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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046344
UUCD1 version UUC-HoS-00990
Ensembl Protein ID ENSP00000439450.1
UniProt Accession Q9NYS7; B4DIE6; B4DPV6; Q9NRX9; WSB2_HUMAN
Genbank Protein ID AAF71302.1; AAF80478.1; BAG58458.1; BAG60718.1; AAH15887.1
Protein Name WD repeat and SOCS box-containing protein 2; CS box-containing WD protein
Genbank Nucleotide ID AF229181; AF163324; AK295555; AK298513; AC131159
Gene Name WSB2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000176871.8 ENST00000315436.7 ENSP00000319474.3
ENSG00000176871.8 ENST00000441406.6 ENSP00000409131.2
ENSG00000176871.8 ENST00000543218.5 ENSP00000438433.1
ENSG00000176871.8 ENST00000535496.5 ENSP00000439450.1
ENSG00000176871.8 ENST00000543186.1 ENSP00000445547.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
InWeb_IM
Disease-associated Information
GWASdb
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box SOCS 17001306
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box 2.20e-14 54.7 358 405
E3 adaptor/Cullin RING/DCX/DWD 1.30e-31 108.9 153 186
UBD/Beta-Prp 1.40e-45 157.4 127 362
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box
   S: 1    lsklwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyed 51
           ++++w++++   SL+hLCR+a r++l+++++    +LP+Pk++k++L y++
   Q: 358  HVQFWTAPRVLSSLKHLCRKALRSFLTTYQV---LALPIPKKMKEFLTYRT 405
           689****************************...***************86 PP
   

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf..sd.tllvsGsdDgtikvWDlr 31
           gH+d v++l+f  s+  +lvs+s+D+t+++WDl 
   Q: 153  GHQDVVRDLSFtpSGsLILVSASRDKTLRIWDLN 186
           8***********6556779*************85 PP
   

   UBD/Beta-Prp
   S: 24   llatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk.ilvtgseDrtikvwdls.tgkcvhtlkghedsvlslsfspsgdklvsGs 113
           +latg  dg ik+w+v+tg ll  lsgh++ v++++f p+g+ ilv++s+D+t+++wdl+  gk++++l+gh + v+++s+sp+ + l s+ 
   Q: 127  VLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSlILVSASRDKTLRIWDLNkHGKQIQVLSGHLQWVYCCSISPDCSMLCSAA 218
           79****************************************9****************9789********************99******* PP
   S: 114  hdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl...........tgghtdsvyslsfdsngke 194
             + + +w +++++ ++  l+gh+++v +  ++pd+ llv++s+D+ v +Wd  tg+ lr l           +  h +s +s+ f+++g +
   Q: 219  GEKSVFLWSMRSYTLIR-KLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPYTGERLRSLhhtqvdpamddSDVHISSLRSVCFSPEGLY 309
           *****************.********************************************99999999888777888888888******* PP
   S: 195  lvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW 249
           l+++++d+ +++w l+ ++   +  +  +n ++  f+p++  +++g+ Dg +++W
   Q: 310  LATVADDRLLRIWALELKT--PIAFAPMTNGLCCTFFPHGGVIATGTRDGHVQFW 362
           ***************9885..7899****************************** PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
 May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Protein Sequence
(Fasta)
MLSPAPEEPL LLAELKPGRP HQFDWKSSCE TWSVAFSPDG SWFAWSQGHC IVKLIPWPLE 60
EQFIPKGFEA KSRSSKNETK GRGSPKEKTL DCGQIVWGLA FSPWPSPPSR KLWARHHPQV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046344|E3,SOCS;E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GACTTGAATG AAGCTGACAC CAAGAACCGC GGGAAGAGCT TGGGCCCAAA GCAGGAAAGG 60
GAAGCGCTCG AGTTGGGGGT AAGGGGAGGC ATTTTGGGGA CAATGAGCTG AGCTCAGTAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046344|E3,SOCS;E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR020472--G-protein_beta_WD-40_rep
IPR001496--SOCS_box
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS50225--SOCS
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF07525--SOCS_box
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00253--SOCS
SM00969--SOCS_box
SM00320--WD40
Gene Ontology

GO:0005622--C:intracellular
GO:0035556--P:intracellular signal transduction
GO:0016567--P:protein ubiquitination
KEGG hsa:55884
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002221 Ailuropoda melanoleuca 97.78 0.00e+00 819.00
IUUC-Apl-004107 Anas platyrhynchos 69.29 1.00e-131 462.00
IUUC-Aca-004354 Anolis carolinensis 73.63 5.00e-169 587.00
IUUC-Bta-012627 Bos taurus 98.77 0.00e+00 779.00
IUUC-Cja-018897 Callithrix jacchus 98.20 0.00e+00 784.00
IUUC-Cfa-020122 Canis familiaris 98.03 0.00e+00 820.00
IUUC-Cpo-022540 Cavia porcellus 97.54 0.00e+00 790.00
IUUC-Csa-023719 Chlorocebus sabaeus 99.74 0.00e+00 797.00
IUUC-Cho-024367 Choloepus hoffmanni 97.32 4.00e-172 596.00
IUUC-Dno-029021 Dasypus novemcinctus 98.28 0.00e+00 795.00
IUUC-Dor-030321 Dipodomys ordii 97.68 0.00e+00 786.00
IUUC-Ete-032955 Echinops telfairi 97.24 0.00e+00 780.00
IUUC-Eca-033485 Equus caballus 98.47 0.00e+00 768.00
IUUC-Fca-035389 Felis catus 98.20 0.00e+00 791.00
IUUC-Fal-037184 Ficedula albicollis 84.45 1.00e-142 499.00
IUUC-Gga-041014 Gallus gallus 77.00 2.00e-177 615.00
IUUC-Ggo-045585 Gorilla gorilla 100.00 0.00e+00 806.00
IUUC-Itr-049085 Ictidomys tridecemlineatus 97.94 0.00e+00 793.00
IUUC-Lch-050131 Latimeria chalumnae 69.76 6.00e-168 583.00
IUUC-Loc-052807 Lepisosteus oculatus 53.92 3.00e-117 415.00
IUUC-Laf-053528 Loxodonta africana 98.28 0.00e+00 776.00
IUUC-Mcc-055665 Macaca mulatta 100.00 0.00e+00 806.00
IUUC-Meu-056054 Macropus eugenii 87.88 0.00e+00 699.00
IUUC-Mga-059326 Meleagris gallopavo 77.44 0.00e+00 631.00
IUUC-Mmr-060815 Microcebus murinus 97.04 0.00e+00 787.00
IUUC-Mdo-062000 Monodelphis domestica 90.57 0.00e+00 748.00
IUUC-Mmu-063927 Mus musculus 96.14 0.00e+00 780.00
IUUC-Mpu-065726 Mustela putorius furo 96.40 0.00e+00 776.00
IUUC-Mlu-067527 Myotis lucifugus 97.14 2.00e-119 421.00
IUUC-Nle-069680 Nomascus leucogenys 99.49 0.00e+00 797.00
IUUC-Opr-070356 Ochotona princeps 97.74 0.00e+00 802.00
IUUC-Oan-073647 Ornithorhynchus anatinus 83.94 2.00e-136 478.00
IUUC-Ocu-073973 Oryctolagus cuniculus 97.29 0.00e+00 784.00
IUUC-Oga-088797 Otolemur garnettii 99.02 0.00e+00 795.00
IUUC-Oar-089187 Ovis aries 98.72 0.00e+00 778.00
IUUC-Ptr-091317 Pan troglodytes 100.00 0.00e+00 805.00
IUUC-Pan-092694 Papio anubis 91.95 0.00e+00 687.00
IUUC-Psi-093392 Pelodiscus sinensis 79.40 0.00e+00 642.00
IUUC-Pab-098145 Pongo abelii 99.74 0.00e+00 797.00
IUUC-Pca-100454 Procavia capensis 88.72 0.00e+00 720.00
IUUC-Pva-102986 Pteropus vampyrus 89.97 0.00e+00 729.00
IUUC-Rno-104931 Rattus norvegicus 94.85 0.00e+00 767.00
IUUC-Sha-106476 Sarcophilus harrisii 91.77 0.00e+00 746.00
IUUC-Ssc-115643 Sus scrofa 98.71 0.00e+00 790.00
IUUC-Tgu-117522 Taeniopygia guttata 64.53 4.00e-137 481.00
IUUC-Tsy-119301 Tarsius syrichta 99.50 0.00e+00 818.00
IUUC-Ttr-128683 Tursiops truncatus 98.71 0.00e+00 791.00
Created Date 25-Jun-2017

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