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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063556
UUCD1 version UUC-MuM-00998
Ensembl Protein ID ENSMUSP00000036505.4
UniProt Accession Q9JMJ2; Q9QXW3; FBXW4_MOUSE
Genbank Protein ID BAA94666.1; AAF22827.1; AAH27031.1
Protein Name F-box/WD repeat-containing protein 4; F-box and WD-40 domain-containing protein 4; Protein hagoromo
Genbank Nucleotide ID AB022163; AF176519; BC027031
Gene Name Fbxw4; Fbw4
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000040913.10 ENSMUST00000046869.10 ENSMUSP00000036505.4
ENSMUSG00000040913.10 ENSMUST00000160018.7 ENSMUSP00000125641.1
ENSMUSG00000040913.10 ENSMUST00000160438.1 ENSMUSP00000125136.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitecircBasemicroRNATRANSFAC
RepTarmiRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 7.30e-17 61.9 199 232
UBD/Beta-Prp 7.10e-41 141.4 270 408
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    HtdsvtclafsdtllvsGsdDgtikvWDlrtgvl 35
           H+ +v+c++  ++++vsGs+D t kvW l +g+l
   Q: 199  HEQEVNCVDCKGGIIVSGSRDRTAKVWPLASGRL 232
           99*******9449***************999875 PP
   

   UBD/Beta-Prp
   S: 161  vrlWdlktgkllrtltgghtdsvyslsfdsng.kelvsgsldgtvklwdlq..tgecvrtlng.htdnvksvrfspnderlvsgs.sDg 244
           +r+Wdl++g+l+++l ++  +    l++ +++   l+s+++d++v++wdl+  t +cv+++++ h++++++++++  +++l++gs   g
   Q: 270  LRIWDLNSGQLITHLGSDFPPGAGVLDVMYESpSTLLSCGYDTYVRYWDLRtsTRKCVMEWEEpHDSTFYCLQTD-GNHLLATGSsYYG 357
           79*************99999999****99999789****************9999*******99***********.999999999789* PP
   S: 245  siriWdlrsgdllktlqlhn.ssvisvavlsfgdnvlvlgsedskvniwklk 295
            +r+Wd r++ +l++++l+    +++v +l+f+ ++l+++ +  ++++++++
   Q: 358  LVRLWDRRQRACLHAFSLTStPLSSPVYCLRFTTRHLYAALS-YNLHVLDFQ 408
           ******************99667889**********999866.467777665 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Part of a SCF (SKP1-cullin-F-box) protein ligase complex.
 Part of a SCF (SKP1-cullin-F-box) protein ligase complex.
Protein Sequence
(Fasta)
MAEDAAEDAA AAAVEPATRP AAGPALWRLP EELLLLICSY LDTRALGRLA QVCRWLRRFT 60
SCDLLWRPIA RASLNTGFTR LGTDLMAGIP VKERVKLSQN WRLGRCRDRI LLKWRYSQMP 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063556|E3,WD_repeat;UBD,Beta-Prp|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGGTACCGGG CACGGCGGAA GAGGAAGCGG GGCGGAAGGA AAGCCGGGCC TGCAGCCGGA 60
GAGGAAGGCA GCGGGGCCGG CGGCTGAGGC AGGCCGGGGA CAGGAAGGCG AGGGAGGCGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063556|E3,WD_repeat;UBD,Beta-Prp|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0217--Developmental protein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
KW-0879--Wnt signaling pathway
Interpro

IPR001810--F-box_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50181--FBOX
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF12937--F-box-like
PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0019005--C:SCF ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0051216--P:cartilage development
GO:0042733--P:embryonic digit morphogenesis
GO:0060173--P:limb development
GO:0002053--P:positive regulation of mesenchymal cell proliferation
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0016055--P:Wnt signaling pathway
KEGG mmu:30838
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002129 Ailuropoda melanoleuca 93.05 0.00e+00 729.00
IUUC-Apl-003837 Anas platyrhynchos 73.15 7.00e-144 503.00
IUUC-Aca-004776 Anolis carolinensis 68.19 1.00e-140 492.00
IUUC-Ame-010651 Astyanax mexicanus 61.92 2.00e-112 398.00
IUUC-Bta-013495 Bos taurus 92.51 0.00e+00 691.00
IUUC-Cja-018901 Callithrix jacchus 92.95 0.00e+00 689.00
IUUC-Cfa-021251 Canis familiaris 91.98 0.00e+00 722.00
IUUC-Cpo-021750 Cavia porcellus 91.08 0.00e+00 627.00
IUUC-Csa-024026 Chlorocebus sabaeus 93.22 0.00e+00 723.00
IUUC-Cho-024496 Choloepus hoffmanni 71.54 2.00e-149 521.00
IUUC-Cin-025142 Ciona intestinalis 31.35 1.00e-26 113.00
IUUC-Csv-025883 Ciona savignyi 36.87 5.00e-67 248.00
IUUC-Dre-027447 Danio rerio 58.07 6.00e-130 457.00
IUUC-Dno-029572 Dasypus novemcinctus 77.75 4.00e-164 571.00
IUUC-Dor-030982 Dipodomys ordii 85.91 0.00e+00 651.00
IUUC-Dme-031804 Drosophila melanogaster 22.56 2.00e-11 63.90
IUUC-Ete-032917 Echinops telfairi 91.69 0.00e+00 632.00
IUUC-Eca-033969 Equus caballus 92.60 0.00e+00 690.00
IUUC-Eeu-034850 Erinaceus europaeus 82.66 0.00e+00 627.00
IUUC-Fca-036182 Felis catus 88.50 0.00e+00 664.00
IUUC-Fal-037391 Ficedula albicollis 69.60 5.00e-148 517.00
IUUC-Gmo-038632 Gadus morhua 56.77 9.00e-127 446.00
IUUC-Gga-040783 Gallus gallus 73.32 1.00e-159 555.00
IUUC-Gac-042314 Gasterosteus aculeatus 56.85 4.00e-111 394.00
IUUC-Ggo-044739 Gorilla gorilla 93.50 0.00e+00 719.00
IUUC-Hsa-046705 Homo sapiens 93.22 0.00e+00 689.00
IUUC-Itr-048014 Ictidomys tridecemlineatus 95.16 7.00e-167 579.00
IUUC-Loc-052397 Lepisosteus oculatus 65.71 2.00e-140 491.00
IUUC-Laf-054544 Loxodonta africana 90.77 0.00e+00 636.00
IUUC-Meu-056363 Macropus eugenii 58.46 3.00e-101 361.00
IUUC-Mga-059275 Meleagris gallopavo 74.06 8.00e-144 503.00
IUUC-Mmr-060906 Microcebus murinus 92.95 0.00e+00 719.00
IUUC-Mdo-062400 Monodelphis domestica 77.01 2.00e-175 608.00
IUUC-Mpu-066500 Mustela putorius furo 92.78 0.00e+00 728.00
IUUC-Mlu-068074 Myotis lucifugus 92.31 0.00e+00 632.00
IUUC-Nle-069601 Nomascus leucogenys 93.50 0.00e+00 720.00
IUUC-Opr-070904 Ochotona princeps 84.34 8.00e-141 493.00
IUUC-Ont-072679 Oreochromis niloticus 56.06 6.00e-122 430.00
IUUC-Oan-073434 Ornithorhynchus anatinus 70.70 2.00e-81 294.00
IUUC-Ocu-074649 Oryctolagus cuniculus 91.60 0.00e+00 701.00
IUUC-Ola-087336 Oryzias latipes 50.26 3.00e-104 372.00
IUUC-Oga-088590 Otolemur garnettii 90.24 0.00e+00 674.00
IUUC-Oar-090178 Ovis aries 89.87 0.00e+00 646.00
IUUC-Pan-092881 Papio anubis 93.22 0.00e+00 720.00
IUUC-Pfo-096176 Poecilia formosa 54.71 2.00e-111 395.00
IUUC-Pab-098285 Pongo abelii 93.50 0.00e+00 721.00
IUUC-Pca-100888 Procavia capensis 88.24 0.00e+00 671.00
IUUC-Pva-102184 Pteropus vampyrus 79.13 1.00e-168 585.00
IUUC-Rno-105668 Rattus norvegicus 96.21 0.00e+00 743.00
IUUC-Sha-106629 Sarcophilus harrisii 77.33 9.00e-154 535.00
IUUC-Ssc-116183 Sus scrofa 93.58 0.00e+00 732.00
IUUC-Tgu-116630 Taeniopygia guttata 72.25 3.00e-167 581.00
IUUC-Tru-118761 Takifugu rubripes 52.63 2.00e-115 408.00
IUUC-Tni-120651 Tetraodon nigroviridis 50.99 7.00e-59 219.00
IUUC-Ttr-128582 Tursiops truncatus 91.18 0.00e+00 681.00
IUUC-Vpa-130431 Vicugna pacos 75.32 2.00e-96 345.00
IUUC-Xtr-132655 Xenopus tropicalis 66.67 7.00e-148 516.00
Created Date 25-Jun-2017

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