iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000236399.7	ENST00000425845.5	ENSP00000414258.1
ENSG00000236399.7	ENST00000418267.6	ENSP00000415169.2

Annotation

Cancer Mutation
TCGA	CGAP	IntOGen
mRNA Expression
ArrayExpress	TCGA	ICGC	THPA
HPM
DNA & RNA Element
UTRdb	RepTar	miRcode	RAID2
Disease-associated Variation
GWASdb
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	4.90e-09	38.2	14	57

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C+iC+e++k+  ++++CgH+f++ Cl q++   k s+s+ f CPlCr
   Q: 14   CPICQESLKE-AVSTNCGHLFCRVCLtQHV--EKASASGVFCCPLCR 57
           ********99.999************8888..8889**********8 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MIPLQKDNQE EGVCPICQES LKEAVSTNCG HLFCRVCLTQ HVEKASASGV FCCPLCRKPC 60
SEEVLGTGYI CPNHQKRVCR FCEESRLLLC VECLVSPEHM SHHELTIENA LSHYKERLNR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATAAGAACCA CTCGTCTGCT GGCCATCTCT CCAGGTCTGG AGCCAGAGAA GATGATCTGA 60
AATTGTAGCA GGAGAAATTG AGGTAGGATA CTAAGAAAGC TTTTCAGGAG TGGGGCTAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000315--Znf_B-box
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00097--zf-C3HC4

SMART

SM00184--RING

Gene Ontology

GO:0005622--C:intracellular
GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Bta-012543	Bos taurus	59.13	1.00e-67	249.00
IUUC-Cja-018793	Callithrix jacchus	78.43	3.00e-97	347.00
IUUC-Cho-024926	Choloepus hoffmanni	69.01	1.00e-25	110.00
IUUC-Dno-029338	Dasypus novemcinctus	50.39	1.00e-53	202.00
IUUC-Meu-055981	Macropus eugenii	40.81	5.00e-40	157.00
IUUC-Mdo-062958	Monodelphis domestica	44.84	1.00e-40	159.00
IUUC-Mmu-063571	Mus musculus	66.67	1.00e-82	299.00
IUUC-Opr-071083	Ochotona princeps	61.42	3.00e-84	305.00
IUUC-Oar-089914	Ovis aries	64.17	9.00e-87	313.00
IUUC-Rno-106090	Rattus norvegicus	63.60	3.00e-83	301.00
IUUC-Ssc-115942	Sus scrofa	68.11	3.00e-91	328.00
IUUC-Tbe-127279	Tupaia belangeri	70.28	1.00e-76	279.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence