrofa	97.81	0.00e+00	1088.00
IUUC-Tru-117849	Takifugu rubripes	81.68	0.00e+00	885.00
IUUC-Tni-120843	Tetraodon nigroviridis	80.98	0.00e+00	901.00
IUUC-Ttr-128702	Tursiops truncatus	93.17	0.00e+00	1023.00
IUUC-Vvi-131181	Vitis vinifera	33.21	4.00e-22	100.00
IUUC-Xtr-132291	Xenopus tropicalis	87.13	0.00e+00	941.00
IUUC-Xma-133134	Xiphophorus maculatus	81.13	0.00e+00	918.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence