iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000019988.7	ENSMUST00000020163.6	ENSMUSP00000020163.6
ENSMUSG00000019988.7	ENSMUST00000216086.1	ENSMUSP00000150817.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
miRNAMap	RAID2
Protein-protein Interaction
IID	Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	UniProt
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	5.10e-22	78.2	81	111
UBD/Beta-Prp	1.70e-46	159.9	79	300

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 7    tclaf.sd.tllvsGsdDgtikvWDlrtgvl 35
           tc+++ s+  +l+sG+ ++t+ +WDl++ +l
   Q: 81   TCVDLnSTsMYLASGGLNNTVNIWDLKSKRL 111
           79999866699***************98776 PP

UBD/Beta-Prp

   S: 12   vitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlk.ghedsvls 99
             tcv+    + +la+g+ ++t+ +wd++++ l rsl++h+ evt+v ++ ++ ++++gs  + i + ++ t++    +  g ++ ++ 
   Q: 79   KQTCVDLNSTSMYLASGGLNNTVNIWDLKSKRLHRSLKDHKCEVTCVAYNWNDCYIASGSLSGEIILHSVTTNTSSTPFGhGSKQPIRH 167
           568999999*******************************************99**************999776665554499****** PP
   S: 100  lsfsp.sgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdg.nllvsGslDrtvrlWdlktgkllrtltgghtdsvysl 186
           +++s   ++ l s s+  ++ +wd+++++ +++++s h++  ++++++p +  l+v+ +lD+ + l+d +++kl++tl    + + + +
   Q: 168  IKYSLfRKSLLGSVSDNGVVTLWDVNSQSSYHTFDSTHKAPASGICFSPVNeLLFVTIGLDKRIILYDTSSKKLVKTLVA--DTPLTAV 254
           *****7778899***************************************999************************65..899**** PP
   S: 187  sfdsngkelvsgsldgtvklwdlq.tgecvrtlnghtdnvksvrfs 231
           +f ++g  l+ gs  g++  +dl+  ++ v+t  +h++ v++++f 
   Q: 255  DFMPDGATLAIGSSRGKIYQYDLRmLKSPVKTISAHKTSVQCIAFQ 300
           ************************98889***************98 PP

Organism

Mus musculus

Functional Description
(View)

Required for mitosis progression. Promotes the nucleation of microtubules from the spindle (By similarity). May play an important role during the embryonic development and differentiation of the central nervous system (PubMed:1378265).

Protein Sequence
(Fasta)

MQENLRFASS GDDVKIWDAS FLTLVDKFNP HTSPHGISSI CWSSNNNFLV TASSSGDKIV 60
VSSCKCKPVP LLELAEGQKQ TCVDLNSTSM YLASGGLNNT VNIWDLKSKR LHRSLKDHKC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GACTTCCGGC CGCCCAAGTT TAACAGTCCA GGCGGGAGCC GGAAGCGCAG CGAGGAACGG 60
GTGGAGCTGG GCCTCCCCTG TGGCCCCACG CTTGAGAGGT GAGGTTCCGC CTGACAGGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0498--Mitosis
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0045177--C:apical part of cell
GO:0005814--C:centriole
GO:0005813--C:centrosome
GO:0036064--C:ciliary basal body
GO:0005737--C:cytoplasm
GO:0000924--C:gamma-tubulin ring complex, centrosomal
GO:0000242--C:pericentriolar material
GO:0000922--C:spindle pole
GO:0051301--P:cell division
GO:0007019--P:microtubule depolymerization
GO:0031109--P:microtubule polymerization or depolymerization
GO:0007067--P:mitotic nuclear division
GO:0071539--P:protein localization to centrosome
GO:0070201--P:regulation of establishment of protein localization

KEGG

mmu:17997

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000871	Aegilops tauschii	35.14	8.00e-15	76.30
IUUC-Aml-002397	Ailuropoda melanoleuca	83.94	0.00e+00	1104.00
IUUC-Atr-002464	Amborella trichopoda	30.89	3.00e-36	147.00
IUUC-Apl-003870	Anas platyrhynchos	64.64	0.00e+00	848.00
IUUC-Aca-004925	Anolis carolinensis	61.22	0.00e+00	775.00
IUUC-Aly-005931	Arabidopsis lyrata	31.73	5.00e-38	152.00
IUUC-Ath-006681	Arabidopsis thaliana	31.43	1.00e-37	151.00
IUUC-Ame-010906	Astyanax mexicanus	44.07	2.00e-151	529.00
IUUC-Bta-013389	Bos taurus	84.70	0.00e+00	1109.00
IUUC-Bdi-014340	Brachypodium distachyon	29.08	4.00e-35	143.00
IUUC-Bol-015773	Brassica oleracea	29.34	7.00e-39	155.00
IUUC-Bra-016623	Brassica rapa	29.34	2.00e-38	155.00
IUUC-Cja-019541	Callithrix jacchus	85.15	0.00e+00	1138.00
IUUC-Cfa-021218	Canis familiaris	83.64	0.00e+00	1100.00
IUUC-Cpo-021697	Cavia porcellus	80.03	0.00e+00	1063.00
IUUC-Csa-023620	Chlorocebus sabaeus	84.70	0.00e+00	1147.00
IUUC-Cho-025105	Choloepus hoffmanni	79.41	0.00e+00	863.00
IUUC-Cin-025293	Ciona intestinalis	31.53	4.00e-72	265.00
IUUC-Csv-026234	Ciona savignyi	36.26	3.00e-51	194.00
IUUC-Dre-028251	Danio rerio	43.88	3.00e-138	485.00
IUUC-Dno-029281	Dasypus novemcinctus	82.03	0.00e+00	906.00
IUUC-Dor-031020	Dipodomys ordii	71.19	2.00e-162	565.00
IUUC-Ete-033113	Echinops telfairi	81.54	0.00e+00	650.00
IUUC-Eca-034230	Equus caballus	85.33	0.00e+00	1108.00
IUUC-Eeu-034671	Erinaceus europaeus	68.46	0.00e+00	733.00
IUUC-Fca-035775	Felis catus	85.45	0.00e+00	1134.00
IUUC-Fal-037557	Ficedula albicollis	61.98	0.00e+00	764.00
IUUC-Gmo-038586	Gadus morhua	56.44	4.00e-100	358.00
IUUC-Gga-040153	Gallus gallus	64.84	0.00e+00	854.00
IUUC-Gac-041385	Gasterosteus aculeatus	44.18	1.00e-134	473.00
IUUC-Gma-042844	Glycine max	32.29	4.00e-40	159.00
IUUC-Ggo-044576	Gorilla gorilla	85.30	0.00e+00	1169.00
IUUC-Hsa-046198	Homo sapiens	85.45	0.00e+00	1171.00
IUUC-Hvu-047794	Hordeum vulgare	35.14	3.00e-15	74.70
IUUC-Lch-050561	Latimeria chalumnae	50.08	1.00e-155	543.00
IUUC-Lpe-051469	Leersia perrieri	29.08	2.00e-33	137.00
IUUC-Loc-052816	Lepisosteus oculatus	48.74	7.00e-155	541.00
IUUC-Laf-053880	Loxodonta africana	82.15	0.00e+00	1056.00
IUUC-Mcc-054977	Macaca mulatta	84.55	0.00e+00	1144.00
IUUC-Meu-056141	Macropus eugenii	57.04	2.00e-161	562.00
IUUC-Mtr-058441	Medicago truncatula	32.20	2.00e-39	157.00
IUUC-Mga-060141	Meleagris gallopavo	63.36	0.00e+00	819.00
IUUC-Mmr-061201	Microcebus murinus	85.15	0.00e+00	1152.00
IUUC-Mdo-061855	Monodelphis domestica	69.00	0.00e+00	905.00
IUUC-Mac-065368	Musa acuminata	28.80	3.00e-36	147.00
IUUC-Mpu-066191	Mustela putorius furo	83.64	0.00e+00	1100.00
IUUC-Mlu-067310	Myotis lucifugus	84.70	0.00e+00	1119.00
IUUC-Nle-069990	Nomascus leucogenys	85.61	0.00e+00	1175.00
IUUC-Opr-070336	Ochotona princeps	77.88	0.00e+00	1013.00
IUUC-Ont-071675	Oreochromis niloticus	44.73	5.00e-138	484.00
IUUC-Oan-072772	Ornithorhynchus anatinus	68.53	0.00e+00	762.00
IUUC-Ocu-074095	Oryctolagus cuniculus	86.36	0.00e+00	1151.00
IUUC-Oba-075327	Oryza barthii	27.84	8.00e-35	142.00
IUUC-Obr-076119	Oryza brachyantha	29.19	2.00e-35	144.00
IUUC-Ogl-077820	Oryza glaberrima	27.84	1.00e-34	142.00
IUUC-Ogu-078679	Oryza glumaepatula	28.33	3.00e-35	144.00
IUUC-Oin-079891	Oryza indica	28.12	2.00e-35	145.00
IUUC-Olo-080414	Oryza longistaminata	30.19	3.00e-34	140.00
IUUC-Ome-081888	Oryza meridionalis	28.41	1.00e-35	145.00
IUUC-Oni-082417	Oryza nivara	28.12	3.00e-35	144.00
IUUC-Opu-083393	Oryza punctata	28.85	7.00e-35	142.00
IUUC-Oru-084698	Oryza rufipogon	28.12	1.00e-35	145.00
IUUC-Osa-086121	Oryza sativa	28.12	3.00e-35	144.00
IUUC-Ola-086806	Oryzias latipes	40.67	6.00e-136	478.00
IUUC-Olu-087591	Ostreococcus lucimarinus	23.91	1.00e-15	77.80
IUUC-Oga-088622	Otolemur garnettii	83.99	0.00e+00	1132.00
IUUC-Oar-090391	Ovis aries	81.27	0.00e+00	943.00
IUUC-Ptr-091036	Pan troglodytes	85.15	0.00e+00	1169.00
IUUC-Pan-092576	Papio anubis	84.85	0.00e+00	1149.00
IUUC-Psi-093450	Pelodiscus sinensis	65.52	0.00e+00	853.00
IUUC-Pma-094101	Petromyzon marinus	54.02	8.00e-104	370.00
IUUC-Ppa-095262	Physcomitrella patens	30.18	1.00e-40	162.00
IUUC-Pfo-097142	Poecilia formosa	43.19	5.00e-141	494.00
IUUC-Pab-097829	Pongo abelii	85.15	0.00e+00	1164.00
IUUC-Pop-099687	Populus trichocarpa	31.75	4.00e-39	156.00
IUUC-Pca-100217	Procavia capensis	78.80	0.00e+00	662.00
IUUC-Ppe-101502	Prunus persica	31.41	2.00e-38	154.00
IUUC-Pva-102736	Pteropus vampyrus	83.33	0.00e+00	1115.00
IUUC-Rno-104977	Rattus norvegicus	94.39	0.00e+00	1206.00
IUUC-Sha-107003	Sarcophilus harrisii	69.60	0.00e+00	905.00
IUUC-Smo-109002	Selaginella moellendorffii	30.25	4.00e-38	153.00
IUUC-Sit-109796	Setaria italica	29.64	9.00e-35	142.00
IUUC-Sly-110941	Solanum lycopersicum	30.29	1.00e-35	145.00
IUUC-Stu-112314	Solanum tuberosum	30.62	1.00e-35	144.00
IUUC-Sar-112926	Sorex araneus	77.42	0.00e+00	1026.00
IUUC-Sbi-113822	Sorghum bicolor	31.46	2.00e-25	111.00
IUUC-Ssc-116242	Sus scrofa	86.60	0.00e+00	632.00
IUUC-Tgu-116765	Taeniopygia guttata	62.82	0.00e+00	788.00
IUUC-Tru-117738	Takifugu rubripes	43.60	3.00e-151	529.00
IUUC-Tsy-118856	Tarsius syrichta	80.81	0.00e+00	1009.00
IUUC-Tni-120871	Tetraodon nigroviridis	44.21	5.00e-148	518.00
IUUC-Tca-120965	Theobroma cacao	30.70	1.00e-37	151.00
IUUC-Tae-124830	Triticum aestivum	28.76	4.00e-36	146.00
IUUC-Tur-126840	Triticum urartu	28.81	6.00e-36	145.00
IUUC-Ttr-128551	Tursiops truncatus	82.12	0.00e+00	1072.00
IUUC-Vpa-130324	Vicugna pacos	84.85	0.00e+00	1099.00
IUUC-Vvi-131699	Vitis vinifera	31.11	1.00e-37	151.00
IUUC-Xtr-131956	Xenopus tropicalis	58.85	0.00e+00	786.00
IUUC-Xma-132982	Xiphophorus maculatus	43.98	5.00e-107	382.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence