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Basic Information Integrated Annotations

Tag Content
iUUCD ID IUUC-Hsa-046952
UUCD1 version UUC-HoS-00100
Ensembl Protein ID ENSP00000247668.2
UniProt Accession Q12933; A8K107; B4DPJ7; Q7Z337; Q96NT2; TRAF2_HUMAN
Genbank Protein ID AAA87706.1; BAB70792.1; BAF82411.1; BAG60609.1; CAD98040.1; AAT27320.1; CAI12703.1; CAI12703.1; CAI15106.1; CAI15106.1; EAW88299.1; AAH32410.1; AAH33810.1; AAH43492.1; AAH64662.1
Protein Name TNF receptor-associated factor 2; E3 ubiquitin-protein ligase TRAF2; RING-type E3 ubiquitin transferase TRAF2; Tumor necrosis factor type 2 receptor-associated protein 3
Genbank Nucleotide ID U12597; AK054686; AK289722; AK298370; BX538160; AY623660; AL355987; AL449425; AL449425; AL355987; CH471090; BC032410; BC033810; BC043492; BC064662
Gene Name TRAF2; TRAP3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000127191.17 ENST00000247668.6 ENSP00000247668.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Drug and target
PDTD
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtPHOSIDABioGRID
mUbiSiDa
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 17878343; 12591926; 20047764; 18671942; 19854138; 18997792; 16936264
Organism Homo sapiens
Functional Description
(View)

Functional Description



     Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE.
Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE.
Protein Sequence
(Fasta)
MAAASVTPPG SLELLQPGFS KTLLGTKLEA KYLCSACRNV LRRPFQAQCG HRYCSFCLAS 60
ILSSGPQNCA ACVHEGIYEE GISILESSSA FPDNAARREV ESLPAVCPSD GCTWKGTLKE 120
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Protein Fasta Sequence



>IUUC-Hsa-046952|E3,RING|Homo sapiens
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Nucleotide Sequence
(Fasta)
AGATGACTGC AGAGTGAGAG TGAAACCAGC TTCCCTCGGA GGCTGCAGCA CAGGGCTGAC 60
ATGCAAACGT CTGAAAAAGA GGCAAGCTCT CGGTGTGAGC AAGTGGACTG CGGCTATTTG 120
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Nucleotide Fasta Sequence



>IUUC-Hsa-046952|E3,RING|Homo sapiens
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Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0446--Lipid-binding
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR002083--MATH/TRAF_dom
IPR012227--TNF_rcpt--assoc_TRAF
IPR008974--TRAF-like
IPR027133--TRAF2
IPR032070--TRAF_BIRC3-bd
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
IPR001293--Znf_TRAF

PROSITE

PS50144--MATH
PS00518--ZF_RING_1
PS50089--ZF_RING_2
PS50145--ZF_TRAF

Pfam

PF16673--TRAF_BIRC3_bd
PF00097--zf-C3HC4
PF02176--zf-TRAF

SMART

SM00061--MATH
SM00184--RING

Gene Ontology

GO:1990597--C:AIP1-IRE1 complex
GO:0035631--C:CD40 receptor complex
GO:0005938--C:cell cortex
GO:0009898--C:cytoplasmic side of plasma membrane
GO:0005829--C:cytosol
GO:1990604--C:IRE1-TRAF2-ASK1 complex
GO:0045121--C:membrane raft
GO:0005654--C:nucleoplasm
GO:0097057--C:TRAF2-GSTP1 complex
GO:0000151--C:ubiquitin ligase complex
GO:0012506--C:vesicle membrane
GO:0005174--F:CD40 receptor binding
GO:0019899--F:enzyme binding
GO:0042802--F:identical protein binding
GO:0019901--F:protein kinase binding
GO:0019903--F:protein phosphatase binding
GO:0004871--F:signal transducer activity
GO:0046625--F:sphingolipid binding
GO:0031996--F:thioesterase binding
GO:0005164--F:tumor necrosis factor receptor binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0097296--P:activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0007250--P:activation of NF-kappaB-inducing kinase activity
GO:0043623--P:cellular protein complex assembly
GO:0071732--P:cellular response to nitric oxide
GO:0071550--P:death-inducing signaling complex assembly
GO:0007249--P:I-kappaB kinase/NF-kappaB signaling
GO:0070059--P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:1902042--P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0034351--P:negative regulation of glial cell apoptotic process
GO:1901215--P:negative regulation of neuron death
GO:2001238--P:positive regulation of extrinsic apoptotic signaling pathway
GO:1903721--P:positive regulation of I-kappaB phosphorylation
GO:0032743--P:positive regulation of interleukin-2 production
GO:0043507--P:positive regulation of JUN kinase activity
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0090073--P:positive regulation of protein homodimerization activity
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0050870--P:positive regulation of T cell activation
GO:0002726--P:positive regulation of T cell cytokine production
GO:1903265--P:positive regulation of tumor necrosis factor-mediated signaling pathway
GO:0097300--P:programmed necrotic cell death
GO:0051865--P:protein autoubiquitination
GO:0030163--P:protein catabolic process
GO:0006461--P:protein complex assembly
GO:0016579--P:protein deubiquitination
GO:0051291--P:protein heterooligomerization
GO:0070207--P:protein homotrimerization
GO:0070534--P:protein K63-linked ubiquitination
GO:0042981--P:regulation of apoptotic process
GO:1902041--P:regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0051023--P:regulation of immunoglobulin secretion
GO:0060544--P:regulation of necroptotic process
GO:0010803--P:regulation of tumor necrosis factor-mediated signaling pathway
GO:0034976--P:response to endoplasmic reticulum stress
GO:0007165--P:signal transduction
GO:0033209--P:tumor necrosis factor-mediated signaling pathway

KEGG hsa:7186
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000744 Aegilops tauschii 27.12 8.00e-06 46.60
IUUC-Aml-002344 Ailuropoda melanoleuca 85.85 0.00e+00 904.00
IUUC-Apl-004202 Anas platyrhynchos 74.48 0.00e+00 832.00
IUUC-Aca-005029 Anolis carolinensis 58.47 7.00e-148 516.00
IUUC-Ame-011841 Astyanax mexicanus 55.59 0.00e+00 642.00
IUUC-Bta-013180 Bos taurus 85.94 0.00e+00 891.00
IUUC-Cja-019813 Callithrix jacchus 97.01 0.00e+00 1014.00
IUUC-Cfa-021205 Canis familiaris 90.42 0.00e+00 920.00
IUUC-Cpo-021346 Cavia porcellus 89.42 0.00e+00 926.00
IUUC-Csa-023809 Chlorocebus sabaeus 97.31 0.00e+00 902.00
IUUC-Dre-027669 Danio rerio 58.73 2.00e-178 619.00
IUUC-Dno-029458 Dasypus novemcinctus 84.14 0.00e+00 894.00
IUUC-Dor-030338 Dipodomys ordii 86.83 0.00e+00 835.00
IUUC-Eca-034401 Equus caballus 90.10 0.00e+00 945.00
IUUC-Eeu-034668 Erinaceus europaeus 70.36 2.00e-107 382.00
IUUC-Fca-036057 Felis catus 86.62 0.00e+00 930.00
IUUC-Fal-037560 Ficedula albicollis 72.83 0.00e+00 738.00
IUUC-Gmo-038964 Gadus morhua 62.82 0.00e+00 667.00
IUUC-Gga-040425 Gallus gallus 75.33 0.00e+00 829.00
IUUC-Gac-041908 Gasterosteus aculeatus 64.09 0.00e+00 684.00
IUUC-Ggo-044606 Gorilla gorilla 91.22 0.00e+00 936.00
IUUC-Hvu-047095 Hordeum vulgare 26.27 3.00e-05 44.70
IUUC-Itr-049016 Ictidomys tridecemlineatus 76.25 0.00e+00 780.00
IUUC-Lch-049571 Latimeria chalumnae 59.76 0.00e+00 712.00
IUUC-Loc-051973 Lepisosteus oculatus 62.98 0.00e+00 635.00
IUUC-Laf-053815 Loxodonta africana 83.89 0.00e+00 854.00
IUUC-Mcc-054888 Macaca mulatta 98.40 0.00e+00 1022.00
IUUC-Meu-056547 Macropus eugenii 74.43 0.00e+00 671.00
IUUC-Mga-059819 Meleagris gallopavo 75.25 0.00e+00 786.00
IUUC-Mdo-062570 Monodelphis domestica 82.87 0.00e+00 858.00
IUUC-Mmu-063133 Mus musculus 86.83 0.00e+00 873.00
IUUC-Mac-064547 Musa acuminata 32.65 5.00e-06 47.40
IUUC-Mpu-065802 Mustela putorius furo 87.50 0.00e+00 925.00
IUUC-Nle-070155 Nomascus leucogenys 98.80 0.00e+00 1028.00
IUUC-Opr-070856 Ochotona princeps 85.96 8.00e-114 404.00
IUUC-Ont-071930 Oreochromis niloticus 64.10 0.00e+00 711.00
IUUC-Ola-087397 Oryzias latipes 61.08 0.00e+00 688.00
IUUC-Oga-088109 Otolemur garnettii 94.41 0.00e+00 992.00
IUUC-Oar-090310 Ovis aries 76.49 0.00e+00 793.00
IUUC-Ptr-090643 Pan troglodytes 99.40 0.00e+00 1031.00
IUUC-Pan-091933 Papio anubis 98.20 0.00e+00 1020.00
IUUC-Psi-093681 Pelodiscus sinensis 73.53 0.00e+00 786.00
IUUC-Pfo-096148 Poecilia formosa 60.52 0.00e+00 694.00
IUUC-Pab-098631 Pongo abelii 99.20 0.00e+00 1032.00
IUUC-Pca-100582 Procavia capensis 67.44 7.00e-90 324.00
IUUC-Pva-102396 Pteropus vampyrus 75.05 0.00e+00 744.00
IUUC-Rno-106120 Rattus norvegicus 86.63 0.00e+00 860.00
IUUC-Sha-106493 Sarcophilus harrisii 82.87 0.00e+00 882.00
IUUC-Sit-110103 Setaria italica 26.27 6.00e-05 43.90
IUUC-Sar-113570 Sorex araneus 93.37 7.00e-100 357.00
IUUC-Ssc-115843 Sus scrofa 85.19 0.00e+00 918.00
IUUC-Tgu-117144 Taeniopygia guttata 70.28 0.00e+00 706.00
IUUC-Tru-117853 Takifugu rubripes 62.14 0.00e+00 691.00
IUUC-Tni-120256 Tetraodon nigroviridis 65.07 0.00e+00 719.00
IUUC-Tae-123531 Triticum aestivum 27.12 9.00e-06 46.60
IUUC-Tur-126325 Triticum urartu 26.27 3.00e-05 45.10
IUUC-Tbe-127943 Tupaia belangeri 66.33 2.00e-101 361.00
IUUC-Ttr-129246 Tursiops truncatus 89.09 0.00e+00 904.00
IUUC-Xtr-132279 Xenopus tropicalis 60.60 4.00e-175 607.00
Created Date 25-Jun-2017

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