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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-047003
Ensembl Protein ID ENSP00000272638.9
UniProt Accession Q92575; A8K9W4; Q4ZG56; Q8IYM5; UBXN4_HUMAN
Genbank Protein ID BAF85518.1; ABM90426.1; BAA13437.1; AAX88923.1; EAX11623.1; AAH35594.1
Protein Name UBX domain-containing protein 4; Erasin; UBX domain-containing protein 2
Genbank Nucleotide ID AK292829; EF199840; D87684; BX647662; CH471058; BC035594
Gene Name UBXN4; KIAA0242; UBXD2; UBXDC1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000144224.16 ENST00000272638.13 ENSP00000272638.9
ENSG00000144224.16 ENST00000415164.5 ENSP00000401748.1
ENSG00000144224.16 ENST00000426921.5 ENSP00000410516.1
ENSG00000144224.16 ENST00000416538.5 ENSP00000391586.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtBioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
ULD/UDP/UFD/UBX UBX 16968747
Classification
Family E-value Score Start End
ULD/UDP/UFD/UBX 2.90e-18 67.8 316 393
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   ULD/UDP/UFD/UBX
   S: 2    tteqatlqiRlpdGkrlvrkFpssttleqiyqfveyllvessdpFeLvspfPrrtlkpeehmstlqeagLvpsgsllv 79
           +++ a++q+RlpdG+ ++++Fps+++le+ +qf ++  ++   +F+L + fPrr++++e++++ l +++L+ps+s+++
   Q: 316  RSTVARIQFRLPDGSSFTNQFPSDAPLEEARQFAAQTVGNTYGNFSLATMFPRREFTKEDYKKKLLDLELAPSASVVL 393
           5679***********************************************************************986 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD (PubMed:19822669).
 Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD (PubMed:19822669).
Protein Sequence
(Fasta)
MLWFQGAIPA AIATAKRSGA VFVVFVAGDD EQSTQMAASW EDDKVTEASS NSFVAIKIDT 60
KSEACLQFSQ IYPVVCVPSS FFIGDSGIPL EVIAGSVSAD ELVTRIHKVR QMHLLKSETS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-047003|ULD,UBX|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TTCCTCCACT TCCTGGACTG CGCGACCGGA GGCCTAGCGG GCGCGCGCCC GCACCATCGA 60
CTCGCCAACG AGAGAAGGTC CTGGGGCACG GACACCGACG GGTTGCGACT GTGACGTGAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-047003|ULD,UBX|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0834--Unfolded protein response
Interpro

IPR012336--Thioredoxin-like_fold
IPR029071--Ubiquitin-rel_dom
IPR001012--UBX_dom
PROSITE

PS50033--UBX
Pfam

PF00789--UBX
SMART

SM00166--UBX
Gene Ontology

GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0005635--C:nuclear envelope
GO:0006986--P:response to unfolded protein
GO:0030433--P:ubiquitin-dependent ERAD pathway
KEGG hsa:23190
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000602 Aegilops tauschii 23.56 5.00e-10 59.30
IUUC-Aml-002137 Ailuropoda melanoleuca 87.13 2.00e-101 361.00
IUUC-Apl-003590 Anas platyrhynchos 71.11 1.00e-144 506.00
IUUC-Aca-005239 Anolis carolinensis 68.58 2.00e-158 552.00
IUUC-Aly-005889 Arabidopsis lyrata 28.99 4.00e-12 66.20
IUUC-Ath-007102 Arabidopsis thaliana 31.15 4.00e-12 66.60
IUUC-Ame-010667 Astyanax mexicanus 50.28 2.00e-117 416.00
IUUC-Bta-012601 Bos taurus 91.93 0.00e+00 759.00
IUUC-Bdi-015056 Brachypodium distachyon 22.94 3.00e-08 53.50
IUUC-Cel-018205 Caenorhabditis elegans 28.12 4.00e-10 59.70
IUUC-Cja-018874 Callithrix jacchus 94.71 0.00e+00 855.00
IUUC-Cfa-021091 Canis familiaris 91.54 0.00e+00 733.00
IUUC-Cpo-021590 Cavia porcellus 81.03 0.00e+00 686.00
IUUC-Csa-023978 Chlorocebus sabaeus 98.62 0.00e+00 824.00
IUUC-Cho-024553 Choloepus hoffmanni 74.66 2.00e-161 562.00
IUUC-Cin-025438 Ciona intestinalis 34.80 6.00e-22 97.80
IUUC-Csv-025905 Ciona savignyi 34.90 1.00e-18 85.90
IUUC-Cgl-026427 Colletotrichum gloeosporioides 26.49 1.00e-05 44.30
IUUC-Dre-027410 Danio rerio 58.62 3.00e-21 94.00
IUUC-Dno-029341 Dasypus novemcinctus 83.24 0.00e+00 688.00
IUUC-Dor-030260 Dipodomys ordii 69.83 2.00e-103 369.00
IUUC-Dme-031927 Drosophila melanogaster 40.16 2.00e-12 67.80
IUUC-Ete-032704 Echinops telfairi 71.88 2.00e-97 349.00
IUUC-Eca-033338 Equus caballus 92.73 0.00e+00 727.00
IUUC-Eeu-034735 Erinaceus europaeus 77.80 6.00e-165 573.00
IUUC-Fca-035445 Felis catus 85.15 0.00e+00 688.00
IUUC-Fal-037033 Ficedula albicollis 70.71 2.00e-148 519.00
IUUC-Fox-037707 Fusarium oxysporum 27.07 2.00e-08 53.90
IUUC-Fso-038439 Fusarium solani 29.30 2.00e-06 47.40
IUUC-Gmo-038720 Gadus morhua 59.64 4.00e-66 245.00
IUUC-Ggr-039876 Gaeumannomyces graminis 24.11 4.00e-05 43.10
IUUC-Gga-040965 Gallus gallus 70.96 2.00e-154 539.00
IUUC-Gac-041907 Gasterosteus aculeatus 60.68 7.00e-64 238.00
IUUC-Ggo-044983 Gorilla gorilla 85.16 0.00e+00 658.00
IUUC-Hvu-047128 Hordeum vulgare 22.44 7.00e-11 62.00
IUUC-Itr-047924 Ictidomys tridecemlineatus 96.05 2.00e-126 445.00
IUUC-Lch-049859 Latimeria chalumnae 62.64 8.00e-143 500.00
IUUC-Lpe-050823 Leersia perrieri 24.34 2.00e-11 64.30
IUUC-Loc-052883 Lepisosteus oculatus 67.36 1.00e-77 284.00
IUUC-Laf-053624 Loxodonta africana 92.53 0.00e+00 703.00
IUUC-Mcc-055456 Macaca mulatta 98.82 0.00e+00 827.00
IUUC-Meu-056658 Macropus eugenii 69.16 7.00e-157 547.00
IUUC-Mor-057066 Magnaporthe oryzae 27.68 7.00e-06 45.40
IUUC-Mpo-057604 Magnaporthe poae 25.89 2.00e-05 44.30
IUUC-Mga-059234 Meleagris gallopavo 71.29 4.00e-147 514.00
IUUC-Mmr-060821 Microcebus murinus 94.51 0.00e+00 802.00
IUUC-Mdo-062524 Monodelphis domestica 83.27 0.00e+00 683.00
IUUC-Mmu-064283 Mus musculus 88.39 0.00e+00 726.00
IUUC-Mac-064888 Musa acuminata 32.38 7.00e-13 68.90
IUUC-Mpu-066521 Mustela putorius furo 91.73 0.00e+00 731.00
IUUC-Mlu-067190 Myotis lucifugus 90.57 0.00e+00 695.00
IUUC-Nle-069046 Nomascus leucogenys 98.62 0.00e+00 752.00
IUUC-Opr-071030 Ochotona princeps 82.00 3.00e-80 292.00
IUUC-Ont-072301 Oreochromis niloticus 57.50 7.00e-121 427.00
IUUC-Oan-073577 Ornithorhynchus anatinus 66.53 2.00e-136 478.00
IUUC-Ocu-074086 Oryctolagus cuniculus 93.70 0.00e+00 768.00
IUUC-Oba-075038 Oryza barthii 28.00 4.00e-11 62.80
IUUC-Obr-076558 Oryza brachyantha 26.64 8.00e-11 62.00
IUUC-Ogl-077635 Oryza glaberrima 32.17 5.00e-12 65.90
IUUC-Ogu-078069 Oryza glumaepatula 28.00 2.00e-10 60.80
IUUC-Oin-079112 Oryza indica 33.04 4.00e-12 66.60
IUUC-Olo-080902 Oryza longistaminata 28.00 3.00e-11 63.20
IUUC-Ome-081339 Oryza meridionalis 26.67 3.00e-11 63.50
IUUC-Oni-083032 Oryza nivara 28.00 5.00e-11 62.40
IUUC-Opu-083735 Oryza punctata 26.67 2.00e-09 57.80
IUUC-Oru-084847 Oryza rufipogon 28.00 9.00e-11 61.60
IUUC-Osa-085514 Oryza sativa 33.04 4.00e-12 66.60
IUUC-Ola-087011 Oryzias latipes 63.16 1.00e-41 162.00
IUUC-Oga-089165 Otolemur garnettii 81.80 0.00e+00 749.00
IUUC-Oar-089397 Ovis aries 84.20 0.00e+00 673.00
IUUC-Ptr-091568 Pan troglodytes 96.85 0.00e+00 880.00
IUUC-Pan-092296 Papio anubis 95.91 0.00e+00 857.00
IUUC-Psi-093004 Pelodiscus sinensis 71.12 6.00e-167 580.00
IUUC-Pma-094440 Petromyzon marinus 50.45 9.00e-80 291.00
IUUC-Pno-094996 Phaeosphaeria nodorum 30.00 3.00e-03 36.60
IUUC-Ppa-095357 Physcomitrella patens 29.63 2.00e-09 57.40
IUUC-Pfo-097131 Poecilia formosa 53.92 4.00e-125 441.00
IUUC-Pab-098365 Pongo abelii 88.03 0.00e+00 721.00
IUUC-Pop-099823 Populus trichocarpa 32.74 6.00e-12 65.90
IUUC-Pca-100585 Procavia capensis 93.33 7.00e-108 384.00
IUUC-Ppe-101615 Prunus persica 29.79 5.00e-11 62.80
IUUC-Pva-102447 Pteropus vampyrus 91.48 8.00e-171 593.00
IUUC-Ptt-103907 Puccinia triticina 24.75 6.30e-02 33.10
IUUC-Rno-105184 Rattus norvegicus 88.98 0.00e+00 714.00
IUUC-Sha-107366 Sarcophilus harrisii 81.62 0.00e+00 694.00
IUUC-Sar-113335 Sorex araneus 68.96 3.00e-150 525.00
IUUC-Ssc-115907 Sus scrofa 90.66 5.00e-179 620.00
IUUC-Tgu-116959 Taeniopygia guttata 70.12 5.00e-154 537.00
IUUC-Tru-117812 Takifugu rubripes 60.48 3.00e-75 275.00
IUUC-Tsy-118965 Tarsius syrichta 94.02 3.00e-134 471.00
IUUC-Tni-120776 Tetraodon nigroviridis 57.26 2.00e-71 263.00
IUUC-Tca-121557 Theobroma cacao 33.90 4.00e-10 59.70
IUUC-Tae-124725 Triticum aestivum 33.33 1.00e-10 61.20
IUUC-Tur-126844 Triticum urartu 23.08 1.00e-09 57.80
IUUC-Tme-127065 Tuber melanosporum 28.00 1.00e-06 47.80
IUUC-Tbe-128049 Tupaia belangeri 100.00 5.00e-40 159.00
IUUC-Ttr-128913 Tursiops truncatus 91.34 0.00e+00 710.00
IUUC-Vda-129816 Verticillium dahliae 24.04 6.00e-05 42.40
IUUC-Vpa-130251 Vicugna pacos 91.14 0.00e+00 627.00
IUUC-Vvi-131692 Vitis vinifera 23.71 3.00e-05 43.50
IUUC-Xtr-131944 Xenopus tropicalis 61.84 2.00e-133 469.00
IUUC-Xma-134134 Xiphophorus maculatus 55.75 3.00e-132 465.00
Created Date 25-Jun-2017

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