iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-045808

Ensembl Protein ID

ENSP00000339186.4

UniProt Accession

O75791; B7Z8I3; O43726; Q9NRB7; GRAP2_HUMAN

Genbank Protein ID

AAD04926.1; AAD41782.1; AAC69273.1; AAF60319.1; AAF60320.1; AAF31758.1; AAL58573.1; CAA77021.1; CAA09757.1; AAD13027.1; CAG30384.1; BAH13969.1; CAI42713.1; AAH25692.1; AAH26002.1

Protein Name

GRB2-related adapter protein 2; Adapter protein GRID; GRB-2-like protein; GRBLG; GRBX; Grf40 adapter protein; Growth factor receptor-binding protein; Hematopoietic cell-associated adapter protein GrpL; P38; Protein GADS; SH3-SH2-SH3 adapter Mona

Genbank Nucleotide ID

AF102694; AF129476; AF042380; AF236119; AF236120; AF121002; AY069959; Y18051; AJ011736; AF090456; CR456498; AK303470; Z82206; BC025692; BC026002

Gene Name

GRAP2; GADS; GRB2L; GRID

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000100351.16	ENST00000344138.8	ENSP00000339186.4

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.50e-29	102.7	277	328

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
           ++lyd+ea +ddeL +++G+vv+v+  ++ +  W+ g   l++k GlfP+n+v+ +
   Q: 277  RALYDFEALEDDELGFHSGEVVEVL--DSSNPSWWTG--RLHNKLGLFPANYVAPM 328
           79***********************..999*******..8*************875 PP

Organism

Homo sapiens

Functional Description
(View)

Interacts with phosphorylated LIME1 upon TCR activation (By similarity). Interacts with phosphorylated LAT and LAX1 upon TCR activation. Interacts with SHB. Interacts with PTPN23.

Protein Sequence
(Fasta)

MEAVAKFDFT ASGEDELSFH TGDVLKILSN QEEWFKAELG SQEGYVPKNF IDIQFPKWFH 60
EGLSRHQAEN LLMGKEVGFF IIRASQSSPG DFSISVRHED DVQHFKVMRD NKGNYFLWTE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACAGACTGCA GGGCTGACTA GGGTTAGTTT GGAGGAGGGA GTAAGAGGTG GGGAGGAGGA 60
GGCACAGTTA ATGGATCTGT AAACTTGCAC CCTCTTTCAG AGTGGTACAT GGAAGACAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0967--Endosome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0727--SH2 domain
KW-0728--SH3 domain

Interpro

IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50001--SH2
PS50002--SH3

Pfam

PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005768--C:endosome
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005634--C:nucleus
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0005070--F:SH3/SH2 adaptor activity
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0007267--P:cell-cell signaling
GO:0038095--P:Fc-epsilon receptor signaling pathway
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0007265--P:Ras protein signal transduction
GO:0042127--P:regulation of cell proliferation
GO:0031295--P:T cell costimulation
GO:0050852--P:T cell receptor signaling pathway
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

hsa:9402

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001994	Ailuropoda melanoleuca	86.36	8.00e-165	572.00
IUUC-Apl-003684	Anas platyrhynchos	61.28	2.00e-105	375.00
IUUC-Aca-005371	Anolis carolinensis	53.64	7.00e-93	333.00
IUUC-Ame-011392	Astyanax mexicanus	42.99	6.00e-68	250.00
IUUC-Bta-013508	Bos taurus	82.12	3.00e-155	540.00
IUUC-Cja-019613	Callithrix jacchus	82.46	1.00e-69	255.00
IUUC-Cfa-020290	Canis familiaris	86.67	4.00e-165	573.00
IUUC-Cpo-022534	Cavia porcellus	85.15	1.00e-160	558.00
IUUC-Csa-023438	Chlorocebus sabaeus	98.48	6.00e-168	583.00
IUUC-Cho-024466	Choloepus hoffmanni	61.62	4.00e-81	294.00
IUUC-Dre-027927	Danio rerio	46.46	4.00e-74	271.00
IUUC-Dno-029894	Dasypus novemcinctus	85.76	9.00e-162	562.00
IUUC-Dor-030493	Dipodomys ordii	94.12	3.00e-83	301.00
IUUC-Ete-032335	Echinops telfairi	75.76	2.00e-129	455.00
IUUC-Eca-033750	Equus caballus	88.18	7.00e-164	569.00
IUUC-Eeu-034884	Erinaceus europaeus	71.21	3.00e-117	414.00
IUUC-Fca-036001	Felis catus	86.97	1.00e-164	572.00
IUUC-Fal-036692	Ficedula albicollis	61.63	2.00e-104	372.00
IUUC-Gmo-039524	Gadus morhua	63.27	3.00e-53	201.00
IUUC-Gac-041301	Gasterosteus aculeatus	60.12	9.00e-58	217.00
IUUC-Ggo-045424	Gorilla gorilla	99.09	7.00e-168	582.00
IUUC-Itr-048000	Ictidomys tridecemlineatus	89.09	4.00e-156	543.00
IUUC-Lch-049610	Latimeria chalumnae	68.18	1.00e-55	209.00
IUUC-Loc-052925	Lepisosteus oculatus	46.87	6.00e-77	280.00
IUUC-Laf-054004	Loxodonta africana	88.48	1.00e-166	578.00
IUUC-Mcc-055020	Macaca mulatta	98.79	2.00e-168	584.00
IUUC-Meu-056169	Macropus eugenii	73.00	6.00e-125	440.00
IUUC-Mga-059483	Meleagris gallopavo	62.28	3.00e-109	388.00
IUUC-Mmr-061755	Microcebus murinus	91.21	4.00e-170	590.00
IUUC-Mdo-062504	Monodelphis domestica	72.89	1.00e-131	462.00
IUUC-Mmu-063557	Mus musculus	83.94	3.00e-155	540.00
IUUC-Mpu-066852	Mustela putorius furo	85.76	1.00e-164	572.00
IUUC-Mlu-067510	Myotis lucifugus	85.54	1.00e-162	565.00
IUUC-Nle-069691	Nomascus leucogenys	99.39	1.00e-168	585.00
IUUC-Opr-070271	Ochotona princeps	82.73	2.00e-150	525.00
IUUC-Ont-072651	Oreochromis niloticus	44.51	3.00e-69	255.00
IUUC-Oan-073183	Ornithorhynchus anatinus	72.51	5.00e-124	437.00
IUUC-Ocu-074899	Oryctolagus cuniculus	76.20	1.00e-134	472.00
IUUC-Ola-086462	Oryzias latipes	46.27	2.00e-71	262.00
IUUC-Oga-088553	Otolemur garnettii	87.69	3.00e-164	571.00
IUUC-Oar-089572	Ovis aries	83.69	2.00e-157	548.00
IUUC-Ptr-090582	Pan troglodytes	99.70	6.00e-169	586.00
IUUC-Pan-092063	Papio anubis	98.79	2.00e-168	584.00
IUUC-Psi-094056	Pelodiscus sinensis	64.95	2.00e-112	398.00
IUUC-Pfo-096115	Poecilia formosa	60.37	1.00e-56	213.00
IUUC-Pab-098217	Pongo abelii	99.39	2.00e-168	584.00
IUUC-Pca-100838	Procavia capensis	87.27	5.00e-157	546.00
IUUC-Pva-102559	Pteropus vampyrus	84.31	6.00e-130	456.00
IUUC-Rno-105926	Rattus norvegicus	72.75	4.00e-130	457.00
IUUC-Sha-106948	Sarcophilus harrisii	70.48	4.00e-124	437.00
IUUC-Ssc-115605	Sus scrofa	84.85	8.00e-155	539.00
IUUC-Tgu-117211	Taeniopygia guttata	59.57	9.00e-106	376.00
IUUC-Tru-118347	Takifugu rubripes	53.03	3.00e-57	214.00
IUUC-Tsy-119441	Tarsius syrichta	86.06	6.00e-163	566.00
IUUC-Tni-119732	Tetraodon nigroviridis	65.99	4.00e-56	211.00
IUUC-Tbe-127289	Tupaia belangeri	81.42	4.00e-137	480.00
IUUC-Ttr-128961	Tursiops truncatus	76.67	5.00e-145	506.00
IUUC-Vpa-130320	Vicugna pacos	77.66	2.00e-80	291.00
IUUC-Xtr-131814	Xenopus tropicalis	49.39	2.00e-79	288.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence