iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/Cullin	4.60e-195	649.9	196	832

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/Cullin

   S: 2    lreavkkilrqesvkkeyeelytavynlclskvgaklYkklkevleefi.kqvkkkveesedeqlLktynreWekfreqlkvlrkifayldrtyvkks 98
           l++a+++i++++++  ++e+ly+++yn++l+k+g++lY  l+ev+ e++ ++v+++v e+  +++L ++n++W++++++++++r+i++y+dr+yv++ 
   Q: 196  LKNAIQEIQKKNNSGLSFEQLYRNAYNMVLHKHGNRLYYGLREVVSEHLeHKVRADVLEALHSNFLPKLNQAWTDHQTSMVMIRDILMYMDRVYVQQ- 292
           799**********************************************999*********************************************. PP
   S: 99   kkvsevrkLaldlwrkeived..ikkrllelllklieaeRkgeavdrrllsgvveslveLslnklaiykesFEakfleatqefykaesaeflqenevd 194
           ++v +v++L+l l+r+++v++  i+k l e+ll ++ +eR+gea+++  +++++++l+ L++n++++y+e+FE++fl +++ fyk es++fl+en+  
   Q: 293  REVDNVYNLGLILFRDQVVRYseIQKALREKLLGMVMEERHGEAINHLAIKNACSMLITLGINSRTVYEEDFEKPFLAQSAAFYKFESQNFLAENNAG 390
           *******************9999*************************************************************************** PP
   S: 195  eYlkkvearlneeeeraaryleestetkLlevvekeliakhlesll....aelvallrdkktedlsrmykLlsrvln.gleellkeleshikeqgkaa 287
            Y+kkvear++ee++raa yl++ te  +++vve+eli+kh+  ++    +++v +++++ktedl++ ykL+sr ++ gl+ ++++++++++eqg+ +
   Q: 391  VYIKKVEARITEESSRAALYLDKDTEPRIVRVVEEELIKKHMRPIVemenSGVVYMIKNSKTEDLACTYKLFSRLKEeGLKVIADTMSAYLREQGRML 488
           **********************************************99999*************************99******************** PP
   S: 288  lt.aeekekdpkkyVerllelknklqklvseaFnndakFlkaldkafetfvnknsvlkaakspEllAryiDqlLrksskglteeeleaqldkvllvfk 384
           +  +e+ +++p ++V++ll+lk+++++++ ++F nd+ F + + ++fe+f+n n      kspE+l+ +iD++L+k+ kg+ e+e+e +ldk +++f+
   Q: 489  VKeEENGNTNPITFVQNLLDLKDRFDQFLVHSFANDRIFKNVISSDFEHFLNLN-----NKSPEYLSLFIDDKLKKGGKGMSEQEIESILDKTMVLFR 581
           **56666779********************************************.....9************************************** PP
   S: 385  yisekdvFekyYkkhLakRLlsgksasseaEesviekLkeecgaeftskLerMfqdlkvSedlnrqFkeekentees.esvelsvlvLsagaWptase 481
           ++ ekdvFe+yYk hLakRLl++ks+s++ E+++i+kLk+ecg++ftskLe+Mf+d++vS++++++Fk+  +n++ s  +vel+v++L++g+Wpt+++
   Q: 582  FLLEKDVFERYYKTHLAKRLLLNKSVSDDFEKNMISKLKTECGCQFTSKLEGMFKDMSVSNTIMDEFKNFVNNNNLSlGGVELTVRILTTGFWPTQTA 679
           ********************************************************************876666655599****************** PP
   S: 482  tekvsLPaelektiekfeefYlekhsgRkLqWqhtlgraelkael..........................kkgkyelqVstfQmavLLafnnsekvs 553
           t+++++Pa  ++++++f++fYl+khsgR+L++q ++g+a ++a++                          +++k++lqVst+Qm+vLL+fnn++ ++
   Q: 680  TPNCNIPAAPREAFDIFKNFYLNKHSGRQLTLQPQMGTAYINAVFygrkavesekdkdapsssssgcgvptTTRKHILQVSTYQMCVLLLFNNRDVLT 777
           ********************************************************999999999888888888************************ PP
   S: 554  veelkkatelpeeeLrrtlqsLvssk..kqvlkkepes..keieeedlfsvNqef 604
           +++++++t++pe+eL r+lqsL  +k  +++l  ++++  k+ie +d f+vN++f
   Q: 778  YDDIHQETDIPERELVRALQSLSMGKpaQRLLVRNSKTktKDIEPTDEFYVNDAF 832
           ***************************999998877763366***********98 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MQGRDPRQQQ PEPLNNLNAN GRYHNRMVAG SNNFNGATVG NVDSAVPCRI ARQNVLGQQA 60
RSMNINVPNA SSMQQHQQSQ NRLSAQGLAS ASRRSYHLAA SGGRVRADNR INTNHPLTPT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAATGCTACT TTTGTCGCCC ATCGCTATTA AAACCTACAA TCAATATGAA ATGCAAGTAA 60
ACGTTGAAAA CAGCAACAAA TCAAGCTAAA TAATAGTAGT GACTTTACTA ATGCATTCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR016157--Cullin_CS
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR016159--Cullin_repeat-like_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS01256--CULLIN_1
PS50069--CULLIN_2

Pfam

PF00888--Cullin
PF10557--Cullin_Nedd8

SMART

SM00182--CULLIN
SM00884--Cullin_Nedd8

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007409--P:axonogenesis
GO:0001745--P:compound eye morphogenesis
GO:0048813--P:dendrite morphogenesis
GO:0007476--P:imaginal disc-derived wing morphogenesis
GO:0045475--P:locomotor rhythm
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0045187--P:regulation of circadian sleep/wake cycle, sleep
GO:0030162--P:regulation of proteolysis
GO:0007423--P:sensory organ development
GO:0030431--P:sleep
GO:0007291--P:sperm individualization
GO:0007283--P:spermatogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000335	Aegilops tauschii	44.21	0.00e+00	642.00
IUUC-Aml-002278	Ailuropoda melanoleuca	68.61	0.00e+00	1053.00
IUUC-Atr-002616	Amborella trichopoda	50.40	0.00e+00	711.00
IUUC-Apl-004172	Anas platyrhynchos	69.63	0.00e+00	1051.00
IUUC-Aca-004309	Anolis carolinensis	69.57	0.00e+00	1057.00
IUUC-Aly-005566	Arabidopsis lyrata	49.34	0.00e+00	704.00
IUUC-Ath-007587	Arabidopsis thaliana	49.60	0.00e+00	704.00
IUUC-Acl-008317	Aspergillus clavatus	35.35	7.00e-137	480.00
IUUC-Afl-008727	Aspergillus flavus	35.65	7.00e-135	474.00
IUUC-Afu-008879	Aspergillus fumigatus	36.55	1.00e-123	436.00
IUUC-Ani-009393	Aspergillus nidulans	35.16	3.00e-131	461.00
IUUC-Ang-009626	Aspergillus niger	35.32	1.00e-131	462.00
IUUC-Aor-010207	Aspergillus oryzae	35.72	3.00e-136	478.00
IUUC-Ate-010305	Aspergillus terreus	35.98	3.00e-130	458.00
IUUC-Ame-011805	Astyanax mexicanus	69.04	0.00e+00	1047.00
IUUC-Bgr-012098	Blumeria graminis	34.73	2.00e-114	405.00
IUUC-Bta-013445	Bos taurus	69.57	0.00e+00	1057.00
IUUC-Bci-013612	Botrytis cinerea	35.69	3.00e-128	451.00
IUUC-Bdi-014269	Brachypodium distachyon	49.22	0.00e+00	681.00
IUUC-Bol-015350	Brassica oleracea	50.00	0.00e+00	704.00
IUUC-Bra-016763	Brassica rapa	50.00	0.00e+00	706.00
IUUC-Cel-018641	Caenorhabditis elegans	48.31	0.00e+00	708.00
IUUC-Cja-019175	Callithrix jacchus	69.57	0.00e+00	1057.00
IUUC-Cfa-020905	Canis familiaris	69.30	0.00e+00	1052.00
IUUC-Cpo-021293	Cavia porcellus	69.57	0.00e+00	1057.00
IUUC-Cre-022776	Chlamydomonas reinhardtii	47.62	0.00e+00	664.00
IUUC-Csa-023800	Chlorocebus sabaeus	69.43	0.00e+00	1056.00
IUUC-Cho-024839	Choloepus hoffmanni	67.78	0.00e+00	913.00
IUUC-Cin-025201	Ciona intestinalis	61.54	0.00e+00	848.00
IUUC-Csv-026107	Ciona savignyi	61.82	0.00e+00	920.00
IUUC-Cgl-026630	Colletotrichum gloeosporioides	35.24	2.00e-114	406.00
IUUC-Cne-027048	Cryptococcus neoformans	34.43	3.00e-108	385.00
IUUC-Cme-027254	Cyanidioschyzon merolae	29.66	9.00e-77	280.00
IUUC-Dre-028488	Danio rerio	68.87	0.00e+00	1048.00
IUUC-Dno-029784	Dasypus novemcinctus	69.57	0.00e+00	1056.00
IUUC-Dor-030682	Dipodomys ordii	64.06	0.00e+00	919.00
IUUC-Dse-031326	Dothistroma septosporum	34.72	5.00e-123	434.00
IUUC-Ete-032347	Echinops telfairi	58.09	0.00e+00	807.00
IUUC-Eca-033560	Equus caballus	69.63	0.00e+00	1051.00
IUUC-Eeu-034502	Erinaceus europaeus	67.20	0.00e+00	909.00
IUUC-Fca-035544	Felis catus	69.63	0.00e+00	1050.00
IUUC-Fal-036751	Ficedula albicollis	69.35	0.00e+00	1051.00
IUUC-Fox-037857	Fusarium oxysporum	33.41	9.00e-118	417.00
IUUC-Fso-038163	Fusarium solani	33.05	3.00e-122	431.00
IUUC-Gmo-038830	Gadus morhua	69.26	0.00e+00	1056.00
IUUC-Ggr-039999	Gaeumannomyces graminis	33.03	2.00e-118	419.00
IUUC-Gga-040329	Gallus gallus	69.57	0.00e+00	1058.00
IUUC-Gac-041915	Gasterosteus aculeatus	68.91	0.00e+00	1049.00
IUUC-Gma-043659	Glycine max	49.32	0.00e+00	676.00
IUUC-Ggo-044903	Gorilla gorilla	69.40	0.00e+00	1045.00
IUUC-Hsa-046000	Homo sapiens	69.43	0.00e+00	1056.00
IUUC-Hvu-047541	Hordeum vulgare	47.45	0.00e+00	670.00
IUUC-Itr-049067	Ictidomys tridecemlineatus	70.00	0.00e+00	664.00
IUUC-Kpa-049372	Komagataella pastoris	34.47	3.00e-112	398.00
IUUC-Lch-050458	Latimeria chalumnae	69.08	0.00e+00	1055.00
IUUC-Lpe-051396	Leersia perrieri	50.46	0.00e+00	700.00
IUUC-Loc-052186	Lepisosteus oculatus	69.30	0.00e+00	1055.00
IUUC-Lma-053030	Leptosphaeria maculans	36.97	9.00e-135	473.00
IUUC-Laf-053684	Loxodonta africana	69.63	0.00e+00	1050.00
IUUC-Mcc-055770	Macaca mulatta	69.43	0.00e+00	1056.00
IUUC-Meu-056852	Macropus eugenii	70.24	7.00e-155	540.00
IUUC-Mor-057273	Magnaporthe oryzae	32.93	4.00e-116	411.00
IUUC-Mpo-057403	Magnaporthe poae	32.78	8.00e-116	410.00
IUUC-Mtr-058018	Medicago truncatula	49.00	0.00e+00	679.00
IUUC-Mla-059055	Melampsora laricipopulina	36.79	1.00e-130	459.00
IUUC-Mga-060076	Meleagris gallopavo	68.57	0.00e+00	1023.00
IUUC-Mvi-060470	Microbotryum violaceum	33.63	5.00e-129	454.00
IUUC-Mmr-060976	Microcebus murinus	69.57	0.00e+00	1057.00
IUUC-Mdo-062741	Monodelphis domestica	69.57	0.00e+00	1057.00
IUUC-Mmu-063905	Mus musculus	69.57	0.00e+00	1056.00
IUUC-Mac-064718	Musa acuminata	48.69	0.00e+00	677.00
IUUC-Mpu-066356	Mustela putorius furo	69.63	0.00e+00	1050.00
IUUC-Mlu-067768	Myotis lucifugus	69.63	0.00e+00	1051.00
IUUC-Nfi-068285	Neosartorya fischeri	35.47	4.00e-137	481.00
IUUC-Ncr-068883	Neurospora crassa	35.46	5.00e-126	444.00
IUUC-Nle-069638	Nomascus leucogenys	69.50	0.00e+00	1050.00
IUUC-Opr-070333	Ochotona princeps	70.96	0.00e+00	780.00
IUUC-Ont-071601	Oreochromis niloticus	69.17	0.00e+00	1078.00
IUUC-Oan-073281	Ornithorhynchus anatinus	68.08	0.00e+00	883.00
IUUC-Ocu-074504	Oryctolagus cuniculus	69.48	0.00e+00	1051.00
IUUC-Oba-075332	Oryza barthii	50.54	0.00e+00	696.00
IUUC-Obr-076790	Oryza brachyantha	46.88	0.00e+00	675.00
IUUC-Ogl-077655	Oryza glaberrima	50.66	0.00e+00	706.00
IUUC-Ogu-078458	Oryza glumaepatula	50.54	0.00e+00	697.00
IUUC-Oin-079567	Oryza indica	50.53	0.00e+00	704.00
IUUC-Olo-080930	Oryza longistaminata	49.55	0.00e+00	708.00
IUUC-Ome-081353	Oryza meridionalis	50.66	0.00e+00	704.00
IUUC-Oni-082378	Oryza nivara	50.66	0.00e+00	706.00
IUUC-Opu-084055	Oryza punctata	50.53	0.00e+00	706.00
IUUC-Oru-084202	Oryza rufipogon	50.54	0.00e+00	696.00
IUUC-Osa-085290	Oryza sativa	50.66	0.00e+00	706.00
IUUC-Ola-087562	Oryzias latipes	69.17	0.00e+00	1051.00
IUUC-Olu-087866	Ostreococcus lucimarinus	37.14	7.00e-135	473.00
IUUC-Oga-088833	Otolemur garnettii	69.63	0.00e+00	1050.00
IUUC-Oar-089958	Ovis aries	69.63	0.00e+00	1050.00
IUUC-Ptr-091013	Pan troglodytes	69.43	0.00e+00	1056.00
IUUC-Pan-091796	Papio anubis	69.58	0.00e+00	1047.00
IUUC-Psi-093564	Pelodiscus sinensis	68.57	0.00e+00	1027.00
IUUC-Pno-094939	Phaeosphaeria nodorum	38.32	5.00e-140	491.00
IUUC-Ppa-095920	Physcomitrella patens	49.73	0.00e+00	701.00
IUUC-Pfo-096588	Poecilia formosa	68.60	0.00e+00	1047.00
IUUC-Pab-098164	Pongo abelii	69.43	0.00e+00	1056.00
IUUC-Pop-099206	Populus trichocarpa	49.93	0.00e+00	702.00
IUUC-Pca-100702	Procavia capensis	64.69	0.00e+00	937.00
IUUC-Ppe-101971	Prunus persica	49.73	0.00e+00	678.00
IUUC-Pva-103129	Pteropus vampyrus	69.57	0.00e+00	1057.00
IUUC-Pgr-103600	Puccinia graminis	35.41	5.00e-109	388.00
IUUC-Ptt-103961	Puccinia triticina	35.19	4.00e-107	381.00
IUUC-Pte-104325	Pyrenophora teres	38.32	8.00e-133	467.00
IUUC-Pyt-104746	Pyrenophora triticirepentis	36.27	1.00e-131	462.00
IUUC-Rno-105935	Rattus norvegicus	69.63	0.00e+00	1051.00
IUUC-Sce-106354	Saccharomyces cerevisiae	26.82	8.00e-45	174.00
IUUC-Sha-106569	Sarcophilus harrisii	68.70	0.00e+00	944.00
IUUC-Sja-107676	Schizosaccharomyces japonicus	38.68	3.00e-148	518.00
IUUC-Spo-108135	Schizosaccharomyces pombe	37.52	5.00e-126	444.00
IUUC-Smo-109555	Selaginella moellendorffii	50.93	0.00e+00	727.00
IUUC-Sit-110763	Setaria italica	50.33	0.00e+00	706.00
IUUC-Sly-111090	Solanum lycopersicum	50.27	0.00e+00	711.00
IUUC-Stu-112351	Solanum tuberosum	50.40	0.00e+00	712.00
IUUC-Sar-113144	Sorex araneus	70.96	0.00e+00	786.00
IUUC-Sbi-114690	Sorghum bicolor	49.93	0.00e+00	703.00
IUUC-Sre-115005	Sporisorium reilianum	36.92	6.00e-129	454.00
IUUC-Ssc-116053	Sus scrofa	69.23	0.00e+00	786.00
IUUC-Tgu-116523	Taeniopygia guttata	69.63	0.00e+00	1050.00
IUUC-Tru-118189	Takifugu rubripes	66.09	0.00e+00	979.00
IUUC-Tsy-118962	Tarsius syrichta	65.07	0.00e+00	940.00
IUUC-Tni-120614	Tetraodon nigroviridis	47.76	0.00e+00	713.00
IUUC-Tca-121282	Theobroma cacao	50.27	0.00e+00	702.00
IUUC-Tre-122201	Trichoderma reesei	34.79	2.00e-124	439.00
IUUC-Tvi-122321	Trichoderma virens	34.67	3.00e-123	435.00
IUUC-Tae-124292	Triticum aestivum	49.48	0.00e+00	684.00
IUUC-Tur-126800	Triticum urartu	49.67	0.00e+00	682.00
IUUC-Tme-127053	Tuber melanosporum	40.18	4.00e-155	541.00
IUUC-Tbe-127427	Tupaia belangeri	63.21	0.00e+00	729.00
IUUC-Ttr-128662	Tursiops truncatus	68.30	0.00e+00	1018.00
IUUC-Uma-129597	Ustilago maydis	37.26	2.00e-128	452.00
IUUC-Vda-129726	Verticillium dahliae	34.51	4.00e-121	428.00
IUUC-Vpa-130809	Vicugna pacos	68.63	3.00e-143	501.00
IUUC-Vvi-131194	Vitis vinifera	49.34	0.00e+00	699.00
IUUC-Xtr-131887	Xenopus tropicalis	69.51	0.00e+00	1055.00
IUUC-Xma-133517	Xiphophorus maculatus	69.04	0.00e+00	1051.00
IUUC-Yli-134576	Yarrowia lipolytica	33.96	5.00e-100	358.00
IUUC-Zma-135030	Zea mays	49.80	0.00e+00	702.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence