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Basic Information Integrated Annotations

Tag Content
UUCD2 ID IUUC-Mmu-064184
UUCD1 version UUC-MuM-00961
Ensembl Protein ID ENSMUSP00000040846.9
UniProt Accession Q9DCE5; Q3UBK7; Q80UT4; Q8C5N6; Q923K2; Q9D3E9; PK1IP_MOUSE
Genbank Protein ID AAK51599.1; AAL40652.1; BAB22407.1; BAC37076.1; BAE29818.1; BAE29957.1; AAH51498.1
Protein Name p21-activated protein kinase-interacting protein 1; PAK1-interacting protein 1; Putative PAK inhibitor Skb15
Genbank Nucleotide ID AY030406; AF386076; AK002852; AK077941; AK150747; AK150919; BC051498
Gene Name Pak1ip1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000038683.15 ENSMUST00000046951.9 ENSMUSP00000040846.9
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarRAID2
Protein-protein Interaction
IIDiRefIndexPINA
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 8.10e-25 87.0 81 117
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sdtllvsGsdDgtikvWDlrtgvllk 37
    H++ vtcl+f + +l+sG+ Dg i +WD+++ ++lk
   Q: 81 HAGTVTCLKFhGNQHLISGAEDGHICIWDVKRWKCLK 117
    999*******7449****************9998887 PP
   

Organism Mus musculus
Functional Description
(View)

Functional Description



     Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which have been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42 (By similarity).
Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which have been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42 (By similarity).
Protein Sequence
(Fasta)
MELVAGSYEQ VLFGFTVQRG PAKSGHQETW TPVADFTHHS HTASLSVLAS NSRYVVSGSK 60
DETIHIYDMK RKVEHGALVH HAGTVTCLKF HGNQHLISGA EDGHICIWDV KRWKCLKTFK 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Mmu-064184|E3,WD_repeat|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CATTTCCCAA GGCCGGCGGA GCCCACGGCT TCCCAGGACT TGCCTGCTTG ACACAACTTT 60
TCTTTCTCTC TGCTCTGAGA GCCTCCTCCC GCGGCTTCCT TCCTTAAGCT CGTCGCAGAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Mmu-064184|E3,WD_repeat|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0734--Signal transduction inhibitor
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005730--C:nucleolus
GO:0008283--P:cell proliferation
GO:0009968--P:negative regulation of signal transduction
GO:0060021--P:palate development

KEGG mmu:68083
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001803 Ailuropoda melanoleuca 74.93 2.00e-167 581.00
IUUC-Atr-003018 Amborella trichopoda 32.59 1.00e-43 170.00
IUUC-Apl-004199 Anas platyrhynchos 68.46 4.00e-121 427.00
IUUC-Aca-005157 Anolis carolinensis 67.32 2.00e-118 418.00
IUUC-Aly-006245 Arabidopsis lyrata 31.76 4.00e-38 151.00
IUUC-Ath-007309 Arabidopsis thaliana 32.08 5.00e-39 154.00
IUUC-Ago-007878 Ashbya gossypii 29.94 4.00e-33 135.00
IUUC-Acl-008015 Aspergillus clavatus 21.05 6.00e-15 75.90
IUUC-Afu-008760 Aspergillus fumigatus 22.94 1.00e-17 84.70
IUUC-Ame-011121 Astyanax mexicanus 51.99 2.00e-105 375.00
IUUC-Bgr-012152 Blumeria graminis 23.04 2.00e-13 70.10
IUUC-Bta-012383 Bos taurus 71.84 8.00e-162 563.00
IUUC-Bdi-014505 Brachypodium distachyon 25.95 1.00e-15 77.00
IUUC-Bol-015458 Brassica oleracea 32.39 3.00e-40 159.00
IUUC-Bra-017790 Brassica rapa 32.70 3.00e-41 162.00
IUUC-Cja-018803 Callithrix jacchus 68.80 3.00e-143 501.00
IUUC-Cfa-020178 Canis familiaris 72.78 3.00e-164 571.00
IUUC-Cpo-021785 Cavia porcellus 70.21 2.00e-159 555.00
IUUC-Cre-022703 Chlamydomonas reinhardtii 31.45 4.00e-36 146.00
IUUC-Csa-023179 Chlorocebus sabaeus 72.09 2.00e-162 565.00
IUUC-Cho-025088 Choloepus hoffmanni 75.77 1.00e-127 449.00
IUUC-Cin-025484 Ciona intestinalis 32.76 2.00e-20 92.40
IUUC-Csv-025887 Ciona savignyi 36.59 2.00e-48 186.00
IUUC-Cne-027021 Cryptococcus neoformans 27.95 3.00e-26 114.00
IUUC-Dre-027360 Danio rerio 58.70 3.00e-110 391.00
IUUC-Dno-029836 Dasypus novemcinctus 75.77 2.00e-161 561.00
IUUC-Dor-030677 Dipodomys ordii 80.00 2.00e-140 491.00
IUUC-Dse-031177 Dothistroma septosporum 22.97 3.00e-17 83.60
IUUC-Dme-032004 Drosophila melanogaster 31.40 3.00e-31 129.00
IUUC-Ete-032837 Echinops telfairi 78.21 4.00e-136 477.00
IUUC-Eca-033291 Equus caballus 74.54 7.00e-170 589.00
IUUC-Eeu-035347 Erinaceus europaeus 78.78 2.00e-135 474.00
IUUC-Fca-036577 Felis catus 72.36 6.00e-159 553.00
IUUC-Fal-036810 Ficedula albicollis 61.54 4.00e-120 424.00
IUUC-Fso-038338 Fusarium solani 28.90 1.00e-16 81.60
IUUC-Gmo-038537 Gadus morhua 63.50 4.00e-106 377.00
IUUC-Gga-040566 Gallus gallus 59.09 6.00e-129 453.00
IUUC-Gac-042422 Gasterosteus aculeatus 57.69 2.00e-117 416.00
IUUC-Gma-044199 Glycine max 30.57 1.00e-33 136.00
IUUC-Ggo-045365 Gorilla gorilla 63.03 5.00e-134 470.00
IUUC-Hsa-046121 Homo sapiens 74.10 9.00e-165 572.00
IUUC-Itr-048361 Ictidomys tridecemlineatus 74.26 1.00e-152 532.00
IUUC-Kpa-049407 Komagataella pastoris 32.01 1.00e-39 157.00
IUUC-Lch-049767 Latimeria chalumnae 64.69 4.00e-122 431.00
IUUC-Lpe-051569 Leersia perrieri 27.02 5.00e-19 88.60
IUUC-Loc-051940 Lepisosteus oculatus 54.34 2.00e-110 392.00
IUUC-Lma-053288 Leptosphaeria maculans 23.58 2.00e-17 83.60
IUUC-Laf-054463 Loxodonta africana 72.09 8.00e-161 559.00
IUUC-Mcc-055412 Macaca mulatta 72.36 6.00e-163 566.00
IUUC-Mtr-057886 Medicago truncatula 31.51 3.00e-31 129.00
IUUC-Mla-058862 Melampsora laricipopulina 24.18 4.00e-19 89.40
IUUC-Mga-060109 Meleagris gallopavo 59.94 5.00e-122 430.00
IUUC-Mvi-060326 Microbotryum violaceum 25.55 3.00e-28 120.00
IUUC-Mmr-060681 Microcebus murinus 72.43 5.00e-160 557.00
IUUC-Mdo-063004 Monodelphis domestica 69.02 2.00e-152 531.00
IUUC-Mac-064987 Musa acuminata 30.57 2.00e-34 139.00
IUUC-Mpu-065847 Mustela putorius furo 72.68 6.00e-171 593.00
IUUC-Mlu-067608 Myotis lucifugus 73.42 1.00e-169 589.00
IUUC-Nfi-068531 Neosartorya fischeri 22.94 1.00e-17 84.70
IUUC-Nle-069302 Nomascus leucogenys 72.90 3.00e-164 571.00
IUUC-Ont-072591 Oreochromis niloticus 60.93 2.00e-101 362.00
IUUC-Oan-073558 Ornithorhynchus anatinus 64.86 1.00e-115 409.00
IUUC-Ocu-074558 Oryctolagus cuniculus 72.63 8.00e-151 526.00
IUUC-Ogl-076960 Oryza glaberrima 27.50 3.00e-25 108.00
IUUC-Ogu-078660 Oryza glumaepatula 28.44 1.00e-22 100.00
IUUC-Oin-079790 Oryza indica 27.67 1.00e-28 120.00
IUUC-Ome-081631 Oryza meridionalis 25.26 2.00e-14 72.80
IUUC-Oni-083082 Oryza nivara 27.36 1.00e-24 107.00
IUUC-Opu-083394 Oryza punctata 26.50 1.00e-26 113.00
IUUC-Oru-084461 Oryza rufipogon 26.71 7.00e-23 101.00
IUUC-Osa-085655 Oryza sativa 27.69 8.00e-22 97.10
IUUC-Ola-086955 Oryzias latipes 63.04 5.00e-118 417.00
IUUC-Olu-087657 Ostreococcus lucimarinus 28.22 3.00e-22 99.80
IUUC-Oga-088108 Otolemur garnettii 71.04 3.00e-157 547.00
IUUC-Oar-090019 Ovis aries 70.53 7.00e-161 560.00
IUUC-Ptr-091544 Pan troglodytes 73.17 6.00e-165 573.00
IUUC-Pan-092562 Papio anubis 72.36 2.00e-162 565.00
IUUC-Psi-094025 Pelodiscus sinensis 62.30 4.00e-99 354.00
IUUC-Pma-094322 Petromyzon marinus 55.47 1.00e-95 342.00
IUUC-Ppa-095541 Physcomitrella patens 34.57 4.00e-40 158.00
IUUC-Pfo-096667 Poecilia formosa 59.38 2.00e-95 342.00
IUUC-Pab-098064 Pongo abelii 72.63 4.00e-163 567.00
IUUC-Pop-099969 Populus trichocarpa 34.81 5.00e-39 154.00
IUUC-Pca-101053 Procavia capensis 78.19 2.00e-155 541.00
IUUC-Ppe-101839 Prunus persica 34.08 1.00e-42 166.00
IUUC-Pva-102963 Pteropus vampyrus 73.02 1.00e-157 549.00
IUUC-Pgr-103276 Puccinia graminis 27.83 1.00e-18 87.80
IUUC-Pte-104117 Pyrenophora teres 25.37 5.00e-16 79.30
IUUC-Pyt-104649 Pyrenophora triticirepentis 25.00 2.00e-15 77.40
IUUC-Rno-105975 Rattus norvegicus 83.51 0.00e+00 662.00
IUUC-Sce-106226 Saccharomyces cerevisiae 26.99 6.00e-32 132.00
IUUC-Sha-106907 Sarcophilus harrisii 66.49 1.00e-154 539.00
IUUC-Sja-107867 Schizosaccharomyces japonicus 25.73 2.00e-22 99.80
IUUC-Spo-108377 Schizosaccharomyces pombe 28.62 2.00e-24 106.00
IUUC-Smo-109068 Selaginella moellendorffii 30.87 2.00e-33 136.00
IUUC-Sit-110114 Setaria italica 26.42 4.00e-20 92.00
IUUC-Sly-111581 Solanum lycopersicum 33.87 3.00e-38 152.00
IUUC-Stu-112770 Solanum tuberosum 33.55 3.00e-37 149.00
IUUC-Sbi-114797 Sorghum bicolor 25.77 1.00e-15 77.40
IUUC-Sre-114941 Sporisorium reilianum 27.99 1.00e-34 140.00
IUUC-Ssc-116346 Sus scrofa 72.31 8.00e-155 539.00
IUUC-Tgu-116628 Taeniopygia guttata 65.02 2.00e-125 441.00
IUUC-Tru-117646 Takifugu rubripes 60.73 3.00e-106 378.00
IUUC-Tsy-119593 Tarsius syrichta 56.59 3.00e-124 438.00
IUUC-Tni-119872 Tetraodon nigroviridis 60.26 6.00e-113 400.00
IUUC-Tca-121500 Theobroma cacao 33.44 4.00e-39 155.00
IUUC-Tre-122151 Trichoderma reesei 23.94 2.00e-17 83.60
IUUC-Tae-125015 Triticum aestivum 27.22 2.00e-22 100.00
IUUC-Tbe-127959 Tupaia belangeri 76.55 6.00e-135 473.00
IUUC-Ttr-129125 Tursiops truncatus 71.92 1.00e-160 559.00
IUUC-Uma-129567 Ustilago maydis 30.56 1.00e-32 134.00
IUUC-Vpa-130157 Vicugna pacos 79.39 6.00e-78 283.00
IUUC-Vvi-131065 Vitis vinifera 33.55 6.00e-36 144.00
IUUC-Xtr-132601 Xenopus tropicalis 61.09 3.00e-109 388.00
IUUC-Xma-133142 Xiphophorus maculatus 61.72 3.00e-102 365.00
IUUC-Yli-134580 Yarrowia lipolytica 30.80 2.00e-32 133.00
IUUC-Zma-135330 Zea mays 29.28 2.00e-28 119.00
Created Date 25-Jun-2017

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