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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064158
UUCD1 version UUC-MuM-01016
Ensembl Protein ID ENSMUSP00000101331.1
UniProt Accession Q9QZN4; A2A7H0; A2A7H2; B2KFL0; B2KFL2; Q3TML5; Q3UCB0; FBX6_MOUSE
Genbank Protein ID AAF09135.1; BAB22397.1; BAE29703.1; BAE31571.1; BAE38426.1; BAE41996.1; BAE42484.1; CAM14906.1; CAM14908.1; CAQ51912.1; CAQ51912.1; CAQ51914.1; CAQ51914.1; CAQ52204.1; CAQ52204.1; CAQ52206.1; CAQ52206.1; EDL14804.1; EDL14805.1; EDL14807.1; AAH17512.1
Protein Name F-box only protein 6; F-box only protein 6b; F-box protein that recognizes sugar chains 2; F-box/G-domain protein 2
Genbank Nucleotide ID AF176526; AK002840; AK150612; AK152888; AK165867; AK170743; AK171483; AL606929; AL606929; CU207376; CU207417; CU207376; CU207417; CU207417; CU207376; CU207417; CU207376; CH466594; CH466594; CH466594; BC017512
Gene Name Fbxo6; Fbs2; Fbxo6b
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000055401.14 ENSMUST00000105706.7 ENSMUSP00000101331.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarRAID2
Protein-protein Interaction
IIDMentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMPhospho.ELM
UniProtPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 adaptor/Cullin RING/SCF/F-box 29.73 1.00e-12 70.50 IUUC-Cel-018409
E3 adaptor/Cullin RING/SCF/F-box 74.60 2.00e-111 399.00 IUUC-Hsa-046047
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication (By similarity). Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranlocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans.
 Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication (By similarity). Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranlocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans.
Protein Sequence
(Fasta)
MVHINELPEN ILLELFIHIP APQLLRNCRL VCRLWRDLID VVSLWKRKSL REGFFTKDRC 60
EPVEDWKVFY ILCSLQRNLL RNPCAEENLS SWRIDSNGGD RWKVETLPGS CGTSFPDNKV 120
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Protein Fasta Sequence


>IUUC-Mmu-064158|E3,F-box|Mus musculus
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Nucleotide Sequence
(Fasta)
GATTCTAAGT AGCGCTTCCT TCGCTGGAGG AGGAAGCAGG CCCGAGGTGG GAGCAAGCTG 60
CTGAACCGCT TGTCGCCTGG AGGGGGAGAC GGAAGCCGGG GAAGCCCGGC CAGTGGAGCA 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-064158|E3,F-box|Mus musculus
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Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0227--DNA damage
KW-0234--DNA repair
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0834--Unfolded protein response
Interpro

IPR007397--F-box-assoc_dom
IPR001810--F-box_dom
IPR008979--Galactose-bd-like
PROSITE

PS51114--FBA
PS50181--FBOX
Pfam

PF12937--F-box-like
PF04300--FBA
SMART

SM01198--FBA
SM00256--FBOX
Gene Ontology

GO:0005737--C:cytoplasm
GO:0044322--C:endoplasmic reticulum quality control compartment
GO:0019005--C:SCF ubiquitin ligase complex
GO:0030246--F:carbohydrate binding
GO:0001948--F:glycoprotein binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006281--P:DNA repair
GO:0006516--P:glycoprotein catabolic process
GO:0006986--P:response to unfolded protein
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0030433--P:ubiquitin-dependent ERAD pathway
GO:0097466--P:ubiquitin-dependent glycoprotein ERAD pathway
KEGG mmu:50762
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000136 Aegilops tauschii 51.43 2.00e-04 40.40
IUUC-Aml-002387 Ailuropoda melanoleuca 68.77 1.00e-112 399.00
IUUC-Afl-008397 Aspergillus flavus 25.74 6.30e-02 31.20
IUUC-Aor-010183 Aspergillus oryzae 25.74 6.30e-02 31.20
IUUC-Ame-011181 Astyanax mexicanus 45.87 3.00e-59 221.00
IUUC-Bta-012446 Bos taurus 78.71 5.00e-128 449.00
IUUC-Cel-018409 Caenorhabditis elegans 29.73 1.00e-13 70.50
IUUC-Cja-019690 Callithrix jacchus 71.08 6.00e-107 380.00
IUUC-Cfa-020399 Canis familiaris 74.55 6.00e-121 427.00
IUUC-Cpo-022113 Cavia porcellus 71.43 5.00e-118 417.00
IUUC-Csa-023732 Chlorocebus sabaeus 73.20 3.00e-112 397.00
IUUC-Dre-027973 Danio rerio 46.91 4.00e-65 241.00
IUUC-Dno-029725 Dasypus novemcinctus 75.61 4.00e-111 394.00
IUUC-Dor-030820 Dipodomys ordii 80.51 4.00e-114 404.00
IUUC-Ete-032617 Echinops telfairi 78.65 3.00e-84 304.00
IUUC-Eca-033658 Equus caballus 74.10 6.00e-114 403.00
IUUC-Eeu-035144 Erinaceus europaeus 70.56 2.00e-108 385.00
IUUC-Fca-036511 Felis catus 77.86 1.00e-123 435.00
IUUC-Fal-037154 Ficedula albicollis 60.35 6.00e-84 303.00
IUUC-Gac-041813 Gasterosteus aculeatus 48.97 8.00e-65 240.00
IUUC-Ggo-044771 Gorilla gorilla 74.00 2.00e-113 402.00
IUUC-Hsa-046047 Homo sapiens 74.00 7.00e-113 399.00
IUUC-Itr-048961 Ictidomys tridecemlineatus 81.15 6.00e-119 419.00
IUUC-Lpe-050860 Leersia perrieri 48.57 1.40e-01 33.10
IUUC-Loc-051984 Lepisosteus oculatus 50.23 4.00e-58 218.00
IUUC-Laf-054388 Loxodonta africana 75.93 3.00e-117 414.00
IUUC-Mcc-055219 Macaca mulatta 74.19 7.00e-113 399.00
IUUC-Mga-060039 Meleagris gallopavo 62.67 6.00e-85 306.00
IUUC-Mmr-060599 Microcebus murinus 74.44 1.00e-117 415.00
IUUC-Mpu-065798 Mustela putorius furo 76.36 1.00e-117 415.00
IUUC-Mlu-067931 Myotis lucifugus 69.46 8.00e-125 439.00
IUUC-Opr-070619 Ochotona princeps 73.36 6.00e-108 383.00
IUUC-Ont-072665 Oreochromis niloticus 50.00 6.00e-71 260.00
IUUC-Ocu-074270 Oryctolagus cuniculus 71.10 8.00e-112 396.00
IUUC-Ola-086867 Oryzias latipes 46.09 2.00e-64 238.00
IUUC-Oga-088988 Otolemur garnettii 79.22 2.00e-121 428.00
IUUC-Oar-089871 Ovis aries 76.81 5.00e-125 440.00
IUUC-Ptr-091362 Pan troglodytes 73.20 6.00e-112 396.00
IUUC-Pan-091935 Papio anubis 73.79 3.00e-112 397.00
IUUC-Pno-094803 Phaeosphaeria nodorum 50.00 4.00e-03 35.40
IUUC-Pfo-097249 Poecilia formosa 46.85 2.00e-57 216.00
IUUC-Pab-098167 Pongo abelii 74.00 8.00e-113 399.00
IUUC-Pca-100483 Procavia capensis 72.63 4.00e-81 293.00
IUUC-Pva-103073 Pteropus vampyrus 76.14 3.00e-121 427.00
IUUC-Rno-106045 Rattus norvegicus 85.99 4.00e-134 470.00
IUUC-Sar-113378 Sorex araneus 76.13 3.00e-114 404.00
IUUC-Ssc-115889 Sus scrofa 75.29 5.00e-122 430.00
IUUC-Tgu-116573 Taeniopygia guttata 60.89 4.00e-82 297.00
IUUC-Tru-117734 Takifugu rubripes 48.76 2.00e-62 232.00
IUUC-Tni-120432 Tetraodon nigroviridis 44.90 1.00e-63 235.00
IUUC-Tbe-127475 Tupaia belangeri 78.68 1.00e-123 435.00
IUUC-Ttr-129048 Tursiops truncatus 74.63 2.00e-117 415.00
IUUC-Xtr-132515 Xenopus tropicalis 50.48 5.00e-61 227.00
Created Date 25-Jun-2017

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