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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Spo-108195
UUCD1 version UUC-ScP-00068
Ensembl Protein ID SPAC23C11.12.1:pep
UniProt Accession O13916; HCN1_SCHPO
Genbank Protein ID BAD34487.1; CAB11170.1
Protein Name Anaphase-promoting complex subunit hcn1; 20S cyclosome/APC complex protein hcn1; Chaperone-like protein hcn1; High copy suppressor of cut9 protein 1
Genbank Nucleotide ID AB001373; CU329670
Gene Name hcn1; SPAC23C11.12
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
SPAC23C11.12 SPAC23C11.12.1 SPAC23C11.12.1:pep
Annotation
mRNA Expression
GEO
Protein-protein Interaction
iRefIndexHINT
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
UniProt
Protein Expression/Proteomics
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 adaptor/Cullin RING/APC_C/APC_C 40.54 3.90e-02 30.80 IUUC-Sce-106324
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Schizosaccharomyces pombe
Functional Description
(View)

Functional Description


     Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. Has a role in assembling cut9 in the 20S APC/cyclosome.
 Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. Has a role in assembling cut9 in the 20S APC/cyclosome.
Protein Sequence
(Fasta)
MLRRNPTAIQ ITAEDVLAYD EEKLRQTLDS ESTTEEALQK NEESTRLSPE KKKIIRERRI 60
GITQIFDSSM HPSQGGAAQS
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Spo-108195|E3,APC_C|Schizosaccharomyces pombe
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGTTACGAA GAAATCCTAC GGCAATACAA ATTACTGCTG AAGATGTTCT TGCATATGAC 60
GAAGAAAAGC TAAGACAAAC GCTTGATTCC GAGTCAACAA CAGAAGAAGC ATTGCAGAAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Spo-108195|E3,APC_C|Schizosaccharomyces pombe
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0143--Chaperone
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR018860--APC_suCDC26
Pfam

PF10471--ANAPC_CDC26
Gene Ontology

GO:0005680--C:anaphase-promoting complex
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0007127--P:meiosis I
GO:0030071--P:regulation of mitotic metaphase/anaphase transition
KEGG spo:SPAC23C11.12
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001456 Ailuropoda melanoleuca 28.95 2.90e-01 24.30
IUUC-Atr-002458 Amborella trichopoda 60.00 6.30e-01 23.10
IUUC-Ago-007754 Ashbya gossypii 62.50 7.60e-02 26.90
IUUC-Acl-008116 Aspergillus clavatus 35.14 8.00e-07 42.70
IUUC-Ani-009376 Aspergillus nidulans 36.99 1.00e-06 42.40
IUUC-Bta-012581 Bos taurus 28.95 2.90e-01 24.30
IUUC-Bci-013595 Botrytis cinerea 52.38 6.40e-02 28.10
IUUC-Cja-019622 Callithrix jacchus 28.21 2.40e-01 24.30
IUUC-Cfa-021044 Canis familiaris 28.95 2.90e-01 24.30
IUUC-Cpo-022441 Cavia porcellus 30.56 2.50e-01 24.30
IUUC-Csa-024091 Chlorocebus sabaeus 33.33 5.10e-01 23.50
IUUC-Csv-025958 Ciona savignyi 47.37 2.40e-01 24.60
IUUC-Dno-029137 Dasypus novemcinctus 28.21 2.30e-01 24.60
IUUC-Dor-030181 Dipodomys ordii 28.95 3.20e-01 23.90
IUUC-Ete-032555 Echinops telfairi 30.77 1.10e-01 25.40
IUUC-Eca-033227 Equus caballus 33.33 5.60e-01 23.10
IUUC-Fca-035838 Felis catus 28.95 2.60e-01 24.30
IUUC-Fal-036994 Ficedula albicollis 43.75 9.10e-01 22.30
IUUC-Gga-040675 Gallus gallus 36.67 3.00e-01 24.30
IUUC-Hsa-046899 Homo sapiens 33.33 4.20e-01 23.50
IUUC-Itr-048643 Ictidomys tridecemlineatus 30.56 3.10e-01 24.30
IUUC-Loc-052390 Lepisosteus oculatus 45.00 1.30e-01 25.40
IUUC-Laf-053681 Loxodonta africana 33.33 4.70e-01 23.50
IUUC-Mcc-054912 Macaca mulatta 33.33 5.10e-01 23.50
IUUC-Mor-057242 Magnaporthe oryzae 67.86 1.00e-04 37.40
IUUC-Mmr-061790 Microcebus murinus 28.21 2.10e-01 24.60
IUUC-Mmu-064350 Mus musculus 26.51 2.40e-01 24.30
IUUC-Nle-069077 Nomascus leucogenys 33.33 5.20e-01 23.50
IUUC-Opr-071004 Ochotona princeps 30.56 3.20e-01 23.90
IUUC-Oan-073200 Ornithorhynchus anatinus 34.48 5.30e-01 23.10
IUUC-Ocu-074476 Oryctolagus cuniculus 28.95 3.10e-01 23.90
IUUC-Oba-075520 Oryza barthii 53.33 2.30e+00 21.20
IUUC-Ogu-078445 Oryza glumaepatula 53.33 2.30e+00 21.20
IUUC-Oga-088195 Otolemur garnettii 33.33 4.80e-01 23.50
IUUC-Oar-089399 Ovis aries 28.95 2.80e-01 24.30
IUUC-Ptr-090822 Pan troglodytes 33.33 4.20e-01 23.50
IUUC-Pan-092857 Papio anubis 33.33 5.10e-01 23.50
IUUC-Ppa-095794 Physcomitrella patens 52.38 6.30e-02 26.20
IUUC-Pab-098774 Pongo abelii 33.33 4.20e-01 23.50
IUUC-Pca-100745 Procavia capensis 33.33 4.60e-01 23.50
IUUC-Pte-104296 Pyrenophora teres 30.56 1.20e-01 25.40
IUUC-Pyt-104747 Pyrenophora triticirepentis 24.68 1.10e-02 28.90
IUUC-Rno-106085 Rattus norvegicus 28.21 2.30e-01 24.60
IUUC-Sce-106324 Saccharomyces cerevisiae 40.54 9.00e-03 30.40
IUUC-Sha-107235 Sarcophilus harrisii 33.33 4.30e-01 23.50
IUUC-Sja-107826 Schizosaccharomyces japonicus 41.79 1.00e-10 55.10
IUUC-Ssl-108598 Sclerotinia sclerotiorum 52.38 3.80e-02 28.50
IUUC-Sre-115101 Sporisorium reilianum 43.75 4.10e+00 20.80
IUUC-Ssc-115650 Sus scrofa 30.56 4.50e-01 23.50
IUUC-Tgu-117309 Taeniopygia guttata 36.67 2.50e-01 24.30
IUUC-Tsy-119267 Tarsius syrichta 33.33 4.70e-01 23.50
IUUC-Tre-122142 Trichoderma reesei 61.90 6.00e-03 34.70
IUUC-Tvi-122490 Trichoderma virens 66.67 5.00e-04 34.70
IUUC-Ttr-129250 Tursiops truncatus 30.56 2.80e-01 24.30
IUUC-Uma-129460 Ustilago maydis 43.75 1.70e+00 21.90
Created Date 25-Jun-2017

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