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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Rno-105820
Ensembl Protein ID ENSRNOP00000032608.4
UniProt Accession B6ID11; B6ID11_RAT
Genbank Protein ID AAI69094.1
Protein Name Ubiquitin-related modifier 1
Genbank Nucleotide ID AC114363
Gene Name Urm1; URM1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000026636.5 ENSRNOT00000037494.5 ENSRNOP00000032608.4
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
miRNAMapRAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
ULD/UDP/UBQ/UBQ_Other 43.43 4.00e-17 80.90 IUUC-Sce-106366
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
 Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Protein Sequence
(Fasta)
MAAPLCVEVE FGGGAELLFD GVKKHQVTLP GQEEPWDIRN LLVWIKTNLL KERPELFIQG 60
DSVRPGILVL INDADWELLG ELDYQLQDQD SILFISTLHG G 101
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Protein Fasta Sequence


>IUUC-Rno-105820|ULD,UBQ_Other|Rattus norvegicus
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Nucleotide Sequence
(Fasta)
GCTAGTTTGG CTTCCTCAAC ATGGCGGCGC CCTTATGTGT GGAGGTGGAG TTCGGGTGAG 60
TGAGATCTGG GTCGCCTTGG GGATGGAGCG AAGCCGTAAG ACCTGAAACT CCGGACCTCC 120
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Nucleotide Fasta Sequence


>IUUC-Rno-105820|ULD,UBQ_Other|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0819--tRNA processing
KW-0833--Ubl conjugation pathway
Interpro

IPR012675--Beta-grasp_dom
IPR016155--Mopterin_synth/thiamin_S_b
IPR015221--Urm1
Pfam

PF09138--Urm1
Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0016783--F:sulfurtransferase activity
GO:0032447--P:protein urmylation
GO:0034227--P:tRNA thio-modification
GO:0002098--P:tRNA wobble uridine modification
KEGG rno:311840
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002254 Ailuropoda melanoleuca 95.05 9.00e-53 197.00
IUUC-Atr-003089 Amborella trichopoda 61.05 4.00e-30 122.00
IUUC-Apl-003382 Anas platyrhynchos 89.01 5.00e-44 168.00
IUUC-Aca-004981 Anolis carolinensis 81.19 3.00e-47 179.00
IUUC-Aly-005517 Arabidopsis lyrata 56.52 4.00e-28 115.00
IUUC-Ath-006718 Arabidopsis thaliana 57.14 9.00e-25 104.00
IUUC-Ago-007917 Ashbya gossypii 43.30 5.00e-20 89.00
IUUC-Acl-008054 Aspergillus clavatus 68.00 3.00e-15 72.80
IUUC-Afl-008704 Aspergillus flavus 55.06 3.00e-20 89.40
IUUC-Aor-009890 Aspergillus oryzae 56.44 2.00e-24 103.00
IUUC-Bta-012448 Bos taurus 95.05 2.00e-52 196.00
IUUC-Bci-013865 Botrytis cinerea 46.53 5.00e-21 92.40
IUUC-Bdi-014980 Brachypodium distachyon 62.34 3.00e-24 102.00
IUUC-Bol-016055 Brassica oleracea 56.25 2.00e-24 103.00
IUUC-Bra-016845 Brassica rapa 56.25 2.00e-24 103.00
IUUC-Cel-018485 Caenorhabditis elegans 34.95 1.00e-11 61.20
IUUC-Cja-019587 Callithrix jacchus 97.03 5.00e-53 198.00
IUUC-Cfa-020653 Canis familiaris 96.04 2.00e-52 196.00
IUUC-Cpo-021622 Cavia porcellus 97.03 5.00e-53 198.00
IUUC-Cre-023015 Chlamydomonas reinhardtii 53.12 4.00e-25 105.00
IUUC-Csa-023756 Chlorocebus sabaeus 96.20 4.00e-40 156.00
IUUC-Cgl-026518 Colletotrichum gloeosporioides 47.42 2.00e-20 90.50
IUUC-Cne-026953 Cryptococcus neoformans 57.28 1.00e-27 114.00
IUUC-Cme-027314 Cyanidioschyzon merolae 42.71 2.00e-17 80.10
IUUC-Dre-027884 Danio rerio 77.23 2.00e-44 169.00
IUUC-Dno-029262 Dasypus novemcinctus 91.36 3.00e-38 150.00
IUUC-Dor-030601 Dipodomys ordii 64.36 5.00e-27 112.00
IUUC-Dme-031893 Drosophila melanogaster 62.75 2.00e-32 129.00
IUUC-Ete-032773 Echinops telfairi 90.10 9.00e-48 181.00
IUUC-Eca-034187 Equus caballus 98.02 4.00e-53 198.00
IUUC-Eeu-034808 Erinaceus europaeus 94.06 5.00e-52 195.00
IUUC-Fca-036107 Felis catus 95.05 2.00e-52 196.00
IUUC-Fal-036607 Ficedula albicollis 86.81 1.00e-42 163.00
IUUC-Fox-037698 Fusarium oxysporum 48.08 1.00e-22 97.80
IUUC-Gmo-039492 Gadus morhua 75.25 2.00e-43 166.00
IUUC-Ggr-039965 Gaeumannomyces graminis 49.04 5.00e-20 90.10
IUUC-Gga-041268 Gallus gallus 86.14 2.00e-48 182.00
IUUC-Gac-042111 Gasterosteus aculeatus 79.21 5.00e-46 174.00
IUUC-Gma-043240 Glycine max 53.57 2.00e-23 99.80
IUUC-Ggo-045176 Gorilla gorilla 93.67 7.00e-32 129.00
IUUC-Hsa-046077 Homo sapiens 94.06 9.00e-45 171.00
IUUC-Itr-048111 Ictidomys tridecemlineatus 95.51 2.00e-38 149.00
IUUC-Kpa-049157 Komagataella pastoris 49.49 8.00e-20 87.80
IUUC-Lch-049889 Latimeria chalumnae 78.22 2.00e-45 172.00
IUUC-Lpe-050783 Leersia perrieri 56.63 6.00e-23 98.60
IUUC-Loc-052400 Lepisosteus oculatus 77.23 1.00e-44 170.00
IUUC-Lma-053259 Leptosphaeria maculans 47.47 8.00e-21 91.70
IUUC-Laf-053596 Loxodonta africana 94.17 4.00e-51 192.00
IUUC-Mcc-054845 Macaca mulatta 89.80 1.00e-46 176.00
IUUC-Meu-055968 Macropus eugenii 91.09 2.00e-50 190.00
IUUC-Mor-057126 Magnaporthe oryzae 45.19 1.00e-18 85.10
IUUC-Mpo-057311 Magnaporthe poae 49.50 8.00e-21 92.40
IUUC-Mtr-058266 Medicago truncatula 51.16 5.00e-23 98.60
IUUC-Mla-058847 Melampsora laricipopulina 41.58 1.00e-12 64.70
IUUC-Mga-059468 Meleagris gallopavo 87.91 3.00e-43 166.00
IUUC-Mvi-060235 Microbotryum violaceum 36.42 4.00e-19 87.00
IUUC-Mdo-061948 Monodelphis domestica 90.10 2.00e-50 189.00
IUUC-Mmu-063946 Mus musculus 97.03 3.00e-53 199.00
IUUC-Mac-064812 Musa acuminata 58.33 9.00e-25 104.00
IUUC-Mpu-066763 Mustela putorius furo 96.04 1.00e-51 193.00
IUUC-Mlu-066970 Myotis lucifugus 97.47 3.00e-40 155.00
IUUC-Ncr-068824 Neurospora crassa 46.46 3.00e-19 86.30
IUUC-Nle-069849 Nomascus leucogenys 94.94 1.00e-39 154.00
IUUC-Opr-070227 Ochotona princeps 97.03 5.00e-53 198.00
IUUC-Ont-072530 Oreochromis niloticus 80.20 7.00e-46 174.00
IUUC-Oan-073191 Ornithorhynchus anatinus 83.51 3.00e-43 165.00
IUUC-Ocu-074460 Oryctolagus cuniculus 95.92 1.00e-50 190.00
IUUC-Oba-075499 Oryza barthii 65.62 1.00e-22 98.60
IUUC-Obr-076896 Oryza brachyantha 56.25 7.00e-22 97.10
IUUC-Ogl-077834 Oryza glaberrima 65.62 4.00e-23 99.00
IUUC-Ogu-078622 Oryza glumaepatula 65.62 4.00e-23 99.00
IUUC-Oin-079358 Oryza indica 65.62 2.00e-22 99.00
IUUC-Olo-081035 Oryza longistaminata 51.55 1.00e-23 102.00
IUUC-Oni-082425 Oryza nivara 65.62 4.00e-23 99.00
IUUC-Opu-083461 Oryza punctata 65.08 2.00e-22 97.80
IUUC-Oru-084875 Oryza rufipogon 59.15 6.00e-21 91.70
IUUC-Oga-089128 Otolemur garnettii 97.03 8.00e-53 197.00
IUUC-Oar-089896 Ovis aries 95.05 2.00e-52 196.00
IUUC-Ptr-091618 Pan troglodytes 93.67 7.00e-32 129.00
IUUC-Pan-092238 Papio anubis 96.20 5.00e-40 156.00
IUUC-Psi-093879 Pelodiscus sinensis 84.16 4.00e-47 179.00
IUUC-Pma-094484 Petromyzon marinus 78.22 1.00e-34 137.00
IUUC-Ppa-095801 Physcomitrella patens 56.79 3.00e-22 96.30
IUUC-Pfo-097192 Poecilia formosa 81.19 7.00e-46 174.00
IUUC-Pab-098203 Pongo abelii 93.07 2.00e-44 169.00
IUUC-Pop-099614 Populus trichocarpa 55.95 7.00e-24 101.00
IUUC-Pca-100507 Procavia capensis 96.20 5.00e-40 155.00
IUUC-Ppe-101174 Prunus persica 57.89 9.00e-29 117.00
IUUC-Pva-102735 Pteropus vampyrus 95.05 4.00e-49 185.00
IUUC-Pgr-103510 Puccinia graminis 39.60 7.00e-12 62.40
IUUC-Ptt-103918 Puccinia triticina 35.64 4.00e-10 56.60
IUUC-Pte-104173 Pyrenophora teres 48.54 6.00e-23 98.60
IUUC-Pyt-104806 Pyrenophora triticirepentis 48.54 7.00e-23 98.60
IUUC-Sce-106366 Saccharomyces cerevisiae 43.43 1.00e-17 80.90
IUUC-Sja-107727 Schizosaccharomyces japonicus 39.58 1.00e-15 74.70
IUUC-Spo-108074 Schizosaccharomyces pombe 39.22 3.00e-09 53.10
IUUC-Smo-108944 Selaginella moellendorffii 60.67 3.00e-26 108.00
IUUC-Sit-110277 Setaria italica 55.95 8.00e-24 101.00
IUUC-Sly-111505 Solanum lycopersicum 54.76 6.00e-25 105.00
IUUC-Stu-112076 Solanum tuberosum 55.95 2.00e-25 106.00
IUUC-Sbi-114274 Sorghum bicolor 57.14 1.00e-23 100.00
IUUC-Sre-114953 Sporisorium reilianum 59.00 1.00e-26 110.00
IUUC-Ssc-115418 Sus scrofa 96.04 1.00e-52 196.00
IUUC-Tgu-117311 Taeniopygia guttata 86.81 2.00e-42 163.00
IUUC-Tru-118598 Takifugu rubripes 82.02 2.00e-40 156.00
IUUC-Tni-120109 Tetraodon nigroviridis 77.45 7.00e-43 164.00
IUUC-Tca-120942 Theobroma cacao 55.42 1.00e-23 100.00
IUUC-Tre-122099 Trichoderma reesei 48.94 8.00e-16 74.70
IUUC-Tvi-122285 Trichoderma virens 51.92 4.00e-20 89.40
IUUC-Tae-125193 Triticum aestivum 56.63 3.00e-23 99.80
IUUC-Tur-126677 Triticum urartu 49.47 1.00e-20 91.70
IUUC-Tme-127120 Tuber melanosporum 48.08 2.00e-23 100.00
IUUC-Tbe-128050 Tupaia belangeri 70.30 2.00e-33 133.00
IUUC-Ttr-129019 Tursiops truncatus 94.06 1.00e-49 186.00
IUUC-Uma-129483 Ustilago maydis 57.00 1.00e-24 104.00
IUUC-Vda-129690 Verticillium dahliae 41.07 4.00e-16 76.30
IUUC-Vvi-131174 Vitis vinifera 57.83 2.00e-24 103.00
IUUC-Xma-133862 Xiphophorus maculatus 81.19 7.00e-46 174.00
IUUC-Yli-134398 Yarrowia lipolytica 47.47 2.00e-19 86.30
IUUC-Zma-134964 Zea mays 58.54 3.00e-22 96.30
Created Date 25-Jun-2017

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