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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046353
Ensembl Protein ID ENSP00000254029.3
UniProt Accession Q5JSH3; B4DSE9; F8W913; Q0JS52; Q0JTF3; Q5JSH2; Q6ZSC1; Q7Z365; Q7Z3P6; Q8NAU8; Q8NHU5; Q9NUV4; WDR44_HUMAN
Genbank Protein ID BAA92015.1; BAC03799.1; BAC87033.1; BAG61611.1; CAL38210.1; CAL38662.1; CAD97788.1; CAD98010.1; CAI41402.1; CAI41402.1; CAI41402.1; CAI41403.1; CAI41403.1; CAI41403.1; CAI41482.1; CAI41482.1; CAI41482.1; CAI41483.1; CAI41483.1; CAI41483.1; CAI41512.1; CAI41512.1; CAI41512.1; CAI41513.1; CAI41513.1; CAI41513.1; AAH28697.3
Protein Name WD repeat-containing protein 44; Rabphilin-11
Genbank Nucleotide ID AK001978; AK092077; AK127556; AK299711; AM393332; AM393787; BX537578; BX538087; AL391474; AL391803; AL391830; AL391474; AL391803; AL391830; AL391803; AL391474; AL391830; AL391803; AL391474; AL391830; AL391830; AL391474; AL391803; AL391830; AL391474; AL391803; BC028697
Gene Name WDR44
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000131725.13 ENST00000254029.7 ENSP00000254029.3
ENSG00000131725.13 ENST00000371825.7 ENSP00000360890.3
ENSG00000131725.13 ENST00000371848.3 ENSP00000360914.3
ENSG00000131725.13 ENST00000371822.9 ENSP00000360887.5
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
ClinVarGWAS Central
Post-translational Modifications (PTMs)
CPLMdbPAFPhosSNPPhosphositePlus
dbPTMHPRDPhospho.ELMUniProt
PHOSIDABioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 8.90e-26 90.5 646 678
UBD/Beta-Prp 1.50e-39 137.6 495 788
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf...sdtllvsGsdDgtikvWDlr 31
           H d vt++af   +d++++sGs Dg++++W++ 
   Q: 646  HIDFVTAIAFhprDDRYFLSGSLDGKLRLWNIP 678
           8888********555****************75 PP
   

   UBD/Beta-Prp
   S: 37   wdvttgkllrsl.sgheaevtavkfspdgkilvtgseDrtikvwdls............................................. 82
           +d+++ k+++ l  +h ++v+++kfs+ g +l+++++D+++++w l+                                             
   Q: 495  YDFDQIKVVQDLsGEHMGAVWTMKFSHCGRLLASAGQDNVVRIWALKnafdyfnnmrmkyntegrvspspsqeslsssksdtdtgvcsgtde 586
           899999******567999**************************8888889999999*********************************** PP
   S: 83   .........tgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdg.nllvsGslDrtvrlW 164
                       ++ ++kgh++++l+ls+s+ +++l+s s d+t+r+w+++ ++cl  +  +h ++v+ +++hp + +++ sGslD+++rlW
   Q: 587  dpddknapfRQRPFCKYKGHTADLLDLSWSK-NYFLLSSSMDKTVRLWHISRRECL--CCFQHIDFVTAIAFHPRDdRYFLSGSLDGKLRLW 675
           *******************************.9***********************..7888999*************************** PP
   S: 165  dlktgk..llrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlq.....tgecvrtlnght...dnvksvrfspnderlvsgssDgsi 246
           +++ +k  l  +  g +t+ ++  +f +ngk+ v g +dg+ +++d +     t+  vr+ +g +   + ++ ++ +p ++ ++++s D  i
   Q: 676  NIPDKKvaLWNEVDG-QTKLITAANFCQNGKYAVIGTYDGRCIFYDTEhlkyhTQIHVRSTRGRNkvgRKITGIEPLPGENKILVTSNDSRI 766
           **6666114555687.********************************66554333366666655666899999999*************** PP
   S: 247  riWdlrsgdllktlqlhnssvi 268
           r++dlr   l  ++++  +s++
   Q: 767  RLYDLRDLSLSMKYKGYVNSSS 788
           *****98887777776666655 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Downstream effector for RAB11. May be involved in vesicle recycling (By similarity).
 Downstream effector for RAB11. May be involved in vesicle recycling (By similarity).
Protein Sequence
(Fasta)
MASESDTEEF YDAPEDVHLG GGYPVGSPGK VGLSTFKETE NTAYKVGNES PVQELKQDVS 60
KKIIESIIEE SQKVLQLEDD SLDSKGKELS DQATASPIVA RTDLSNIPGL LAIDQVLPEE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046353|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CCCTCCGAAA TCTCGCGAGG GTAGGTGCGC GTCGGTATTT TGCGGGCAAC TAGCTCTTCC 60
AGCTGCTGTA AATTGCTGCT GCGGGAGAAA CTGGAGCCGC TGTAGCCGGC GCGCCCTTCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046353|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0967--Endosome
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0005829--C:cytosol
GO:0010008--C:endosome membrane
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
KEGG hsa:54521
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000228 Aegilops tauschii 37.67 9.00e-58 218.00
IUUC-Aml-001198 Ailuropoda melanoleuca 93.98 0.00e+00 1573.00
IUUC-Atr-002683 Amborella trichopoda 39.82 3.00e-54 207.00
IUUC-Apl-003781 Anas platyrhynchos 77.78 0.00e+00 1225.00
IUUC-Aca-005216 Anolis carolinensis 75.84 0.00e+00 1214.00
IUUC-Aly-005741 Arabidopsis lyrata 33.07 1.00e-53 205.00
IUUC-Ath-007063 Arabidopsis thaliana 32.57 1.00e-53 205.00
IUUC-Ago-007814 Ashbya gossypii 33.43 1.00e-42 167.00
IUUC-Acl-008290 Aspergillus clavatus 33.03 1.00e-60 228.00
IUUC-Afl-008536 Aspergillus flavus 41.77 4.00e-82 299.00
IUUC-Afu-008761 Aspergillus fumigatus 42.18 5.00e-89 322.00
IUUC-Ani-009270 Aspergillus nidulans 40.90 3.00e-82 300.00
IUUC-Ang-009627 Aspergillus niger 45.88 3.00e-80 294.00
IUUC-Aor-010153 Aspergillus oryzae 41.77 3.00e-82 300.00
IUUC-Ate-010263 Aspergillus terreus 41.08 2.00e-86 314.00
IUUC-Ame-011096 Astyanax mexicanus 77.43 0.00e+00 1007.00
IUUC-Bgr-012014 Blumeria graminis 39.03 3.00e-76 279.00
IUUC-Bta-012991 Bos taurus 92.22 0.00e+00 1551.00
IUUC-Bci-013651 Botrytis cinerea 34.61 2.00e-93 337.00
IUUC-Bdi-014809 Brachypodium distachyon 36.02 3.00e-60 226.00
IUUC-Bol-016459 Brassica oleracea 29.31 3.00e-57 217.00
IUUC-Bra-017437 Brassica rapa 40.38 2.00e-51 198.00
IUUC-Cel-018681 Caenorhabditis elegans 50.34 1.00e-122 434.00
IUUC-Cja-019169 Callithrix jacchus 97.48 0.00e+00 1646.00
IUUC-Cfa-020909 Canis familiaris 94.19 0.00e+00 1595.00
IUUC-Cpo-021357 Cavia porcellus 91.83 0.00e+00 1456.00
IUUC-Cre-022638 Chlamydomonas reinhardtii 33.50 2.00e-20 93.20
IUUC-Csa-023121 Chlorocebus sabaeus 98.24 0.00e+00 1630.00
IUUC-Cin-025347 Ciona intestinalis 50.73 8.00e-171 593.00
IUUC-Csv-025844 Ciona savignyi 56.31 6.00e-163 567.00
IUUC-Cgl-026610 Colletotrichum gloeosporioides 41.71 4.00e-83 303.00
IUUC-Cme-027130 Cyanidioschyzon merolae 35.16 2.00e-60 228.00
IUUC-Dre-028529 Danio rerio 67.24 0.00e+00 1058.00
IUUC-Dno-028930 Dasypus novemcinctus 90.43 0.00e+00 1014.00
IUUC-Dor-030184 Dipodomys ordii 85.54 0.00e+00 1349.00
IUUC-Dse-031178 Dothistroma septosporum 34.98 6.00e-91 329.00
IUUC-Dme-032135 Drosophila melanogaster 57.53 0.00e+00 677.00
IUUC-Ete-032457 Echinops telfairi 74.33 0.00e+00 1142.00
IUUC-Eca-033319 Equus caballus 94.66 0.00e+00 1576.00
IUUC-Eeu-035325 Erinaceus europaeus 76.73 0.00e+00 922.00
IUUC-Fca-036159 Felis catus 91.06 0.00e+00 1437.00
IUUC-Fal-037153 Ficedula albicollis 80.29 0.00e+00 1251.00
IUUC-Fox-037744 Fusarium oxysporum 42.48 3.00e-56 212.00
IUUC-Fso-038143 Fusarium solani 39.39 7.00e-79 289.00
IUUC-Gmo-039226 Gadus morhua 83.63 0.00e+00 960.00
IUUC-Ggr-039923 Gaeumannomyces graminis 42.12 5.00e-79 290.00
IUUC-Gga-040349 Gallus gallus 80.11 0.00e+00 1288.00
IUUC-Gac-041620 Gasterosteus aculeatus 67.17 0.00e+00 1033.00
IUUC-Gma-044105 Glycine max 49.09 4.00e-52 200.00
IUUC-Ggo-044646 Gorilla gorilla 99.78 0.00e+00 1677.00
IUUC-Hvu-047755 Hordeum vulgare 37.67 1.00e-57 218.00
IUUC-Itr-048620 Ictidomys tridecemlineatus 92.90 0.00e+00 1509.00
IUUC-Kpa-049365 Komagataella pastoris 32.20 2.00e-47 184.00
IUUC-Lch-049794 Latimeria chalumnae 73.33 0.00e+00 1189.00
IUUC-Lpe-051282 Leersia perrieri 35.95 2.00e-48 187.00
IUUC-Loc-052691 Lepisosteus oculatus 70.74 0.00e+00 1104.00
IUUC-Lma-053232 Leptosphaeria maculans 38.07 2.00e-81 297.00
IUUC-Laf-054066 Loxodonta africana 91.79 0.00e+00 1534.00
IUUC-Mcc-055055 Macaca mulatta 98.03 0.00e+00 1631.00
IUUC-Meu-056678 Macropus eugenii 70.09 0.00e+00 1116.00
IUUC-Mor-057274 Magnaporthe oryzae 43.77 5.00e-80 293.00
IUUC-Mpo-057592 Magnaporthe poae 41.71 1.00e-78 289.00
IUUC-Mtr-058330 Medicago truncatula 39.20 2.00e-52 201.00
IUUC-Mla-059075 Melampsora laricipopulina 35.88 5.00e-34 139.00
IUUC-Mga-059659 Meleagris gallopavo 79.48 0.00e+00 1272.00
IUUC-Mvi-060254 Microbotryum violaceum 45.93 2.00e-79 291.00
IUUC-Mmr-060832 Microcebus murinus 95.84 0.00e+00 1617.00
IUUC-Mdo-062300 Monodelphis domestica 82.15 0.00e+00 1383.00
IUUC-Mmu-064277 Mus musculus 91.92 0.00e+00 1520.00
IUUC-Mac-064816 Musa acuminata 38.42 3.00e-53 204.00
IUUC-Mpu-065914 Mustela putorius furo 91.18 0.00e+00 1545.00
IUUC-Mlu-067853 Myotis lucifugus 93.26 0.00e+00 1519.00
IUUC-Nfi-068449 Neosartorya fischeri 34.83 2.00e-61 230.00
IUUC-Ncr-068874 Neurospora crassa 44.63 3.00e-83 304.00
IUUC-Nle-069802 Nomascus leucogenys 99.12 0.00e+00 1656.00
IUUC-Opr-071139 Ochotona princeps 95.59 2.00e-175 609.00
IUUC-Ont-072128 Oreochromis niloticus 66.85 0.00e+00 1073.00
IUUC-Oan-072824 Ornithorhynchus anatinus 77.47 0.00e+00 964.00
IUUC-Ocu-074311 Oryctolagus cuniculus 93.32 0.00e+00 1568.00
IUUC-Oba-075809 Oryza barthii 35.16 8.00e-52 198.00
IUUC-Obr-076536 Oryza brachyantha 44.49 1.00e-48 187.00
IUUC-Ogl-077530 Oryza glaberrima 40.62 7.00e-60 225.00
IUUC-Ogu-077983 Oryza glumaepatula 34.93 1.00e-51 197.00
IUUC-Oin-080074 Oryza indica 40.62 7.00e-60 225.00
IUUC-Olo-080838 Oryza longistaminata 39.22 2.00e-38 154.00
IUUC-Ome-081629 Oryza meridionalis 35.16 2.00e-51 197.00
IUUC-Oni-082452 Oryza nivara 31.10 7.00e-62 232.00
IUUC-Opu-083458 Oryza punctata 43.73 1.00e-47 185.00
IUUC-Oru-084429 Oryza rufipogon 38.08 2.00e-56 215.00
IUUC-Osa-085616 Oryza sativa 40.62 5.00e-60 226.00
IUUC-Ola-086963 Oryzias latipes 63.98 0.00e+00 992.00
IUUC-Olu-087651 Ostreococcus lucimarinus 48.98 6.00e-51 194.00
IUUC-Oga-088623 Otolemur garnettii 93.64 0.00e+00 1519.00
IUUC-Oar-090357 Ovis aries 92.00 0.00e+00 1543.00
IUUC-Pan-092290 Papio anubis 96.35 0.00e+00 1522.00
IUUC-Psi-094089 Pelodiscus sinensis 81.20 0.00e+00 1292.00
IUUC-Pma-094528 Petromyzon marinus 68.95 0.00e+00 664.00
IUUC-Pno-094806 Phaeosphaeria nodorum 41.60 6.00e-82 298.00
IUUC-Ppa-095184 Physcomitrella patens 38.98 7.00e-62 232.00
IUUC-Pab-098364 Pongo abelii 97.81 0.00e+00 1629.00
IUUC-Pop-099728 Populus trichocarpa 34.99 9.00e-54 205.00
IUUC-Pca-100159 Procavia capensis 79.41 0.00e+00 1301.00
IUUC-Ppe-101329 Prunus persica 29.35 5.00e-57 216.00
IUUC-Pva-102846 Pteropus vampyrus 89.28 0.00e+00 1442.00
IUUC-Pte-104369 Pyrenophora teres 34.08 1.00e-85 311.00
IUUC-Pyt-104811 Pyrenophora triticirepentis 38.73 1.00e-85 311.00
IUUC-Rno-105467 Rattus norvegicus 91.59 0.00e+00 1528.00
IUUC-Sce-106277 Saccharomyces cerevisiae 35.31 2.00e-45 177.00
IUUC-Sha-106778 Sarcophilus harrisii 80.54 0.00e+00 1309.00
IUUC-Sja-107954 Schizosaccharomyces japonicus 40.92 2.00e-85 311.00
IUUC-Spo-108181 Schizosaccharomyces pombe 48.06 2.00e-84 307.00
IUUC-Smo-108748 Selaginella moellendorffii 42.39 2.00e-57 217.00
IUUC-Sit-110115 Setaria italica 39.88 1.00e-60 228.00
IUUC-Sly-111902 Solanum lycopersicum 29.44 9.00e-51 195.00
IUUC-Stu-112158 Solanum tuberosum 30.49 5.00e-52 199.00
IUUC-Sar-112958 Sorex araneus 92.09 6.00e-121 428.00
IUUC-Sbi-114454 Sorghum bicolor 36.91 6.00e-60 226.00
IUUC-Sre-114996 Sporisorium reilianum 36.34 9.00e-50 191.00
IUUC-Tgu-116614 Taeniopygia guttata 79.76 0.00e+00 1268.00
IUUC-Tru-117808 Takifugu rubripes 67.72 0.00e+00 1001.00
IUUC-Tsy-118845 Tarsius syrichta 84.73 0.00e+00 973.00
IUUC-Tni-120013 Tetraodon nigroviridis 66.35 0.00e+00 1018.00
IUUC-Tca-121052 Theobroma cacao 47.49 4.00e-45 177.00
IUUC-Tre-122175 Trichoderma reesei 43.55 4.00e-73 269.00
IUUC-Tvi-122654 Trichoderma virens 45.77 2.00e-79 290.00
IUUC-Tae-122935 Triticum aestivum 46.29 9.00e-56 212.00
IUUC-Tur-126660 Triticum urartu 32.03 1.00e-61 231.00
IUUC-Tme-126882 Tuber melanosporum 43.90 2.00e-98 353.00
IUUC-Tbe-127531 Tupaia belangeri 97.30 1.00e-178 620.00
IUUC-Ttr-128970 Tursiops truncatus 91.79 0.00e+00 1502.00
IUUC-Uma-129369 Ustilago maydis 36.20 8.00e-43 169.00
IUUC-Vda-129935 Verticillium dahliae 39.68 3.00e-80 293.00
IUUC-Vpa-130109 Vicugna pacos 84.12 0.00e+00 1311.00
IUUC-Vvi-130979 Vitis vinifera 35.00 1.00e-51 198.00
IUUC-Xtr-132836 Xenopus tropicalis 72.73 0.00e+00 1125.00
IUUC-Xma-134131 Xiphophorus maculatus 80.11 0.00e+00 1078.00
IUUC-Yli-134376 Yarrowia lipolytica 37.47 2.00e-63 238.00
IUUC-Zma-135851 Zea mays 37.11 1.00e-53 204.00
Created Date 25-Jun-2017

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