iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-045914

UUCD1 version

UUC-HoS-01144

Ensembl Protein ID

ENSP00000309031.4

UniProt Accession

Q96JH7; Q504T4; Q86T93; Q86W01; Q8N3A9; Q9H5R8; VCIP1_HUMAN

Genbank Protein ID

BAB47479.1; CAD39135.1; CAD89944.1; AAH49379.1; AAH94799.1; BAB15552.1

Protein Name

Deubiquitinating protein VCIP135; Valosin-containing protein p97/p47 complex-interacting protein 1; Valosin-containing protein p97/p47 complex-interacting protein p135

Genbank Nucleotide ID

AB058753; AL834476; AL832606; BC049379; BC094799; AK026785

Gene Name

VCPIP1; KIAA1850; VCIP135

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000175073.7	ENST00000310421.4	ENSP00000309031.4

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	miRNAMap	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/OTU	OTU	15749824; 21103003

Classification

Family	E-value	Score	Start	End
DUB/OTU	7.00e-29	102.7	208	360

Active Site

Position(s)	Description	Evidence
216	N/A	{ECO:0000250}
219	Nucleophile	ECO:0000250}
354		{ECO:0000250}

Domain Profile

DUB/OTU

   S: 1    llilktkgDGnCLlrAvsqsllgvfdddslsdalveaLreltseyl....qkesdffsefieek..edekefcqklvepe...akg..eeih 81
           l++++++gDG+CL++Avs++   ++++++    +++aLre++++++    +++++ f++fi+++  ed+ ++c+ l+ p+        ++ih
   Q: 208  LIPVHVDGDGHCLVHAVSRA---LVGREL----FWHALRENLKQHFqqhlARYQALFHDFIDAAewEDIINECDPLFVPPegvP-LglRNIH 291
           5789****************...******....666666666666544449999*********999************995542.047**** PP
   S: 82   ifaLaqiLsrpiivvdvdsles...kvggillpllfpeek.......lkkpivLlYrsg...HYdaLva 137
           if La++L+rpii++d+ s+++   ++++++lp l+p+ek       l+kpi+++++s+   HY +Lv 
   Q: 292  IFGLANVLHRPIILLDSLSGMRssgDYSATFLPGLIPAEKctgkdghLNKPICIAWSSSgrnHYIPLVG 360
           *******************99999**********************9*********644488*****96 PP

Organism

Homo sapiens

Functional Description
(View)

Acts as a deubiquitinating enzyme. Necessary for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP (By similarity). Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains.

Protein Sequence
(Fasta)

MSQPPPPPPP LPPPPPPPEA PQTPSSLASA AASGGLLKRR DRRILSGSCP DPKCQARLFF 60
PASGSVSIEC TECGQRHEQQ QLLGVEEVTD PDVVLHNLLR NALLGVTGAP KKNTELVKVM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGAGCGAGA GTGAGTGAGT GTGAGTGCGG GGTGGGGTGG TGGCCGTTAC GTTCGGGGCA 60
ACGGCTACGG CAGTGGAGAA GTAAGAAGAG AAACAACGTC CGGCGCTTCC GCCTTCGCTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR003323--OTU_dom
IPR029071--Ubiquitin-rel_dom

PROSITE

PS50802--OTU

Pfam

PF02338--OTU

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005783--C:endoplasmic reticulum
GO:0005795--C:Golgi stack
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016320--P:endoplasmic reticulum membrane fusion
GO:0090168--P:Golgi reassembly
GO:0007067--P:mitotic nuclear division
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0016567--P:protein ubiquitination

KEGG

hsa:80124

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001319	Ailuropoda melanoleuca	97.30	0.00e+00	2276.00
IUUC-Apl-004212	Anas platyrhynchos	84.58	0.00e+00	1972.00
IUUC-Aca-005351	Anolis carolinensis	82.40	0.00e+00	1940.00
IUUC-Ate-010437	Aspergillus terreus	29.79	1.20e-01	30.80
IUUC-Ame-010733	Astyanax mexicanus	73.46	0.00e+00	1320.00
IUUC-Bta-012792	Bos taurus	95.03	0.00e+00	2268.00
IUUC-Cja-019980	Callithrix jacchus	98.06	0.00e+00	2350.00
IUUC-Cfa-020680	Canis familiaris	97.47	0.00e+00	2282.00
IUUC-Cpo-022087	Cavia porcellus	95.36	0.00e+00	2306.00
IUUC-Csa-023550	Chlorocebus sabaeus	99.75	0.00e+00	2365.00
IUUC-Cho-024668	Choloepus hoffmanni	93.43	0.00e+00	2203.00
IUUC-Cin-025548	Ciona intestinalis	44.34	4.00e-154	539.00
IUUC-Csv-026169	Ciona savignyi	46.99	4.00e-45	174.00
IUUC-Cme-027341	Cyanidioschyzon merolae	33.33	6.20e-02	32.30
IUUC-Dre-028151	Danio rerio	70.43	0.00e+00	1531.00
IUUC-Dno-029986	Dasypus novemcinctus	96.37	0.00e+00	2289.00
IUUC-Dor-030555	Dipodomys ordii	89.96	0.00e+00	2057.00
IUUC-Ete-033114	Echinops telfairi	92.66	0.00e+00	2136.00
IUUC-Eca-034153	Equus caballus	96.96	0.00e+00	2260.00
IUUC-Eeu-034681	Erinaceus europaeus	90.76	0.00e+00	818.00
IUUC-Fca-035911	Felis catus	97.38	0.00e+00	2330.00
IUUC-Fal-037214	Ficedula albicollis	85.23	0.00e+00	1979.00
IUUC-Gmo-039664	Gadus morhua	75.16	0.00e+00	1504.00
IUUC-Ggr-039893	Gaeumannomyces graminis	34.15	7.00e-02	32.70
IUUC-Gga-040302	Gallus gallus	84.73	0.00e+00	1982.00
IUUC-Gac-041575	Gasterosteus aculeatus	73.02	0.00e+00	1610.00
IUUC-Ggo-044624	Gorilla gorilla	99.34	0.00e+00	2364.00
IUUC-Itr-048269	Ictidomys tridecemlineatus	97.01	0.00e+00	2306.00
IUUC-Lch-050083	Latimeria chalumnae	77.25	0.00e+00	1799.00
IUUC-Loc-052258	Lepisosteus oculatus	74.08	0.00e+00	1733.00
IUUC-Laf-054209	Loxodonta africana	96.96	0.00e+00	2323.00
IUUC-Mcc-055670	Macaca mulatta	99.83	0.00e+00	2367.00
IUUC-Meu-056397	Macropus eugenii	96.85	0.00e+00	1029.00
IUUC-Mla-058941	Melampsora laricipopulina	26.49	1.00e-03	37.70
IUUC-Mga-059426	Meleagris gallopavo	85.03	0.00e+00	1947.00
IUUC-Mmr-060911	Microcebus murinus	97.89	0.00e+00	1960.00
IUUC-Mdo-061844	Monodelphis domestica	91.82	0.00e+00	2145.00
IUUC-Mmu-064417	Mus musculus	95.78	0.00e+00	2260.00
IUUC-Mpu-066037	Mustela putorius furo	97.47	0.00e+00	2311.00
IUUC-Mlu-067718	Myotis lucifugus	95.70	0.00e+00	2228.00
IUUC-Nle-069487	Nomascus leucogenys	99.92	0.00e+00	2361.00
IUUC-Opr-070955	Ochotona princeps	92.10	0.00e+00	880.00
IUUC-Ont-071417	Oreochromis niloticus	71.12	0.00e+00	1697.00
IUUC-Oan-072968	Ornithorhynchus anatinus	88.45	0.00e+00	2081.00
IUUC-Ocu-073928	Oryctolagus cuniculus	96.71	0.00e+00	2278.00
IUUC-Olo-080471	Oryza longistaminata	27.55	1.90e-02	33.50
IUUC-Ola-086984	Oryzias latipes	70.26	0.00e+00	1610.00
IUUC-Oga-088277	Otolemur garnettii	97.30	0.00e+00	2249.00
IUUC-Oar-089250	Ovis aries	95.44	0.00e+00	2256.00
IUUC-Ptr-090602	Pan troglodytes	99.25	0.00e+00	2363.00
IUUC-Pan-092319	Papio anubis	99.83	0.00e+00	2367.00
IUUC-Psi-093378	Pelodiscus sinensis	86.17	0.00e+00	1987.00
IUUC-Pma-094476	Petromyzon marinus	52.32	0.00e+00	915.00
IUUC-Pfo-096606	Poecilia formosa	74.12	0.00e+00	1663.00
IUUC-Pab-098367	Pongo abelii	99.00	0.00e+00	2355.00
IUUC-Pca-100395	Procavia capensis	97.27	0.00e+00	2141.00
IUUC-Pva-103143	Pteropus vampyrus	99.15	0.00e+00	1256.00
IUUC-Rno-104865	Rattus norvegicus	95.93	0.00e+00	2286.00
IUUC-Sha-106910	Sarcophilus harrisii	91.82	0.00e+00	2137.00
IUUC-Sit-109693	Setaria italica	32.76	3.00e-03	37.00
IUUC-Sly-111690	Solanum lycopersicum	45.95	7.40e-02	32.70
IUUC-Stu-112644	Solanum tuberosum	48.48	1.30e-01	32.00
IUUC-Sar-113767	Sorex araneus	92.19	0.00e+00	1115.00
IUUC-Sbi-113844	Sorghum bicolor	36.36	3.00e-04	37.40
IUUC-Ssc-115468	Sus scrofa	98.06	0.00e+00	1742.00
IUUC-Tgu-116788	Taeniopygia guttata	85.23	0.00e+00	2003.00
IUUC-Tru-118008	Takifugu rubripes	72.41	0.00e+00	1616.00
IUUC-Tsy-119457	Tarsius syrichta	97.55	0.00e+00	2301.00
IUUC-Tni-120146	Tetraodon nigroviridis	71.38	0.00e+00	1561.00
IUUC-Tvi-122364	Trichoderma virens	42.42	1.80e-01	32.00
IUUC-Tbe-128060	Tupaia belangeri	98.57	0.00e+00	1565.00
IUUC-Ttr-128257	Tursiops truncatus	92.32	0.00e+00	2155.00
IUUC-Vpa-130661	Vicugna pacos	95.02	0.00e+00	2306.00
IUUC-Xtr-131761	Xenopus tropicalis	78.49	0.00e+00	1844.00
IUUC-Xma-133775	Xiphophorus maculatus	74.61	0.00e+00	1667.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence