iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000102981.9	ENST00000602551.5	ENSP00000473257.1
ENSG00000102981.9	ENST00000458121.6	ENSP00000392388.1
ENSG00000102981.9	ENST00000219255.3	ENSP00000219255.3

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM	SZDB
DNA & RNA Element
UTRdb	miRTarBase	microRNA	TRANSFAC
miRWalk	RepTar	miRNAMap	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
ULD/UDP/UFD/PB1	PB1	15590654; 16949360

Classification

Family	E-value	Score	Start	End
ULD/UDP/UFD/PB1	1.10e-17	65.7	16	94

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UFD/PB1

   S: 2    vrvkvsykgeirsfaldlekpgkfedLlkavrtltelknsevalkYeDedGDlvtlksDedldkavsllaskksllrlliqk 83
           v+vk+++++e+r+fal ++++ +f+++ +++r+++++++ +v l+Y+D++GDl++l++D+ l+ a+    s  + lrll+qk
   Q: 16   VEVKSKFDAEFRRFALPRASVSGFQEFSRLLRAVHQIPGLDVLLGYTDAHGDLLPLTNDDSLHRALA---SGPPPLRLLVQK 94
           79*****************************************************************...**********98 PP

Organism

Homo sapiens

Functional Description
(View)

Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10873802). Regulates centrosome organization and function. Essential for the centrosomal recruitment of key proteins that control centrosomal microtubule organization (PubMed:20719959).

Protein Sequence
(Fasta)

MARPQRTPAR SPDSIVEVKS KFDAEFRRFA LPRASVSGFQ EFSRLLRAVH QIPGLDVLLG 60
YTDAHGDLLP LTNDDSLHRA LASGPPPLRL LVQKRAEADS SGLAFASNSL QRRKKGLLLR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGGGCGGGG CGGCGCGGGC GGGCCGGCCG GGCTGTGCAC CTGCGCCTCG GCGGGCCGCC 60
TGGGGCACCG TCCCCGGCCC GCCCGGCCCC GCCATGGCCC GGCCGCAGAG GACTCCGGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0132--Cell division
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0796--Tight junction

Interpro

IPR000270--PB1_dom
IPR001478--PDZ

PROSITE

PS51745--PB1
PS50106--PDZ

Pfam

PF00564--PB1
PF00595--PDZ

SMART

SM00666--PB1
SM00228--PDZ

Gene Ontology

GO:0045177--C:apical part of cell
GO:0005923--C:bicellular tight junction
GO:0005938--C:cell cortex
GO:0034451--C:centriolar satellite
GO:0005813--C:centrosome
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0043234--C:protein complex
GO:0001726--C:ruffle
GO:0030742--F:GTP-dependent protein binding
GO:0017048--F:Rho GTPase binding
GO:0008134--F:transcription factor binding
GO:0070830--P:bicellular tight junction assembly
GO:0007049--P:cell cycle
GO:0051301--P:cell division
GO:0045217--P:cell-cell junction maintenance
GO:0051297--P:centrosome organization
GO:0001933--P:negative regulation of protein phosphorylation
GO:1904781--P:positive regulation of protein localization to centrosome
GO:0007179--P:transforming growth factor beta receptor signaling pathway
GO:0016032--P:viral process
GO:0060071--P:Wnt signaling pathway, planar cell polarity pathway

KEGG

hsa:50855

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001436	Ailuropoda melanoleuca	95.66	0.00e+00	636.00
IUUC-Apl-004064	Anas platyrhynchos	71.60	1.00e-103	369.00
IUUC-Aca-004789	Anolis carolinensis	75.21	6.00e-107	380.00
IUUC-Bta-012518	Bos taurus	93.93	1.00e-166	578.00
IUUC-Cel-018478	Caenorhabditis elegans	56.92	9.00e-78	283.00
IUUC-Cja-019906	Callithrix jacchus	97.11	2.00e-179	621.00
IUUC-Cfa-020182	Canis familiaris	95.38	0.00e+00	627.00
IUUC-Cpo-021341	Cavia porcellus	94.80	1.00e-176	612.00
IUUC-Csa-023165	Chlorocebus sabaeus	98.84	0.00e+00	629.00
IUUC-Dno-028998	Dasypus novemcinctus	94.22	6.00e-173	600.00
IUUC-Dor-030206	Dipodomys ordii	93.93	2.00e-172	598.00
IUUC-Ete-032644	Echinops telfairi	77.37	2.00e-121	428.00
IUUC-Eca-033390	Equus caballus	95.95	1.00e-175	608.00
IUUC-Fca-035382	Felis catus	92.77	4.00e-168	583.00
IUUC-Fal-037196	Ficedula albicollis	76.21	2.00e-99	355.00
IUUC-Gga-040804	Gallus gallus	75.88	2.00e-113	402.00
IUUC-Ggo-044974	Gorilla gorilla	99.71	0.00e+00	636.00
IUUC-Itr-047959	Ictidomys tridecemlineatus	96.54	0.00e+00	632.00
IUUC-Loc-051759	Lepisosteus oculatus	68.95	8.00e-109	387.00
IUUC-Laf-054157	Loxodonta africana	92.49	1.00e-175	608.00
IUUC-Mcc-054932	Macaca mulatta	98.27	1.00e-178	618.00
IUUC-Meu-056725	Macropus eugenii	74.77	3.00e-122	431.00
IUUC-Mpo-057356	Magnaporthe poae	47.37	2.50e-02	35.80
IUUC-Mvi-060532	Microbotryum violaceum	31.25	1.00e-01	32.00
IUUC-Mmr-061600	Microcebus murinus	96.67	4.00e-176	610.00
IUUC-Mdo-062981	Monodelphis domestica	76.55	2.00e-139	488.00
IUUC-Mmu-063824	Mus musculus	93.06	6.00e-161	560.00
IUUC-Mpu-066720	Mustela putorius furo	95.09	0.00e+00	627.00
IUUC-Mlu-067104	Myotis lucifugus	93.43	1.00e-173	602.00
IUUC-Nle-070003	Nomascus leucogenys	97.98	0.00e+00	649.00
IUUC-Opr-070932	Ochotona princeps	84.44	3.00e-150	524.00
IUUC-Ont-072310	Oreochromis niloticus	66.03	6.00e-94	337.00
IUUC-Oan-073018	Ornithorhynchus anatinus	80.55	3.00e-119	421.00
IUUC-Ocu-074524	Oryctolagus cuniculus	93.92	2.00e-160	558.00
IUUC-Oga-089103	Otolemur garnettii	92.77	2.00e-173	601.00
IUUC-Oar-090055	Ovis aries	93.93	8.00e-167	580.00
IUUC-Ptr-090840	Pan troglodytes	99.13	0.00e+00	628.00
IUUC-Pan-092904	Papio anubis	98.84	0.00e+00	627.00
IUUC-Psi-093762	Pelodiscus sinensis	71.43	2.00e-86	311.00
IUUC-Pfo-096234	Poecilia formosa	64.84	5.00e-90	324.00
IUUC-Pab-097709	Pongo abelii	98.84	0.00e+00	632.00
IUUC-Pca-100345	Procavia capensis	92.10	2.00e-162	565.00
IUUC-Pva-102267	Pteropus vampyrus	94.51	4.00e-173	600.00
IUUC-Rno-105067	Rattus norvegicus	91.91	1.00e-159	555.00
IUUC-Smo-109040	Selaginella moellendorffii	27.50	3.00e-03	37.40
IUUC-Sar-113091	Sorex araneus	82.37	6.00e-142	496.00
IUUC-Tgu-117416	Taeniopygia guttata	76.37	1.00e-105	376.00
IUUC-Tni-120748	Tetraodon nigroviridis	62.31	2.00e-93	335.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence