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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064322
UUCD1 version UUC-MuM-01133
Ensembl Protein ID ENSMUSP00000035166.5
UniProt Accession Q8VE47; Q3TG27; Q3U8X9; Q3U9E7; Q9CYD6; UBA5_MOUSE
Genbank Protein ID BAB30933.1; BAE30720.1; BAE30888.1; BAE40721.1; EDL21084.1; AAH19764.1
Protein Name Ubiquitin-like modifier-activating enzyme 5; UFM1-activating enzyme; Ubiquitin-activating enzyme E1 domain-containing protein 1
Genbank Nucleotide ID AK017787; AK151823; AK152029; AK168907; CH466560; BC019764
Gene Name Uba5; Ube1dc1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000032557.12 ENSMUST00000035166.11 ENSMUSP00000035166.5
ENSMUSG00000032557.12 ENSMUST00000144195.2 ENSMUSP00000118535.2
ENSMUSG00000032557.12 ENSMUST00000140768.2 ENSMUSP00000118734.1
ENSMUSG00000032557.12 ENSMUST00000214222.1 ENSMUSP00000149909.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarmiRNAMap
RAID2
Protein-protein Interaction
IIDPINAHINTMentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMUniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E1 88.53 5.00e-179 624.00 IUUC-Hsa-046777
Active Site
Position(s) Description Evidence
248 Glycyl thioester intermediate {ECO:0000250|UniProtKB:Q9GZZ9}
Organism Mus musculus
Functional Description
(View)

Functional Description


     E1-like enzyme which activates UFM1 and SUMO2.
 E1-like enzyme which activates UFM1 and SUMO2.
Protein Sequence
(Fasta)
MADSVERLRQ RVEELEQELA RERTRRSGGD GHCGRTRIQE MSDEVLDSNP YSRLMALKRM 60
GIVSDYKKIR TYAVAIVGVG GVGSVTAEML TRCGIGKLLL FDYDKVELAN MNRLFFQPYQ 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064322|E1,E1_ThiF|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AAGCCCGGTG GGCGTGCCGG AGACGTGTCT TACTGGGAGC CTTGGAGCCG CTTCGCCGGT 60
GTCTGGACCT GGAAGGCTGT GTCTGTTCCT CCTGCGCTTC GTGGGCCCAG CGAGGCAGCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064322|E1,E1_ThiF|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
Interpro

IPR029752--D-isomer_DH_CS1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
Pfam

PF00899--ThiF
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0043231--C:intracellular membrane-bounded organelle
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0046872--F:metal ion binding
GO:0071566--F:UFM1 activating enzyme activity
GO:1990592--P:protein K69-linked ufmylation
GO:0071569--P:protein ufmylation
GO:0033146--P:regulation of intracellular estrogen receptor signaling pathway
GO:0034976--P:response to endoplasmic reticulum stress
KEGG mmu:66663
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001324 Ailuropoda melanoleuca 89.07 3.00e-179 620.00
IUUC-Atr-002660 Amborella trichopoda 65.59 2.00e-111 395.00
IUUC-Apl-003722 Anas platyrhynchos 83.24 2.00e-153 534.00
IUUC-Aca-004584 Anolis carolinensis 81.68 3.00e-162 564.00
IUUC-Aly-005881 Arabidopsis lyrata 57.03 4.00e-112 397.00
IUUC-Ath-007286 Arabidopsis thaliana 59.73 4.00e-116 411.00
IUUC-Ame-011679 Astyanax mexicanus 79.48 7.00e-136 476.00
IUUC-Bta-012517 Bos taurus 89.07 2.00e-180 624.00
IUUC-Bdi-014894 Brachypodium distachyon 58.71 5.00e-114 404.00
IUUC-Bol-016054 Brassica oleracea 60.16 7.00e-116 410.00
IUUC-Bra-016708 Brassica rapa 60.16 4.00e-118 418.00
IUUC-Cel-018424 Caenorhabditis elegans 63.22 8.00e-117 413.00
IUUC-Cja-019825 Callithrix jacchus 88.93 6.00e-137 479.00
IUUC-Cfa-021160 Canis familiaris 86.17 0.00e+00 640.00
IUUC-Cpo-022255 Cavia porcellus 82.99 1.00e-176 612.00
IUUC-Csa-023827 Chlorocebus sabaeus 87.90 0.00e+00 666.00
IUUC-Cho-025078 Choloepus hoffmanni 84.82 1.00e-172 599.00
IUUC-Cin-025217 Ciona intestinalis 70.22 8.00e-151 526.00
IUUC-Dre-027578 Danio rerio 76.25 5.00e-163 566.00
IUUC-Dno-029330 Dasypus novemcinctus 83.71 4.00e-178 617.00
IUUC-Dor-030425 Dipodomys ordii 70.23 5.00e-99 354.00
IUUC-Dme-031645 Drosophila melanogaster 61.03 1.00e-130 459.00
IUUC-Ete-032912 Echinops telfairi 82.09 4.00e-52 198.00
IUUC-Eca-033247 Equus caballus 89.07 3.00e-180 624.00
IUUC-Eeu-034472 Erinaceus europaeus 90.03 3.00e-173 600.00
IUUC-Fca-035684 Felis catus 88.08 6.00e-180 623.00
IUUC-Fal-037654 Ficedula albicollis 81.84 3.00e-157 548.00
IUUC-Gmo-039449 Gadus morhua 65.62 8.00e-125 440.00
IUUC-Gga-041051 Gallus gallus 83.06 4.00e-162 563.00
IUUC-Gac-042325 Gasterosteus aculeatus 75.00 8.00e-167 579.00
IUUC-Gma-043136 Glycine max 61.07 2.00e-120 425.00
IUUC-Ggo-044414 Gorilla gorilla 85.93 0.00e+00 659.00
IUUC-Hsa-046777 Homo sapiens 86.42 0.00e+00 665.00
IUUC-Hvu-047549 Hordeum vulgare 64.26 1.00e-96 346.00
IUUC-Itr-048175 Ictidomys tridecemlineatus 88.00 0.00e+00 629.00
IUUC-Lch-050142 Latimeria chalumnae 78.08 2.00e-171 595.00
IUUC-Lpe-050769 Leersia perrieri 67.02 2.00e-102 365.00
IUUC-Loc-052405 Lepisosteus oculatus 82.22 3.00e-153 534.00
IUUC-Laf-054152 Loxodonta africana 85.19 0.00e+00 638.00
IUUC-Mcc-055618 Macaca mulatta 90.26 3.00e-172 597.00
IUUC-Meu-056486 Macropus eugenii 87.32 3.00e-163 567.00
IUUC-Mtr-057871 Medicago truncatula 60.21 8.00e-119 420.00
IUUC-Mga-059284 Meleagris gallopavo 82.79 2.00e-161 561.00
IUUC-Mmr-061242 Microcebus murinus 87.30 0.00e+00 638.00
IUUC-Mdo-063034 Monodelphis domestica 86.41 1.00e-175 608.00
IUUC-Mac-065128 Musa acuminata 60.94 9.00e-68 254.00
IUUC-Mpu-066438 Mustela putorius furo 88.52 2.00e-178 617.00
IUUC-Mlu-067578 Myotis lucifugus 89.34 2.00e-180 624.00
IUUC-Nle-069542 Nomascus leucogenys 88.80 0.00e+00 637.00
IUUC-Opr-070710 Ochotona princeps 81.39 1.00e-169 588.00
IUUC-Ont-072067 Oreochromis niloticus 81.30 5.00e-158 550.00
IUUC-Oan-073593 Ornithorhynchus anatinus 85.55 3.00e-165 574.00
IUUC-Ocu-073964 Oryctolagus cuniculus 84.69 0.00e+00 632.00
IUUC-Oba-075476 Oryza barthii 59.51 6.00e-116 410.00
IUUC-Obr-076517 Oryza brachyantha 62.39 8.00e-114 403.00
IUUC-Ogu-078664 Oryza glumaepatula 59.78 3.00e-116 411.00
IUUC-Olo-081012 Oryza longistaminata 59.51 7.00e-116 410.00
IUUC-Ome-081129 Oryza meridionalis 59.24 4.00e-115 408.00
IUUC-Oni-082265 Oryza nivara 59.78 5.00e-115 407.00
IUUC-Opu-084121 Oryza punctata 62.57 7.00e-115 407.00
IUUC-Oru-084451 Oryza rufipogon 58.44 2.00e-99 356.00
IUUC-Osa-086132 Oryza sativa 59.51 6.00e-116 410.00
IUUC-Ola-086842 Oryzias latipes 78.86 1.00e-154 539.00
IUUC-Oga-088160 Otolemur garnettii 88.00 5.00e-178 617.00
IUUC-Oar-089362 Ovis aries 89.89 0.00e+00 637.00
IUUC-Ptr-091256 Pan troglodytes 86.91 0.00e+00 670.00
IUUC-Pan-092913 Papio anubis 86.67 4.00e-180 623.00
IUUC-Psi-093740 Pelodiscus sinensis 84.66 5.00e-155 540.00
IUUC-Pma-094485 Petromyzon marinus 82.51 2.00e-104 371.00
IUUC-Ppa-095673 Physcomitrella patens 69.42 7.00e-111 394.00
IUUC-Pfo-096196 Poecilia formosa 78.22 1.00e-158 552.00
IUUC-Pab-098449 Pongo abelii 87.16 0.00e+00 674.00
IUUC-Pop-099049 Populus trichocarpa 61.01 2.00e-114 405.00
IUUC-Pca-100917 Procavia capensis 87.92 9.00e-117 413.00
IUUC-Ppe-101797 Prunus persica 57.11 2.00e-118 419.00
IUUC-Pva-102852 Pteropus vampyrus 89.16 0.00e+00 629.00
IUUC-Rno-105213 Rattus norvegicus 95.48 0.00e+00 684.00
IUUC-Sha-107569 Sarcophilus harrisii 81.42 6.00e-178 616.00
IUUC-Smo-109146 Selaginella moellendorffii 62.57 4.00e-114 405.00
IUUC-Sit-109794 Setaria italica 61.49 8.00e-115 407.00
IUUC-Sly-111622 Solanum lycopersicum 62.05 3.00e-116 411.00
IUUC-Stu-112522 Solanum tuberosum 59.84 3.00e-116 411.00
IUUC-Sar-113045 Sorex araneus 77.48 8.00e-160 556.00
IUUC-Sbi-113861 Sorghum bicolor 57.98 2.00e-113 402.00
IUUC-Ssc-115290 Sus scrofa 90.20 3.00e-153 534.00
IUUC-Tgu-117125 Taeniopygia guttata 81.47 9.00e-159 553.00
IUUC-Tru-118041 Takifugu rubripes 81.03 4.00e-164 570.00
IUUC-Tsy-119300 Tarsius syrichta 79.49 1.00e-142 499.00
IUUC-Tni-120310 Tetraodon nigroviridis 80.76 2.00e-155 542.00
IUUC-Tca-121405 Theobroma cacao 60.16 2.00e-115 409.00
IUUC-Tae-123656 Triticum aestivum 58.71 5.00e-115 407.00
IUUC-Tur-125985 Triticum urartu 61.21 2.00e-114 405.00
IUUC-Tbe-127478 Tupaia belangeri 69.55 2.00e-144 504.00
IUUC-Ttr-128169 Tursiops truncatus 68.89 7.00e-139 486.00
IUUC-Vpa-130508 Vicugna pacos 82.62 1.00e-150 525.00
IUUC-Vvi-131252 Vitis vinifera 59.89 4.00e-116 411.00
IUUC-Xtr-132776 Xenopus tropicalis 80.75 2.00e-163 568.00
IUUC-Xma-133110 Xiphophorus maculatus 77.95 4.00e-161 561.00
Created Date 25-Jun-2017

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