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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046705
UUCD1 version UUC-HoS-00081
Ensembl Protein ID ENSP00000359149.2
UniProt Accession P57775; Q5SVS1; Q96IM6; FBXW4_HUMAN
Genbank Protein ID AAG22739.1; CAI12232.1; CAI12232.1; CAI12232.1; CAI41027.1; CAI41027.1; CAI41027.1; AAH07380.2; AAH63415.1
Protein Name F-box/WD repeat-containing protein 4; Dactylin; F-box and WD-40 domain-containing protein 4
Genbank Nucleotide ID AF281859; AL627144; AC010789; AL627424; AL627424; AL627144; AC010789; BC007380; BC063415
Gene Name FBXW4; FBW4; SHFM3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000107829.13 ENST00000331272.7 ENSP00000359149.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBasecircRNADbCircNet
microRNATRANSFACTargetScanRepTar
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
ClinVarOMIM
Post-translational Modifications (PTMs)
CPLMPHOSIDABioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box F-box 23658844
UBD/Beta-Prp Beta-Prp 21070969
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/SCF/F-box 0.0021 19.8 28 71
E3 adaptor/Cullin RING/DCX/DWD 4.50e-17 63.1 201 234
UBD/Beta-Prp 1.50e-39 137.7 272 410
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/SCF/F-box
   S: 103  ldrlpeeilveilklldkeellraarvcrrwqelasqkalwktv 146
           l rlpee+l+ i+++ld + l+r+a+vcr +++++s + lw+++
   Q: 28   LWRLPEELLLLICSYLDMRALGRLAQVCRWLRRFTSCDLLWRRI 71
           569********************************999**9986 PP
   

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    HtdsvtclafsdtllvsGsdDgtikvWDlrtgvl 35
           H+ +v+c++  ++++vsGs+D t kvW l +g+l
   Q: 201  HEQEVNCVDCKGGIIVSGSRDRTAKVWPLASGRL 234
           99*******9449***************999875 PP
   

   UBD/Beta-Prp
   S: 161  vrlWdlktgkllrtltgghtdsvyslsfdsng.kelvsgsldgtvklwdlq..tgecvrtlng.htdnvksvrfspnderlvsgs.sDgsir 247
           +r+Wdl++g+l+++l ++  +    l++ +++ + l+s+++d++v++wdl+    +cv+++++ h+++ ++++++  +++l++gs   g++r
   Q: 272  LRIWDLNSGQLMTHLGSDFPPGAGVLDVMYESpFTLLSCGYDTYVRYWDLRtsVRKCVMEWEEpHDSTLYCLQTD-GNHLLATGSsYYGVVR 362
           79*************99999*******9999989*****************88789*****9999**********.999999999789**** PP
   S: 248  iWdlrsgdllktlqlhn.ssvisvavlsfgdnvlvlgsedskvniwklk 295
           +Wd r++ +l+++ l+    +++v +l+++ ++l+++ +  ++++++++
   Q: 363  LWDRRQRACLHAFPLTStPLSSPVYCLRLTTKHLYAALS-YNLHVLDFQ 410
           ***************99667889**********999866.467777665 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Part of a SCF (SKP1-cullin-F-box) protein ligase complex.
 Part of a SCF (SKP1-cullin-F-box) protein ligase complex.
Protein Sequence
(Fasta)
MAAAAGEEEE EEEAARESAA RPAAGPALWR LPEELLLLIC SYLDMRALGR LAQVCRWLRR 60
FTSCDLLWRR IARASLNSGF TRLGTDLMTS VPVKERVKVS QNWRLGRCRE GILLKWRCSQ 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046705|E3,F-box;UBD,Beta-Prp;E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGTGGTGTCA GCGCCCCGGC CCCAGCCCGC ACCCCGAAGT GGCTCCAAGG CTGCAGGTGT 60
GAGGGGCGTG CCCAGGGCTC GGCCCGCGCC GCCCCATGTG ACCCGGTCCG ACATGGTGTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046705|E3,F-box;UBD,Beta-Prp;E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0217--Developmental protein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
KW-0879--Wnt signaling pathway
Interpro

IPR001810--F-box_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50181--FBOX
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF12937--F-box-like
PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0005829--C:cytosol
GO:0019005--C:SCF ubiquitin ligase complex
GO:0000151--C:ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0051216--P:cartilage development
GO:0042733--P:embryonic digit morphogenesis
GO:0030326--P:embryonic limb morphogenesis
GO:0002053--P:positive regulation of mesenchymal cell proliferation
GO:0000209--P:protein polyubiquitination
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0016055--P:Wnt signaling pathway
KEGG hsa:6468
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002129 Ailuropoda melanoleuca 97.59 0.00e+00 761.00
IUUC-Apl-003837 Anas platyrhynchos 72.05 9.00e-142 496.00
IUUC-Aca-004776 Anolis carolinensis 67.65 6.00e-140 490.00
IUUC-Ame-010651 Astyanax mexicanus 62.42 3.00e-114 404.00
IUUC-Bta-013495 Bos taurus 96.52 0.00e+00 718.00
IUUC-Cja-018901 Callithrix jacchus 99.73 0.00e+00 733.00
IUUC-Cfa-021251 Canis familiaris 96.52 0.00e+00 753.00
IUUC-Cpo-021750 Cavia porcellus 94.46 0.00e+00 647.00
IUUC-Csa-024026 Chlorocebus sabaeus 98.92 0.00e+00 766.00
IUUC-Cho-024496 Choloepus hoffmanni 75.61 2.00e-158 551.00
IUUC-Cin-025142 Ciona intestinalis 31.50 2.00e-24 106.00
IUUC-Csv-025883 Ciona savignyi 36.87 1.00e-65 243.00
IUUC-Dre-027447 Danio rerio 58.85 2.00e-132 465.00
IUUC-Dno-029572 Dasypus novemcinctus 81.79 6.00e-173 600.00
IUUC-Dor-030982 Dipodomys ordii 89.16 0.00e+00 672.00
IUUC-Dme-031804 Drosophila melanogaster 22.70 2.00e-11 63.50
IUUC-Ete-032917 Echinops telfairi 95.08 0.00e+00 653.00
IUUC-Eca-033969 Equus caballus 98.21 0.00e+00 728.00
IUUC-Eeu-034850 Erinaceus europaeus 85.91 0.00e+00 649.00
IUUC-Fca-036182 Felis catus 92.25 0.00e+00 690.00
IUUC-Fal-037391 Ficedula albicollis 68.53 1.00e-147 516.00
IUUC-Gmo-038632 Gadus morhua 56.51 1.00e-127 449.00
IUUC-Gga-040783 Gallus gallus 73.05 4.00e-160 557.00
IUUC-Gac-042314 Gasterosteus aculeatus 56.07 1.00e-111 396.00
IUUC-Ggo-044739 Gorilla gorilla 99.46 0.00e+00 766.00
IUUC-Itr-048014 Ictidomys tridecemlineatus 98.27 2.00e-172 597.00
IUUC-Loc-052397 Lepisosteus oculatus 65.19 2.00e-139 488.00
IUUC-Laf-054544 Loxodonta africana 94.35 0.00e+00 658.00
IUUC-Meu-056363 Macropus eugenii 59.38 2.00e-102 365.00
IUUC-Mga-059275 Meleagris gallopavo 73.35 2.00e-143 501.00
IUUC-Mmr-060906 Microcebus murinus 98.92 0.00e+00 764.00
IUUC-Mdo-062400 Monodelphis domestica 77.81 2.00e-175 608.00
IUUC-Mmu-063556 Mus musculus 93.22 0.00e+00 719.00
IUUC-Mpu-066500 Mustela putorius furo 97.33 0.00e+00 759.00
IUUC-Mlu-068074 Myotis lucifugus 97.23 0.00e+00 663.00
IUUC-Nle-069601 Nomascus leucogenys 99.73 0.00e+00 768.00
IUUC-Opr-070904 Ochotona princeps 88.65 4.00e-148 517.00
IUUC-Ont-072679 Oreochromis niloticus 55.75 1.00e-121 429.00
IUUC-Oan-073434 Ornithorhynchus anatinus 73.36 1.00e-84 305.00
IUUC-Ocu-074649 Oryctolagus cuniculus 96.48 0.00e+00 734.00
IUUC-Ola-087336 Oryzias latipes 49.22 4.00e-104 371.00
IUUC-Oga-088590 Otolemur garnettii 95.93 0.00e+00 709.00
IUUC-Oar-090178 Ovis aries 93.87 0.00e+00 671.00
IUUC-Pan-092881 Papio anubis 99.19 0.00e+00 765.00
IUUC-Pfo-096176 Poecilia formosa 55.22 1.00e-113 402.00
IUUC-Pab-098285 Pongo abelii 99.73 0.00e+00 769.00
IUUC-Pca-100888 Procavia capensis 91.44 0.00e+00 693.00
IUUC-Pva-102184 Pteropus vampyrus 83.20 2.00e-177 615.00
IUUC-Rno-105668 Rattus norvegicus 93.77 0.00e+00 725.00
IUUC-Sha-106629 Sarcophilus harrisii 77.64 4.00e-154 537.00
IUUC-Ssc-116183 Sus scrofa 98.13 0.00e+00 768.00
IUUC-Tgu-116630 Taeniopygia guttata 71.73 2.00e-167 582.00
IUUC-Tru-118761 Takifugu rubripes 52.11 7.00e-117 413.00
IUUC-Tni-120651 Tetraodon nigroviridis 51.49 5.00e-59 220.00
IUUC-Ttr-128582 Tursiops truncatus 95.72 0.00e+00 710.00
IUUC-Vpa-130431 Vicugna pacos 76.62 1.00e-97 349.00
IUUC-Xtr-132655 Xenopus tropicalis 66.40 4.00e-148 517.00
Created Date 25-Jun-2017

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