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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063161
UUCD1 version UUC-MuM-00842
Ensembl Protein ID ENSMUSP00000066031.4
UniProt Accession Q91ZA6; Q149F7; Q149F8; SOCS4_MOUSE
Genbank Protein ID AAL03942.1; EDL20739.1; AAI17815.1; AAI17816.1
Protein Name Suppressor of cytokine signaling 4; Suppressor of cytokine signaling 7
Genbank Nucleotide ID AY046322; CH466605; BC117814; BC117815
Gene Name Socs4; Socs7
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000048379.8 ENSMUST00000065562.4 ENSMUSP00000066031.4
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
miRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box 3.20e-16 60.0 375 422
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box
   S: 3    klwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedyq 53
           +++l+r+ p+SLqh+CR +I++c++++++   d+LP+P+ +k YL++++y+
   Q: 375  STPLIRTFPFSLQHICRTVICNCTTYDGI---DALPIPSPMKLYLKEYHYK 422
           678899***********************...****************985 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR (By similarity).
 SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR (By similarity).
Protein Sequence
(Fasta)
MAENNSKNVD VRPKTSRSRS ADRKDGYVWS GKKLSWSKKS ESCSESEAIG TVENVEIPLR 60
SQERQLSCSS IELDLDHSCG HRFLGRSLKQ KLQDAVGQCF PIKNCSGRHS PGLPSKRKIH 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063161|E3,SOCS|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCCGCCTCGA AGCCGAGAGC TGGTGGCTGG GGCCGCTCTG AAAGAAAAGG TGGGAGCCGA 60
ACCCGGAAGT GGCGGCGGTC CCTGGAGAGC AGGCGGAGGC AGCGGCAAGT CTGACTCTGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063161|E3,SOCS|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0341--Growth regulation
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0734--Signal transduction inhibitor
KW-0833--Ubl conjugation pathway
Interpro

IPR000980--SH2
IPR028416--SOCS4
IPR022252--SOCS4/SOCS5_dom
IPR001496--SOCS_box
PROSITE

PS50001--SH2
PS50225--SOCS
Pfam

PF00017--SH2
PF12610--SOCS
PF07525--SOCS_box
SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box
Gene Ontology

GO:0005737--C:cytoplasm
GO:0004860--F:protein kinase inhibitor activity
GO:0019221--P:cytokine-mediated signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0016567--P:protein ubiquitination
GO:0040008--P:regulation of growth
KEGG mmu:67296
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001789 Ailuropoda melanoleuca 88.36 0.00e+00 745.00
IUUC-Apl-003839 Anas platyrhynchos 76.13 9.00e-172 596.00
IUUC-Aca-004840 Anolis carolinensis 74.94 0.00e+00 640.00
IUUC-Bta-012503 Bos taurus 87.02 0.00e+00 729.00
IUUC-Bol-016597 Brassica oleracea 31.65 5.60e-02 32.70
IUUC-Cja-019284 Callithrix jacchus 87.02 0.00e+00 733.00
IUUC-Cfa-020890 Canis familiaris 88.15 0.00e+00 746.00
IUUC-Cpo-022081 Cavia porcellus 76.75 0.00e+00 645.00
IUUC-Csa-023076 Chlorocebus sabaeus 86.87 0.00e+00 729.00
IUUC-Cho-024700 Choloepus hoffmanni 87.61 0.00e+00 758.00
IUUC-Dno-029961 Dasypus novemcinctus 88.30 0.00e+00 757.00
IUUC-Dor-030273 Dipodomys ordii 88.76 0.00e+00 742.00
IUUC-Ete-032972 Echinops telfairi 87.14 9.00e-168 582.00
IUUC-Eca-034289 Equus caballus 87.39 0.00e+00 732.00
IUUC-Eeu-035208 Erinaceus europaeus 86.01 0.00e+00 719.00
IUUC-Fal-036829 Ficedula albicollis 76.31 1.00e-171 595.00
IUUC-Gga-040725 Gallus gallus 75.45 3.00e-178 617.00
IUUC-Ggo-044886 Gorilla gorilla 87.02 0.00e+00 735.00
IUUC-Hsa-046322 Homo sapiens 86.79 0.00e+00 733.00
IUUC-Itr-048585 Ictidomys tridecemlineatus 88.97 0.00e+00 749.00
IUUC-Lch-049459 Latimeria chalumnae 55.17 6.00e-129 454.00
IUUC-Laf-053484 Loxodonta africana 89.20 0.00e+00 741.00
IUUC-Mcc-054890 Macaca mulatta 86.64 0.00e+00 728.00
IUUC-Meu-056532 Macropus eugenii 80.10 9.00e-174 602.00
IUUC-Mvi-060418 Microbotryum violaceum 32.10 1.40e-02 33.10
IUUC-Mmr-061714 Microcebus murinus 88.28 0.00e+00 729.00
IUUC-Mpu-066499 Mustela putorius furo 87.73 0.00e+00 751.00
IUUC-Mlu-066945 Myotis lucifugus 85.91 0.00e+00 720.00
IUUC-Nle-069976 Nomascus leucogenys 87.02 0.00e+00 733.00
IUUC-Opr-070255 Ochotona princeps 83.22 0.00e+00 709.00
IUUC-Ocu-074764 Oryctolagus cuniculus 88.07 0.00e+00 735.00
IUUC-Oga-088910 Otolemur garnettii 83.72 0.00e+00 714.00
IUUC-Oar-090330 Ovis aries 87.02 0.00e+00 730.00
IUUC-Ptr-090709 Pan troglodytes 87.02 0.00e+00 735.00
IUUC-Pan-092540 Papio anubis 86.87 0.00e+00 729.00
IUUC-Psi-093678 Pelodiscus sinensis 77.90 0.00e+00 685.00
IUUC-Pfo-097139 Poecilia formosa 80.35 1.00e-86 313.00
IUUC-Pab-097970 Pongo abelii 84.99 4.00e-173 600.00
IUUC-Pop-098820 Populus trichocarpa 41.18 1.50e-01 30.80
IUUC-Pca-100211 Procavia capensis 77.47 5.00e-177 613.00
IUUC-Rno-106014 Rattus norvegicus 92.43 0.00e+00 790.00
IUUC-Sha-106822 Sarcophilus harrisii 80.05 0.00e+00 678.00
IUUC-Ssc-115821 Sus scrofa 88.30 0.00e+00 736.00
IUUC-Tgu-117117 Taeniopygia guttata 76.54 2.00e-172 598.00
IUUC-Tsy-118979 Tarsius syrichta 91.91 4.00e-121 427.00
IUUC-Tca-121131 Theobroma cacao 30.77 4.00e-03 35.80
IUUC-Vpa-130626 Vicugna pacos 87.47 0.00e+00 736.00
IUUC-Vvi-131327 Vitis vinifera 43.24 1.10e-01 31.20
IUUC-Xtr-132138 Xenopus tropicalis 67.65 3.00e-167 581.00
Created Date 25-Jun-2017

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