iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046710

UUCD1 version

UUC-HoS-01073

Ensembl Protein ID

ENSP00000428813.2

UniProt Accession

Q96B02; B4DIV1; Q1XBE0; Q9H823; Q9HAG6; Q9NV07; UBE2W_HUMAN

Genbank Protein ID

AAY24555.1; BAA91954.1; BAB13883.1; BAB14800.1; BAG58613.1; CAG33556.1; EAW87009.1; EAW87011.1; AAH16326.1

Protein Name

Ubiquitin-conjugating enzyme E2 W; E2 ubiquitin-conjugating enzyme W; N-terminal E2 ubiquitin-conjugating enzyme; N-terminus-conjugating E2; Ubiquitin carrier protein W; Ubiquitin-conjugating enzyme 16; Ubiquitin-protein ligase W

Genbank Nucleotide ID

AY948289; AK001873; AK021735; AK024050; AK295792; CR457275; CH471068; CH471068; AC022826

Gene Name

UBE2W; UBC16

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000104343.19	ENST00000523278.5	ENSP00000428835.1
ENSG00000104343.19	ENST00000517608.5	ENSP00000428813.2
ENSG00000104343.19	ENST00000422906.6	ENSP00000414771.2
ENSG00000104343.19	ENST00000419880.7	ENSP00000397453.3

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
PhosphositePlus	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/UBC	E2_UBC	18179693; 23696636

Classification

Family	E-value	Score	Start	End
E2/UBC	6.90e-36	124.7	36	169

Active Site

Position(s)	Description	Evidence
91	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 1    Rlkkelkelekdppegisakpvdesd.ltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltk..ifhPnvyenGkvClsilkee 89
           Rl+kel +l++dpp+g++++ ++ ++ +t+w v ++G ++t Yeg++F+l ++f+++YPf++P+v+f+ +    hP+vy+nG++Clsil+  
   Q: 36   RLQKELLALQNDPPPGMTLNEKSVQNsITQWIVDMEGAPGTLYEGEKFQLLFKFSSRYPFDSPQVMFTGEniPVHPHVYSNGHICLSILT-- 125
           9*********************99989*****************************************99989****************9.. PP
   S: 90   ekWspalsvesvllsiqsll..aepnpesplneeaaellkknre 131
           e+Wspalsv+sv+lsi+s+l  ++ + + p n+  +++++kn++
   Q: 126  EDWSPALSVQSVCLSIISMLssCKEKRRPPDNSFYVRTCNKNPK 169
           ********************655577788999999999999987 PP

Organism

Homo sapiens

Functional Description
(View)

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in degradation of misfolded chaperone substrates by mediating monoubiquitination of STUB1/CHIP, leading to recruitment of ATXN3 to monoubiquitinated STUB1/CHIP, and restriction of the length of ubiquitin chain attached to STUB1/CHIP substrates by ATXN3. After UV irradiation, but not after mitomycin-C (MMC) treatment, acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Transfers ubiquitin in complex with RING/U-box type E3s that do not have active site cysteine residues to form thioester bonds with ubiquitin, and preferentially ubiquitinates the N-terminus of substrates, such as ATXN3, STUB1 and SUMO2.

Protein Sequence
(Fasta)

MLSPRGVTRA RQLLPLRLWP RRSWGDGSIM ASMQKRLQKE LLALQNDPPP GMTLNEKSVQ 60
NSITQWIVDM EGAPGTLYEG EKFQLLFKFS SRYPFDSPQV MFTGENIPVH PHVYSNGHIC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATGTTGAGC CCCCGCGGCG TGACGCGAGC ACGGCAGCTC CTCCCCCTGC GTCTCTGGCC 60
TCGCCGGTCT TGGGGGGATG GTTCCATCAT GGCGTCAATG CAGGTGAGAG GAGTTTGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0071218--P:cellular response to misfolded protein
GO:0006281--P:DNA repair
GO:0006515--P:misfolded or incompletely synthesized protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070979--P:protein K11-linked ubiquitination
GO:0006513--P:protein monoubiquitination
GO:0016567--P:protein ubiquitination

KEGG

hsa:55284

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000363	Aegilops tauschii	42.18	2.00e-30	126.00
IUUC-Aml-002375	Ailuropoda melanoleuca	84.83	1.00e-86	311.00
IUUC-Aly-006450	Arabidopsis lyrata	51.03	9.00e-41	159.00
IUUC-Ath-007383	Arabidopsis thaliana	51.72	1.00e-34	138.00
IUUC-Acl-008034	Aspergillus clavatus	34.87	5.00e-23	100.00
IUUC-Afl-008476	Aspergillus flavus	37.82	2.00e-26	111.00
IUUC-Afu-008827	Aspergillus fumigatus	36.54	2.00e-25	107.00
IUUC-Ani-009244	Aspergillus nidulans	35.46	4.00e-20	90.50
IUUC-Ang-009545	Aspergillus niger	36.84	2.00e-23	101.00
IUUC-Aor-009924	Aspergillus oryzae	36.62	6.00e-23	99.80
IUUC-Ate-010478	Aspergillus terreus	30.17	2.00e-19	88.60
IUUC-Ame-011757	Astyanax mexicanus	98.01	1.00e-87	315.00
IUUC-Bgr-012004	Blumeria graminis	39.10	3.00e-27	114.00
IUUC-Bta-013365	Bos taurus	100.00	7.00e-89	318.00
IUUC-Bci-013609	Botrytis cinerea	37.91	7.00e-25	106.00
IUUC-Bdi-014373	Brachypodium distachyon	51.72	4.00e-41	160.00
IUUC-Bol-016083	Brassica oleracea	51.72	2.00e-40	159.00
IUUC-Bra-017578	Brassica rapa	52.74	4.00e-35	140.00
IUUC-Cel-018273	Caenorhabditis elegans	61.38	9.00e-55	205.00
IUUC-Cja-018997	Callithrix jacchus	97.28	5.00e-84	302.00
IUUC-Cfa-020790	Canis familiaris	97.78	2.00e-95	341.00
IUUC-Cpo-021615	Cavia porcellus	98.63	7.00e-84	301.00
IUUC-Cre-022615	Chlamydomonas reinhardtii	43.05	1.00e-28	119.00
IUUC-Csa-024236	Chlorocebus sabaeus	100.00	7.00e-89	318.00
IUUC-Cin-025579	Ciona intestinalis	67.12	1.00e-58	218.00
IUUC-Cgl-026554	Colletotrichum gloeosporioides	40.40	1.00e-26	112.00
IUUC-Cne-026943	Cryptococcus neoformans	56.16	1.00e-20	92.40
IUUC-Cme-027157	Cyanidioschyzon merolae	50.00	1.00e-38	152.00
IUUC-Dre-027411	Danio rerio	97.40	5.00e-89	319.00
IUUC-Dno-029321	Dasypus novemcinctus	100.00	7.00e-89	318.00
IUUC-Dor-030985	Dipodomys ordii	99.11	4.00e-65	239.00
IUUC-Dse-031193	Dothistroma septosporum	41.67	8.00e-28	116.00
IUUC-Dme-032116	Drosophila melanogaster	72.60	1.00e-65	242.00
IUUC-Ete-032344	Echinops telfairi	100.00	8.00e-86	308.00
IUUC-Eeu-034593	Erinaceus europaeus	100.00	8.00e-86	308.00
IUUC-Fal-037512	Ficedula albicollis	98.45	1.00e-74	271.00
IUUC-Fox-038001	Fusarium oxysporum	40.38	6.00e-27	113.00
IUUC-Fso-038237	Fusarium solani	39.74	3.00e-26	110.00
IUUC-Gmo-039574	Gadus morhua	98.68	6.00e-88	315.00
IUUC-Ggr-040091	Gaeumannomyces graminis	39.07	2.00e-27	115.00
IUUC-Gga-040125	Gallus gallus	99.34	2.00e-88	317.00
IUUC-Gma-043703	Glycine max	51.03	3.00e-34	137.00
IUUC-Ggo-044461	Gorilla gorilla	93.21	5.00e-86	309.00
IUUC-Itr-048816	Ictidomys tridecemlineatus	100.00	5.00e-87	312.00
IUUC-Kpa-049405	Komagataella pastoris	41.06	3.00e-31	127.00
IUUC-Lpe-051342	Leersia perrieri	51.72	5.00e-41	159.00
IUUC-Loc-052247	Lepisosteus oculatus	94.81	8.00e-86	308.00
IUUC-Lma-053151	Leptosphaeria maculans	40.67	1.00e-26	112.00
IUUC-Mcc-055520	Macaca mulatta	94.24	2.00e-93	334.00
IUUC-Mor-057224	Magnaporthe oryzae	38.82	2.00e-28	118.00
IUUC-Mpo-057368	Magnaporthe poae	38.41	7.00e-27	113.00
IUUC-Mtr-058312	Medicago truncatula	50.34	5.00e-34	136.00
IUUC-Mla-059112	Melampsora laricipopulina	49.07	2.00e-32	131.00
IUUC-Mga-059919	Meleagris gallopavo	99.32	2.00e-85	307.00
IUUC-Mvi-060408	Microbotryum violaceum	48.72	4.00e-37	146.00
IUUC-Mmr-061136	Microcebus murinus	97.73	3.00e-93	333.00
IUUC-Mdo-062768	Monodelphis domestica	99.34	2.00e-88	317.00
IUUC-Mmu-063097	Mus musculus	96.91	1.00e-91	328.00
IUUC-Mac-064973	Musa acuminata	50.34	6.00e-41	159.00
IUUC-Mpu-066887	Mustela putorius furo	98.30	4.00e-92	330.00
IUUC-Mlu-067762	Myotis lucifugus	92.64	4.00e-89	319.00
IUUC-Nfi-068242	Neosartorya fischeri	33.14	3.00e-23	101.00
IUUC-Ncr-068788	Neurospora crassa	39.74	1.00e-28	119.00
IUUC-Nle-070082	Nomascus leucogenys	99.44	5.00e-95	339.00
IUUC-Ont-072026	Oreochromis niloticus	87.78	8.00e-91	325.00
IUUC-Oan-073013	Ornithorhynchus anatinus	98.45	9.00e-75	271.00
IUUC-Oba-075077	Oryza barthii	51.72	2.00e-41	160.00
IUUC-Obr-076142	Oryza brachyantha	50.00	8.00e-40	155.00
IUUC-Ogl-077944	Oryza glaberrima	51.72	2.00e-41	161.00
IUUC-Ogu-078453	Oryza glumaepatula	51.72	2.00e-41	160.00
IUUC-Oin-079726	Oryza indica	51.72	6.00e-41	159.00
IUUC-Olo-080356	Oryza longistaminata	51.72	2.00e-41	161.00
IUUC-Ome-081601	Oryza meridionalis	51.72	2.00e-41	161.00
IUUC-Oni-082554	Oryza nivara	51.72	2.00e-41	160.00
IUUC-Opu-083614	Oryza punctata	51.72	2.00e-41	161.00
IUUC-Oru-085028	Oryza rufipogon	51.72	2.00e-41	161.00
IUUC-Osa-085386	Oryza sativa	51.72	2.00e-41	161.00
IUUC-Oga-087990	Otolemur garnettii	100.00	5.00e-87	312.00
IUUC-Ptr-090701	Pan troglodytes	100.00	1.00e-85	308.00
IUUC-Pan-092007	Papio anubis	93.19	3.00e-92	330.00
IUUC-Psi-093380	Pelodiscus sinensis	97.35	1.00e-86	311.00
IUUC-Pma-094682	Petromyzon marinus	85.71	4.00e-80	289.00
IUUC-Ppa-095667	Physcomitrella patens	53.10	7.00e-35	139.00
IUUC-Pfo-097000	Poecilia formosa	98.68	4.00e-88	316.00
IUUC-Pab-098188	Pongo abelii	100.00	7.00e-89	318.00
IUUC-Pop-099724	Populus trichocarpa	48.97	4.00e-32	130.00
IUUC-Ppe-101296	Prunus persica	51.03	2.00e-34	137.00
IUUC-Pva-102207	Pteropus vampyrus	100.00	2.00e-65	239.00
IUUC-Pgr-103668	Puccinia graminis	44.17	5.00e-33	133.00
IUUC-Pte-104294	Pyrenophora teres	39.26	3.00e-23	100.00
IUUC-Pyt-104534	Pyrenophora triticirepentis	39.26	1.00e-23	102.00
IUUC-Rno-105466	Rattus norvegicus	100.00	6.00e-86	308.00
IUUC-Sha-106707	Sarcophilus harrisii	85.14	3.00e-86	310.00
IUUC-Smo-109161	Selaginella moellendorffii	49.11	9.00e-43	166.00
IUUC-Sit-110749	Setaria italica	53.42	5.00e-43	166.00
IUUC-Sly-111213	Solanum lycopersicum	51.03	2.00e-34	138.00
IUUC-Stu-112148	Solanum tuberosum	51.03	5.00e-34	136.00
IUUC-Sar-113531	Sorex araneus	100.00	1.00e-85	308.00
IUUC-Sbi-114432	Sorghum bicolor	52.05	2.00e-35	141.00
IUUC-Sre-114974	Sporisorium reilianum	44.16	3.00e-33	134.00
IUUC-Ssc-115770	Sus scrofa	98.68	6.00e-88	315.00
IUUC-Tgu-117316	Taeniopygia guttata	97.95	2.00e-84	303.00
IUUC-Tru-117640	Takifugu rubripes	96.62	2.00e-84	304.00
IUUC-Tni-120737	Tetraodon nigroviridis	98.01	6.00e-88	315.00
IUUC-Tca-121226	Theobroma cacao	50.34	1.00e-33	135.00
IUUC-Tre-121998	Trichoderma reesei	39.22	2.00e-20	91.70
IUUC-Tvi-122565	Trichoderma virens	39.42	1.00e-24	105.00
IUUC-Tae-124081	Triticum aestivum	51.72	5.00e-41	159.00
IUUC-Tur-126577	Triticum urartu	51.13	1.00e-37	148.00
IUUC-Tme-127110	Tuber melanosporum	40.13	2.00e-27	114.00
IUUC-Tbe-127701	Tupaia belangeri	98.65	1.00e-85	308.00
IUUC-Ttr-128279	Tursiops truncatus	93.71	8.00e-76	275.00
IUUC-Uma-129371	Ustilago maydis	44.97	9.00e-33	132.00
IUUC-Vda-129698	Verticillium dahliae	38.41	3.00e-27	114.00
IUUC-Vpa-130053	Vicugna pacos	93.28	3.00e-72	263.00
IUUC-Vvi-131254	Vitis vinifera	51.03	8.00e-35	139.00
IUUC-Xtr-132804	Xenopus tropicalis	72.60	1.00e-59	221.00
IUUC-Xma-133451	Xiphophorus maculatus	98.68	4.00e-88	316.00
IUUC-Yli-134332	Yarrowia lipolytica	45.45	2.00e-29	121.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence