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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064044
UUCD1 version UUC-MuM-01219
Ensembl Protein ID ENSMUSP00000030289.2
UniProt Accession Q8BJQ2; Q8VE17; Q8VEM4; UBP1_MOUSE
Genbank Protein ID BAC38059.1; CAM21066.1; AAH18179.1; AAH20007.1
Protein Name Ubiquitin carboxyl-terminal hydrolase 1; Deubiquitinating enzyme 1; Ubiquitin thioesterase 1; Ubiquitin-specific-processing protease 1
Genbank Nucleotide ID AK080882; AL627349; BC018179; BC020007
Gene Name Usp1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000028560.11 ENSMUST00000030289.8 ENSMUSP00000030289.2
ENSMUSG00000028560.11 ENSMUST00000169053.1 ENSMUSP00000130307.1
ENSMUSG00000028560.11 ENSMUST00000125104.1 ENSMUSP00000135496.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
miRecordsRepTarmiRNAMapRAID2
Protein-protein Interaction
IIDMentha
Drug and target
GRAC
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMUniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 1.70e-87 294.9 81 783
Active Site
Position(s) Description Evidence
90 Nucleophile ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
592 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle......kkkeklneenpkepkg..........ellkslqklfeel.......w..... 61
           +Gl+NlgNtCY+NS+LQ+L+++p ++  +++      +kke+l++++++++kg          el++slq+l+ ++       +     
   Q: 81   VGLNNLGNTCYLNSILQVLYFCPGFKTGVKHlfniisRKKEALKDDSNQKDKGsckeeslasyELICSLQSLIISVeqlqasfLlnpek 169
           6***********************************999999999999999999999999***99999999999995555555144555 PP
   S: 62   kskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkk.................eknkpkeeeeeedkselsde.... 129
           ++++ a++pr+ll++l++++++++g+ q+DaqE+l+++l +++e+++                  e                  +    
   Q: 170  YTDELATQPRRLLNTLRELNPMYEGFLQHDAQEVLQCILGNIQETCQLlkkeeiknlaelsgkveE------------------Qslqk 240
           88888*****************************************55333322222222222211..................13344 PP
   S: 130  ......................................................................................... 129
                                                                                                    
   Q: 241  eetggitsteidsmrntedvkeqlpkgnwkrksdsessnvkkkvklsresqpleenqrqtrskrkaigdtleaapkiipkcvsesesak 329
           57788888888889*************************************************************************** PP
   S: 130  ...................................................................................aeekkk 135
                                                                                               ++   
   Q: 330  psqkkskvkinwlkpstkqpsilskfcslgkittnqrskgqpkekegdveedlekygsdhtanggpespgssvtpvdsseaksGNKG-- 416
           ***************************************************************************987654443333.. PP
   S: 136  kknk.....slisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke..............slqdcLesftkeeelegenk 205
                    +l+++lFqgql  +++clec++ ++r+e+f+d+s+pv+++e +k e              +l++++++f++ e++ ge+k
   Q: 417  ---AeqigfELVEKLFQGQLVLRTRCLECESLTERREDFQDISVPVQEDELSKVEesseispepktemkTLRWAISQFASVERIVGEDK 502
           ...245566*****************************************99998********************************** PP
   S: 206  yycekckkkqeaekklklkklPevLilhLkRf.....sfseeqksrekinkkvefpleLdlspfctspeekqkekkkYeLiavvvHsG. 288
           y+ce+c++++eae++l ++k+Pev+++hLk+f     +f+++++  +kin+ + +pl+L+l+++ t+p+     +++Y L+avv+HsG 
   Q: 503  YFCENCHHYTEAERSLLFDKMPEVITIHLKCFaasglEFDCYGGGLSKINTPLLTPLKLSLEEWSTKPT-----NDSYGLFAVVMHSGi 586
           *******************************************************************99.....678************ PP
   S: 289  slssGHYvayvkn............................................................................ 301
           ++ssGHY+a vk                                                                             
   Q: 587  TISSGHYTASVKVtdlnsleldegnfvvdqmcelgkpeplteeqargtagnyddevsirvggnaqpskvlnkknvegigllggqkskad 675
           ***************************************************************************************** PP
   S: 302  ..................................................................ekgkWllfdDskVtevkeeevle 324
                                                                              +gkWllfdDs+V++++e+++l+
   Q: 676  yelynkasnpdkvvgtpftdnrnsetndttngthesdrnkessdqtgvnmnglenkisyvvqslkeYEGKWLLFDDSEVKVTEEKDFLN 764
           ******************************9999999999999999999999988888888877766999******************* PP
   S: 325  etg......staYvlfYkr 337
           + +      st+Y+lfYk+
   Q: 765  SLSpstsptSTPYLLFYKK 783
           888**************97 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2. Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity.
 Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2. Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity.
Protein Sequence
(Fasta)
MPGVIPSESN GLSRGSPSKK NRLSLKFFQK KETKRALDFT DSQENEEKTS EYRGSEIDQV 60
VPAAQSSPVS CEKRENLLPF VGLNNLGNTC YLNSILQVLY FCPGFKTGVK HLFNIISRKK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064044|DUB,USP|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGTCGCGCGG CGGCTCGCGC CTTTCGCGCC TCTGCAACGT GGAGAGGAGA ACCGGCACTT 60
TCCGTGGACG CCACCTCCAG CCGCGACGCT GGCGCGGGCG GGGGTTCACT CGCGGGGGTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064044|DUB,USP|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0068--Autocatalytic cleavage
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR001394--Peptidase_C19_UCH
IPR033815--USP1
IPR018200--USP_CS
IPR028889--USP_dom
PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
Pfam

PF00443--UCH
Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0008233--F:peptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0006281--P:DNA repair
GO:0035520--P:monoubiquitinated protein deubiquitination
GO:0016579--P:protein deubiquitination
GO:0006282--P:regulation of DNA repair
GO:0009411--P:response to UV
GO:0001501--P:skeletal system development
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG mmu:230484
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001939 Ailuropoda melanoleuca 87.04 0.00e+00 1321.00
IUUC-Apl-004204 Anas platyrhynchos 71.52 0.00e+00 917.00
IUUC-Aca-004637 Anolis carolinensis 64.98 0.00e+00 915.00
IUUC-Ame-011718 Astyanax mexicanus 48.08 7.00e-167 580.00
IUUC-Bta-012552 Bos taurus 85.62 0.00e+00 1306.00
IUUC-Cja-019588 Callithrix jacchus 88.03 0.00e+00 1364.00
IUUC-Cfa-020211 Canis familiaris 88.17 0.00e+00 1347.00
IUUC-Cpo-021551 Cavia porcellus 80.10 0.00e+00 1221.00
IUUC-Csa-024186 Chlorocebus sabaeus 88.68 0.00e+00 1377.00
IUUC-Cho-024739 Choloepus hoffmanni 75.22 0.00e+00 665.00
IUUC-Dre-028184 Danio rerio 48.90 1.00e-172 600.00
IUUC-Dno-029669 Dasypus novemcinctus 83.88 0.00e+00 1291.00
IUUC-Dor-030168 Dipodomys ordii 81.96 0.00e+00 1190.00
IUUC-Dme-031732 Drosophila melanogaster 30.39 1.00e-17 85.90
IUUC-Ete-032825 Echinops telfairi 80.59 0.00e+00 872.00
IUUC-Eca-033595 Equus caballus 85.87 0.00e+00 1229.00
IUUC-Eeu-034877 Erinaceus europaeus 74.93 3.00e-146 512.00
IUUC-Fca-035381 Felis catus 86.32 0.00e+00 929.00
IUUC-Fal-037592 Ficedula albicollis 68.88 0.00e+00 955.00
IUUC-Gmo-039680 Gadus morhua 44.24 5.00e-151 528.00
IUUC-Gga-041196 Gallus gallus 71.70 0.00e+00 1037.00
IUUC-Gac-042292 Gasterosteus aculeatus 50.56 3.00e-143 502.00
IUUC-Ggo-044671 Gorilla gorilla 88.30 0.00e+00 1364.00
IUUC-Hsa-047020 Homo sapiens 88.42 0.00e+00 1367.00
IUUC-Itr-048800 Ictidomys tridecemlineatus 79.16 0.00e+00 1174.00
IUUC-Lch-050543 Latimeria chalumnae 57.33 0.00e+00 685.00
IUUC-Loc-052338 Lepisosteus oculatus 52.28 0.00e+00 695.00
IUUC-Laf-053707 Loxodonta africana 84.81 0.00e+00 1312.00
IUUC-Mcc-055885 Macaca mulatta 88.42 0.00e+00 1375.00
IUUC-Meu-056573 Macropus eugenii 67.22 0.00e+00 956.00
IUUC-Mga-059346 Meleagris gallopavo 71.62 0.00e+00 988.00
IUUC-Mmr-061612 Microcebus murinus 86.13 0.00e+00 1299.00
IUUC-Mdo-062887 Monodelphis domestica 71.78 0.00e+00 1053.00
IUUC-Mpu-066847 Mustela putorius furo 87.40 0.00e+00 1333.00
IUUC-Mlu-067684 Myotis lucifugus 85.64 0.00e+00 1324.00
IUUC-Nle-070057 Nomascus leucogenys 88.42 0.00e+00 1369.00
IUUC-Opr-070463 Ochotona princeps 79.21 0.00e+00 1179.00
IUUC-Ont-071975 Oreochromis niloticus 51.27 7.00e-141 494.00
IUUC-Oan-073062 Ornithorhynchus anatinus 87.76 2.00e-47 181.00
IUUC-Ocu-074840 Oryctolagus cuniculus 87.15 0.00e+00 1326.00
IUUC-Ola-087088 Oryzias latipes 47.14 1.00e-169 590.00
IUUC-Oga-088472 Otolemur garnettii 86.01 0.00e+00 1308.00
IUUC-Oar-089498 Ovis aries 85.88 0.00e+00 1310.00
IUUC-Ptr-091395 Pan troglodytes 88.30 0.00e+00 1366.00
IUUC-Pan-092462 Papio anubis 88.55 0.00e+00 1375.00
IUUC-Psi-093583 Pelodiscus sinensis 69.84 0.00e+00 872.00
IUUC-Pma-094644 Petromyzon marinus 34.85 2.00e-27 115.00
IUUC-Pfo-096314 Poecilia formosa 46.80 3.00e-166 579.00
IUUC-Pab-098568 Pongo abelii 88.30 0.00e+00 1368.00
IUUC-Pca-100948 Procavia capensis 76.11 0.00e+00 1150.00
IUUC-Pva-102853 Pteropus vampyrus 86.48 0.00e+00 1325.00
IUUC-Rno-105573 Rattus norvegicus 93.76 0.00e+00 1433.00
IUUC-Sha-107495 Sarcophilus harrisii 72.12 0.00e+00 893.00
IUUC-Sar-113545 Sorex araneus 72.77 0.00e+00 1029.00
IUUC-Ssc-115962 Sus scrofa 86.71 0.00e+00 1335.00
IUUC-Tgu-116731 Taeniopygia guttata 69.32 0.00e+00 971.00
IUUC-Tru-117893 Takifugu rubripes 45.94 2.00e-154 539.00
IUUC-Tsy-119644 Tarsius syrichta 78.44 0.00e+00 1154.00
IUUC-Tni-119819 Tetraodon nigroviridis 44.96 2.00e-169 589.00
IUUC-Tbe-127272 Tupaia belangeri 81.51 0.00e+00 1145.00
IUUC-Ttr-128404 Tursiops truncatus 87.52 0.00e+00 1343.00
IUUC-Vpa-130205 Vicugna pacos 85.86 0.00e+00 1316.00
IUUC-Xtr-132613 Xenopus tropicalis 55.31 0.00e+00 729.00
Created Date 25-Jun-2017

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