iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	19898466

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	1.10e-05	27.0	12	94

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf.................................kdgplvlpCgHvfhadCl..qkw...pglknssskefrCPlCr 46
           C++C+e++                                 ++ ++vlpC H+f++ Cl  +++    g    +  + rCP+C+
   Q: 12   CLLCKEMCgspaplssnssasssssqtstssaggggpgaaaRR-LHVLPCLHAFCRPCLeaHRLpapGGAGPAEALKLRCPVCD 94
           9999888888888888888888777777777777777777444.***************5555599855555589999*****5 PP

Organism

Mus musculus

Functional Description
(View)

E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance. Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A. Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1.

Protein Sequence
(Fasta)

MASFPETDFQ ICLLCKEMCG SPAPLSSNSS ASSSSSQTST SSAGGGGPGA AARRLHVLPC 60
LHAFCRPCLE AHRLPAPGGA GPAEALKLRC PVCDQKVVLA EAAGMDALPS SAFLLSNLLD 120

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Nucleotide Sequence
(Fasta)

GTTTGCTCCT TTGGAGATTA AAAGGATTCC GAATTCCGAT CAGTCCCAAT AACCCGCGTT 60
CTGAGAGGCG GCAAAGCGGA GAAAGAAGGG GGACACGCGC ACGCACACAG CCCCTCGTTC 120

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Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0694--RNA-binding
KW-0943--RNA-mediated gene silencing
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR017868--Filamin/ABP280_repeat-like
IPR001298--Filamin/ABP280_rpt
IPR013783--Ig-like_fold
IPR014756--Ig_E-set
IPR001258--NHL_repeat
IPR013017--NHL_repeat_subgr
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50194--FILAMIN_REPEAT
PS51125--NHL
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00630--Filamin
PF01436--NHL
PF00643--zf-B_box

SMART

SM00336--BBOX
SM00557--IG_FLMN
SM00184--RING

Gene Ontology

GO:0000932--C:P-body
GO:0035198--F:miRNA binding
GO:0030371--F:translation repressor activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0061158--P:3'-UTR-mediated mRNA destabilization
GO:0071310--P:cellular response to organic substance
GO:0008543--P:fibroblast growth factor receptor signaling pathway
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0035278--P:miRNA mediated inhibition of translation
GO:0010586--P:miRNA metabolic process
GO:0017148--P:negative regulation of translation
GO:0001843--P:neural tube closure
GO:0021915--P:neural tube development
GO:2000637--P:positive regulation of gene silencing by miRNA
GO:0051865--P:protein autoubiquitination
GO:0060964--P:regulation of gene silencing by miRNA
GO:2000177--P:regulation of neural precursor cell proliferation
GO:0051246--P:regulation of protein metabolic process
GO:0072089--P:stem cell proliferation

KEGG

mmu:636931

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001234	Ailuropoda melanoleuca	92.36	0.00e+00	1151.00
IUUC-Apl-003905	Anas platyrhynchos	90.58	0.00e+00	1118.00
IUUC-Aca-004326	Anolis carolinensis	83.53	0.00e+00	1187.00
IUUC-Ani-009171	Aspergillus nidulans	27.27	4.30e-02	32.70
IUUC-Ame-011573	Astyanax mexicanus	70.03	0.00e+00	1170.00
IUUC-Bta-013395	Bos taurus	92.51	0.00e+00	1273.00
IUUC-Cel-018188	Caenorhabditis elegans	35.06	9.00e-106	378.00
IUUC-Cja-019863	Callithrix jacchus	94.64	0.00e+00	1278.00
IUUC-Cfa-020285	Canis familiaris	92.56	0.00e+00	1265.00
IUUC-Cpo-021879	Cavia porcellus	88.11	0.00e+00	1429.00
IUUC-Csa-024271	Chlorocebus sabaeus	94.64	0.00e+00	1275.00
IUUC-Cho-024376	Choloepus hoffmanni	93.84	0.00e+00	1137.00
IUUC-Cin-025406	Ciona intestinalis	49.93	0.00e+00	652.00
IUUC-Cne-027010	Cryptococcus neoformans	25.00	8.20e-02	29.60
IUUC-Dre-027699	Danio rerio	71.61	0.00e+00	1191.00
IUUC-Dno-029022	Dasypus novemcinctus	92.99	0.00e+00	1134.00
IUUC-Dor-031072	Dipodomys ordii	94.83	0.00e+00	1295.00
IUUC-Dme-031997	Drosophila melanogaster	48.54	1.00e-69	258.00
IUUC-Ete-032228	Echinops telfairi	93.77	0.00e+00	790.00
IUUC-Eca-033373	Equus caballus	94.94	0.00e+00	1016.00
IUUC-Eeu-034463	Erinaceus europaeus	92.23	0.00e+00	1093.00
IUUC-Fca-036184	Felis catus	92.49	0.00e+00	1155.00
IUUC-Fal-036918	Ficedula albicollis	82.26	0.00e+00	1155.00
IUUC-Fox-038003	Fusarium oxysporum	32.20	4.00e-03	35.40
IUUC-Gmo-039415	Gadus morhua	70.08	0.00e+00	868.00
IUUC-Gga-040379	Gallus gallus	87.90	0.00e+00	1233.00
IUUC-Gac-042330	Gasterosteus aculeatus	65.77	0.00e+00	1046.00
IUUC-Gma-043819	Glycine max	23.18	1.00e-11	66.20
IUUC-Ggo-045208	Gorilla gorilla	94.64	0.00e+00	1272.00
IUUC-Hsa-045988	Homo sapiens	94.79	0.00e+00	1275.00
IUUC-Itr-048371	Ictidomys tridecemlineatus	94.87	0.00e+00	1152.00
IUUC-Kpa-049184	Komagataella pastoris	25.93	3.00e-02	32.00
IUUC-Lch-050324	Latimeria chalumnae	84.33	0.00e+00	1188.00
IUUC-Loc-052322	Lepisosteus oculatus	71.30	0.00e+00	1235.00
IUUC-Laf-054272	Loxodonta africana	90.90	0.00e+00	1217.00
IUUC-Mcc-055125	Macaca mulatta	94.64	0.00e+00	1273.00
IUUC-Meu-055934	Macropus eugenii	81.49	0.00e+00	1110.00
IUUC-Mga-059930	Meleagris gallopavo	90.26	0.00e+00	1113.00
IUUC-Mmr-060662	Microcebus murinus	92.73	0.00e+00	1266.00
IUUC-Mdo-062918	Monodelphis domestica	86.02	0.00e+00	1250.00
IUUC-Mpu-066325	Mustela putorius furo	94.36	0.00e+00	1014.00
IUUC-Mlu-067171	Myotis lucifugus	88.29	0.00e+00	1204.00
IUUC-Nle-069692	Nomascus leucogenys	94.64	0.00e+00	1274.00
IUUC-Opr-070354	Ochotona princeps	92.64	0.00e+00	1133.00
IUUC-Ont-072125	Oreochromis niloticus	67.40	0.00e+00	1141.00
IUUC-Oan-073079	Ornithorhynchus anatinus	91.79	0.00e+00	1125.00
IUUC-Ocu-073910	Oryctolagus cuniculus	92.86	0.00e+00	1261.00
IUUC-Ola-087162	Oryzias latipes	68.10	0.00e+00	1121.00
IUUC-Oga-088523	Otolemur garnettii	84.37	0.00e+00	1152.00
IUUC-Oar-090009	Ovis aries	92.46	0.00e+00	658.00
IUUC-Ptr-091173	Pan troglodytes	94.79	0.00e+00	1277.00
IUUC-Pan-091750	Papio anubis	94.50	0.00e+00	1271.00
IUUC-Psi-093053	Pelodiscus sinensis	85.98	0.00e+00	1053.00
IUUC-Pma-094227	Petromyzon marinus	58.86	2.00e-174	605.00
IUUC-Pfo-096980	Poecilia formosa	65.66	0.00e+00	1102.00
IUUC-Pab-098189	Pongo abelii	94.49	0.00e+00	1272.00
IUUC-Pva-103126	Pteropus vampyrus	91.85	0.00e+00	1253.00
IUUC-Rno-105653	Rattus norvegicus	97.66	0.00e+00	1461.00
IUUC-Sce-106389	Saccharomyces cerevisiae	24.36	6.80e-02	31.60
IUUC-Sha-107178	Sarcophilus harrisii	90.57	0.00e+00	1117.00
IUUC-Sar-113613	Sorex araneus	81.80	0.00e+00	942.00
IUUC-Tgu-116963	Taeniopygia guttata	90.09	0.00e+00	1112.00
IUUC-Tru-117942	Takifugu rubripes	68.46	0.00e+00	1126.00
IUUC-Tsy-119075	Tarsius syrichta	85.79	0.00e+00	1023.00
IUUC-Tni-120704	Tetraodon nigroviridis	80.03	0.00e+00	994.00
IUUC-Tbe-128141	Tupaia belangeri	75.40	0.00e+00	790.00
IUUC-Ttr-128908	Tursiops truncatus	88.81	0.00e+00	686.00
IUUC-Xtr-132272	Xenopus tropicalis	73.25	0.00e+00	1219.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence