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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046145
UUCD1 version UUC-HoS-00656
Ensembl Protein ID ENSP00000291576.6
UniProt Accession Q15269; B2RAG8; Q96A77; PWP2_HUMAN
Genbank Protein ID CAA64560.1; CAA65284.1; CAA65285.1; AAB08084.1; AAC50904.1; AAC50905.1; AAC50905.1; AAC50905.1; AAC50905.1; BAA21137.1; BAG36865.1; BAA95553.1; EAX09458.1; AAH13309.1; AAH14988.1; BAA21100.1
Protein Name Periodic tryptophan protein 2 homolog
Genbank Nucleotide ID X95263; X96424; X96425; U53346; U56085; U56089; U56086; U56087; U56088; AB001517; AK314184; AP001753; CH471079; BC013309; BC014988; AB001523
Gene Name PWP2; PWP2H
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000241945.7 ENST00000291576.11 ENSP00000291576.6
ENSG00000241945.7 ENST00000456705.1 ENSP00000411749.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarmiRNAMapSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMBioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.50e-23 83.5 499 530
UBD/Beta-Prp 2.60e-57 196.0 290 491
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDl 30
           gH++++++l+f +    l+s+s+D+t+++WD+
   Q: 499  GHEGPISGLCFnPMkSVLASASWDKTVRLWDM 530
           8**********977778**************6 PP
   

   UBD/Beta-Prp
   S: 12   vitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseD.rtikvwdlstgkcvhtlkghedsvlslsf 102
            +t+ +f++++ ll+tg+++g   ++++ + +l++sls  ++ +++v ++++g++++ g +  + + vw+ ++ ++v + +gh +s ++l++
   Q: 290  NLTAAAFHKKSHLLVTGFASGIFHLHELPEFNLIHSLSISDQSIASVAINSSGDWIAFGCSGlGQLLVWEWQSESYVLKQQGHFNSMVALAY 381
           578999********************************************************9***************************** PP
   S: 103  spsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngke 194
           sp+g+++v+G++d  ++vw++ +g c+  t+++h++ v++v++  +g ++v++s D+tvr +dl + +  rt+t+    +  ++++d +g+ 
   Q: 382  SPDGQYIVTGGDDGKVKVWNTLSGFCFV-TFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFTSPRPTQFSCVAVDASGEI 472
           ****************************.*************************************************************** PP
   S: 195  lvsgsldg.tvklwdlqtg 212
           + +g++d+  + +w++qtg
   Q: 473  VSAGAQDSfEIFVWSMQTG 491
           *******956999****98 PP
   
Organism Homo sapiens
Protein Sequence
(Fasta)
MKFAYRFSNL LGTVYRRGNL NFTCDGNSVI SPVGNRVTVF DLKNNKSDTL PLATRYNVKC 60
VGLSPDGRLA IIVDEGGDAL LVSLVCRSVL HHFHFKGSVH SVSFSPDGRK FVVTKGNIAQ 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046145|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCGCTGTGGG CGGTGCACGC CGTCGCTTCC CGGAAGTGCG TGCTGTGGGC GGTGCCGCGC 60
GGACCCCCGG GAAGTGTCTC TGTGGGCGGC CGCCGGGTTG AGCTGCGGCA CACGTGCGAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046145|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR003143--Cyt_cd1_C
IPR020472--G-protein_beta_WD-40_rep
IPR027145--PWP2
IPR011047--Quinoprotein_ADH-like_supfam
IPR007148--SSU_processome_Utp12
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF04003--Utp12
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0005654--C:nucleoplasm
GO:0034388--C:Pwp2p-containing subcomplex of 90S preribosome
GO:0032040--C:small-subunit processome
GO:0003723--F:RNA binding
GO:0030515--F:snoRNA binding
GO:0000462--P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000028--P:ribosomal small subunit assembly
GO:0006364--P:rRNA processing
KEGG hsa:102724159; hsa:5822
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001932 Ailuropoda melanoleuca 88.29 0.00e+00 1641.00
IUUC-Atr-003033 Amborella trichopoda 40.30 0.00e+00 673.00
IUUC-Apl-003219 Anas platyrhynchos 77.21 0.00e+00 1443.00
IUUC-Aca-004950 Anolis carolinensis 75.82 0.00e+00 1417.00
IUUC-Ago-007916 Ashbya gossypii 43.56 0.00e+00 727.00
IUUC-Acl-008225 Aspergillus clavatus 45.83 0.00e+00 793.00
IUUC-Afl-008390 Aspergillus flavus 45.48 0.00e+00 787.00
IUUC-Afu-009039 Aspergillus fumigatus 46.14 0.00e+00 791.00
IUUC-Ani-009228 Aspergillus nidulans 42.37 0.00e+00 689.00
IUUC-Ang-009663 Aspergillus niger 44.43 0.00e+00 760.00
IUUC-Aor-009923 Aspergillus oryzae 45.48 0.00e+00 787.00
IUUC-Ate-010264 Aspergillus terreus 45.94 0.00e+00 794.00
IUUC-Ame-010790 Astyanax mexicanus 66.34 1.00e-161 562.00
IUUC-Bgr-012066 Blumeria graminis 44.31 0.00e+00 769.00
IUUC-Bta-012399 Bos taurus 90.95 0.00e+00 1625.00
IUUC-Bdi-015028 Brachypodium distachyon 41.18 0.00e+00 667.00
IUUC-Cel-018690 Caenorhabditis elegans 39.32 0.00e+00 643.00
IUUC-Cja-019229 Callithrix jacchus 94.57 0.00e+00 1740.00
IUUC-Cfa-020504 Canis familiaris 88.99 0.00e+00 1662.00
IUUC-Cpo-021574 Cavia porcellus 88.53 0.00e+00 1689.00
IUUC-Cre-022756 Chlamydomonas reinhardtii 43.32 1.00e-150 527.00
IUUC-Csa-023436 Chlorocebus sabaeus 98.26 0.00e+00 1784.00
IUUC-Cin-025397 Ciona intestinalis 57.60 0.00e+00 881.00
IUUC-Cgl-026684 Colletotrichum gloeosporioides 49.15 1.00e-167 583.00
IUUC-Cne-027031 Cryptococcus neoformans 45.39 0.00e+00 805.00
IUUC-Cme-027276 Cyanidioschyzon merolae 31.71 7.00e-110 392.00
IUUC-Dor-030149 Dipodomys ordii 88.24 0.00e+00 1654.00
IUUC-Dme-032043 Drosophila melanogaster 46.02 0.00e+00 832.00
IUUC-Eca-033223 Equus caballus 90.43 0.00e+00 1672.00
IUUC-Fca-035795 Felis catus 80.80 0.00e+00 1495.00
IUUC-Fal-036830 Ficedula albicollis 76.92 0.00e+00 1436.00
IUUC-Fox-037835 Fusarium oxysporum 43.38 0.00e+00 749.00
IUUC-Fso-038324 Fusarium solani 43.37 0.00e+00 738.00
IUUC-Gmo-039355 Gadus morhua 70.53 0.00e+00 1316.00
IUUC-Ggr-039840 Gaeumannomyces graminis 43.77 0.00e+00 712.00
IUUC-Gga-040907 Gallus gallus 79.81 0.00e+00 923.00
IUUC-Gac-042624 Gasterosteus aculeatus 71.30 0.00e+00 1305.00
IUUC-Hvu-047416 Hordeum vulgare 41.55 0.00e+00 665.00
IUUC-Itr-049083 Ictidomys tridecemlineatus 90.33 0.00e+00 1694.00
IUUC-Kpa-049150 Komagataella pastoris 43.85 0.00e+00 736.00
IUUC-Lpe-050840 Leersia perrieri 42.14 0.00e+00 676.00
IUUC-Loc-052733 Lepisosteus oculatus 71.38 0.00e+00 1345.00
IUUC-Lma-053277 Leptosphaeria maculans 45.20 0.00e+00 757.00
IUUC-Laf-054294 Loxodonta africana 90.37 0.00e+00 1591.00
IUUC-Mcc-054624 Macaca mulatta 98.69 0.00e+00 1793.00
IUUC-Meu-056665 Macropus eugenii 71.32 0.00e+00 986.00
IUUC-Mor-057288 Magnaporthe oryzae 43.27 0.00e+00 729.00
IUUC-Mpo-057594 Magnaporthe poae 43.80 0.00e+00 712.00
IUUC-Mla-058846 Melampsora laricipopulina 44.55 0.00e+00 761.00
IUUC-Mga-059207 Meleagris gallopavo 69.29 0.00e+00 1258.00
IUUC-Mvi-060327 Microbotryum violaceum 46.75 0.00e+00 801.00
IUUC-Mmr-061264 Microcebus murinus 91.81 0.00e+00 1642.00
IUUC-Mdo-062327 Monodelphis domestica 82.90 0.00e+00 1535.00
IUUC-Mmu-063542 Mus musculus 89.43 0.00e+00 1645.00
IUUC-Mac-065142 Musa acuminata 41.69 0.00e+00 684.00
IUUC-Mlu-067056 Myotis lucifugus 84.51 0.00e+00 1501.00
IUUC-Nfi-068323 Neosartorya fischeri 45.94 0.00e+00 794.00
IUUC-Ncr-068925 Neurospora crassa 43.33 0.00e+00 773.00
IUUC-Nle-068970 Nomascus leucogenys 98.76 0.00e+00 1779.00
IUUC-Ont-071252 Oreochromis niloticus 72.47 0.00e+00 1337.00
IUUC-Oan-072737 Ornithorhynchus anatinus 79.01 0.00e+00 1469.00
IUUC-Oba-075794 Oryza barthii 41.04 0.00e+00 644.00
IUUC-Obr-076617 Oryza brachyantha 41.65 0.00e+00 675.00
IUUC-Ogl-077022 Oryza glaberrima 42.26 0.00e+00 680.00
IUUC-Ogu-078757 Oryza glumaepatula 34.16 5.00e-131 462.00
IUUC-Oin-079813 Oryza indica 41.92 0.00e+00 675.00
IUUC-Olo-080265 Oryza longistaminata 42.26 0.00e+00 681.00
IUUC-Ome-081494 Oryza meridionalis 42.03 0.00e+00 674.00
IUUC-Oni-082639 Oryza nivara 34.27 2.00e-131 463.00
IUUC-Opu-084005 Oryza punctata 42.47 0.00e+00 691.00
IUUC-Oru-084883 Oryza rufipogon 34.05 1.00e-130 460.00
IUUC-Osa-086158 Oryza sativa 42.03 0.00e+00 676.00
IUUC-Ola-086822 Oryzias latipes 72.06 0.00e+00 1339.00
IUUC-Olu-087741 Ostreococcus lucimarinus 32.29 5.00e-20 90.10
IUUC-Oga-088887 Otolemur garnettii 92.54 0.00e+00 1645.00
IUUC-Oar-090110 Ovis aries 87.65 0.00e+00 1554.00
IUUC-Pan-092808 Papio anubis 96.74 0.00e+00 1786.00
IUUC-Psi-093954 Pelodiscus sinensis 77.60 0.00e+00 1451.00
IUUC-Pno-094922 Phaeosphaeria nodorum 45.80 0.00e+00 774.00
IUUC-Ppa-095678 Physcomitrella patens 42.89 0.00e+00 663.00
IUUC-Pfo-097175 Poecilia formosa 72.62 0.00e+00 1363.00
IUUC-Pab-098155 Pongo abelii 97.50 0.00e+00 1801.00
IUUC-Pca-100947 Procavia capensis 82.83 0.00e+00 1544.00
IUUC-Pva-102744 Pteropus vampyrus 81.40 0.00e+00 1460.00
IUUC-Pgr-103389 Puccinia graminis 45.25 0.00e+00 760.00
IUUC-Ptt-103953 Puccinia triticina 39.82 4.00e-177 615.00
IUUC-Pte-104079 Pyrenophora teres 45.37 0.00e+00 764.00
IUUC-Pyt-104656 Pyrenophora triticirepentis 45.48 0.00e+00 763.00
IUUC-Rno-105502 Rattus norvegicus 89.65 0.00e+00 1676.00
IUUC-Sce-106390 Saccharomyces cerevisiae 43.71 0.00e+00 754.00
IUUC-Sja-107674 Schizosaccharomyces japonicus 42.81 0.00e+00 748.00
IUUC-Spo-108348 Schizosaccharomyces pombe 44.71 0.00e+00 751.00
IUUC-Smo-108982 Selaginella moellendorffii 43.48 0.00e+00 714.00
IUUC-Sit-110304 Setaria italica 42.33 0.00e+00 706.00
IUUC-Sbi-114702 Sorghum bicolor 42.38 0.00e+00 700.00
IUUC-Sre-115129 Sporisorium reilianum 41.14 0.00e+00 704.00
IUUC-Tgu-116787 Taeniopygia guttata 76.36 0.00e+00 1431.00
IUUC-Tru-118218 Takifugu rubripes 70.96 0.00e+00 1318.00
IUUC-Tsy-119401 Tarsius syrichta 92.39 0.00e+00 916.00
IUUC-Tni-120046 Tetraodon nigroviridis 70.06 0.00e+00 1271.00
IUUC-Tre-122154 Trichoderma reesei 43.79 0.00e+00 758.00
IUUC-Tvi-122451 Trichoderma virens 42.71 0.00e+00 748.00
IUUC-Tur-126650 Triticum urartu 41.21 3.00e-179 622.00
IUUC-Tme-127005 Tuber melanosporum 46.50 0.00e+00 778.00
IUUC-Ttr-128259 Tursiops truncatus 88.50 0.00e+00 1554.00
IUUC-Uma-129511 Ustilago maydis 42.41 0.00e+00 698.00
IUUC-Vda-129833 Verticillium dahliae 41.82 0.00e+00 687.00
IUUC-Xma-133887 Xiphophorus maculatus 72.75 0.00e+00 1316.00
IUUC-Yli-134427 Yarrowia lipolytica 44.61 0.00e+00 766.00
IUUC-Zma-135980 Zea mays 42.89 0.00e+00 697.00
Created Date 25-Jun-2017

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