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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Rno-104998
UUCD1 version UUC-RaN-00002
Ensembl Protein ID ENSRNOP00000024850.3
UniProt Accession O70277; TRIM3_RAT
Genbank Protein ID AAC17997.1
Protein Name Tripartite motif-containing protein 3; Brain-expressed RING finger protein; RING finger protein 22
Genbank Nucleotide ID AF036255
Gene Name Trim3; Berp; Rnf22
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000018356.6 ENSRNOT00000024850.5 ENSRNOP00000024850.3
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNATRANSFACmiRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusUniProt
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 20352094
Classification
Family E-value Score Start End
E3 activity/RING/RING 6.70e-08 33.3 22 63
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iCl+++++ p+vlpC H+f++ Clq++  ++  +s + +CP+Cr
   Q: 22   CSICLDRYRC-PKVLPCLHTFCERCLQNY-IPP--QSLTLSCPVCR 63
           ********99.******************.555..9999******8 PP
   
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Positively regulates motility of microtubule-dependent motor protein KIF21B.
 Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Positively regulates motility of microtubule-dependent motor protein KIF21B.
Protein Sequence
(Fasta)
MAKREDSPGP EVQPMDKQFL VCSICLDRYR CPKVLPCLHT FCERCLQNYI PPQSLTLSCP 60
VCRQTSILPE QGVSALQNNF FISSLMEAMQ QAPDGAHDPE DPHPLSAVAG RPLSCPNHEG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-104998|E3,RING|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCGGCGGCGG CGCCGGCGCG GGGACAGACG GAGGCGCGGG ACGTGGGGCG GCGCCGCGGG 60
CAGGGCCGGG CGGACGAGCG CTGGCAGCGG GGGCAGCGCT GCGGGCCGCT CCGAGTGGCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-104998|E3,RING|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0966--Cell projection
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0967--Endosome
KW-0333--Golgi apparatus
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR003649--Bbox_C
IPR017868--Filamin/ABP280_repeat-like
IPR001298--Filamin/ABP280_rpt
IPR013783--Ig-like_fold
IPR014756--Ig_E-set
IPR001258--NHL_repeat
IPR013017--NHL_repeat_subgr
IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50194--FILAMIN_REPEAT
PS51125--NHL
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00630--Filamin
PF01436--NHL
PF00643--zf-B_box
PF13445--zf-RING_UBOX
SMART

SM00502--BBC
SM00336--BBOX
SM00557--IG_FLMN
SM00184--RING
Gene Ontology

GO:0005737--C:cytoplasm
GO:0030425--C:dendrite
GO:0005769--C:early endosome
GO:0005794--C:Golgi apparatus
GO:0008270--F:zinc ion binding
GO:0015031--P:protein transport
KEGG rno:83616
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001769 Ailuropoda melanoleuca 98.66 0.00e+00 1487.00
IUUC-Bta-013091 Bos taurus 98.92 0.00e+00 1516.00
IUUC-Cja-019116 Callithrix jacchus 98.79 0.00e+00 1512.00
IUUC-Cfa-020946 Canis familiaris 98.92 0.00e+00 1514.00
IUUC-Cpo-021747 Cavia porcellus 99.33 0.00e+00 1519.00
IUUC-Csa-023901 Chlorocebus sabaeus 98.66 0.00e+00 1510.00
IUUC-Csv-026112 Ciona savignyi 27.51 2.00e-79 290.00
IUUC-Dre-028509 Danio rerio 73.51 0.00e+00 1157.00
IUUC-Dno-029414 Dasypus novemcinctus 98.92 0.00e+00 1516.00
IUUC-Ete-032776 Echinops telfairi 97.58 0.00e+00 1486.00
IUUC-Eca-034308 Equus caballus 98.92 0.00e+00 1512.00
IUUC-Eeu-034845 Erinaceus europaeus 90.99 0.00e+00 1367.00
IUUC-Fca-035594 Felis catus 98.92 0.00e+00 1516.00
IUUC-Gga-040515 Gallus gallus 79.49 0.00e+00 1233.00
IUUC-Gac-042506 Gasterosteus aculeatus 74.83 0.00e+00 1135.00
IUUC-Gma-044219 Glycine max 37.50 2.00e-07 51.60
IUUC-Ggo-045603 Gorilla gorilla 98.92 0.00e+00 1512.00
IUUC-Hsa-046416 Homo sapiens 98.79 0.00e+00 1513.00
IUUC-Itr-048448 Ictidomys tridecemlineatus 98.79 0.00e+00 1512.00
IUUC-Lch-050005 Latimeria chalumnae 69.15 0.00e+00 1103.00
IUUC-Loc-052433 Lepisosteus oculatus 74.77 0.00e+00 1185.00
IUUC-Laf-053930 Loxodonta africana 98.25 0.00e+00 1505.00
IUUC-Mcc-055778 Macaca mulatta 98.66 0.00e+00 1509.00
IUUC-Meu-056100 Macropus eugenii 91.57 0.00e+00 1316.00
IUUC-Mmr-060733 Microcebus murinus 98.92 0.00e+00 1514.00
IUUC-Mdo-062705 Monodelphis domestica 90.99 0.00e+00 1402.00
IUUC-Mmu-063965 Mus musculus 99.87 0.00e+00 1530.00
IUUC-Mpu-066757 Mustela putorius furo 99.06 0.00e+00 1516.00
IUUC-Mlu-067822 Myotis lucifugus 87.04 0.00e+00 1145.00
IUUC-Nle-069595 Nomascus leucogenys 98.44 0.00e+00 1422.00
IUUC-Ont-071250 Oreochromis niloticus 76.27 0.00e+00 1161.00
IUUC-Ocu-074675 Oryctolagus cuniculus 98.92 0.00e+00 1510.00
IUUC-Ola-087179 Oryzias latipes 75.20 0.00e+00 1146.00
IUUC-Oga-089121 Otolemur garnettii 99.06 0.00e+00 1516.00
IUUC-Oar-089931 Ovis aries 95.70 0.00e+00 1438.00
IUUC-Ptr-090907 Pan troglodytes 98.79 0.00e+00 1513.00
IUUC-Pan-092076 Papio anubis 98.66 0.00e+00 1509.00
IUUC-Pfo-097324 Poecilia formosa 72.77 0.00e+00 1131.00
IUUC-Pab-097602 Pongo abelii 94.49 0.00e+00 1425.00
IUUC-Pva-103232 Pteropus vampyrus 98.79 0.00e+00 1484.00
IUUC-Sha-107604 Sarcophilus harrisii 91.26 0.00e+00 1405.00
IUUC-Stu-112510 Solanum tuberosum 37.50 1.00e-08 53.10
IUUC-Sar-113243 Sorex araneus 98.01 0.00e+00 894.00
IUUC-Ssc-115253 Sus scrofa 91.26 0.00e+00 1378.00
IUUC-Tru-118267 Takifugu rubripes 74.37 0.00e+00 1163.00
IUUC-Tsy-119487 Tarsius syrichta 99.22 0.00e+00 1036.00
IUUC-Tni-120733 Tetraodon nigroviridis 74.97 0.00e+00 1154.00
Created Date 25-Jun-2017

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