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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063471
UUCD1 version UUC-MuM-01008
Ensembl Protein ID ENSMUSP00000015239.3
UniProt Accession Q9QXW2; A2AJ36; A2AJ37; E9QMP0; Q3U368; FBXW5_MOUSE
Genbank Protein ID AAF09130.1; BAB31841.1; BAE32921.1; CAM25629.1; CAM25630.1; EDL08255.1; AAH10776.1
Protein Name F-box/WD repeat-containing protein 5; F-box and WD-40 domain-containing protein 5
Genbank Nucleotide ID AF176520; AK019715; AK154911; AL732557; AL732557; CH466542; BC010776
Gene Name Fbxw5; Fbw5
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000015095.12 ENSMUST00000015239.9 ENSMUSP00000015239.3
ENSMUSG00000015095.12 ENSMUST00000124375.1 ENSMUSP00000117676.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
miRTarBasemicroRNATRANSFACRepTar
miRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
Post-translational Modifications (PTMs)
CPLMPhosphositePlusmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.60e-12 48.3 91 120
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf..sdtllvsGsdDgtikvWD 29
           Htd v  l+f  s+  ++s+s D+t+k+W+
   Q: 91   HTDQVLHLSFshSGYQFASCSKDCTVKIWN 120
           9*********955588*************9 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication (By similarity). The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression.
 Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication (By similarity). The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression.
Protein Sequence
(Fasta)
MDEGGLPLLP DSLVYQIFLS LGPADVLAAG LVCRQWQAVS RDEFLWKEQF YRYYQVARDV 60
PRHPAATSWY EEFRRLYDMV PCVEVQTLKE HTDQVLHLSF SHSGYQFASC SKDCTVKIWN 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063471|E3,WD_repeat|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GAAGGGGGGG GGGGGGGAAC GGTCCATCGA TGCCTCGGGG CTCTCAGCGT CGAGCCTGGC 60
GCCTCCATAA AGACGTGGAG GTGGAGACTA GAGCGGCGGC GGAAGCCGGG CGCAGCGCAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063471|E3,WD_repeat|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
Interpro

IPR001810--F-box_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50181--FBOX
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF12937--F-box-like
PF00400--WD40
SMART

SM00256--FBOX
SM00320--WD40
Gene Ontology

GO:0080008--C:Cul4-RING E3 ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0019901--F:protein kinase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016567--P:protein ubiquitination
GO:0010824--P:regulation of centrosome duplication
GO:0007088--P:regulation of mitotic nuclear division
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
KEGG mmu:30839
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001942 Ailuropoda melanoleuca 89.22 0.00e+00 993.00
IUUC-Apl-003274 Anas platyrhynchos 76.68 0.00e+00 771.00
IUUC-Aca-004626 Anolis carolinensis 59.74 1.00e-97 349.00
IUUC-Ame-011823 Astyanax mexicanus 59.56 3.00e-176 611.00
IUUC-Bta-012523 Bos taurus 88.85 0.00e+00 999.00
IUUC-Cja-018729 Callithrix jacchus 90.43 0.00e+00 1048.00
IUUC-Cfa-020303 Canis familiaris 88.87 0.00e+00 1003.00
IUUC-Cpo-022134 Cavia porcellus 92.32 0.00e+00 1070.00
IUUC-Csa-023253 Chlorocebus sabaeus 89.57 0.00e+00 1041.00
IUUC-Cin-025742 Ciona intestinalis 35.04 3.00e-84 305.00
IUUC-Dre-027511 Danio rerio 68.40 0.00e+00 727.00
IUUC-Dno-029044 Dasypus novemcinctus 85.39 0.00e+00 984.00
IUUC-Dor-030565 Dipodomys ordii 90.23 0.00e+00 1041.00
IUUC-Dme-031713 Drosophila melanogaster 40.77 9.00e-127 447.00
IUUC-Eca-033709 Equus caballus 87.80 0.00e+00 1003.00
IUUC-Eeu-035093 Erinaceus europaeus 96.13 9.00e-103 367.00
IUUC-Fca-035674 Felis catus 87.80 0.00e+00 1001.00
IUUC-Fal-037104 Ficedula albicollis 74.15 0.00e+00 819.00
IUUC-Gmo-039041 Gadus morhua 62.57 0.00e+00 649.00
IUUC-Gga-041230 Gallus gallus 73.77 0.00e+00 860.00
IUUC-Gac-042594 Gasterosteus aculeatus 61.89 0.00e+00 658.00
IUUC-Ggo-044486 Gorilla gorilla 88.70 0.00e+00 1004.00
IUUC-Hsa-045701 Homo sapiens 88.52 0.00e+00 1002.00
IUUC-Itr-048811 Ictidomys tridecemlineatus 93.19 0.00e+00 1084.00
IUUC-Kpa-049204 Komagataella pastoris 31.88 2.00e-06 48.10
IUUC-Lch-050058 Latimeria chalumnae 69.55 0.00e+00 816.00
IUUC-Loc-052525 Lepisosteus oculatus 69.66 0.00e+00 725.00
IUUC-Laf-054120 Loxodonta africana 87.65 0.00e+00 1007.00
IUUC-Mcc-054915 Macaca mulatta 89.39 0.00e+00 1029.00
IUUC-Meu-056715 Macropus eugenii 74.91 0.00e+00 870.00
IUUC-Mga-059831 Meleagris gallopavo 73.86 0.00e+00 766.00
IUUC-Mvi-060236 Microbotryum violaceum 35.90 2.00e-07 52.00
IUUC-Mmr-060655 Microcebus murinus 89.41 0.00e+00 1037.00
IUUC-Mdo-062641 Monodelphis domestica 80.38 0.00e+00 926.00
IUUC-Mpu-066586 Mustela putorius furo 87.80 0.00e+00 995.00
IUUC-Nle-069429 Nomascus leucogenys 88.87 0.00e+00 1035.00
IUUC-Ont-071780 Oreochromis niloticus 66.15 0.00e+00 709.00
IUUC-Ola-086458 Oryzias latipes 66.38 0.00e+00 725.00
IUUC-Oga-088739 Otolemur garnettii 88.91 0.00e+00 1033.00
IUUC-Oar-089275 Ovis aries 93.02 5.00e-47 178.00
IUUC-Ptr-090716 Pan troglodytes 87.22 0.00e+00 821.00
IUUC-Pan-092182 Papio anubis 81.04 0.00e+00 901.00
IUUC-Psi-093449 Pelodiscus sinensis 73.94 0.00e+00 849.00
IUUC-Pma-094289 Petromyzon marinus 54.43 8.00e-175 607.00
IUUC-Pfo-096062 Poecilia formosa 66.15 0.00e+00 716.00
IUUC-Pab-098726 Pongo abelii 87.48 0.00e+00 1001.00
IUUC-Pca-100163 Procavia capensis 81.91 6.00e-88 318.00
IUUC-Pva-103051 Pteropus vampyrus 86.81 2.00e-132 466.00
IUUC-Rno-105707 Rattus norvegicus 97.73 0.00e+00 1119.00
IUUC-Sha-107074 Sarcophilus harrisii 82.72 0.00e+00 896.00
IUUC-Ssc-116020 Sus scrofa 89.05 0.00e+00 840.00
IUUC-Tgu-116683 Taeniopygia guttata 70.97 8.00e-100 356.00
IUUC-Tru-118143 Takifugu rubripes 66.15 0.00e+00 711.00
IUUC-Tni-120777 Tetraodon nigroviridis 65.76 0.00e+00 719.00
IUUC-Ttr-128439 Tursiops truncatus 88.83 0.00e+00 1013.00
IUUC-Xtr-132774 Xenopus tropicalis 56.83 5.00e-146 511.00
Created Date 25-Jun-2017

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