iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
TRANSFAC	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	6.30e-08	33.7	14	81

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 6    flCpIslelMrdPvvlpsGitydrssIekwl.asggk......tcPvtrqplteedlvPnltlrrliq 66
             C+I + +M++Pv + +G++y +s+I+ +  + + k       cP++++p++ e+l Pn++l  +i+
   Q: 14   TSCSICKAMMSHPVSINCGHSYCKSCIQSYYcNVSPKtgwkmlGCPLCSSPFSLENLRPNKELETIID 81
           68****************************9644444688899********************99986 PP

Organism

Mus musculus

Protein Sequence
(Fasta)

MGSDFSTVKI RKVTSCSICK AMMSHPVSIN CGHSYCKSCI QSYYCNVSPK TGWKMLGCPL 60
CSSPFSLENL RPNKELETII DMIKGMEEQD QDMVCEEHEE KFNRFCEDDG QLLCWRCYWE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGCTCAG ACTTTAGCAC GGTGAAGATA AGAAAGGTCA CTTCTTGCTC CATCTGCAAG 60
GCCATGATGT CTCACCCAGT GAGCATCAAC TGTGGACACA GCTACTGCAA ATCCTGCATA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005622--C:intracellular
GO:0004871--F:signal transducer activity
GO:0008270--F:zinc ion binding
GO:0050687--P:negative regulation of defense response to virus
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0046598--P:positive regulation of viral entry into host cell
GO:0045070--P:positive regulation of viral genome replication
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0032648--P:regulation of interferon-beta production

KEGG

mmu:214158

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001649	Ailuropoda melanoleuca	53.56	3.00e-143	501.00
IUUC-Bta-012574	Bos taurus	55.51	5.00e-144	504.00
IUUC-Cja-019759	Callithrix jacchus	55.41	2.00e-137	482.00
IUUC-Cfa-020431	Canis familiaris	50.75	4.00e-128	451.00
IUUC-Cpo-022541	Cavia porcellus	53.21	5.00e-144	504.00
IUUC-Csa-023320	Chlorocebus sabaeus	55.86	1.00e-145	509.00
IUUC-Cho-024964	Choloepus hoffmanni	55.96	3.00e-93	335.00
IUUC-Dno-029741	Dasypus novemcinctus	50.86	1.00e-131	462.00
IUUC-Dor-030298	Dipodomys ordii	50.68	1.00e-81	296.00
IUUC-Ete-032493	Echinops telfairi	48.39	8.00e-125	440.00
IUUC-Eca-033962	Equus caballus	55.11	1.00e-143	502.00
IUUC-Eeu-035228	Erinaceus europaeus	55.35	3.00e-96	345.00
IUUC-Fca-036349	Felis catus	52.46	2.00e-139	488.00
IUUC-Ggo-044493	Gorilla gorilla	56.10	7.00e-147	513.00
IUUC-Hsa-046161	Homo sapiens	56.32	2.00e-147	515.00
IUUC-Itr-048162	Ictidomys tridecemlineatus	50.00	1.00e-118	419.00
IUUC-Laf-054150	Loxodonta africana	52.68	3.00e-131	461.00
IUUC-Mcc-055076	Macaca mulatta	55.89	2.00e-144	505.00
IUUC-Mpu-065752	Mustela putorius furo	53.03	7.00e-140	490.00
IUUC-Mlu-067758	Myotis lucifugus	43.98	1.00e-105	377.00
IUUC-Nle-069117	Nomascus leucogenys	56.66	6.00e-149	520.00
IUUC-Opr-071144	Ochotona princeps	50.32	7.00e-121	427.00
IUUC-Ocu-074825	Oryctolagus cuniculus	52.03	6.00e-137	480.00
IUUC-Oga-088744	Otolemur garnettii	49.67	5.00e-76	277.00
IUUC-Oar-089951	Ovis aries	55.08	1.00e-143	502.00
IUUC-Ptr-090519	Pan troglodytes	55.86	5.00e-146	511.00
IUUC-Pan-092059	Papio anubis	55.89	6.00e-145	507.00
IUUC-Pab-098747	Pongo abelii	56.45	2.00e-148	518.00
IUUC-Pca-100294	Procavia capensis	50.86	3.00e-128	451.00
IUUC-Pva-102129	Pteropus vampyrus	50.64	3.00e-131	461.00
IUUC-Sar-113760	Sorex araneus	47.25	2.00e-111	395.00
IUUC-Tsy-119422	Tarsius syrichta	53.43	2.00e-132	465.00
IUUC-Ttr-129039	Tursiops truncatus	55.46	2.00e-145	508.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence