iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA
DNA & RNA Element
UTRdb	microRNA	TRANSFAC	TargetScan
RepTar	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
InWeb_IM
Disease-associated Variation
ClinVar
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	8.20e-07	31.1	11	53

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++Cl+ f++  ++l+C Hvf++dC+q++ + +     +++CPlCr
   Q: 11   CPVCLDFFSC-SISLSCTHVFCFDCIQRYILEN--HDFRAMCPLCR 53
           ********99.999***************3333..666779****8 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MAKRLQAELS CPVCLDFFSC SISLSCTHVF CFDCIQRYIL ENHDFRAMCP LCRDVVKVPA 60
LEEWQVSVLT LMTKQHNSRL EQSLHVREEL RHFREDVTLD AATASSLLVF SNDLRSAQCK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGAGGAGCA GAGGTCTGTA GAGGTAGAGA CGTAGGCTTC GGATCTTTTA GAATTCTGCT 60
GGAAGTCTCC AAGTCAAGGT AAGTTATACC TTCTGTTTAA GCTATTTCCA ATGTCCTATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00622--SPRY

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0008270--F:zinc ion binding

KEGG

hsa:442247

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002238	Ailuropoda melanoleuca	56.13	9.00e-80	290.00
IUUC-Cfa-021050	Canis familiaris	54.65	9.00e-83	300.00
IUUC-Csa-023067	Chlorocebus sabaeus	83.71	2.00e-129	454.00
IUUC-Cho-024322	Choloepus hoffmanni	55.93	7.00e-81	293.00
IUUC-Dno-029147	Dasypus novemcinctus	56.67	3.00e-80	291.00
IUUC-Ete-033115	Echinops telfairi	39.70	1.00e-43	169.00
IUUC-Eca-033495	Equus caballus	57.04	4.00e-74	271.00
IUUC-Fca-035930	Felis catus	53.90	7.00e-80	290.00
IUUC-Ggo-044763	Gorilla gorilla	90.87	1.00e-136	478.00
IUUC-Itr-047901	Ictidomys tridecemlineatus	54.07	3.00e-70	258.00
IUUC-Laf-054355	Loxodonta africana	57.99	2.00e-73	268.00
IUUC-Mcc-055277	Macaca mulatta	83.71	1.00e-128	452.00
IUUC-Mmu-063128	Mus musculus	36.73	9.00e-31	127.00
IUUC-Mpu-066251	Mustela putorius furo	55.39	4.00e-80	290.00
IUUC-Mlu-067985	Myotis lucifugus	53.96	9.00e-75	273.00
IUUC-Ocu-074601	Oryctolagus cuniculus	54.89	6.00e-65	240.00
IUUC-Oga-088942	Otolemur garnettii	59.48	5.00e-80	290.00
IUUC-Ptr-091432	Pan troglodytes	93.16	1.00e-138	485.00
IUUC-Pan-092583	Papio anubis	83.33	5.00e-128	450.00
IUUC-Pab-097777	Pongo abelii	85.23	4.00e-129	453.00
IUUC-Rno-105863	Rattus norvegicus	36.28	3.00e-28	118.00
IUUC-Sha-107318	Sarcophilus harrisii	35.74	1.00e-34	140.00
IUUC-Sar-113316	Sorex araneus	47.41	1.00e-55	209.00
IUUC-Ssc-116277	Sus scrofa	55.56	2.00e-80	291.00
IUUC-Tsy-118880	Tarsius syrichta	56.75	1.00e-78	286.00
IUUC-Tur-126024	Triticum urartu	45.10	3.00e-05	43.50
IUUC-Tbe-127955	Tupaia belangeri	57.04	7.00e-83	300.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence