iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Post-translational Modifications (PTMs)
dbPAF	dbPTM	Phospho.ELM	UniProt
PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.80e-82	276.7	396	778

Active Site

Position(s)	Description	Evidence
405	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
720	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaf 98
           +Gl N+  tCY+NS+LQ+L+++pe+r++l +    ++++   +++ +++  +lqklf +l++s k av++++l++++++ + e    +q+D qE++++
   Q: 396  VGLVNQAMTCYLNSLLQALFMTPEFRNALYR---WEFDN---DNEAKNIPYQLQKLFLNLQTSPKAAVETTDLTRSFGWDSTE--AWQQHDIQELCRV 485
           6******************************...44433...456889******************************99987..9************ PP
   S: 99   lldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgk.eetkkeslqdcLesft 195
           ++d+le ++                          k++k+ +lis+l++g++ + +kclec+++++re++fld++lpv+   ++++  s++++L++f+
   Q: 486  MFDALEHKF--------------------------KNTKQANLISNLYEGKMNDYVKCLECNTEKTREDTFLDIPLPVRPFgSSSAYGSIEEALRAFV 557
           *********..........................78999**************************************9541345577********** PP
   S: 196  keeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqke................... 274
           ++e+l+g+n+y cekckkk++a k l +k++P +L+lhLkRf f+ ++++r+k+n++v+fp++L+l+ f +++ ++ ++                   
   Q: 558  QPETLDGNNQYLCEKCKKKCDAHKGLHFKSFPYILTLHLKRFDFDYQTMHRIKLNDRVTFPQTLNLNTFINRSGNSGEQnsqlngtvddcstadsgsa 655
           ********************************************************************999944444335566666666666666666 PP
   S: 275  .............................................kkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleet 326
                                                        ++ YeL+a+++HsGs+s+GHY+ay+k+ +++ W++f+D++Vt++++e+++++ 
   Q: 656  meddnlssgvvttasssqhendlndedegidmssstsksakqgsgPYLYELFAIMIHSGSASGGHYYAYIKDFDNNeWFCFNDQNVTSITQEDIQRSF 753
           666777777777777777777777888888888888888888999***************************77777*******************98 PP
   S: 327  g..............staYvlfYkr 337
           g              ++aY+l+Y++
   Q: 754  GgpngsyyssaytssTNAYMLMYRQ 778
           8**********************97 PP

Organism

Drosophila melanogaster

Functional Description
(View)

Belongs to the peptidase C19 family.

Protein Sequence
(Fasta)

MTDKESEQCT VSVFDQTPGS EQKKINVVVR SHFTVKRVID LIGTQFSYEK FELLLQPHDN 60
KDLVNLNALE SQLMYEVAGF EPQLKNHLIL LPSGSWDGDV TKRFELPIKR VVVKKVMKSD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TACAGTCAGC GGCGGGCAGT CACACCGGAA CGAGCACGTC TGGTAAAACA GCCGAACGGA 60
ACAACAAAAA ACAATTGTAA AAATGACCCG TCGAGGCTCG TTTTAAGCGA ATTTCTAGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0006284--P:base-excision repair
GO:0042675--P:compound eye cone cell differentiation
GO:0030177--P:positive regulation of Wnt signaling pathway
GO:0016579--P:protein deubiquitination
GO:0050821--P:protein stabilization
GO:0042981--P:regulation of apoptotic process
GO:0031935--P:regulation of chromatin silencing
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

dme:Dmel_CG5486

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002228	Ailuropoda melanoleuca	49.65	5.00e-149	521.00
IUUC-Apl-003486	Anas platyrhynchos	49.22	3.00e-148	518.00
IUUC-Aca-005061	Anolis carolinensis	48.96	8.00e-145	507.00
IUUC-Ame-011206	Astyanax mexicanus	50.09	9.00e-149	520.00
IUUC-Bta-012942	Bos taurus	49.40	9.00e-150	524.00
IUUC-Cel-018600	Caenorhabditis elegans	41.22	4.00e-120	425.00
IUUC-Cja-018950	Callithrix jacchus	50.09	2.00e-151	529.00
IUUC-Cfa-020299	Canis familiaris	49.74	3.00e-150	525.00
IUUC-Cpo-021943	Cavia porcellus	49.91	3.00e-150	525.00
IUUC-Csa-023285	Chlorocebus sabaeus	50.09	2.00e-151	530.00
IUUC-Cho-025006	Choloepus hoffmanni	48.70	5.00e-140	491.00
IUUC-Cin-025145	Ciona intestinalis	45.88	2.00e-136	479.00
IUUC-Csv-025839	Ciona savignyi	47.91	1.00e-142	500.00
IUUC-Dre-027959	Danio rerio	50.09	1.00e-149	523.00
IUUC-Dno-030023	Dasypus novemcinctus	48.43	2.00e-141	496.00
IUUC-Eca-033913	Equus caballus	49.74	2.00e-150	526.00
IUUC-Eeu-034518	Erinaceus europaeus	49.39	2.00e-145	509.00
IUUC-Fca-035997	Felis catus	49.74	4.00e-150	525.00
IUUC-Fal-037088	Ficedula albicollis	49.57	2.00e-145	509.00
IUUC-Gmo-038920	Gadus morhua	50.09	2.00e-142	499.00
IUUC-Gga-040953	Gallus gallus	49.57	2.00e-147	516.00
IUUC-Gac-042400	Gasterosteus aculeatus	49.23	4.00e-144	505.00
IUUC-Ggo-044820	Gorilla gorilla	50.00	2.00e-151	529.00
IUUC-Hsa-046634	Homo sapiens	50.09	4.00e-151	528.00
IUUC-Lch-050440	Latimeria chalumnae	50.09	4.00e-151	528.00
IUUC-Loc-051904	Lepisosteus oculatus	48.95	4.00e-145	508.00
IUUC-Laf-053760	Loxodonta africana	49.74	4.00e-150	525.00
IUUC-Mcc-054637	Macaca mulatta	50.09	4.00e-151	528.00
IUUC-Meu-056904	Macropus eugenii	48.20	8.00e-129	454.00
IUUC-Mga-059556	Meleagris gallopavo	49.57	4.00e-147	515.00
IUUC-Mmr-061192	Microcebus murinus	50.26	3.00e-151	528.00
IUUC-Mdo-061929	Monodelphis domestica	49.25	1.00e-151	530.00
IUUC-Mmu-063726	Mus musculus	49.91	1.00e-149	523.00
IUUC-Mpu-066014	Mustela putorius furo	49.74	4.00e-150	525.00
IUUC-Mlu-067232	Myotis lucifugus	49.65	1.00e-149	524.00
IUUC-Nle-069619	Nomascus leucogenys	50.09	2.00e-151	529.00
IUUC-Opr-070224	Ochotona princeps	57.25	2.00e-133	470.00
IUUC-Ont-071384	Oreochromis niloticus	50.17	9.00e-149	520.00
IUUC-Oan-073208	Ornithorhynchus anatinus	49.83	2.00e-147	516.00
IUUC-Ocu-074285	Oryctolagus cuniculus	49.57	3.00e-149	522.00
IUUC-Ola-087051	Oryzias latipes	50.00	4.00e-146	512.00
IUUC-Oga-088928	Otolemur garnettii	50.09	2.00e-150	526.00
IUUC-Oar-090215	Ovis aries	48.58	2.00e-149	523.00
IUUC-Ptr-091035	Pan troglodytes	50.09	4.00e-151	528.00
IUUC-Pan-092377	Papio anubis	49.74	5.00e-148	518.00
IUUC-Pfo-096722	Poecilia formosa	50.96	3.00e-150	526.00
IUUC-Pab-098723	Pongo abelii	49.91	1.00e-150	527.00
IUUC-Pca-100105	Procavia capensis	44.52	3.00e-121	429.00
IUUC-Pva-102514	Pteropus vampyrus	60.43	9.00e-113	401.00
IUUC-Rno-105384	Rattus norvegicus	50.09	1.00e-149	524.00
IUUC-Sha-106982	Sarcophilus harrisii	49.91	4.00e-150	525.00
IUUC-Sar-113723	Sorex araneus	51.07	6.00e-98	352.00
IUUC-Ssc-115671	Sus scrofa	43.07	1.00e-94	340.00
IUUC-Tgu-116722	Taeniopygia guttata	49.74	5.00e-146	511.00
IUUC-Tru-118380	Takifugu rubripes	50.09	2.00e-146	513.00
IUUC-Tsy-119646	Tarsius syrichta	45.29	2.00e-121	429.00
IUUC-Tni-120762	Tetraodon nigroviridis	50.00	4.00e-147	515.00
IUUC-Tbe-127861	Tupaia belangeri	46.83	7.00e-145	507.00
IUUC-Ttr-129254	Tursiops truncatus	44.52	9.00e-123	434.00
IUUC-Vpa-130141	Vicugna pacos	59.19	2.00e-138	486.00
IUUC-Xtr-132700	Xenopus tropicalis	46.39	2.00e-151	530.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence