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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064420
UUCD1 version UUC-MuM-01138
Ensembl Protein ID ENSMUSP00000037172.7
UniProt Accession Q5D1E7; Q3U8J3; Q3UE76; Q8JZW9; Q922T4; ZC12A_MOUSE
Genbank Protein ID AAX14018.1; BAE25089.1; BAE29035.1; BAE31025.1; BAE36216.1; BAE42965.1; CAM20905.1; AAH06817.1; AAH36563.1
Protein Name Endoribonuclease ZC3H12A; Monocyte chemotactic protein-induced protein 1; Regnase-1; Zinc finger CCCH domain-containing protein 12A
Genbank Nucleotide ID AY920404; AK142501; AK149698; AK152196; AK161150; AK172357; AL626775; BC006817; BC036563
Gene Name Zc3h12a; Mcpip; Mcpip1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000042677.7 ENSMUST00000036188.7 ENSMUSP00000037172.7
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMUniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
DUB/Other 82.14 0.00e+00 815.00 IUUC-Hsa-046924
UBD/Other/Other 82.14 0.00e+00 815.00 IUUC-Hsa-046924
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Endoribonuclease involved in various biological functions such as cellular inflammatory response and immune homeostasis, glial differentiation of neuroprogenitor cells, cell death of cardiomyocytes, adipogenesis and angiogenesis. Functions as an endoribonuclease involved in mRNA decay (PubMed:26000482). Modulates the inflammatory response by promoting the degradation of a set of translationally active cytokine-induced inflammation-related mRNAs, such as IL6 and IL12B, during the early phase of inflammation (PubMed:19322177, PubMed:21115689, PubMed:23185455, PubMed:26000482). Prevents aberrant T-cell-mediated immune reaction by degradation of multiple mRNAs controlling T-cell activation, such as those encoding cytokines (IL6 and IL2), cell surface receptors (ICOS, TNFRSF4 and TNFR2) and transcription factor (REL) (PubMed:23706741). Self regulates by destabilizing its own mRNA (PubMed:22037600). Cleaves mRNA harboring a stem-loop (SL), often located in their 3'-UTRs, during the early phase of inflammation in a helicase UPF1-dependent manner (PubMed:19322177, PubMed:23185455, PubMed:23706741, PubMed:26000482, PubMed:26134560). Plays a role in the inhibition of microRNAs (miRNAs) biogenesis (By similarity). Cleaves the terminal loop of a set of precursor miRNAs (pre-miRNAs) important for the regulation of the inflammatory response leading to their degradation, and thus preventing the biosynthesis of mature miRNAs (By similarity). Plays also a role in promoting angiogenesis in response to inflammatory cytokines by inhibiting the production of antiangiogenic microRNAs via its anti-dicer RNase activity (By similarity). Affects the overall ubiquitination of cellular proteins (PubMed:21115689). Positively regulates deubiquitinase activity promoting the cleavage at 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains on TNF receptor-associated factors (TRAFs), preventing JNK and NF-kappa-B signaling pathway activation, and hence negatively regulating macrophage-mediated inflammatory response and immune homeostasis (PubMed:21115689). Induces also deubiquitination of the transcription factor HIF1A, probably leading to its stabilization and nuclear import, thereby positively regulating the expression of proangiogenic HIF1A-targeted genes. Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (By similarity). Prevents stress granules (SGs) formation and promotes macrophage apoptosis under stress conditions, including arsenite-induced oxidative stress, heat shock, and energy deprivation (PubMed:21971051). Plays a role in the regulation of macrophage polarization; promotes IL4-induced polarization of macrophages M1 into anti-inflammatory M2 state (PubMed:25934862). May also act as a transcription factor that regulates the expression of multiple genes involved in inflammatory response, angiogenesis, adipogenesis and apoptosis (PubMed:18178554, PubMed:19666473, PubMed:22739135). Functions as a positive regulator of glial differentiation of neuroprogenitor cells through an amyloid precursor protein (APP)-dependent signaling pathway (By similarity). Attenuates septic myocardial contractile dysfunction in response to lipopolysaccharide (LPS) by reducing I-kappa-B-kinase (IKK)-mediated NF-kappa-B activation, and hence myocardial proinflammatory cytokine production (PubMed:21616078).
 Endoribonuclease involved in various biological functions such as cellular inflammatory response and immune homeostasis, glial differentiation of neuroprogenitor cells, cell death of cardiomyocytes, adipogenesis and angiogenesis. Functions as an endoribonuclease involved in mRNA decay (PubMed:26000482). Modulates the inflammatory response by promoting the degradation of a set of translationally active cytokine-induced inflammation-related mRNAs, such as IL6 and IL12B, during the early phase of inflammation (PubMed:19322177, PubMed:21115689, PubMed:23185455, PubMed:26000482). Prevents aberrant T-cell-mediated immune reaction by degradation of multiple mRNAs controlling T-cell activation, such as those encoding cytokines (IL6 and IL2), cell surface receptors (ICOS, TNFRSF4 and TNFR2) and transcription factor (REL) (PubMed:23706741). Self regulates by destabilizing its own mRNA (PubMed:22037600). Cleaves mRNA harboring a stem-loop (SL), often located in their 3'-UTRs, during the early phase of inflammation in a helicase UPF1-dependent manner (PubMed:19322177, PubMed:23185455, PubMed:23706741, PubMed:26000482, PubMed:26134560). Plays a role in the inhibition of microRNAs (miRNAs) biogenesis (By similarity). Cleaves the terminal loop of a set of precursor miRNAs (pre-miRNAs) important for the regulation of the inflammatory response leading to their degradation, and thus preventing the biosynthesis of mature miRNAs (By similarity). Plays also a role in promoting angiogenesis in response to inflammatory cytokines by inhibiting the production of antiangiogenic microRNAs via its anti-dicer RNase activity (By similarity). Affects the overall ubiquitination of cellular proteins (PubMed:21115689). Positively regulates deubiquitinase activity promoting the cleavage at 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains on TNF receptor-associated factors (TRAFs), preventing JNK and NF-kappa-B signaling pathway activation, and hence negatively regulating macrophage-mediated inflammatory response and immune homeostasis (PubMed:21115689). Induces also deubiquitination of the transcription factor HIF1A, probably leading to its stabilization and nuclear import, thereby positively regulating the expression of proangiogenic HIF1A-targeted genes. Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (By similarity). Prevents stress granules (SGs) formation and promotes macrophage apoptosis under stress conditions, including arsenite-induced oxidative stress, heat shock, and energy deprivation (PubMed:21971051). Plays a role in the regulation of macrophage polarization; promotes IL4-induced polarization of macrophages M1 into anti-inflammatory M2 state (PubMed:25934862). May also act as a transcription factor that regulates the expression of multiple genes involved in inflammatory response, angiogenesis, adipogenesis and apoptosis (PubMed:18178554, PubMed:19666473, PubMed:22739135). Functions as a positive regulator of glial differentiation of neuroprogenitor cells through an amyloid precursor protein (APP)-dependent signaling pathway (By similarity). Attenuates septic myocardial contractile dysfunction in response to lipopolysaccharide (LPS) by reducing I-kappa-B-kinase (IKK)-mediated NF-kappa-B activation, and hence myocardial proinflammatory cytokine production (PubMed:21616078).
Protein Sequence
(Fasta)
MSDPCGTKPV QESNPTMSLW SLEDRHSSQG RPQPDQDPVA KEAPTSELQM KVDFFRKLGY 60
SSSEIHSVLQ KLGVQADTNT VLGELVKHGS ATERECQALT APSPQPPLVP RGGSTPKPST 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064420|DUB,DUB/Other;UBD,UBD/Other/Other|Mus musculus
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Nucleotide Sequence
(Fasta)
GCTACGAAGG TGCCGTCAGA GCCCGAGACT CGGCTCCATG GACACCTTAC AGACGACGTC 60
CGGCGCTCAG CGGGGTGAGT GCTACCGGGT GGAACGGGTG CTGCGCTGCG TTGGGTCTGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064420|DUB,DUB/Other;UBD,UBD/Other/Other|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0037--Angiogenesis
KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0227--DNA damage
KW-0238--DNA-binding
KW-0255--Endonuclease
KW-0256--Endoplasmic reticulum
KW-0378--Hydrolase
KW-0391--Immunity
KW-0395--Inflammatory response
KW-0460--Magnesium
KW-0472--Membrane
KW-0479--Metal-binding
KW-0524--Neurogenesis
KW-0540--Nuclease
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0694--RNA-binding
KW-0346--Stress response
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR021869--RNase_Zc3h12_NYN
Pfam

PF11977--RNase_Zc3h12a
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0042406--C:extrinsic component of endoplasmic reticulum membrane
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0000932--C:P-body
GO:0043234--C:protein complex
GO:0005791--C:rough endoplasmic reticulum
GO:0030867--C:rough endoplasmic reticulum membrane
GO:0003682--F:chromatin binding
GO:0003677--F:DNA binding
GO:0004521--F:endoribonuclease activity
GO:0004532--F:exoribonuclease activity
GO:0046872--F:metal ion binding
GO:0035198--F:miRNA binding
GO:0035925--F:mRNA 3'-UTR AU-rich region binding
GO:0003730--F:mRNA 3'-UTR binding
GO:0003729--F:mRNA binding
GO:0004540--F:ribonuclease activity
GO:0043022--F:ribosome binding
GO:0003723--F:RNA binding
GO:0035613--F:RNA stem-loop binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0061158--P:3'-UTR-mediated mRNA destabilization
GO:0001525--P:angiogenesis
GO:0006915--P:apoptotic process
GO:0030154--P:cell differentiation
GO:1990869--P:cellular response to chemokine
GO:0006974--P:cellular response to DNA damage stimulus
GO:0042149--P:cellular response to glucose starvation
GO:0071347--P:cellular response to interleukin-1
GO:1904637--P:cellular response to ionomycin
GO:0071222--P:cellular response to lipopolysaccharide
GO:0034599--P:cellular response to oxidative stress
GO:1904628--P:cellular response to phorbol 13-acetate 12-myristate
GO:1903936--P:cellular response to sodium arsenite
GO:0071356--P:cellular response to tumor necrosis factor
GO:0098586--P:cellular response to virus
GO:0002376--P:immune system process
GO:0006954--P:inflammatory response
GO:0044828--P:negative regulation by host of viral genome replication
GO:0055118--P:negative regulation of cardiac muscle contraction
GO:1900016--P:negative regulation of cytokine production involved in inflammatory response
GO:0010629--P:negative regulation of gene expression
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:1902714--P:negative regulation of interferon-gamma secretion
GO:0050713--P:negative regulation of interleukin-1 beta secretion
GO:0032715--P:negative regulation of interleukin-6 production
GO:1900165--P:negative regulation of interleukin-6 secretion
GO:0010656--P:negative regulation of muscle cell apoptotic process
GO:0042347--P:negative regulation of NF-kappaB import into nucleus
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0045019--P:negative regulation of nitric oxide biosynthetic process
GO:1903799--P:negative regulation of production of miRNAs involved in gene silencing by miRNA
GO:0001933--P:negative regulation of protein phosphorylation
GO:0032720--P:negative regulation of tumor necrosis factor production
GO:1904468--P:negative regulation of tumor necrosis factor secretion
GO:0007399--P:nervous system development
GO:0000294--P:nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay
GO:0045766--P:positive regulation of angiogenesis
GO:0010508--P:positive regulation of autophagy
GO:0010942--P:positive regulation of cell death
GO:0002230--P:positive regulation of defense response to virus by host
GO:0010595--P:positive regulation of endothelial cell migration
GO:1900119--P:positive regulation of execution phase of apoptosis
GO:0045600--P:positive regulation of fat cell differentiation
GO:0010628--P:positive regulation of gene expression
GO:0010884--P:positive regulation of lipid storage
GO:2000627--P:positive regulation of miRNA catabolic process
GO:0061014--P:positive regulation of mRNA catabolic process
GO:1900745--P:positive regulation of p38MAPK cascade
GO:1903003--P:positive regulation of protein deubiquitination
GO:0042307--P:positive regulation of protein import into nucleus
GO:2000379--P:positive regulation of reactive oxygen species metabolic process
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0016579--P:protein deubiquitination
GO:0051259--P:protein oligomerization
GO:0010468--P:regulation of gene expression
GO:0090501--P:RNA phosphodiester bond hydrolysis
GO:0090502--P:RNA phosphodiester bond hydrolysis, endonucleolytic
KEGG mmu:230738
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002223 Ailuropoda melanoleuca 80.98 0.00e+00 778.00
IUUC-Apl-003631 Anas platyrhynchos 66.75 5.00e-151 527.00
IUUC-Aca-005301 Anolis carolinensis 53.62 2.00e-148 519.00
IUUC-Ame-010867 Astyanax mexicanus 68.69 5.00e-121 428.00
IUUC-Bta-012505 Bos taurus 80.96 0.00e+00 815.00
IUUC-Cja-019490 Callithrix jacchus 80.98 0.00e+00 821.00
IUUC-Cfa-021149 Canis familiaris 76.84 0.00e+00 772.00
IUUC-Cpo-021301 Cavia porcellus 83.88 0.00e+00 850.00
IUUC-Csa-023367 Chlorocebus sabaeus 81.86 0.00e+00 852.00
IUUC-Cin-025756 Ciona intestinalis 67.12 1.00e-16 79.70
IUUC-Dre-027579 Danio rerio 70.90 3.00e-121 427.00
IUUC-Dno-030064 Dasypus novemcinctus 79.06 0.00e+00 754.00
IUUC-Dor-031093 Dipodomys ordii 72.79 0.00e+00 741.00
IUUC-Ete-032302 Echinops telfairi 65.38 5.00e-163 567.00
IUUC-Eca-033237 Equus caballus 81.48 0.00e+00 835.00
IUUC-Eeu-035130 Erinaceus europaeus 76.06 0.00e+00 656.00
IUUC-Fca-035416 Felis catus 81.65 0.00e+00 791.00
IUUC-Fal-037281 Ficedula albicollis 56.31 4.00e-162 565.00
IUUC-Fso-038424 Fusarium solani 31.11 4.30e-02 32.00
IUUC-Gmo-039204 Gadus morhua 48.44 6.00e-116 411.00
IUUC-Gac-041980 Gasterosteus aculeatus 48.89 2.00e-130 459.00
IUUC-Ggo-044933 Gorilla gorilla 81.64 0.00e+00 830.00
IUUC-Hsa-046924 Homo sapiens 81.30 0.00e+00 831.00
IUUC-Itr-048614 Ictidomys tridecemlineatus 80.63 0.00e+00 835.00
IUUC-Lch-050063 Latimeria chalumnae 57.66 2.00e-169 589.00
IUUC-Loc-051993 Lepisosteus oculatus 53.02 3.00e-149 522.00
IUUC-Laf-053400 Loxodonta africana 80.10 0.00e+00 801.00
IUUC-Mcc-054768 Macaca mulatta 82.20 0.00e+00 838.00
IUUC-Meu-056059 Macropus eugenii 52.85 3.00e-130 459.00
IUUC-Mga-059707 Meleagris gallopavo 59.86 1.00e-172 599.00
IUUC-Mvi-060339 Microbotryum violaceum 36.36 1.10e+00 25.80
IUUC-Mmr-061391 Microcebus murinus 83.31 0.00e+00 830.00
IUUC-Mdo-062040 Monodelphis domestica 66.78 0.00e+00 667.00
IUUC-Mpu-066099 Mustela putorius furo 80.96 0.00e+00 759.00
IUUC-Mlu-067979 Myotis lucifugus 79.56 0.00e+00 821.00
IUUC-Nle-069830 Nomascus leucogenys 79.80 0.00e+00 800.00
IUUC-Opr-071005 Ochotona princeps 80.27 2.00e-177 615.00
IUUC-Ont-072306 Oreochromis niloticus 48.78 5.00e-135 474.00
IUUC-Oan-073138 Ornithorhynchus anatinus 62.85 2.00e-172 598.00
IUUC-Ocu-073908 Oryctolagus cuniculus 87.71 0.00e+00 635.00
IUUC-Ola-087280 Oryzias latipes 46.11 4.00e-126 444.00
IUUC-Oga-088418 Otolemur garnettii 81.64 0.00e+00 842.00
IUUC-Oar-090414 Ovis aries 83.67 0.00e+00 645.00
IUUC-Ptr-091275 Pan troglodytes 81.47 0.00e+00 828.00
IUUC-Pan-092541 Papio anubis 82.03 0.00e+00 830.00
IUUC-Psi-094002 Pelodiscus sinensis 61.36 1.00e-179 622.00
IUUC-Pab-098538 Pongo abelii 81.97 0.00e+00 842.00
IUUC-Pca-100137 Procavia capensis 79.86 1.00e-174 605.00
IUUC-Pva-102367 Pteropus vampyrus 83.26 0.00e+00 652.00
IUUC-Rno-105133 Rattus norvegicus 92.79 0.00e+00 1036.00
IUUC-Sha-106603 Sarcophilus harrisii 65.90 6.00e-157 547.00
IUUC-Tgu-117358 Taeniopygia guttata 60.68 9.00e-143 499.00
IUUC-Tru-118112 Takifugu rubripes 48.08 2.00e-126 446.00
IUUC-Tsy-119005 Tarsius syrichta 75.07 2.00e-150 525.00
IUUC-Ttr-129314 Tursiops truncatus 80.74 0.00e+00 836.00
Created Date 25-Jun-2017

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