iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Mmu-063598

UUCD1 version

UUC-MuM-00026

Ensembl Protein ID

ENSMUSP00000031859.7

UniProt Accession

Q64127; Q64126; TIF1A_MOUSE

Genbank Protein ID

AAB34290.1; AAB34289.1; AAH56959.1

Protein Name

Transcription intermediary factor 1-alpha; E3 ubiquitin-protein ligase Trim24; RING-type E3 ubiquitin transferase TIF1-alpha; Tripartite motif-containing protein 24

Genbank Nucleotide ID

S78221; S78219; BC056959

Gene Name

Trim24; Tif1; Tif1a

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000029833.17	ENSMUST00000031859.13	ENSMUSP00000031859.7
ENSMUSG00000029833.17	ENSMUST00000120428.7	ENSMUSP00000113063.1
ENSMUSG00000029833.17	ENSMUST00000120238.1	ENSMUSP00000114001.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	miRNAMap
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18248090

Classification

Family	E-value	Score	Start	End
E3 activity/RING/PHD	2.30e-09	38.4	828	872
E3 activity/RING/RING	2.20e-05	26.0	52	130

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           ++C+vC++gge    l++CekC ++fH +C+ ++  +++p+ e wiC+ Cr
   Q: 828  DWCAVCQNGGE----LLCCEKCPKVFHLTCHVPT-LTNFPSGE-WICTFCR 872
           79*********....*******************.*******8.******8 PP

E3 activity/RING/RING

   S: 1    CaiCledf.kdgplvlpCgHvfhadCl...qkw..............................pglknssskefrCPlC 45
           Ca+C++ + ++ p++lpC H f++ Cl   q++                              p +   + + +rCP+C
   Q: 52   CAVCHQNIqSRVPKLLPCLHSFCQRCLpapQRYlmltapalgsaetpppapapapapgspaggPSPFATQVGVIRCPVC 130
           ****99887888*********************999998888888888888888887777776666666677777**** PP

Organism

Mus musculus

Functional Description
(View)

Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac) (By similarity). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, such as RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes. Required for normal transition from proliferating neonatal hepatocytes to quiescent adult hepatocytes.

Protein Sequence
(Fasta)

MEVAVEKAAA AAAPAGGPAA AAPSGENEAE SRQGPDSESG GEASRLNLLD TCAVCHQNIQ 60
SRVPKLLPCL HSFCQRCLPA PQRYLMLTAP ALGSAETPPP APAPAPAPGS PAGGPSPFAT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTGGTCCAA GGGGCCCGAG AGAAAGGCTG CTAGGCACGG GCGGGCGCGC TGGGCGGAAT 60
CGAGCGTCTC GGTGGCGGTT TGCCTATCGG CCCGCGCGGC GGCGTCGCGG TGCGGGAACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0103--Bromodomain
KW-0160--Chromosomal rearrangement
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0043--Tumor suppressor
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003649--Bbox_C
IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR019786--Zinc_finger_PHD-type_CS
IPR000315--Znf_B-box
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS50119--ZF_BBOX
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00439--Bromodomain
PF00628--PHD
PF00643--zf-B_box

PRINTS

PR00503--BROMODOMAIN

SMART

SM00502--BBC
SM00336--BBOX
SM00297--BROMO
SM00249--PHD
SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005719--C:nuclear euchromatin
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005726--C:perichromatin fibrils
GO:0003682--F:chromatin binding
GO:0034056--F:estrogen response element binding
GO:0016922--F:ligand-dependent nuclear receptor binding
GO:0070577--F:lysine-acetylated histone binding
GO:0002039--F:p53 binding
GO:0004672--F:protein kinase activity
GO:0043565--F:sequence-specific DNA binding
GO:0003713--F:transcription coactivator activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0055074--P:calcium ion homeostasis
GO:0071391--P:cellular response to estrogen stimulus
GO:0008285--P:negative regulation of cell proliferation
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0010628--P:positive regulation of gene expression
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0046777--P:protein autophosphorylation
GO:0030163--P:protein catabolic process
GO:0006468--P:protein phosphorylation
GO:0016567--P:protein ubiquitination
GO:0042981--P:regulation of apoptotic process
GO:0031647--P:regulation of protein stability
GO:1901796--P:regulation of signal transduction by p53 class mediator
GO:0070562--P:regulation of vitamin D receptor signaling pathway
GO:0006351--P:transcription, DNA-templated

KEGG

mmu:21848

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001838	Ailuropoda melanoleuca	92.96	0.00e+00	1652.00
IUUC-Apl-003697	Anas platyrhynchos	80.17	0.00e+00	1283.00
IUUC-Bta-013282	Bos taurus	92.81	0.00e+00	1688.00
IUUC-Cja-018920	Callithrix jacchus	91.82	0.00e+00	1706.00
IUUC-Cfa-020984	Canis familiaris	93.18	0.00e+00	1701.00
IUUC-Cpo-022035	Cavia porcellus	93.98	0.00e+00	1583.00
IUUC-Csa-024208	Chlorocebus sabaeus	93.37	0.00e+00	1723.00
IUUC-Cho-024413	Choloepus hoffmanni	63.97	3.00e-159	556.00
IUUC-Dno-029145	Dasypus novemcinctus	94.30	0.00e+00	1597.00
IUUC-Dor-030396	Dipodomys ordii	91.95	0.00e+00	1205.00
IUUC-Ete-032414	Echinops telfairi	86.21	0.00e+00	905.00
IUUC-Eca-033489	Equus caballus	95.05	0.00e+00	1568.00
IUUC-Eeu-034654	Erinaceus europaeus	91.85	0.00e+00	747.00
IUUC-Fca-035844	Felis catus	91.64	0.00e+00	1452.00
IUUC-Fal-036735	Ficedula albicollis	79.40	0.00e+00	1293.00
IUUC-Gga-041124	Gallus gallus	78.00	0.00e+00	1354.00
IUUC-Ggo-044542	Gorilla gorilla	93.47	0.00e+00	1724.00
IUUC-Hsa-046785	Homo sapiens	93.37	0.00e+00	1720.00
IUUC-Itr-048262	Ictidomys tridecemlineatus	93.91	0.00e+00	1669.00
IUUC-Laf-054279	Loxodonta africana	90.30	0.00e+00	1642.00
IUUC-Mcc-055668	Macaca mulatta	93.37	0.00e+00	1724.00
IUUC-Meu-056195	Macropus eugenii	76.42	0.00e+00	788.00
IUUC-Mga-059272	Meleagris gallopavo	79.42	0.00e+00	1268.00
IUUC-Mmr-060936	Microcebus murinus	91.36	0.00e+00	1694.00
IUUC-Mdo-062848	Monodelphis domestica	87.93	0.00e+00	1585.00
IUUC-Mpu-066272	Mustela putorius furo	92.75	0.00e+00	1567.00
IUUC-Mlu-067958	Myotis lucifugus	92.81	0.00e+00	1562.00
IUUC-Nle-069375	Nomascus leucogenys	93.47	0.00e+00	1724.00
IUUC-Opr-070836	Ochotona princeps	80.31	0.00e+00	652.00
IUUC-Oan-073393	Ornithorhynchus anatinus	79.50	0.00e+00	993.00
IUUC-Ocu-074873	Oryctolagus cuniculus	93.26	0.00e+00	1550.00
IUUC-Oga-088692	Otolemur garnettii	91.07	0.00e+00	1670.00
IUUC-Oar-090160	Ovis aries	94.62	0.00e+00	1560.00
IUUC-Ptr-090756	Pan troglodytes	93.37	0.00e+00	1720.00
IUUC-Pan-091719	Papio anubis	93.37	0.00e+00	1722.00
IUUC-Psi-093433	Pelodiscus sinensis	81.57	0.00e+00	1336.00
IUUC-Pab-098599	Pongo abelii	92.11	0.00e+00	1694.00
IUUC-Pca-100540	Procavia capensis	87.03	0.00e+00	952.00
IUUC-Pva-102478	Pteropus vampyrus	86.94	0.00e+00	1523.00
IUUC-Rno-105478	Rattus norvegicus	80.54	0.00e+00	678.00
IUUC-Sha-106740	Sarcophilus harrisii	84.83	0.00e+00	1365.00
IUUC-Sar-113615	Sorex araneus	92.86	0.00e+00	1377.00
IUUC-Tgu-117368	Taeniopygia guttata	76.48	0.00e+00	1377.00
IUUC-Tsy-118904	Tarsius syrichta	94.29	0.00e+00	1580.00
IUUC-Tbe-127354	Tupaia belangeri	81.33	0.00e+00	702.00
IUUC-Ttr-128983	Tursiops truncatus	90.23	0.00e+00	1158.00
IUUC-Vpa-130420	Vicugna pacos	92.47	0.00e+00	1524.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence