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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-064219
UUCD1 version UUC-MuM-00069
Ensembl Protein ID ENSMUSP00000052258.6
UniProt Accession Q9R049; Q8K008; Q99LH5; AMFR_MOUSE
Genbank Protein ID AAD56721.1; AAH03256.1; AAH34538.1; AAH40338.1
Protein Name E3 ubiquitin-protein ligase AMFR; Autocrine motility factor receptor; RING-type E3 ubiquitin transferase AMFR
Genbank Nucleotide ID AF124144; BC003256; BC034538; BC040338
Gene Name Amfr
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000031751.14 ENSMUST00000053766.13 ENSMUSP00000052258.6
ENSMUSG00000031751.14 ENSMUST00000143265.1 ENSMUSP00000134924.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDiRefIndexMentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
Phospho.ELMUniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 16709668; 25526307
Classification
Family E-value Score Start End
E3 activity/RING/RING 1.20e-08 36.4 337 375
UBD/Alpha-Helix/CUE 2.00e-11 44.7 452 493
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           CaiC+++++   + lpCgH+fh +Cl  w        +  +CP+Cr
   Q: 337  CAICWDSMQA-ARKLPCGHLFHNSCLRSW------LEQDTSCPTCR 375
           ********99.******************......9*********8 PP
   

   UBD/Alpha-Helix/CUE
   S: 1    dletaleqLkeiFPnldysviqvvLeantgsleaavnnLLegs 43
           +l+ +++q++e+FP+++y ++ ++L ++t s+e +++n+Leg 
   Q: 452  QLNAMAHQIQEMFPQVPYHLVLQDL-QMTRSVEITTDNILEGR 493
           5889*********************.***************95 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction. Also regulates ERAD through the ubiquitination of UBL4A a component of the BAG6/BAT3 complex. Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation. Mediates tumor invasion and metastasis (By similarity).
 E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction. Also regulates ERAD through the ubiquitination of UBL4A a component of the BAG6/BAT3 complex. Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation. Mediates tumor invasion and metastasis (By similarity).
Protein Sequence
(Fasta)
MPLLFLERFP WPSLRTYTGL SGLALLGTIV SAYRALSQPE DGSGEPEPLT APLQPEARLT 60
AGGPRARDVA QYLLSDSLFV WVLVNTACCV LMLVAKLIQC IVFGPLRVSE RQHLKDKFWN 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064219|E3,RING;UBD,CUE|Mus musculus
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Nucleotide Sequence
(Fasta)
GGCCCAGGGT CGCCAAGGAT GCTGCAGGGG GCCGGGACGC GGGGCCCCAG GCCGGGTCCT 60
GTGCTCTCGG GGTTGCAGAG CGCCGGCTGT GGGCGGGGGA CGAAGGCCGC GCCCCCGCGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064219|E3,RING;UBD,CUE|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0675--Receptor
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR003892--CUE
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51140--CUE
PS50089--ZF_RING_2
Pfam

PF02845--CUE
PF13639--zf-RING_2
SMART

SM00546--CUE
SM00184--RING
Gene Ontology

GO:0030425--C:dendrite
GO:0036513--C:Derlin-1 retrotranslocation complex
GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0005794--C:Golgi apparatus
GO:0030426--C:growth cone
GO:0030176--C:integral component of endoplasmic reticulum membrane
GO:0005887--C:integral component of plasma membrane
GO:0016020--C:membrane
GO:0043025--C:neuronal cell body
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0043234--C:protein complex
GO:1904288--F:BAT3 complex binding
GO:0051087--F:chaperone binding
GO:0000166--F:nucleotide binding
GO:0030674--F:protein binding, bridging
GO:0004872--F:receptor activity
GO:0061630--F:ubiquitin protein ligase activity
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:0004842--F:ubiquitin-protein transferase activity
GO:1990381--F:ubiquitin-specific protease binding
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0008270--F:zinc ion binding
GO:0007568--P:aging
GO:0009987--P:cellular process
GO:0030968--P:endoplasmic reticulum unfolded protein response
GO:0007611--P:learning or memory
GO:0032092--P:positive regulation of protein binding
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0051259--P:protein oligomerization
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030433--P:ubiquitin-dependent ERAD pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG mmu:23802
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001300 Ailuropoda melanoleuca 93.49 0.00e+00 1015.00
IUUC-Apl-003404 Anas platyrhynchos 87.99 0.00e+00 942.00
IUUC-Aca-004559 Anolis carolinensis 85.28 0.00e+00 875.00
IUUC-Ame-011640 Astyanax mexicanus 70.81 0.00e+00 838.00
IUUC-Bta-012980 Bos taurus 87.46 0.00e+00 1077.00
IUUC-Cel-018598 Caenorhabditis elegans 25.06 2.00e-34 140.00
IUUC-Cja-019577 Callithrix jacchus 94.09 0.00e+00 1197.00
IUUC-Cfa-020793 Canis familiaris 93.93 0.00e+00 1024.00
IUUC-Cpo-022387 Cavia porcellus 94.40 0.00e+00 1170.00
IUUC-Csa-023168 Chlorocebus sabaeus 94.40 0.00e+00 1204.00
IUUC-Cho-024433 Choloepus hoffmanni 95.98 0.00e+00 852.00
IUUC-Cin-025215 Ciona intestinalis 45.43 2.00e-147 516.00
IUUC-Csv-026133 Ciona savignyi 46.45 1.00e-133 469.00
IUUC-Dre-027594 Danio rerio 70.06 0.00e+00 801.00
IUUC-Dno-029407 Dasypus novemcinctus 95.70 0.00e+00 1026.00
IUUC-Dor-030961 Dipodomys ordii 96.42 0.00e+00 1056.00
IUUC-Ete-032962 Echinops telfairi 86.92 0.00e+00 871.00
IUUC-Eca-033683 Equus caballus 88.82 0.00e+00 1077.00
IUUC-Eeu-034515 Erinaceus europaeus 97.78 1.00e-78 286.00
IUUC-Fca-035398 Felis catus 96.09 0.00e+00 994.00
IUUC-Fal-036758 Ficedula albicollis 81.44 0.00e+00 882.00
IUUC-Gmo-039014 Gadus morhua 69.69 0.00e+00 777.00
IUUC-Gga-040575 Gallus gallus 85.11 0.00e+00 1024.00
IUUC-Gac-041414 Gasterosteus aculeatus 69.37 0.00e+00 763.00
IUUC-Hsa-046272 Homo sapiens 92.85 0.00e+00 1174.00
IUUC-Itr-047956 Ictidomys tridecemlineatus 95.20 0.00e+00 1026.00
IUUC-Lch-050491 Latimeria chalumnae 75.90 0.00e+00 872.00
IUUC-Loc-052758 Lepisosteus oculatus 76.64 0.00e+00 863.00
IUUC-Laf-053452 Loxodonta africana 95.54 0.00e+00 1021.00
IUUC-Mcc-055820 Macaca mulatta 95.44 0.00e+00 1039.00
IUUC-Meu-056726 Macropus eugenii 83.90 0.00e+00 854.00
IUUC-Mga-059937 Meleagris gallopavo 86.98 0.00e+00 944.00
IUUC-Mmr-060730 Microcebus murinus 92.18 0.00e+00 1127.00
IUUC-Mdo-062771 Monodelphis domestica 89.22 0.00e+00 1085.00
IUUC-Mpu-066796 Mustela putorius furo 94.71 0.00e+00 1026.00
IUUC-Mlu-068189 Myotis lucifugus 93.01 0.00e+00 1017.00
IUUC-Nle-069239 Nomascus leucogenys 93.70 0.00e+00 1147.00
IUUC-Opr-070702 Ochotona princeps 89.13 1.00e-143 503.00
IUUC-Ont-072033 Oreochromis niloticus 71.95 0.00e+00 832.00
IUUC-Oan-073717 Ornithorhynchus anatinus 85.14 0.00e+00 867.00
IUUC-Ocu-074145 Oryctolagus cuniculus 92.38 0.00e+00 1158.00
IUUC-Ogl-077929 Oryza glaberrima 53.49 1.00e-11 62.40
IUUC-Ola-087152 Oryzias latipes 70.35 0.00e+00 802.00
IUUC-Oga-088486 Otolemur garnettii 96.09 0.00e+00 1034.00
IUUC-Oar-089310 Ovis aries 94.29 0.00e+00 1046.00
IUUC-Ptr-090649 Pan troglodytes 95.34 0.00e+00 1058.00
IUUC-Pan-091692 Papio anubis 88.96 0.00e+00 1108.00
IUUC-Psi-093064 Pelodiscus sinensis 94.47 0.00e+00 774.00
IUUC-Pma-094763 Petromyzon marinus 77.46 8.00e-97 346.00
IUUC-Ppa-095969 Physcomitrella patens 29.38 6.00e-36 145.00
IUUC-Pfo-096810 Poecilia formosa 71.22 0.00e+00 810.00
IUUC-Pab-097859 Pongo abelii 95.44 0.00e+00 1041.00
IUUC-Pop-099576 Populus trichocarpa 27.65 4.00e-29 122.00
IUUC-Pca-100344 Procavia capensis 91.43 0.00e+00 1087.00
IUUC-Pva-103114 Pteropus vampyrus 66.92 0.00e+00 736.00
IUUC-Rno-105880 Rattus norvegicus 96.72 0.00e+00 1186.00
IUUC-Sha-107015 Sarcophilus harrisii 93.55 0.00e+00 1001.00
IUUC-Sar-113397 Sorex araneus 97.30 0.00e+00 760.00
IUUC-Ssc-115988 Sus scrofa 89.93 5.00e-144 503.00
IUUC-Tgu-116717 Taeniopygia guttata 89.42 0.00e+00 952.00
IUUC-Tru-117805 Takifugu rubripes 68.99 0.00e+00 828.00
IUUC-Tsy-119442 Tarsius syrichta 89.43 0.00e+00 951.00
IUUC-Tni-119777 Tetraodon nigroviridis 72.69 1.00e-172 599.00
IUUC-Tbe-127322 Tupaia belangeri 68.07 5.00e-114 404.00
IUUC-Ttr-128181 Tursiops truncatus 93.73 0.00e+00 1041.00
IUUC-Vpa-130483 Vicugna pacos 85.48 0.00e+00 663.00
IUUC-Xtr-132614 Xenopus tropicalis 74.88 0.00e+00 802.00
Created Date 25-Jun-2017

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