iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
iRefIndex	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	7.40e-79	265.6	6	306

Active Site

Position(s)	Description	Evidence
86	Nucleophile	{ECO:0000256\|PIRSR:PIRSR038120-1}
162	Proton donor	{ECO:0000256\|PIRSR:PIRSR038120-1}

Domain Profile

DUB/UCH

   S: 6    kewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakqvigNsCatyA 103
            +w+ +esdPg+ft+l+++fg+++  qvee++sLd+e+++ + ep++gl++lFk+ ++ e + k+          d +   +iffakqvi+N+Cat+A
   Q: 6    GNWCLIESDPGVFTELIREFGCDGA-QVEEIWSLDSESFKNL-EPIHGLIFLFKWVQEDEPAGKVV--------LDRE---NIFFAKQVINNACATQA 90
           58***********************.****************.********************876........5665...66*************** PP
   S: 104  llsvllncedklldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvsyvningrlyeldglkpfPl 201
           +ls l n +++ + lG+tl ++ke+ + ++p nk+l l+n+ +++ +hns+ar+  ++++++++++    +++++hfv y++i+grlyeldgl++ P+
   Q: 91   ILSLLMNLDHEDIKLGETLTNFKEFCQCFDPYNKGLTLSNASQIRTVHNSFARPTLFELDTKNQKK----DDDVYHFVGYMPIGGRLYELDGLREGPI 184
           ************************************************************988555....79************************** PP
   S: 202  dlgkkketeelkdklkvvraflerikllesdeirfnllaivadrrviktlrl.nvlkidkeLlkLlkdieseeekieaqlddekekrkkfkiddirRt 298
           dlg+ k ++++ d ++ ++   +r++ ++ +ei fnl+a+ +dr+ i+++++ ++l+   + +   +d ++e+      ++ e +k+k++k+++ rR+
   Q: 185  DLGEIKSEQNWIDVVRPII--EKRMQRYSDGEIHFNLMALISDRQRIYEQQIeKLLNPAPNAMDTEEDRQAEISSLRTYIEYEIQKKKRYKVENVRRK 280
           *******************..************************99*9997469999**************************************** PP
   S: 299  enydeficifikdlaregilrklvee 324
           +ny  fi++++k l ++g+l  + e+
   Q: 281  HNYLPFIVELLKILGENGQLMPIYEK 306
           ********************998887 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MGDGAGNWCL IESDPGVFTE LIREFGCDGA QVEEIWSLDS ESFKNLEPIH GLIFLFKWVQ 60
EDEPAGKVVL DRENIFFAKQ VINNACATQA ILSLLMNLDH EDIKLGETLT NFKEFCQCFD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGTCACATC TGGCAAGGTT GGTTCACTCT GTGAGTTGAC AGAAAATTTT GTGCAGTAAA 60
AGCACCATTT TTGTAGCGAA ATCTATAGTA GAAAGATATT CAAGTGACTA CTATTAACAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-0647--Proteasome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR017390--Ubiquitinyl_hydrolase_UCH37

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0000502--C:proteasome complex
GO:0005838--C:proteasome regulatory particle
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0022008--P:neurogenesis
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016579--P:protein deubiquitination

KEGG

dme:Dmel_CG3431

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000936	Aegilops tauschii	48.16	2.00e-81	294.00
IUUC-Aml-001866	Ailuropoda melanoleuca	61.02	9.00e-112	395.00
IUUC-Atr-002966	Amborella trichopoda	44.35	2.00e-69	255.00
IUUC-Apl-003306	Anas platyrhynchos	55.46	1.00e-105	375.00
IUUC-Aca-004763	Anolis carolinensis	60.90	2.00e-111	394.00
IUUC-Aly-005581	Arabidopsis lyrata	46.36	4.00e-71	260.00
IUUC-Ath-007283	Arabidopsis thaliana	46.36	1.00e-73	268.00
IUUC-Ago-007999	Ashbya gossypii	30.36	8.00e-33	133.00
IUUC-Acl-008231	Aspergillus clavatus	45.00	4.00e-53	200.00
IUUC-Afl-008557	Aspergillus flavus	38.41	4.00e-52	197.00
IUUC-Afu-008988	Aspergillus fumigatus	44.58	5.00e-53	200.00
IUUC-Ani-009420	Aspergillus nidulans	37.90	3.00e-49	187.00
IUUC-Ang-009859	Aspergillus niger	41.87	4.00e-50	191.00
IUUC-Aor-010145	Aspergillus oryzae	38.41	4.00e-52	197.00
IUUC-Ate-010347	Aspergillus terreus	39.62	2.00e-48	185.00
IUUC-Ame-010791	Astyanax mexicanus	60.94	1.00e-113	402.00
IUUC-Bgr-012298	Blumeria graminis	38.21	2.00e-44	172.00
IUUC-Bta-013251	Bos taurus	61.54	2.00e-112	397.00
IUUC-Bci-013786	Botrytis cinerea	38.28	5.00e-53	200.00
IUUC-Bdi-014132	Brachypodium distachyon	49.85	2.00e-80	291.00
IUUC-Bol-015611	Brassica oleracea	47.42	3.00e-74	271.00
IUUC-Bra-017769	Brassica rapa	48.02	2.00e-74	271.00
IUUC-Cel-018604	Caenorhabditis elegans	50.64	1.00e-90	325.00
IUUC-Cja-019768	Callithrix jacchus	56.01	1.00e-106	378.00
IUUC-Cfa-020207	Canis familiaris	61.02	9.00e-112	395.00
IUUC-Cpo-021925	Cavia porcellus	58.79	6.00e-106	376.00
IUUC-Cre-022919	Chlamydomonas reinhardtii	44.41	4.00e-72	264.00
IUUC-Csa-023958	Chlorocebus sabaeus	61.86	1.00e-112	398.00
IUUC-Cho-024928	Choloepus hoffmanni	68.00	1.00e-25	109.00
IUUC-Cin-025771	Ciona intestinalis	49.08	6.00e-91	326.00
IUUC-Csv-026149	Ciona savignyi	52.98	2.00e-90	324.00
IUUC-Cgl-026424	Colletotrichum gloeosporioides	35.05	3.00e-44	171.00
IUUC-Cne-026955	Cryptococcus neoformans	37.80	5.00e-60	223.00
IUUC-Cme-027104	Cyanidioschyzon merolae	33.52	7.00e-49	186.00
IUUC-Dre-027409	Danio rerio	60.62	2.00e-112	397.00
IUUC-Dno-028921	Dasypus novemcinctus	61.02	8.00e-112	395.00
IUUC-Dse-031170	Dothistroma septosporum	39.67	1.00e-53	202.00
IUUC-Ete-032707	Echinops telfairi	43.12	1.00e-64	239.00
IUUC-Eca-033776	Equus caballus	60.07	8.00e-100	355.00
IUUC-Eeu-035305	Erinaceus europaeus	54.79	3.00e-55	207.00
IUUC-Fca-035846	Felis catus	56.18	1.00e-106	379.00
IUUC-Fal-037597	Ficedula albicollis	60.42	7.00e-99	352.00
IUUC-Fox-037670	Fusarium oxysporum	38.11	1.00e-45	176.00
IUUC-Fso-038243	Fusarium solani	38.80	8.00e-45	173.00
IUUC-Gmo-038499	Gadus morhua	57.83	2.00e-104	371.00
IUUC-Ggr-039975	Gaeumannomyces graminis	39.11	2.00e-41	161.00
IUUC-Gga-040904	Gallus gallus	61.13	4.00e-115	406.00
IUUC-Gac-042058	Gasterosteus aculeatus	60.06	1.00e-109	388.00
IUUC-Gma-043763	Glycine max	47.13	7.00e-77	279.00
IUUC-Ggo-044699	Gorilla gorilla	57.52	6.00e-99	352.00
IUUC-Hsa-046227	Homo sapiens	61.34	2.00e-112	397.00
IUUC-Hvu-047359	Hordeum vulgare	48.47	4.00e-81	293.00
IUUC-Itr-048989	Ictidomys tridecemlineatus	55.81	1.00e-106	379.00
IUUC-Lch-049829	Latimeria chalumnae	61.34	4.00e-112	396.00
IUUC-Lpe-050899	Leersia perrieri	47.63	1.00e-75	275.00
IUUC-Loc-052264	Lepisosteus oculatus	60.83	8.00e-110	389.00
IUUC-Lma-053110	Leptosphaeria maculans	37.97	2.00e-41	162.00
IUUC-Laf-053639	Loxodonta africana	61.02	9.00e-112	395.00
IUUC-Mcc-055506	Macaca mulatta	61.86	2.00e-112	398.00
IUUC-Mor-057001	Magnaporthe oryzae	33.92	8.00e-48	183.00
IUUC-Mpo-057608	Magnaporthe poae	37.77	3.00e-28	117.00
IUUC-Mtr-057731	Medicago truncatula	45.02	8.00e-78	283.00
IUUC-Mla-059016	Melampsora laricipopulina	44.44	9.00e-47	178.00
IUUC-Mga-060178	Meleagris gallopavo	60.34	5.00e-103	366.00
IUUC-Mvi-060353	Microbotryum violaceum	38.41	6.00e-55	206.00
IUUC-Mmr-060738	Microcebus murinus	61.02	7.00e-112	395.00
IUUC-Mdo-062266	Monodelphis domestica	66.18	3.00e-80	290.00
IUUC-Mmu-063619	Mus musculus	61.98	2.00e-113	400.00
IUUC-Mac-065301	Musa acuminata	50.65	6.00e-83	299.00
IUUC-Mpu-066058	Mustela putorius furo	61.02	8.00e-112	395.00
IUUC-Mlu-067292	Myotis lucifugus	61.54	3.00e-112	397.00
IUUC-Nfi-068275	Neosartorya fischeri	38.71	3.00e-55	207.00
IUUC-Ncr-068713	Neurospora crassa	37.34	2.00e-48	185.00
IUUC-Nle-069013	Nomascus leucogenys	61.86	5.00e-113	400.00
IUUC-Opr-070628	Ochotona princeps	53.24	3.00e-98	350.00
IUUC-Ont-072688	Oreochromis niloticus	60.32	4.00e-109	386.00
IUUC-Oan-073004	Ornithorhynchus anatinus	58.23	1.00e-82	298.00
IUUC-Ocu-074303	Oryctolagus cuniculus	61.02	8.00e-112	396.00
IUUC-Oba-075002	Oryza barthii	47.20	1.00e-77	281.00
IUUC-Obr-076392	Oryza brachyantha	47.32	2.00e-77	281.00
IUUC-Ogl-077271	Oryza glaberrima	47.20	1.00e-77	281.00
IUUC-Ogu-078493	Oryza glumaepatula	47.52	1.00e-78	285.00
IUUC-Oin-080084	Oryza indica	47.52	1.00e-78	285.00
IUUC-Olo-080803	Oryza longistaminata	47.20	3.00e-78	284.00
IUUC-Ome-081146	Oryza meridionalis	46.89	2.00e-77	281.00
IUUC-Oni-082146	Oryza nivara	47.52	1.00e-78	285.00
IUUC-Opu-083633	Oryza punctata	46.69	1.00e-75	275.00
IUUC-Oru-084789	Oryza rufipogon	47.52	1.00e-78	285.00
IUUC-Osa-086196	Oryza sativa	47.52	1.00e-78	285.00
IUUC-Ola-087126	Oryzias latipes	60.70	6.00e-110	389.00
IUUC-Olu-087665	Ostreococcus lucimarinus	43.97	1.00e-67	248.00
IUUC-Oga-089140	Otolemur garnettii	56.47	2.00e-107	381.00
IUUC-Oar-090296	Ovis aries	60.70	3.00e-110	390.00
IUUC-Ptr-090566	Pan troglodytes	61.34	2.00e-112	397.00
IUUC-Pan-092052	Papio anubis	61.86	2.00e-112	398.00
IUUC-Psi-093723	Pelodiscus sinensis	60.07	3.00e-99	353.00
IUUC-Pma-094568	Petromyzon marinus	50.00	2.00e-77	281.00
IUUC-Pno-095120	Phaeosphaeria nodorum	37.61	1.00e-45	176.00
IUUC-Ppa-095761	Physcomitrella patens	46.22	3.00e-77	281.00
IUUC-Pfo-096210	Poecilia formosa	60.38	2.00e-110	390.00
IUUC-Pab-098463	Pongo abelii	61.34	6.00e-112	396.00
IUUC-Pop-099109	Populus trichocarpa	45.92	1.00e-75	275.00
IUUC-Pca-100108	Procavia capensis	63.90	2.00e-90	325.00
IUUC-Ppe-101176	Prunus persica	47.13	2.00e-74	271.00
IUUC-Pva-102629	Pteropus vampyrus	64.85	4.00e-92	330.00
IUUC-Pgr-103419	Puccinia graminis	41.14	3.00e-61	227.00
IUUC-Pte-104207	Pyrenophora teres	43.45	5.00e-29	119.00
IUUC-Pyt-104471	Pyrenophora triticirepentis	39.06	1.00e-48	186.00
IUUC-Rno-105579	Rattus norvegicus	54.66	2.00e-96	345.00
IUUC-Sha-106894	Sarcophilus harrisii	59.48	1.00e-91	328.00
IUUC-Sja-107732	Schizosaccharomyces japonicus	40.00	1.00e-51	195.00
IUUC-Spo-108371	Schizosaccharomyces pombe	41.78	1.00e-54	206.00
IUUC-Ssl-108467	Sclerotinia sclerotiorum	37.59	1.00e-42	166.00
IUUC-Smo-109396	Selaginella moellendorffii	49.23	4.00e-79	287.00
IUUC-Sit-110630	Setaria italica	48.91	7.00e-80	289.00
IUUC-Sly-110972	Solanum lycopersicum	44.66	1.00e-69	255.00
IUUC-Stu-112185	Solanum tuberosum	45.95	2.00e-79	288.00
IUUC-Sar-113294	Sorex araneus	53.12	1.00e-97	348.00
IUUC-Sbi-113951	Sorghum bicolor	47.83	1.00e-79	288.00
IUUC-Ssc-115501	Sus scrofa	59.93	9.00e-103	365.00
IUUC-Tgu-117152	Taeniopygia guttata	60.42	7.00e-99	352.00
IUUC-Tru-118388	Takifugu rubripes	61.02	2.00e-111	394.00
IUUC-Tsy-119109	Tarsius syrichta	61.02	1.00e-111	395.00
IUUC-Tni-120048	Tetraodon nigroviridis	61.02	4.00e-112	396.00
IUUC-Tca-121750	Theobroma cacao	47.29	2.00e-80	291.00
IUUC-Tre-122130	Trichoderma reesei	38.91	7.00e-50	189.00
IUUC-Tvi-122284	Trichoderma virens	38.91	6.00e-45	173.00
IUUC-Tae-124082	Triticum aestivum	48.16	4.00e-81	293.00
IUUC-Tur-126366	Triticum urartu	42.01	4.00e-60	224.00
IUUC-Tme-127187	Tuber melanosporum	40.24	8.00e-56	209.00
IUUC-Tbe-127619	Tupaia belangeri	54.36	1.00e-78	285.00
IUUC-Ttr-128867	Tursiops truncatus	56.67	1.00e-75	275.00
IUUC-Vda-129912	Verticillium dahliae	37.28	5.00e-48	183.00
IUUC-Vpa-130552	Vicugna pacos	65.24	5.00e-81	293.00
IUUC-Vvi-130881	Vitis vinifera	47.13	6.00e-75	273.00
IUUC-Xtr-131934	Xenopus tropicalis	60.00	8.00e-114	402.00
IUUC-Xma-133312	Xiphophorus maculatus	60.38	2.00e-110	390.00
IUUC-Yli-134487	Yarrowia lipolytica	33.95	5.00e-47	180.00
IUUC-Zma-135639	Zea mays	43.30	1.00e-70	258.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence