iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	AREsite	CircNet	microRNA
TRANSFAC	TargetScan	RepTar	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
PhosphositePlus
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	19690564

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.0044	19.2	256	293

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlC 45
           C iC++ f++ p+v+ C H f+++C  +++       + + rC +C
   Q: 256  CFICRQAFQN-PVVTKCRHYFCESCAlEHF-------RATPRCYIC 293
           9*********.999***********73555.......888889888 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MAAPPSPGRT ADQADQVCTF LFKKPGRKGA AGLRKRPACD PEHGESSSSG DEGDTVAQPP 60
RVAPRPRGLH SWQKAAHGDR RGEEAAPESL DVVYRSTRSA KPVGPEDMGA TADFEQDTEK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CACGGCCGTT GGGAGCCTGA GACTCAAACA TGGCAGCGCC ACCTTCTCCA GGAAGGACGG 60
CCGACCAAGC AGACCAGGTA TGCACCTTCC TCTTCAAAAA GCCTGGACGG AAAGGGGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000571--Znf_CCCH
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50103--ZF_C3H1
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00642--zf-CCCH

SMART

SM00184--RING
SM00356--ZnF_C3H1

Gene Ontology

GO:0005684--C:U2-type spliceosomal complex
GO:0008270--F:zinc ion binding
GO:0045292--P:mRNA cis splicing, via spliceosome
GO:0034247--P:snoRNA splicing

KEGG

hsa:140432

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Bol-016607	Brassica oleracea	40.00	2.00e-54	206.00
IUUC-Bra-017747	Brassica rapa	39.69	6.00e-55	207.00
IUUC-Cja-019764	Callithrix jacchus	87.74	1.00e-151	528.00
IUUC-Csa-023933	Chlorocebus sabaeus	91.85	7.00e-150	523.00
IUUC-Ggo-044612	Gorilla gorilla	97.52	3.00e-161	560.00
IUUC-Mla-058921	Melampsora laricipopulina	43.79	2.00e-35	141.00
IUUC-Nle-069057	Nomascus leucogenys	93.17	5.00e-161	560.00
IUUC-Ptr-090719	Pan troglodytes	99.07	2.00e-172	597.00
IUUC-Pab-098171	Pongo abelii	95.92	5.00e-162	563.00
IUUC-Uma-129339	Ustilago maydis	46.20	4.00e-48	185.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence