iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000068308.13	ENST00000156084.8	ENSP00000156084.4
ENSG00000068308.13	ENST00000376488.7	ENSP00000365671.3
ENSG00000068308.13	ENST00000610466.4	ENSP00000481335.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	miRWalk
TargetScan	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/OTU	OTU	19615732
UBD/Alpha-Helix/UIM	UIM	23827681

Classification

Family	E-value	Score	Start	End
DUB/OTU	2.10e-34	120.6	214	340

Active Site

Position(s)	Description	Evidence
221	N/A	{ECO:0000255}
224	Nucleophile	{ECO:0000269\|PubMed:22245969}
334		{ECO:0000305\|PubMed:22245969}

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqsllgvfdddslsdalveaLreltseylqkesdffsefieekedekefcqklvepeakgeeihifaLaqiLsrpi 93
           +i+++k+DG CL+rAv+++   v++d+     ++e++r+++++yl+k++d+fs++++e  d++++++++ +++++g++i+++a+a++++rp+
   Q: 214  IIKQMKEDGACLFRAVADQ---VYGDQD----MHEVVRKHCMDYLMKNADYFSNYVTE--DFTTYINRKRKNNCHGNHIEMQAMAEMYNRPV 296
           799****************...******....*************************9..9******************************* PP
   S: 94   ivvdvdsleskvggillpllfpeeklkkpivLlY.rsgHYdaLva 137
           +v+++++++s+v++i++++ +++++ ++pi ++Y r++HY+++v+
   Q: 297  EVYQYSTGTSAVEPINTFHGIHQNE-DEPIRVSYhRNIHYNSVVN 340
           *************************.********99*******96 PP

Organism

Homo sapiens

Functional Description
(View)

Deubiquitinating enzyme that functions as negative regulator of the innate immune system. Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro).

Protein Sequence
(Fasta)

MTILPKKKPP PPDADPANEP PPPGPMPPAP RRGGGVGVGG GGTGVGGGDR DRDSGVVGAR 60
PRASPPPQGP LPGPPGALHR WALAVPPGAV AGPRPQQASP PPCGGPGGPG GGPGDALGAA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGACGCTAC AGGGGCCAGC TATGCTCCCG GGAGTGTTGA TGTTTTCCAG TCATTCCGGC 60
TGACAGCGTT CAAGTTGGAA TCCTGGAGGG GAGGTGTTTT TCCTGTCGTA CGTGGGACAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR031084--OTU5/OTLD1
IPR003323--OTU_dom

PROSITE

PS50802--OTU

Pfam

PF02338--OTU

Gene Ontology

GO:0005829--C:cytosol
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0061578--F:Lys63-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0101005--F:ubiquitinyl hydrolase activity
GO:0032480--P:negative regulation of type I interferon production
GO:0016579--P:protein deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0032496--P:response to lipopolysaccharide

KEGG

hsa:55593

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000541	Aegilops tauschii	40.59	7.00e-30	124.00
IUUC-Aml-002177	Ailuropoda melanoleuca	97.09	0.00e+00	771.00
IUUC-Aca-004481	Anolis carolinensis	88.52	2.00e-171	595.00
IUUC-Ame-011904	Astyanax mexicanus	87.24	1.00e-101	362.00
IUUC-Bta-012384	Bos taurus	98.14	0.00e+00	789.00
IUUC-Cja-019439	Callithrix jacchus	92.74	0.00e+00	778.00
IUUC-Cfa-020478	Canis familiaris	98.35	0.00e+00	780.00
IUUC-Cpo-021956	Cavia porcellus	89.67	0.00e+00	785.00
IUUC-Csa-023878	Chlorocebus sabaeus	98.16	0.00e+00	722.00
IUUC-Cme-027140	Cyanidioschyzon merolae	26.09	3.00e-08	52.00
IUUC-Dre-028816	Danio rerio	83.46	0.00e+00	633.00
IUUC-Dno-028962	Dasypus novemcinctus	97.99	9.00e-166	576.00
IUUC-Dor-030616	Dipodomys ordii	93.91	6.00e-174	603.00
IUUC-Ete-032848	Echinops telfairi	96.71	0.00e+00	769.00
IUUC-Eca-033321	Equus caballus	97.93	0.00e+00	778.00
IUUC-Eeu-034527	Erinaceus europaeus	98.66	0.00e+00	709.00
IUUC-Fca-036105	Felis catus	97.65	0.00e+00	772.00
IUUC-Gga-040905	Gallus gallus	80.85	2.00e-135	476.00
IUUC-Gac-042254	Gasterosteus aculeatus	76.00	2.00e-17	82.40
IUUC-Itr-048844	Ictidomys tridecemlineatus	99.48	0.00e+00	738.00
IUUC-Lch-050108	Latimeria chalumnae	86.17	0.00e+00	664.00
IUUC-Loc-052485	Lepisosteus oculatus	76.82	1.00e-167	582.00
IUUC-Lma-053089	Leptosphaeria maculans	40.00	1.00e-10	60.80
IUUC-Laf-053682	Loxodonta africana	99.06	0.00e+00	790.00
IUUC-Mcc-055784	Macaca mulatta	98.52	0.00e+00	768.00
IUUC-Mla-059150	Melampsora laricipopulina	29.33	8.00e-17	82.00
IUUC-Mmr-061057	Microcebus murinus	98.27	0.00e+00	765.00
IUUC-Mmu-063714	Mus musculus	98.84	0.00e+00	805.00
IUUC-Mpu-065767	Mustela putorius furo	98.58	0.00e+00	780.00
IUUC-Mlu-067114	Myotis lucifugus	95.53	0.00e+00	780.00
IUUC-Nle-070088	Nomascus leucogenys	98.59	0.00e+00	667.00
IUUC-Opr-070389	Ochotona princeps	98.82	0.00e+00	763.00
IUUC-Ont-072302	Oreochromis niloticus	76.77	3.00e-170	591.00
IUUC-Ocu-074654	Oryctolagus cuniculus	98.58	0.00e+00	780.00
IUUC-Ola-087549	Oryzias latipes	77.00	2.00e-168	586.00
IUUC-Oga-089093	Otolemur garnettii	98.60	0.00e+00	807.00
IUUC-Oar-089766	Ovis aries	97.64	0.00e+00	721.00
IUUC-Ptr-091163	Pan troglodytes	95.75	0.00e+00	743.00
IUUC-Pan-091928	Papio anubis	92.18	0.00e+00	805.00
IUUC-Pfo-096666	Poecilia formosa	77.62	8.00e-172	597.00
IUUC-Pab-098420	Pongo abelii	100.00	0.00e+00	797.00
IUUC-Pca-100850	Procavia capensis	88.84	0.00e+00	745.00
IUUC-Pva-102130	Pteropus vampyrus	99.28	2.00e-160	558.00
IUUC-Rno-105724	Rattus norvegicus	98.52	0.00e+00	770.00
IUUC-Sar-113717	Sorex araneus	98.12	0.00e+00	709.00
IUUC-Ssc-116201	Sus scrofa	97.65	0.00e+00	766.00
IUUC-Tru-118312	Takifugu rubripes	75.77	3.00e-171	595.00
IUUC-Tni-119704	Tetraodon nigroviridis	74.36	9.00e-164	570.00
IUUC-Ttr-129296	Tursiops truncatus	97.13	0.00e+00	818.00
IUUC-Vpa-130415	Vicugna pacos	70.11	6.00e-86	311.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence