iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Spo-108174

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin carboxyl-terminal hydrolase 6; Deubiquitinating enzyme 6; Ubiquitin thiollesterase 6; Ubiquitin-specific-processing protease 6

Genbank Nucleotide ID

CU329670

Gene Name

ubp6; SPAC6G9.08

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPAC6G9.08	SPAC6G9.08.1	SPAC6G9.08.1:pep

Annotation

mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	HINT	Mentha
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	15533439
ULD/UDP/UBQ/UBQ_PIM	UBQ_PIM	14536023; 15117949

Classification

Family	E-value	Score	Start	End
DUB/USP	4.30e-58	195.2	102	464
ULD/UDP/UBQ/UBQ_PIM	6.50e-16	56.1	5	73

Active Site

Position(s)	Description	Evidence
110	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
415	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs.......gy 87
           Gl NlgNtCYmNS++Q+L +ipel +++ +     +n      ++g l+ ++++l++++  +++  v+p ++l++l++e ++f        gy
   Q: 102  GLINLGNTCYMNSTVQMLRAIPELSDAVSQ-----FN------SSGGLVAEYRTLLNSM--QSNAPVTPMRFLQSLRMEYPQFAemsretgGY 181
           9*****************************.....44......5689************..78889*****************99******** PP
   S: 88   eqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvs...sreepfldlslpvp 177
           +qqDa+E+++fll+ l+++l                              +++++++++ g+l s++kc e + +     ++++fl+l+++++
   Q: 182  AQQDAEECWSFLLSVLQRSL------------------------------SSEWVQKNMAGKLLSTMKCDENEVQEqpsISHDTFLSLPCHIS 244
           ********************..............................789****************887644333499************ PP
   S: 178  gkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts... 267
           ++++      q +Le  t++ +       +++  +++   +k  ++++lP++L++++ Rf ++ + +++ ki +kv+fp eLd  +fct    
   Q: 245  MHTSY---MTQGILEGLTQKIS------KHSDVLNRDAMYSKISRISRLPNYLTVNFVRFYWKASIGKKAKILRKVKFPFELDAVEFCTPels 328
           ***88...56666666555433......467889999999**************************************************777 PP
   S: 268  ..............................peekqke..................................kkkYeLiavvvHsG.slssGHY 295
                                         p     +                                  +  Y+L++v++H G s+ssGHY
   Q: 329  qklipvrdklreiekndeeheraakrikiqP-----SedekeaeaecrltqvatcqslvdpeladdeganpTGLYDLVGVLSHAGaSASSGHY 416
           7777777777777766666666666666551.....04445556666777777777777777777777777********************** PP
   S: 296  vayvknekgk..WllfdDskVtevkeeevleetg....staYvlfYkr 337
            a+++n++++  W++f+D kV+ v+ e++++  g    ++aY+l+Yk 
   Q: 417  QAWIRNSNNRaeWFRFNDAKVSIVPAEKIETLDGggeaDSAYILLYKA 464
           ******888888*******************888************96 PP

ULD/UDP/UBQ/UBQ_PIM

   S: 3    ltvktlkgkefelevseddtveelKekiakesgvppeqqkLIyaGkiLkDdttLselgikdgsvvhlvvk 72
           + +++ +gk++ le+++++t + lK+++ + ++vppe+qk+I +G +LkDd  L ++gik + +++++++
   Q: 5    IAIRW-QGKKYDLEIEPNETGSTLKHQLYSLTQVPPERQKVIVKGGQLKDDVLLGSVGIKPNATLLMMGT 73
           67777.9************************************************************987 PP

Organism

Schizosaccharomyces pombe

Functional Description
(View)

Ubiquitin-protein hydrolase is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin.

Protein Sequence
(Fasta)

MMIPIAIRWQ GKKYDLEIEP NETGSTLKHQ LYSLTQVPPE RQKVIVKGGQ LKDDVLLGSV 60
GIKPNATLLM MGTAGELPTA MPIPAVESVE QEESEDDGYP SGLINLGNTC YMNSTVQMLR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGAGTATATA GCTCGTTACT GTATGGCCTT CACCAAGTAC CAGCAACATA TATAATAAGT 60
ATAATTTGCA AAGAATTACA AAAAAAATTA TATTGGGCTT AAACAAGTAT TTCTTTCATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0645--Protease
KW-0647--Proteasome
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR029071--Ubiquitin-rel_dom
IPR019954--Ubiquitin_CS
IPR000626--Ubiquitin_dom
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00299--UBIQUITIN_1
PS50053--UBIQUITIN_2
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00240--ubiquitin
PF00443--UCH

SMART

SM00213--UBQ

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0000502--C:proteasome complex
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016579--P:protein deubiquitination

KEGG

spo:SPAC6G9.08

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000893	Aegilops tauschii	29.94	1.00e-28	119.00
IUUC-Aml-002053	Ailuropoda melanoleuca	36.90	8.00e-82	295.00
IUUC-Atr-002725	Amborella trichopoda	38.45	2.00e-76	277.00
IUUC-Apl-004031	Anas platyrhynchos	36.40	2.00e-82	297.00
IUUC-Aca-004361	Anolis carolinensis	36.44	2.00e-84	304.00
IUUC-Aly-006176	Arabidopsis lyrata	37.20	8.00e-86	308.00
IUUC-Ath-007658	Arabidopsis thaliana	38.41	3.00e-87	313.00
IUUC-Ago-007796	Ashbya gossypii	37.50	5.00e-87	312.00
IUUC-Acl-008258	Aspergillus clavatus	39.72	1.00e-105	375.00
IUUC-Afl-008732	Aspergillus flavus	41.95	5.00e-114	402.00
IUUC-Afu-008755	Aspergillus fumigatus	39.33	2.00e-106	377.00
IUUC-Ani-009148	Aspergillus nidulans	41.95	4.00e-115	406.00
IUUC-Ang-009878	Aspergillus niger	41.62	1.00e-114	404.00
IUUC-Aor-010239	Aspergillus oryzae	41.95	4.00e-114	402.00
IUUC-Ate-010243	Aspergillus terreus	42.01	2.00e-113	400.00
IUUC-Ame-011327	Astyanax mexicanus	27.68	5.00e-30	123.00
IUUC-Bgr-012231	Blumeria graminis	39.93	1.00e-108	384.00
IUUC-Bta-012553	Bos taurus	35.93	7.00e-82	295.00
IUUC-Bci-013606	Botrytis cinerea	44.09	8.00e-112	395.00
IUUC-Bdi-014567	Brachypodium distachyon	39.59	2.00e-86	310.00
IUUC-Bol-016127	Brassica oleracea	38.51	9.00e-88	315.00
IUUC-Bra-017501	Brassica rapa	38.51	3.00e-88	317.00
IUUC-Cel-018140	Caenorhabditis elegans	34.50	1.00e-74	271.00
IUUC-Cja-019516	Callithrix jacchus	36.88	3.00e-82	296.00
IUUC-Cfa-020808	Canis familiaris	36.63	3.00e-82	297.00
IUUC-Cpo-021688	Cavia porcellus	36.81	2.00e-82	297.00
IUUC-Cre-022663	Chlamydomonas reinhardtii	31.66	1.00e-55	208.00
IUUC-Csa-023429	Chlorocebus sabaeus	36.53	9.00e-82	295.00
IUUC-Cho-024347	Choloepus hoffmanni	36.13	4.00e-82	296.00
IUUC-Cin-025198	Ciona intestinalis	36.36	7.00e-74	269.00
IUUC-Csv-026007	Ciona savignyi	35.13	4.00e-74	270.00
IUUC-Cgl-026757	Colletotrichum gloeosporioides	40.87	2.00e-104	370.00
IUUC-Cne-026963	Cryptococcus neoformans	38.16	2.00e-75	274.00
IUUC-Cme-027240	Cyanidioschyzon merolae	31.92	4.00e-63	233.00
IUUC-Dre-027647	Danio rerio	38.10	2.00e-85	307.00
IUUC-Dno-029967	Dasypus novemcinctus	36.73	8.00e-82	295.00
IUUC-Dor-030886	Dipodomys ordii	33.48	2.00e-57	214.00
IUUC-Dse-031466	Dothistroma septosporum	34.93	2.00e-86	311.00
IUUC-Dme-032079	Drosophila melanogaster	37.89	3.00e-86	310.00
IUUC-Ete-032351	Echinops telfairi	37.03	3.00e-79	286.00
IUUC-Eca-033461	Equus caballus	37.72	1.00e-87	315.00
IUUC-Eeu-035220	Erinaceus europaeus	35.64	5.00e-22	97.10
IUUC-Fca-036210	Felis catus	37.00	2.00e-82	297.00
IUUC-Fal-037528	Ficedula albicollis	36.60	9.00e-81	291.00
IUUC-Fox-037805	Fusarium oxysporum	45.23	8.00e-88	315.00
IUUC-Fso-038177	Fusarium solani	41.77	2.00e-110	391.00
IUUC-Gmo-038953	Gadus morhua	35.67	7.00e-75	272.00
IUUC-Ggr-039972	Gaeumannomyces graminis	38.41	7.00e-104	369.00
IUUC-Gga-040462	Gallus gallus	36.01	2.00e-81	294.00
IUUC-Gac-041312	Gasterosteus aculeatus	37.98	2.00e-83	301.00
IUUC-Gma-043255	Glycine max	39.88	3.00e-88	316.00
IUUC-Ggo-045458	Gorilla gorilla	31.51	2.00e-58	218.00
IUUC-Hsa-045706	Homo sapiens	36.53	6.00e-82	296.00
IUUC-Hvu-047821	Hordeum vulgare	42.66	1.00e-40	157.00
IUUC-Itr-048654	Ictidomys tridecemlineatus	37.05	2.00e-86	310.00
IUUC-Lch-050464	Latimeria chalumnae	38.43	3.00e-85	307.00
IUUC-Lpe-051419	Leersia perrieri	38.45	2.00e-81	293.00
IUUC-Loc-052732	Lepisosteus oculatus	37.80	2.00e-86	310.00
IUUC-Lma-053177	Leptosphaeria maculans	39.08	3.00e-104	370.00
IUUC-Laf-053822	Loxodonta africana	36.20	4.00e-82	296.00
IUUC-Mcc-055893	Macaca mulatta	36.53	6.00e-82	296.00
IUUC-Meu-056307	Macropus eugenii	35.33	2.00e-74	271.00
IUUC-Mor-057171	Magnaporthe oryzae	41.70	8.00e-112	395.00
IUUC-Mpo-057415	Magnaporthe poae	40.36	8.00e-110	389.00
IUUC-Mtr-057901	Medicago truncatula	37.25	1.00e-81	295.00
IUUC-Mla-058897	Melampsora laricipopulina	38.24	6.00e-90	322.00
IUUC-Mga-060016	Meleagris gallopavo	36.44	2.00e-81	294.00
IUUC-Mvi-060562	Microbotryum violaceum	42.66	2.00e-66	244.00
IUUC-Mmr-060624	Microcebus murinus	37.42	2.00e-87	313.00
IUUC-Mdo-061809	Monodelphis domestica	36.45	2.00e-81	294.00
IUUC-Mmu-063869	Mus musculus	36.31	5.00e-82	296.00
IUUC-Mac-064876	Musa acuminata	36.23	1.00e-76	278.00
IUUC-Mpu-066480	Mustela putorius furo	36.63	4.00e-82	296.00
IUUC-Mlu-067866	Myotis lucifugus	36.60	5.00e-83	299.00
IUUC-Nfi-068393	Neosartorya fischeri	39.68	2.00e-106	377.00
IUUC-Ncr-068815	Neurospora crassa	41.68	4.00e-114	403.00
IUUC-Nle-070121	Nomascus leucogenys	41.12	1.00e-37	147.00
IUUC-Opr-070712	Ochotona princeps	40.95	8.00e-47	179.00
IUUC-Ont-071544	Oreochromis niloticus	36.60	4.00e-73	266.00
IUUC-Oan-073635	Ornithorhynchus anatinus	35.51	1.00e-65	241.00
IUUC-Ocu-074926	Oryctolagus cuniculus	36.53	7.00e-82	295.00
IUUC-Oba-075633	Oryza barthii	38.04	2.00e-79	287.00
IUUC-Obr-076423	Oryza brachyantha	39.14	5.00e-86	309.00
IUUC-Ogl-077913	Oryza glaberrima	38.73	9.00e-85	305.00
IUUC-Ogu-078435	Oryza glumaepatula	38.04	2.00e-79	287.00
IUUC-Oin-080072	Oryza indica	38.07	4.00e-79	286.00
IUUC-Olo-080535	Oryza longistaminata	36.01	2.00e-70	258.00
IUUC-Ome-081309	Oryza meridionalis	38.04	2.00e-79	287.00
IUUC-Oni-083113	Oryza nivara	38.04	2.00e-79	287.00
IUUC-Opu-083168	Oryza punctata	37.22	2.00e-74	270.00
IUUC-Oru-084253	Oryza rufipogon	38.04	2.00e-79	287.00
IUUC-Osa-085554	Oryza sativa	38.73	7.00e-85	305.00
IUUC-Ola-086998	Oryzias latipes	37.55	1.00e-79	288.00
IUUC-Olu-087818	Ostreococcus lucimarinus	35.46	6.00e-67	246.00
IUUC-Oga-088571	Otolemur garnettii	36.61	2.00e-82	297.00
IUUC-Oar-089526	Ovis aries	35.71	1.00e-81	295.00
IUUC-Ptr-091433	Pan troglodytes	36.53	6.00e-82	296.00
IUUC-Pan-091966	Papio anubis	36.53	9.00e-82	295.00
IUUC-Psi-093458	Pelodiscus sinensis	38.20	7.00e-84	302.00
IUUC-Pma-094343	Petromyzon marinus	36.11	3.00e-40	156.00
IUUC-Pno-095109	Phaeosphaeria nodorum	39.93	4.00e-110	389.00
IUUC-Ppa-095756	Physcomitrella patens	38.88	3.00e-90	323.00
IUUC-Pfo-096514	Poecilia formosa	36.42	2.00e-74	270.00
IUUC-Pab-098477	Pongo abelii	34.67	8.00e-64	235.00
IUUC-Pop-099221	Populus trichocarpa	38.54	1.00e-81	295.00
IUUC-Pca-100791	Procavia capensis	31.24	3.00e-44	170.00
IUUC-Ppe-101812	Prunus persica	36.99	2.00e-79	287.00
IUUC-Pva-102462	Pteropus vampyrus	36.16	2.00e-66	244.00
IUUC-Pgr-103623	Puccinia graminis	43.03	4.00e-69	253.00
IUUC-Ptt-103767	Puccinia triticina	36.13	3.00e-82	296.00
IUUC-Pte-104109	Pyrenophora teres	40.04	6.00e-111	392.00
IUUC-Pyt-104766	Pyrenophora triticirepentis	39.33	3.00e-107	380.00
IUUC-Rno-105351	Rattus norvegicus	36.33	6.00e-81	292.00
IUUC-Sce-106168	Saccharomyces cerevisiae	39.31	4.00e-81	293.00
IUUC-Sha-107491	Sarcophilus harrisii	36.01	9.00e-82	295.00
IUUC-Sja-107769	Schizosaccharomyces japonicus	59.53	4.00e-167	578.00
IUUC-Ssl-108659	Sclerotinia sclerotiorum	41.76	8.00e-110	389.00
IUUC-Smo-108805	Selaginella moellendorffii	37.53	8.00e-83	298.00
IUUC-Sit-110361	Setaria italica	38.68	3.00e-87	313.00
IUUC-Sly-110965	Solanum lycopersicum	39.43	5.00e-85	306.00
IUUC-Sar-113355	Sorex araneus	35.85	4.00e-47	179.00
IUUC-Sbi-114778	Sorghum bicolor	38.89	2.00e-84	303.00
IUUC-Sre-115011	Sporisorium reilianum	42.37	2.00e-70	258.00
IUUC-Ssc-116273	Sus scrofa	36.78	2.00e-80	290.00
IUUC-Tgu-117063	Taeniopygia guttata	36.17	6.00e-81	292.00
IUUC-Tru-118381	Takifugu rubripes	37.13	3.00e-80	290.00
IUUC-Tsy-119076	Tarsius syrichta	36.32	3.00e-37	147.00
IUUC-Tni-119941	Tetraodon nigroviridis	37.38	3.00e-78	283.00
IUUC-Tca-121246	Theobroma cacao	38.06	1.00e-83	301.00
IUUC-Tre-121969	Trichoderma reesei	41.05	2.00e-105	374.00
IUUC-Tvi-122543	Trichoderma virens	41.07	8.00e-111	392.00
IUUC-Tae-125484	Triticum aestivum	38.11	3.00e-83	300.00
IUUC-Tur-126128	Triticum urartu	29.71	6.00e-29	120.00
IUUC-Tbe-128030	Tupaia belangeri	33.01	1.00e-63	235.00
IUUC-Ttr-128701	Tursiops truncatus	36.57	3.00e-64	237.00
IUUC-Uma-129657	Ustilago maydis	37.34	1.00e-87	315.00
IUUC-Vda-129723	Verticillium dahliae	40.50	1.00e-108	384.00
IUUC-Vpa-130284	Vicugna pacos	48.78	1.00e-18	85.90
IUUC-Vvi-131037	Vitis vinifera	38.85	9.00e-87	311.00
IUUC-Xtr-132235	Xenopus tropicalis	37.03	7.00e-85	305.00
IUUC-Xma-133840	Xiphophorus maculatus	36.78	6.00e-80	289.00
IUUC-Yli-134453	Yarrowia lipolytica	44.56	1.00e-106	377.00
IUUC-Zma-135791	Zea mays	34.65	2.00e-67	247.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence