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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046994
UUCD1 version UUC-HoS-00167
Ensembl Protein ID ENSP00000417706.1
UniProt Accession Q6PH85; Q5JSA5; Q5JSA6; Q5JSA7; Q9NVJ1; Q9NXR6; DCNL2_HUMAN
Genbank Protein ID BAA90944.1; BAA91760.1; CAI39428.1; CAI39428.1; CAI39429.1; CAI39429.1; CAI39777.1; CAI39777.1; CAI39778.1; CAI39779.1; CAI39779.1; AAH56669.1
Protein Name DCN1-like protein 2; DCUN1 domain-containing protein 2; Defective in cullin neddylation protein 1-like protein 2
Genbank Nucleotide ID AK000099; AK001566; AL160251; AL442125; AL160251; AL442125; AL442125; AL160251; AL442125; AL442125; AL160251; BC056669
Gene Name DCUN1D2; C13orf17; DCUN1L2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000150401.14 ENST00000375403.6 ENSP00000364552.2
ENSG00000150401.14 ENST00000478244.5 ENSP00000417706.1
ENSG00000150401.14 ENST00000438545.6 ENSP00000403543.2
ENSG00000150401.14 ENST00000496873.1 ENSP00000417398.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTM
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/DCUN1 DCUN1 19617556
UBD/Alpha-Helix/UBA UBA 21813641; 25349211
Classification
Family E-value Score Start End
E3 activity/DCUN1 5.50e-91 305.4 60 247
UBD/Alpha-Helix/UBA 0.001 20.8 7 45
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/DCUN1
   S: 1    vskkkleelferYkdpqed.ligieglekfcedlgvdpediavLvlawkleaatlcefsreefldgltalgcdsieklqeklktleselkde 91
           v+kkkle+l+ rYkdpq++ +ig++g+++fc+dl++dp++i+vLv+awk++aat+cefsr+efldg+t+lgcds+ekl++ l++le+elkd+
   Q: 60   VDKKKLERLYGRYKDPQDEnKIGVDGIQQFCDDLSLDPASISVLVIAWKFRAATQCEFSRKEFLDGMTELGCDSMEKLKALLPRLEQELKDT 151
           589**************999************************************************************************ PP
   S: 92   qkfkdiYrfafnfakdkgqksldldtaialwkLllaerefklldawlkfLeeekkksiskDtWnllLefskviakdlsnYdeegaWPvliDe 183
           +kfkd+Y+f+f+fak++gqk+ldl++a+a+wkL+l++r fk+ld+w++fL+e++k+si++DtWnllL+f ++ia+d+snYdeegaWPvliD+
   Q: 152  AKFKDFYQFTFTFAKNPGQKGLDLEMAVAYWKLVLSGR-FKFLDLWNTFLMEHHKRSIPRDTWNLLLDFGNMIADDMSNYDEEGAWPVLIDD 242
           *************************************9.***************************************************** PP
   S: 184  fveyl 188
           fvey+
   Q: 243  FVEYA 247
           ***97 PP
   

   UBD/Alpha-Helix/UBA
   S: 2    ededkleqlve.MGFdreealqaLraannnleaAveyLl 39
           +++dk++q+++ +   + +a+ +L ++ + l++A++ ++
   Q: 7    SQKDKVRQFMAcTQAGERTAIYCLTQNEWRLDEATDSFF 45
           699********7777777******************998 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Potently stimulates the neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes from the NEDD8-conjugating E2 enzyme UBC12. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.
 Potently stimulates the neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes from the NEDD8-conjugating E2 enzyme UBC12. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.
Protein Sequence
(Fasta)
MHKLKSSQKD KVRQFMACTQ AGERTAIYCL TQNEWRLDEA TDSFFQNPDS LHRESMRNAV 60
DKKKLERLYG RYKDPQDENK IGVDGIQQFC DDLSLDPASI SVLVIAWKFR AATQCEFSRK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046994|E3,DCUN1;UBD,UBA|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGCACTTCCT GGCCGGCGTG GGGCCTGGCA GCCGCAGGCT GGCGTTGGAC CCCGCAGGGG 60
CGAGCCAAGG CCCTCGCAGA GGGCTGGACG CGCAGGGGCT GTGGGGCGCG AGCTCCCGTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046994|E3,DCUN1;UBD,UBA|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR014764--DCN-prot
IPR005176--PONY_dom
IPR009060--UBA-like
PROSITE

PS51229--DCUN1
Pfam

PF03556--Cullin_binding
Gene Ontology

GO:0000151--C:ubiquitin ligase complex
GO:0097602--F:cullin family protein binding
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0032182--F:ubiquitin-like protein binding
GO:0051443--P:positive regulation of ubiquitin-protein transferase activity
GO:0045116--P:protein neddylation
KEGG hsa:55208
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000561 Aegilops tauschii 45.34 6.00e-62 230.00
IUUC-Aml-001808 Ailuropoda melanoleuca 84.15 2.00e-125 441.00
IUUC-Atr-002662 Amborella trichopoda 41.94 9.00e-26 110.00
IUUC-Apl-003933 Anas platyrhynchos 88.24 4.00e-138 483.00
IUUC-Aca-005059 Anolis carolinensis 86.44 5.00e-125 440.00
IUUC-Aly-006285 Arabidopsis lyrata 38.87 2.00e-46 179.00
IUUC-Ath-007531 Arabidopsis thaliana 44.53 1.00e-59 223.00
IUUC-Ame-011739 Astyanax mexicanus 84.65 1.00e-126 445.00
IUUC-Bta-012373 Bos taurus 80.31 1.00e-122 432.00
IUUC-Bci-013824 Botrytis cinerea 31.10 5.00e-31 128.00
IUUC-Bdi-014138 Brachypodium distachyon 45.34 6.00e-62 230.00
IUUC-Bol-016110 Brassica oleracea 44.53 8.00e-59 220.00
IUUC-Bra-017111 Brassica rapa 44.53 2.00e-58 219.00
IUUC-Cja-018854 Callithrix jacchus 96.90 5.00e-151 526.00
IUUC-Cpo-021832 Cavia porcellus 91.92 8.00e-143 499.00
IUUC-Csa-023108 Chlorocebus sabaeus 98.06 2.00e-152 531.00
IUUC-Csv-026372 Ciona savignyi 43.82 2.00e-51 195.00
IUUC-Cgl-026386 Colletotrichum gloeosporioides 31.84 2.00e-23 101.00
IUUC-Dno-029524 Dasypus novemcinctus 91.39 3.00e-135 474.00
IUUC-Dor-030143 Dipodomys ordii 93.02 1.00e-145 508.00
IUUC-Dse-031365 Dothistroma septosporum 26.17 5.00e-26 111.00
IUUC-Eca-033375 Equus caballus 88.84 6.00e-126 442.00
IUUC-Fal-036715 Ficedula albicollis 89.02 5.00e-139 486.00
IUUC-Fso-038150 Fusarium solani 25.50 2.00e-20 93.20
IUUC-Gmo-038750 Gadus morhua 84.31 4.00e-133 466.00
IUUC-Gga-040224 Gallus gallus 88.54 6.00e-137 479.00
IUUC-Gac-041478 Gasterosteus aculeatus 85.10 2.00e-133 468.00
IUUC-Ggo-044972 Gorilla gorilla 99.23 1.00e-154 538.00
IUUC-Hvu-047636 Hordeum vulgare 37.21 9.00e-24 103.00
IUUC-Itr-047902 Ictidomys tridecemlineatus 89.06 1.00e-139 489.00
IUUC-Kpa-049127 Komagataella pastoris 30.36 7.00e-24 103.00
IUUC-Lch-049751 Latimeria chalumnae 85.16 9.00e-136 475.00
IUUC-Loc-051976 Lepisosteus oculatus 84.77 4.00e-135 473.00
IUUC-Lma-053103 Leptosphaeria maculans 30.83 1.00e-32 133.00
IUUC-Laf-053972 Loxodonta africana 91.47 8.00e-143 499.00
IUUC-Mcc-054700 Macaca mulatta 98.07 4.00e-153 533.00
IUUC-Meu-056791 Macropus eugenii 74.42 1.00e-109 389.00
IUUC-Mpo-057299 Magnaporthe poae 24.46 8.00e-18 84.30
IUUC-Mga-060072 Meleagris gallopavo 88.24 8.00e-138 482.00
IUUC-Mdo-062241 Monodelphis domestica 86.07 1.00e-128 452.00
IUUC-Mmu-063816 Mus musculus 91.12 1.00e-144 504.00
IUUC-Mac-065016 Musa acuminata 48.50 2.00e-44 171.00
IUUC-Nle-069475 Nomascus leucogenys 98.46 2.00e-153 534.00
IUUC-Ont-071910 Oreochromis niloticus 84.05 2.00e-134 471.00
IUUC-Ocu-074349 Oryctolagus cuniculus 90.46 2.00e-133 468.00
IUUC-Oba-074993 Oryza barthii 46.96 1.00e-62 232.00
IUUC-Obr-076341 Oryza brachyantha 46.15 6.00e-63 233.00
IUUC-Ogl-077099 Oryza glaberrima 46.96 1.00e-62 232.00
IUUC-Ogu-078285 Oryza glumaepatula 46.15 5.00e-61 227.00
IUUC-Oin-079441 Oryza indica 46.96 2.00e-62 232.00
IUUC-Olo-081037 Oryza longistaminata 46.96 2.00e-62 232.00
IUUC-Ome-081357 Oryza meridionalis 46.96 2.00e-62 232.00
IUUC-Oni-082632 Oryza nivara 46.15 2.00e-62 232.00
IUUC-Oru-084306 Oryza rufipogon 46.96 2.00e-62 232.00
IUUC-Osa-085307 Oryza sativa 46.96 2.00e-62 232.00
IUUC-Oga-088621 Otolemur garnettii 94.96 3.00e-148 517.00
IUUC-Ptr-091595 Pan troglodytes 98.84 2.00e-153 534.00
IUUC-Pan-092825 Papio anubis 97.68 1.00e-152 531.00
IUUC-Psi-093029 Pelodiscus sinensis 87.55 6.00e-129 452.00
IUUC-Pno-095145 Phaeosphaeria nodorum 32.38 7.00e-26 110.00
IUUC-Ppa-095321 Physcomitrella patens 44.58 4.00e-59 221.00
IUUC-Pab-098197 Pongo abelii 98.77 6.00e-145 506.00
IUUC-Pop-098821 Populus trichocarpa 45.19 7.00e-24 102.00
IUUC-Pca-100195 Procavia capensis 90.70 3.00e-140 490.00
IUUC-Pva-102691 Pteropus vampyrus 93.44 2.00e-146 511.00
IUUC-Ptt-103979 Puccinia triticina 25.29 2.00e-04 40.80
IUUC-Rno-105016 Rattus norvegicus 90.27 2.00e-143 501.00
IUUC-Sha-106542 Sarcophilus harrisii 86.10 6.00e-137 479.00
IUUC-Sja-107938 Schizosaccharomyces japonicus 31.72 1.00e-23 103.00
IUUC-Sit-110613 Setaria italica 45.75 4.00e-62 231.00
IUUC-Sbi-114113 Sorghum bicolor 45.38 5.00e-63 234.00
IUUC-Tgu-117196 Taeniopygia guttata 88.63 7.00e-139 486.00
IUUC-Tru-118119 Takifugu rubripes 81.71 2.00e-131 461.00
IUUC-Tni-120315 Tetraodon nigroviridis 82.10 4.00e-132 463.00
IUUC-Tre-121986 Trichoderma reesei 25.33 4.00e-22 98.60
IUUC-Tvi-122607 Trichoderma virens 32.68 5.00e-30 124.00
IUUC-Tae-125740 Triticum aestivum 38.89 5.00e-56 211.00
IUUC-Tur-126375 Triticum urartu 35.33 3.00e-51 196.00
IUUC-Vda-129929 Verticillium dahliae 30.85 2.00e-22 99.80
IUUC-Vvi-130834 Vitis vinifera 44.13 2.00e-60 225.00
IUUC-Zma-135864 Zea mays 45.78 7.00e-63 233.00
Created Date 25-Jun-2017

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