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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046622
UUCD1 version UUC-HoS-01259
Ensembl Protein ID ENSP00000317971.3
UniProt Accession Q8N5D0; D3DPL5; Q5SSC5; Q9NV87; Q9UPW4; WDTC1_HUMAN
Genbank Protein ID BAA91868.1; EAX07770.1; EAX07771.1; AAH32523.1; BAA82989.1
Protein Name WD and tetratricopeptide repeats protein 1
Genbank Nucleotide ID AK001734; AL590640; CH471059; BC032523; AB028960
Gene Name WDTC1; KIAA1037
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000142784.15 ENST00000361771.7 ENSP00000355317.3
ENSG00000142784.15 ENST00000447062.2 ENSP00000434578.1
ENSG00000142784.15 ENST00000319394.7 ENSP00000317971.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarmiRNAMapSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWAS Central
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtBioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD WD_repeat 17588513
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 2.30e-27 95.5 45 76
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDl 30
           gH++ v+cl++   ++ll+sGsdD    vWD+
   Q: 45   GHSGCVNCLEWneKGDLLASGSDDQHTIVWDP 76
           8**********65339***************6 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
 May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
Protein Sequence
(Fasta)
MAKVNITRDL IRRQIKERGA LSFERRYHVT DPFIRRLGLE AELQGHSGCV NCLEWNEKGD 60
LLASGSDDQH TIVWDPLHHK KLLSMHTGHT ANIFSVKFLP HAGDRILITG AADSKVHVHD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046622|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AAGTGGGGGG GCCCGGCTAG CCATTCTGGA AGCGGCCGGG CGCAGTCTTC GTAGCGTACC 60
CGCCGGCTGC GAGGCGCAGG GCGGAGGCGG AGACTGCGTG GCGCAGGCGC GTTGCTGGGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046622|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0802--TPR repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
Interpro

IPR013026--TPR-contain_dom
IPR011990--TPR-like_helical_dom
IPR019734--TPR_repeat
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50293--TPR_REGION
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
SMART

SM00028--TPR
SM00320--WD40
Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0004857--F:enzyme inhibitor activity
GO:0055082--P:cellular chemical homeostasis
GO:0032869--P:cellular response to insulin stimulus
GO:0006006--P:glucose metabolic process
GO:0001701--P:in utero embryonic development
GO:0035264--P:multicellular organism growth
GO:0045717--P:negative regulation of fatty acid biosynthetic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0016567--P:protein ubiquitination
GO:0008361--P:regulation of cell size
KEGG hsa:23038
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000083 Aegilops tauschii 29.02 1.00e-57 218.00
IUUC-Aml-001699 Ailuropoda melanoleuca 98.67 0.00e+00 1356.00
IUUC-Atr-002509 Amborella trichopoda 31.31 1.00e-50 194.00
IUUC-Apl-003379 Anas platyrhynchos 93.35 0.00e+00 1289.00
IUUC-Aca-005202 Anolis carolinensis 90.56 0.00e+00 1259.00
IUUC-Aly-006475 Arabidopsis lyrata 31.49 8.00e-54 205.00
IUUC-Ath-007666 Arabidopsis thaliana 30.95 4.00e-53 203.00
IUUC-Afl-008592 Aspergillus flavus 27.97 7.00e-26 113.00
IUUC-Ani-009263 Aspergillus nidulans 27.35 3.00e-25 110.00
IUUC-Ang-009671 Aspergillus niger 27.32 3.00e-26 115.00
IUUC-Aor-010229 Aspergillus oryzae 27.68 6.00e-26 113.00
IUUC-Ame-010988 Astyanax mexicanus 81.68 0.00e+00 1006.00
IUUC-Bdi-014100 Brachypodium distachyon 29.67 8.00e-50 192.00
IUUC-Bol-016409 Brassica oleracea 31.75 5.00e-52 199.00
IUUC-Bra-016979 Brassica rapa 31.32 2.00e-51 197.00
IUUC-Cel-018561 Caenorhabditis elegans 32.73 2.00e-34 140.00
IUUC-Cja-019212 Callithrix jacchus 97.19 0.00e+00 1310.00
IUUC-Cfa-020200 Canis familiaris 98.53 0.00e+00 1354.00
IUUC-Cpo-021739 Cavia porcellus 98.67 0.00e+00 1353.00
IUUC-Cre-022659 Chlamydomonas reinhardtii 33.85 2.00e-34 140.00
IUUC-Csa-023648 Chlorocebus sabaeus 100.00 0.00e+00 1358.00
IUUC-Cin-025155 Ciona intestinalis 44.56 2.00e-63 236.00
IUUC-Csv-026289 Ciona savignyi 46.25 9.00e-149 520.00
IUUC-Cme-027316 Cyanidioschyzon merolae 27.99 5.00e-26 113.00
IUUC-Dre-028745 Danio rerio 80.80 0.00e+00 1115.00
IUUC-Dno-029403 Dasypus novemcinctus 93.21 0.00e+00 1265.00
IUUC-Dor-030332 Dipodomys ordii 88.22 0.00e+00 1221.00
IUUC-Dme-031811 Drosophila melanogaster 37.56 2.00e-109 389.00
IUUC-Ete-032331 Echinops telfairi 82.24 0.00e+00 723.00
IUUC-Eca-033783 Equus caballus 98.38 0.00e+00 1355.00
IUUC-Eeu-034732 Erinaceus europaeus 95.43 0.00e+00 1300.00
IUUC-Fca-036543 Felis catus 98.67 0.00e+00 1356.00
IUUC-Fal-037245 Ficedula albicollis 92.71 0.00e+00 1300.00
IUUC-Gmo-039346 Gadus morhua 78.47 0.00e+00 1121.00
IUUC-Gga-041034 Gallus gallus 93.21 0.00e+00 1285.00
IUUC-Gac-041297 Gasterosteus aculeatus 79.65 0.00e+00 1113.00
IUUC-Gma-042727 Glycine max 31.62 9.00e-50 192.00
IUUC-Ggo-045309 Gorilla gorilla 100.00 0.00e+00 1358.00
IUUC-Itr-049052 Ictidomys tridecemlineatus 97.99 0.00e+00 1173.00
IUUC-Lch-049810 Latimeria chalumnae 85.67 0.00e+00 1162.00
IUUC-Lpe-051600 Leersia perrieri 27.31 6.00e-67 249.00
IUUC-Loc-052088 Lepisosteus oculatus 85.67 0.00e+00 1188.00
IUUC-Laf-054097 Loxodonta africana 98.82 0.00e+00 1354.00
IUUC-Mcc-054848 Macaca mulatta 100.00 0.00e+00 1358.00
IUUC-Meu-056022 Macropus eugenii 73.47 0.00e+00 812.00
IUUC-Mtr-057735 Medicago truncatula 30.64 6.00e-47 182.00
IUUC-Mga-059622 Meleagris gallopavo 93.21 0.00e+00 1285.00
IUUC-Mmr-060709 Microcebus murinus 99.26 0.00e+00 1357.00
IUUC-Mdo-062401 Monodelphis domestica 95.86 0.00e+00 1310.00
IUUC-Mmu-063899 Mus musculus 96.46 0.00e+00 1324.00
IUUC-Mac-064840 Musa acuminata 31.50 5.00e-49 189.00
IUUC-Mpu-066268 Mustela putorius furo 98.53 0.00e+00 1353.00
IUUC-Mlu-067211 Myotis lucifugus 99.03 0.00e+00 855.00
IUUC-Nle-070019 Nomascus leucogenys 99.85 0.00e+00 1335.00
IUUC-Opr-071008 Ochotona princeps 98.52 0.00e+00 1352.00
IUUC-Ont-072123 Oreochromis niloticus 80.97 0.00e+00 1140.00
IUUC-Ocu-074166 Oryctolagus cuniculus 98.52 0.00e+00 1353.00
IUUC-Oba-075298 Oryza barthii 29.05 8.00e-43 169.00
IUUC-Obr-076849 Oryza brachyantha 33.77 4.00e-37 149.00
IUUC-Ogl-077515 Oryza glaberrima 29.05 1.00e-42 168.00
IUUC-Ogu-077968 Oryza glumaepatula 29.05 1.00e-38 154.00
IUUC-Oin-079231 Oryza indica 28.96 1.00e-37 151.00
IUUC-Olo-081045 Oryza longistaminata 34.40 1.00e-31 133.00
IUUC-Ome-081395 Oryza meridionalis 29.17 3.00e-37 150.00
IUUC-Oni-082801 Oryza nivara 29.05 2.00e-42 167.00
IUUC-Opu-083585 Oryza punctata 29.12 1.00e-42 168.00
IUUC-Oru-085163 Oryza rufipogon 33.77 2.00e-36 147.00
IUUC-Osa-085550 Oryza sativa 33.60 8.00e-29 120.00
IUUC-Ola-086925 Oryzias latipes 78.61 0.00e+00 1101.00
IUUC-Oga-088095 Otolemur garnettii 97.20 0.00e+00 1349.00
IUUC-Oar-090285 Ovis aries 96.76 0.00e+00 1315.00
IUUC-Ptr-091221 Pan troglodytes 100.00 0.00e+00 1358.00
IUUC-Pan-091771 Papio anubis 100.00 0.00e+00 1358.00
IUUC-Psi-093977 Pelodiscus sinensis 92.17 0.00e+00 1274.00
IUUC-Ppa-095373 Physcomitrella patens 30.67 1.00e-48 187.00
IUUC-Pfo-096640 Poecilia formosa 80.35 0.00e+00 1122.00
IUUC-Pab-098513 Pongo abelii 100.00 0.00e+00 1358.00
IUUC-Pop-098837 Populus trichocarpa 31.25 3.00e-45 177.00
IUUC-Pca-101095 Procavia capensis 90.10 0.00e+00 1202.00
IUUC-Ppe-101507 Prunus persica 29.94 1.00e-47 185.00
IUUC-Pva-102444 Pteropus vampyrus 98.67 0.00e+00 1354.00
IUUC-Rno-105952 Rattus norvegicus 97.49 0.00e+00 1332.00
IUUC-Sha-106614 Sarcophilus harrisii 96.16 0.00e+00 1318.00
IUUC-Smo-108844 Selaginella moellendorffii 32.34 1.00e-45 177.00
IUUC-Sit-110154 Setaria italica 28.57 2.00e-66 247.00
IUUC-Sly-111707 Solanum lycopersicum 31.96 3.00e-49 190.00
IUUC-Sar-113129 Sorex araneus 82.30 0.00e+00 1090.00
IUUC-Sbi-113858 Sorghum bicolor 28.16 5.00e-61 229.00
IUUC-Ssc-116275 Sus scrofa 98.97 0.00e+00 1356.00
IUUC-Tgu-117507 Taeniopygia guttata 93.21 0.00e+00 1288.00
IUUC-Tru-117969 Takifugu rubripes 78.47 0.00e+00 1123.00
IUUC-Tsy-119374 Tarsius syrichta 87.20 0.00e+00 865.00
IUUC-Tni-119887 Tetraodon nigroviridis 77.08 0.00e+00 1070.00
IUUC-Tca-121722 Theobroma cacao 32.90 2.00e-49 191.00
IUUC-Tae-124583 Triticum aestivum 30.20 1.00e-42 168.00
IUUC-Tur-125968 Triticum urartu 35.34 2.00e-33 139.00
IUUC-Tme-126910 Tuber melanosporum 34.26 3.00e-24 107.00
IUUC-Tbe-127511 Tupaia belangeri 92.31 1.00e-90 326.00
IUUC-Ttr-128390 Tursiops truncatus 95.63 0.00e+00 1282.00
IUUC-Uma-129509 Ustilago maydis 27.85 2.00e-13 71.60
IUUC-Vpa-130124 Vicugna pacos 59.11 2.00e-147 516.00
IUUC-Vvi-131565 Vitis vinifera 29.08 2.00e-34 141.00
IUUC-Xtr-132290 Xenopus tropicalis 77.53 0.00e+00 1063.00
IUUC-Xma-134025 Xiphophorus maculatus 79.91 0.00e+00 1117.00
Created Date 25-Jun-2017

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