iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UBA	UBA	15988528

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UBA	0.00017	21.9	7	46

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBA

   S: 2    ededkleqlve.MGFdreealqaLraannnleaAveyLld 40
           +++ kl+q+v  +  ++   l  L+ an+n+e A+++++d
   Q: 7    DQKTKLRQFVQwTQVTEAVSLNFLAKANWNIEYAMTLYFD 46
           7899**********9999999999999***********98 PP

Organism

Caenorhabditis elegans

Functional Description
(View)

Required for neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity. Does not act by preventing deneddylation, but rather facilitates neddylation, possibly by acting with rbx-1 to recruit the Nedd8-charged E2 enzyme to the cullin component of SCF-type complexes.

Protein Sequence
(Fasta)

MNRLKSDQKT KLRQFVQWTQ VTEAVSLNFL AKANWNIEYA MTLYFDNPNL FAGSTPQPSV 60
DRSNIERLFN QYVDPKDKVG EKRMGPHGIN RLLTDLGYEA TDRRVLVLAW KFTAQTQCEF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTAACCACT ACGTCTACAC AATGAATCGA CTGAAGTCCG ATCAAAAAAC AAAGGTTTGT 60
AAACGGAAAC AAGACGATGA AGTGGAGATG AGTGATATGG AAACTGATCA CAAAAAGTGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR014764--DCN-prot
IPR005176--PONY_dom
IPR009060--UBA-like

PROSITE

PS51229--DCUN1

Pfam

PF03556--Cullin_binding

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0097602--F:cullin family protein binding
GO:0043130--F:ubiquitin binding
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0030953--P:astral microtubule organization
GO:0040001--P:establishment of mitotic spindle localization
GO:0044254--P:multicellular organismal protein catabolic process
GO:0051443--P:positive regulation of ubiquitin-protein transferase activity
GO:0045116--P:protein neddylation

KEGG

cel:CELE_H38K22.2

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000561	Aegilops tauschii	32.97	5.00e-39	152.00
IUUC-Aml-001879	Ailuropoda melanoleuca	36.50	2.00e-51	194.00
IUUC-Atr-002697	Amborella trichopoda	41.84	3.00e-17	79.30
IUUC-Apl-003451	Anas platyrhynchos	36.86	1.00e-52	198.00
IUUC-Aca-005269	Anolis carolinensis	36.36	5.00e-51	193.00
IUUC-Aly-006285	Arabidopsis lyrata	32.47	2.00e-34	137.00
IUUC-Ath-007531	Arabidopsis thaliana	35.77	3.00e-42	163.00
IUUC-Ago-007806	Ashbya gossypii	21.74	2.00e-14	71.20
IUUC-Acl-008172	Aspergillus clavatus	22.48	4.00e-13	67.00
IUUC-Afl-008569	Aspergillus flavus	23.27	3.00e-17	80.90
IUUC-Afu-009005	Aspergillus fumigatus	19.23	2.00e-05	40.40
IUUC-Ani-009241	Aspergillus nidulans	20.82	6.00e-10	56.60
IUUC-Ang-009664	Aspergillus niger	22.73	6.00e-11	59.70
IUUC-Aor-010044	Aspergillus oryzae	36.17	1.00e-03	36.60
IUUC-Ate-010414	Aspergillus terreus	23.05	1.00e-16	79.00
IUUC-Ame-011763	Astyanax mexicanus	37.45	4.00e-51	193.00
IUUC-Bgr-011991	Blumeria graminis	25.70	2.00e-14	71.60
IUUC-Bta-012373	Bos taurus	36.75	5.00e-46	176.00
IUUC-Bci-013824	Botrytis cinerea	26.64	5.00e-17	80.10
IUUC-Bdi-014138	Brachypodium distachyon	33.33	1.00e-38	152.00
IUUC-Bol-015564	Brassica oleracea	35.06	8.00e-42	162.00
IUUC-Bra-017111	Brassica rapa	35.79	1.00e-42	164.00
IUUC-Cja-019502	Callithrix jacchus	36.86	9.00e-52	195.00
IUUC-Cfa-020523	Canis familiaris	34.88	1.00e-45	174.00
IUUC-Cpo-022196	Cavia porcellus	36.13	2.00e-50	191.00
IUUC-Cre-022620	Chlamydomonas reinhardtii	27.66	2.00e-30	124.00
IUUC-Csa-023551	Chlorocebus sabaeus	36.73	4.00e-52	196.00
IUUC-Cho-024373	Choloepus hoffmanni	36.13	2.00e-47	180.00
IUUC-Cin-025269	Ciona intestinalis	36.76	2.00e-49	187.00
IUUC-Csv-025976	Ciona savignyi	30.89	4.00e-24	103.00
IUUC-Cgl-026386	Colletotrichum gloeosporioides	27.55	1.00e-12	64.70
IUUC-Cne-026950	Cryptococcus neoformans	25.18	1.00e-16	79.00
IUUC-Cme-027199	Cyanidioschyzon merolae	22.18	2.00e-06	45.10
IUUC-Dre-028247	Danio rerio	36.76	1.00e-50	191.00
IUUC-Dno-028974	Dasypus novemcinctus	36.73	4.00e-52	196.00
IUUC-Dor-030143	Dipodomys ordii	37.64	1.00e-48	184.00
IUUC-Dse-031365	Dothistroma septosporum	23.74	5.00e-16	76.60
IUUC-Dme-032197	Drosophila melanogaster	36.00	1.00e-45	175.00
IUUC-Ete-032371	Echinops telfairi	36.50	2.00e-51	194.00
IUUC-Eca-033242	Equus caballus	36.50	2.00e-51	194.00
IUUC-Eeu-035317	Erinaceus europaeus	36.13	4.00e-51	193.00
IUUC-Fca-036061	Felis catus	36.36	2.00e-51	194.00
IUUC-Fal-036715	Ficedula albicollis	39.48	3.00e-52	196.00
IUUC-Fox-037884	Fusarium oxysporum	32.26	2.00e-13	67.00
IUUC-Fso-038150	Fusarium solani	31.64	3.00e-13	67.80
IUUC-Gmo-038750	Gadus morhua	37.27	6.00e-50	189.00
IUUC-Ggr-039959	Gaeumannomyces graminis	21.66	2.00e-06	46.60
IUUC-Gga-040935	Gallus gallus	36.73	1.00e-51	195.00
IUUC-Gac-041478	Gasterosteus aculeatus	36.90	5.00e-50	189.00
IUUC-Gma-043545	Glycine max	33.82	1.00e-40	158.00
IUUC-Ggo-044972	Gorilla gorilla	37.13	1.00e-48	185.00
IUUC-Hsa-046089	Homo sapiens	36.73	4.00e-52	196.00
IUUC-Hvu-047636	Hordeum vulgare	25.78	2.00e-09	53.90
IUUC-Itr-047902	Ictidomys tridecemlineatus	37.05	6.00e-49	186.00
IUUC-Kpa-049127	Komagataella pastoris	25.37	8.00e-16	75.90
IUUC-Lch-050600	Latimeria chalumnae	35.84	5.00e-52	196.00
IUUC-Lpe-051540	Leersia perrieri	32.73	1.00e-40	158.00
IUUC-Loc-052509	Lepisosteus oculatus	36.59	2.00e-51	194.00
IUUC-Lma-053103	Leptosphaeria maculans	21.99	8.00e-13	66.20
IUUC-Laf-053527	Loxodonta africana	36.50	3.00e-51	193.00
IUUC-Mcc-054700	Macaca mulatta	37.13	9.00e-49	185.00
IUUC-Meu-056791	Macropus eugenii	32.10	7.00e-34	135.00
IUUC-Mor-056909	Magnaporthe oryzae	26.60	2.00e-18	84.70
IUUC-Mpo-057299	Magnaporthe poae	24.55	2.00e-12	65.10
IUUC-Mtr-057964	Medicago truncatula	35.27	3.00e-41	160.00
IUUC-Mla-058990	Melampsora laricipopulina	22.58	1.00e-11	62.40
IUUC-Mga-060072	Meleagris gallopavo	38.75	5.00e-51	192.00
IUUC-Mvi-060312	Microbotryum violaceum	25.44	6.00e-24	103.00
IUUC-Mmr-060851	Microcebus murinus	36.50	3.00e-51	193.00
IUUC-Mdo-063074	Monodelphis domestica	36.50	2.00e-51	196.00
IUUC-Mmu-063954	Mus musculus	36.36	3.00e-51	193.00
IUUC-Mac-065016	Musa acuminata	37.24	1.00e-30	124.00
IUUC-Mpu-066870	Mustela putorius furo	34.88	1.00e-45	174.00
IUUC-Mlu-067701	Myotis lucifugus	36.50	2.00e-51	194.00
IUUC-Nfi-068610	Neosartorya fischeri	18.75	1.00e-04	38.10
IUUC-Ncr-068780	Neurospora crassa	21.60	1.00e-11	62.00
IUUC-Nle-069291	Nomascus leucogenys	36.73	4.00e-52	196.00
IUUC-Opr-070682	Ochotona princeps	32.89	7.00e-28	116.00
IUUC-Ont-071813	Oreochromis niloticus	37.27	2.00e-50	190.00
IUUC-Oan-073031	Ornithorhynchus anatinus	36.13	6.00e-51	192.00
IUUC-Ocu-074648	Oryctolagus cuniculus	36.50	2.00e-51	194.00
IUUC-Oba-074993	Oryza barthii	32.61	4.00e-41	159.00
IUUC-Obr-076341	Oryza brachyantha	31.27	1.00e-41	161.00
IUUC-Ogl-077099	Oryza glaberrima	32.61	4.00e-41	159.00
IUUC-Ogu-078285	Oryza glumaepatula	32.61	1.00e-40	158.00
IUUC-Oin-079441	Oryza indica	32.61	6.00e-41	159.00
IUUC-Olo-081037	Oryza longistaminata	32.61	6.00e-41	159.00
IUUC-Ome-081357	Oryza meridionalis	32.61	6.00e-41	159.00
IUUC-Oni-082632	Oryza nivara	31.27	8.00e-41	159.00
IUUC-Opu-083351	Oryza punctata	33.33	4.00e-38	150.00
IUUC-Oru-084306	Oryza rufipogon	32.61	6.00e-41	159.00
IUUC-Osa-085307	Oryza sativa	32.61	6.00e-41	159.00
IUUC-Ola-086371	Oryzias latipes	37.27	3.00e-50	190.00
IUUC-Olu-087646	Ostreococcus lucimarinus	31.60	6.00e-30	122.00
IUUC-Oga-089015	Otolemur garnettii	36.13	8.00e-51	192.00
IUUC-Oar-090405	Ovis aries	36.13	8.00e-51	192.00
IUUC-Ptr-090735	Pan troglodytes	36.50	2.00e-51	194.00
IUUC-Pan-092186	Papio anubis	36.59	1.00e-50	191.00
IUUC-Psi-093110	Pelodiscus sinensis	34.88	3.00e-45	173.00
IUUC-Pma-094196	Petromyzon marinus	33.50	6.00e-27	113.00
IUUC-Pno-095145	Phaeosphaeria nodorum	25.00	3.00e-12	64.30
IUUC-Ppa-095306	Physcomitrella patens	32.36	7.00e-39	152.00
IUUC-Pfo-097121	Poecilia formosa	37.27	6.00e-49	186.00
IUUC-Pab-098197	Pongo abelii	36.22	2.00e-43	167.00
IUUC-Pop-098821	Populus trichocarpa	40.98	3.00e-20	89.40
IUUC-Pca-100218	Procavia capensis	36.50	7.00e-51	192.00
IUUC-Ppe-102032	Prunus persica	34.18	1.00e-41	161.00
IUUC-Pva-102691	Pteropus vampyrus	37.87	7.00e-51	192.00
IUUC-Pgr-103633	Puccinia graminis	23.79	9.00e-15	72.80
IUUC-Ptt-103979	Puccinia triticina	48.00	3.40e-02	31.60
IUUC-Pte-104225	Pyrenophora teres	24.79	2.80e-02	32.00
IUUC-Pyt-104428	Pyrenophora triticirepentis	25.71	3.00e-14	70.90
IUUC-Rno-105554	Rattus norvegicus	36.56	7.00e-52	196.00
IUUC-Sce-106358	Saccharomyces cerevisiae	23.47	8.00e-14	69.30
IUUC-Sha-106542	Sarcophilus harrisii	38.97	1.00e-52	198.00
IUUC-Sja-107938	Schizosaccharomyces japonicus	24.26	2.00e-17	80.90
IUUC-Spo-108207	Schizosaccharomyces pombe	25.94	1.00e-15	75.10
IUUC-Ssl-108410	Sclerotinia sclerotiorum	26.69	8.00e-18	82.80
IUUC-Smo-108750	Selaginella moellendorffii	30.66	4.00e-31	126.00
IUUC-Sit-110052	Setaria italica	33.45	7.00e-43	165.00
IUUC-Sly-111489	Solanum lycopersicum	33.94	3.00e-40	157.00
IUUC-Stu-112517	Solanum tuberosum	31.10	3.00e-36	143.00
IUUC-Sar-113509	Sorex araneus	36.93	2.00e-33	134.00
IUUC-Sbi-114082	Sorghum bicolor	33.45	1.00e-41	161.00
IUUC-Sre-115221	Sporisorium reilianum	21.40	7.00e-06	43.10
IUUC-Ssc-115547	Sus scrofa	36.73	4.00e-52	196.00
IUUC-Tgu-117196	Taeniopygia guttata	39.11	5.00e-52	196.00
IUUC-Tru-118316	Takifugu rubripes	38.32	1.00e-50	191.00
IUUC-Tsy-119599	Tarsius syrichta	36.50	2.00e-51	194.00
IUUC-Tni-120542	Tetraodon nigroviridis	38.43	2.00e-50	191.00
IUUC-Tca-121033	Theobroma cacao	33.82	6.00e-41	159.00
IUUC-Tre-121986	Trichoderma reesei	22.08	1.00e-11	62.40
IUUC-Tvi-122607	Trichoderma virens	26.12	2.00e-15	74.70
IUUC-Tae-125740	Triticum aestivum	28.71	4.00e-33	133.00
IUUC-Tur-126375	Triticum urartu	26.79	3.00e-28	118.00
IUUC-Tme-126878	Tuber melanosporum	29.08	5.00e-29	120.00
IUUC-Tbe-127937	Tupaia belangeri	35.26	2.00e-28	117.00
IUUC-Ttr-129086	Tursiops truncatus	33.58	4.00e-43	166.00
IUUC-Uma-129364	Ustilago maydis	22.33	2.00e-11	62.00
IUUC-Vda-129929	Verticillium dahliae	28.96	5.00e-12	63.90
IUUC-Vpa-130048	Vicugna pacos	36.95	1.00e-38	152.00
IUUC-Vvi-130834	Vitis vinifera	34.18	6.00e-42	162.00
IUUC-Xtr-131888	Xenopus tropicalis	36.13	8.00e-51	192.00
IUUC-Xma-133580	Xiphophorus maculatus	37.50	7.00e-51	192.00
IUUC-Yli-134595	Yarrowia lipolytica	24.53	7.00e-22	95.90
IUUC-Zma-135864	Zea mays	32.36	1.00e-42	164.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence