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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046741
UUCD1 version UUC-HoS-01117
Ensembl Protein ID ENSP00000274030.5
UniProt Accession Q70EK8; Q68DA5; Q8WVQ5; Q9P2J7; UBP53_HUMAN
Genbank Protein ID CAE47751.1; CAH18315.1; BAA92588.1; AAH17382.1
Protein Name Inactive ubiquitin carboxyl-terminal hydrolase 53; Inactive ubiquitin-specific peptidase 53
Genbank Nucleotide ID AJ583824; CR749490; AB037771; BC017382
Gene Name USP53; KIAA1350
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000145390.11 ENST00000274030.10 ENSP00000274030.5
ENSG00000145390.11 ENST00000509769.5 ENSP00000426628.1
ENSG00000145390.11 ENST00000507906.5 ENSP00000421729.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusBioGRID
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
DUB/USP USP 19615732
Classification
Family E-value Score Start End
DUB/USP 1.10e-23 85.7 31 349
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   DUB/USP
   S: 2    GlkNl..gNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaee...fsgye 88
           Gl N   +N+C++NS++Q+L+++  +r+ l   + + ++ +      +++ ++l+++f+++++s++ka    ++ +al++  +    f+   
   Q: 31   GLLNEpgQNSCFLNSAVQVLWQLDIFRRSLRVLTGHVCQGD------ACIFCALKTIFAQFQHSREKALPSDNIRHALAESFKDeqrFQLGL 116
           55555447************************777777765......7*************9999999999987777776543222399*** PP
   S: 89   qqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgke 180
             Da E+++ +l++++ ++                     +++ +  ++++++ ++ F ++l +q++c +c+ +s    pf+++   ++   
   Q: 117  MDDAAECFENMLERIHFHI-------------------VPSRDADMCTSKSCITHQKFAMTLYEQCVCRSCGASSDPL-PFTEFVRYISTTA 188
           *******************...................12235678999***********************999654.8888888888666 PP
   S: 181  etkke.........slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlsp 263
            +++             +++++  ++ + +++ +   ++c +k + ++   l ++Pe+ ++ L +   se+ +  e + +++ + l L    
   Q: 189  LCNEVermlerherFKPEMFAELLQAANTTDDYRKCPSNCGQKIKIRRV--LMNCPEIVTIGLVWD--SEHSDLTEAVVRNLATHLYLPGLF 276
           5544355555555333467777778888877777777888888865444..6688**********9..555566666666666654444433 PP
   S: 264  fctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtev..keeevleetg...staYvlfYk 336
           + +++e+  +++ + +L+++++++      HY+a++ ++k + W+ fdD +V+e+  ++++v++++     ++ +lfY 
   Q: 277  YRVTDEN--AKNSELNLVGMICYTS----QHYCAFAFHTKSSkWVFFDDANVKEIgtRWKDVVSKCIrchFQPLLLFYA 349
           4444343..34999*********97....9********77767***********9656899999766888899999996 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Tight junction-associated protein that is involved in the survival of auditory hair cells and hearing. Maybe by modulating the barrier properties and mechanical stability of tight junctions (By similarity). Has no peptidase activity (PubMed:14715245).
 Tight junction-associated protein that is involved in the survival of auditory hair cells and hearing. Maybe by modulating the barrier properties and mechanical stability of tight junctions (By similarity). Has no peptidase activity (PubMed:14715245).
Protein Sequence
(Fasta)
MAWVKFLRKP GGNLGKVYQP GSMLSLAPTK GLLNEPGQNS CFLNSAVQVL WQLDIFRRSL 60
RVLTGHVCQG DACIFCALKT IFAQFQHSRE KALPSDNIRH ALAESFKDEQ RFQLGLMDDA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046741|DUB,USP|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGGGCTCCAG GGACCTGTTG ATCGCAGGTG TCACTGGCCT GACTGGTCCC TGGGTATTGG 60
GGCGTATGCG CATGCTCCGC TCACAGGGTC GGGCTCTGGG CGGCGGAGAC CAGCCGCCTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046741|DUB,USP|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0965--Cell junction
KW-0181--Complete proteome
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0796--Tight junction
Interpro

IPR001394--Peptidase_C19_UCH
IPR028889--USP_dom
PROSITE

PS50235--USP_3
Pfam

PF00443--UCH
Gene Ontology

GO:0005923--C:bicellular tight junction
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0001508--P:action potential
GO:0051402--P:neuron apoptotic process
GO:0016579--P:protein deubiquitination
GO:0010996--P:response to auditory stimulus
GO:0007605--P:sensory perception of sound
KEGG hsa:54532
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002136 Ailuropoda melanoleuca 85.56 0.00e+00 1821.00
IUUC-Atr-002451 Amborella trichopoda 29.79 9.00e-38 153.00
IUUC-Apl-003843 Anas platyrhynchos 61.15 0.00e+00 1207.00
IUUC-Aca-004689 Anolis carolinensis 60.31 0.00e+00 1148.00
IUUC-Ame-010689 Astyanax mexicanus 69.44 1.00e-161 563.00
IUUC-Bta-012434 Bos taurus 83.06 0.00e+00 1726.00
IUUC-Cja-019625 Callithrix jacchus 94.23 0.00e+00 1991.00
IUUC-Cfa-020038 Canis familiaris 84.88 0.00e+00 1828.00
IUUC-Cpo-021503 Cavia porcellus 76.47 0.00e+00 1646.00
IUUC-Cre-022697 Chlamydomonas reinhardtii 24.38 4.00e-17 85.50
IUUC-Csa-024021 Chlorocebus sabaeus 96.27 0.00e+00 2052.00
IUUC-Cho-024769 Choloepus hoffmanni 75.65 0.00e+00 1551.00
IUUC-Dre-028438 Danio rerio 52.86 0.00e+00 691.00
IUUC-Dno-029317 Dasypus novemcinctus 82.50 0.00e+00 1703.00
IUUC-Dor-030249 Dipodomys ordii 96.02 0.00e+00 795.00
IUUC-Ete-032403 Echinops telfairi 78.48 0.00e+00 1657.00
IUUC-Eca-033216 Equus caballus 84.69 0.00e+00 1789.00
IUUC-Eeu-035319 Erinaceus europaeus 63.81 1.00e-169 590.00
IUUC-Fca-036414 Felis catus 86.31 0.00e+00 1820.00
IUUC-Fal-036886 Ficedula albicollis 60.07 0.00e+00 1205.00
IUUC-Gmo-038617 Gadus morhua 74.52 4.00e-168 583.00
IUUC-Gga-040930 Gallus gallus 61.67 0.00e+00 1256.00
IUUC-Gac-041515 Gasterosteus aculeatus 78.82 1.00e-172 598.00
IUUC-Ggo-045573 Gorilla gorilla 99.07 0.00e+00 2121.00
IUUC-Itr-048229 Ictidomys tridecemlineatus 66.01 0.00e+00 1313.00
IUUC-Lch-049932 Latimeria chalumnae 48.70 0.00e+00 914.00
IUUC-Loc-052180 Lepisosteus oculatus 60.11 0.00e+00 871.00
IUUC-Laf-054545 Loxodonta africana 82.96 0.00e+00 1796.00
IUUC-Mcc-054918 Macaca mulatta 96.27 0.00e+00 2080.00
IUUC-Meu-056802 Macropus eugenii 59.22 0.00e+00 1127.00
IUUC-Mtr-058682 Medicago truncatula 29.48 1.00e-33 139.00
IUUC-Mla-059180 Melampsora laricipopulina 25.22 2.30e-02 35.00
IUUC-Mga-059684 Meleagris gallopavo 60.06 0.00e+00 1165.00
IUUC-Mmr-060991 Microcebus murinus 84.55 0.00e+00 1470.00
IUUC-Mdo-062636 Monodelphis domestica 64.66 0.00e+00 1243.00
IUUC-Mmu-063910 Mus musculus 74.49 0.00e+00 1560.00
IUUC-Mpu-065796 Mustela putorius furo 79.98 0.00e+00 1657.00
IUUC-Nle-069276 Nomascus leucogenys 97.48 0.00e+00 1978.00
IUUC-Opr-070545 Ochotona princeps 74.23 0.00e+00 862.00
IUUC-Ont-072449 Oreochromis niloticus 54.35 0.00e+00 716.00
IUUC-Oan-073493 Ornithorhynchus anatinus 58.45 0.00e+00 998.00
IUUC-Ocu-074445 Oryctolagus cuniculus 80.35 0.00e+00 1699.00
IUUC-Oba-075174 Oryza barthii 30.54 3.00e-34 141.00
IUUC-Ogu-078705 Oryza glumaepatula 30.54 2.00e-34 142.00
IUUC-Olo-080872 Oryza longistaminata 30.54 1.00e-34 142.00
IUUC-Ome-081864 Oryza meridionalis 30.54 6.00e-34 141.00
IUUC-Oni-082109 Oryza nivara 30.54 2.00e-34 141.00
IUUC-Oru-084310 Oryza rufipogon 30.54 2.00e-34 141.00
IUUC-Osa-085583 Oryza sativa 31.56 2.00e-39 156.00
IUUC-Ola-087574 Oryzias latipes 70.57 2.00e-165 574.00
IUUC-Oga-087977 Otolemur garnettii 85.45 0.00e+00 1728.00
IUUC-Oar-089584 Ovis aries 82.92 0.00e+00 1716.00
IUUC-Ptr-091610 Pan troglodytes 99.07 0.00e+00 2081.00
IUUC-Pan-091828 Papio anubis 92.56 0.00e+00 1926.00
IUUC-Psi-093643 Pelodiscus sinensis 64.39 0.00e+00 1330.00
IUUC-Ppa-095930 Physcomitrella patens 31.59 2.00e-39 159.00
IUUC-Pfo-096829 Poecilia formosa 62.93 0.00e+00 631.00
IUUC-Pab-098190 Pongo abelii 98.79 0.00e+00 2048.00
IUUC-Pca-100356 Procavia capensis 72.15 0.00e+00 847.00
IUUC-Pva-102372 Pteropus vampyrus 77.08 0.00e+00 1589.00
IUUC-Rno-105609 Rattus norvegicus 66.33 0.00e+00 810.00
IUUC-Sha-107092 Sarcophilus harrisii 63.92 0.00e+00 1273.00
IUUC-Sar-113376 Sorex araneus 73.56 0.00e+00 850.00
IUUC-Ssc-115969 Sus scrofa 83.87 0.00e+00 1716.00
IUUC-Tgu-117134 Taeniopygia guttata 73.87 0.00e+00 1111.00
IUUC-Tru-117981 Takifugu rubripes 71.53 9.00e-169 586.00
IUUC-Tsy-119297 Tarsius syrichta 78.41 0.00e+00 1556.00
IUUC-Tni-120116 Tetraodon nigroviridis 76.92 2.00e-170 591.00
IUUC-Tbe-127607 Tupaia belangeri 81.06 0.00e+00 1673.00
IUUC-Ttr-128647 Tursiops truncatus 84.35 0.00e+00 1631.00
IUUC-Vpa-130288 Vicugna pacos 81.67 0.00e+00 1730.00
IUUC-Xtr-132277 Xenopus tropicalis 63.40 0.00e+00 941.00
Created Date 25-Jun-2017

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