iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000037112.16	ENSMUST00000176824.7	ENSMUSP00000134936.1
ENSMUSG00000037112.16	ENSMUST00000176663.7	ENSMUSP00000135376.1
ENSMUSG00000037112.16	ENSMUST00000041375.10	ENSMUSP00000038761.10

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	miRNAMap
RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Drug and target
GRAC
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	UniProt
PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UBA	UBA	24561619

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UBA	0.004	18.4	296	333

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBA

   S: 2    ededkleqlveMGFdreealqaLraannnleaAveyLl 39
           ++e++l+ + + G+d+++ ++ L++ ++n  aA+++Ll
   Q: 296  FNEQVLRLMHSLGIDQQKTVESLQNKSYNHFAAIYFLL 333
           68999********************************8 PP

Organism

Mus musculus

Functional Description
(View)

Phosphorylates 'Ser-789' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.

Protein Sequence
(Fasta)

MVMADGPRHL QRGPVRVGFY DIEGTLGKGN FAVVKLGRHR ITKTEVAIKI IDKSQLDAVN 60
LEKIYREVQI MKMLDHPHII KLYQVMETKS MLYLVTEYAK NGEIFDYLAN HGRLNESEAR 120

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Nucleotide Sequence
(Fasta)

GACGTCGGCT CACGTCAGCG CCGGCGCGCG CCTGGCTGGG CCCTGTGGGG CGGGAGGGAA 60
GCAGCGCCGG AGCGAGAGCC GCGGCCGTCG CCCAGAGCCC AGGCGCGCCG CCCGACGCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0418--Kinase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS
IPR017090--Ser/Thr_kinase_SIK1/2
IPR034672--SIK
IPR015940--UBA

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS50030--UBA

Pfam

PF00069--Pkinase

SMART

SM00220--S_TKc

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0000287--F:magnesium ion binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0008286--P:insulin receptor signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0046777--P:protein autophosphorylation
GO:0006468--P:protein phosphorylation
GO:0046626--P:regulation of insulin receptor signaling pathway

KEGG

mmu:235344

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001538	Ailuropoda melanoleuca	89.74	0.00e+00	1146.00
IUUC-Cin-025762	Ciona intestinalis	62.57	2.00e-133	469.00
IUUC-Dme-031957	Drosophila melanogaster	69.39	3.00e-138	486.00
IUUC-Gac-041875	Gasterosteus aculeatus	70.77	0.00e+00	975.00
IUUC-Loc-051827	Lepisosteus oculatus	68.40	0.00e+00	966.00
IUUC-Pfo-096944	Poecilia formosa	71.54	0.00e+00	1027.00
IUUC-Pca-100848	Procavia capensis	91.87	2.00e-174	606.00
IUUC-Ssc-116288	Sus scrofa	92.59	2.00e-153	535.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence