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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046182
UUCD1 version UUC-HoS-00905
Ensembl Protein ID ENSP00000262715.5
UniProt Accession Q99973; A0AUV9; TEP1_HUMAN
Genbank Protein ID AAC51107.1; AAI26108.1; CAE45993.1
Protein Name Telomerase protein component 1; Telomerase-associated protein 1; p240; p80 telomerase homolog
Genbank Nucleotide ID U86136; BC126107; BX640983
Gene Name TEP1; TLP1; TP1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000129566.12 ENST00000553365.5 ENSP00000450475.1
ENSG00000129566.12 ENST00000262715.9 ENSP00000262715.5
ENSG00000129566.12 ENST00000555008.5 ENSP00000450541.1
ENSG00000129566.12 ENST00000555727.5 ENSP00000451634.1
ENSG00000129566.12 ENST00000556935.5 ENSP00000452574.1
ENSG00000129566.12 ENST00000553984.1 ENSP00000450508.1
ENSG00000129566.12 ENST00000557314.5 ENSP00000450830.1
ENSG00000129566.12 ENST00000556488.5 ENSP00000451409.1
ENSG00000129566.12 ENST00000471684.2 ENSP00000451919.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
InWeb_IM
Disease-associated Variation
GWASdbOMIM
Drug and target
TTD
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDBioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.70e-54 181.0 2106 2138
UBD/Beta-Prp 1.40e-79 269.1 2013 2190
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf.sdtllvsGsdDgtikvWDlrtg 33
           H d+vt++a+  d+ll+s+s Dg++ +WD+ +g
   Q: 2106 HRDWVTGCAWtKDNLLISCSSDGSVGLWDPESG 2138
           9*********877****************8877 PP
   

   UBD/Beta-Prp
   S: 53   aevtavkfspdgkilvtgseDrtikvw.........dlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqclee.. 131
           ++v  +  s++  +l+++seD t+++w           ++++c   l+ghe  v ++sfs +g +l++G++dr + +wd++t +      
   Q: 2013 KPVLGLATSQE--LLASASEDFTVQLWprqlltrphKAEDFPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLih 2100
           55666666666..9*************666655555555******************************************988654445 PP
   S: 132  .tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlng 220
            + + h+++v++ ++ + +nll+s+s D+ v lWd ++g+ l ++ g h+++v  ++  +  +++vs+s+dgt+k+wd q  e + +  +
   Q: 2101 sFPACHRDWVTGCAWTK-DNLLISCSSDGSVGLWDPESGQRLGQFLG-HQSAVSAVAAVE--EHVVSVSRDGTLKVWDHQGVE-LTSIPA 2185
           6999*********9999.99**************************9.******999888..69**************98544.566666 PP
   S: 221  htdnv 225
           h+ ++
   Q: 2186 HSGPI 2190
           66555 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini. Also component of the ribonucleoprotein vaults particle, a multi-subunit structure involved in nucleo-cytoplasmic transport. Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to TERC (By similarity).
 Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini. Also component of the ribonucleoprotein vaults particle, a multi-subunit structure involved in nucleo-cytoplasmic transport. Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to TERC (By similarity).
Protein Sequence
(Fasta)
MEKLHGHVSA HPDILSLENR CLAMLPDLQP LEKLHQHVST HSDILSLKNQ CLATLPDLKT 60
MEKPHGYVSA HPDILSLENQ CLATLSDLKT MEKPHGHVSA HPDILSLENR CLATLSSLKS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046182|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CTGCTGCGGG AATCGGACGC CCCAGGTCAG GCACCCAGGG TTTCCAGCCC CAGTCTAAGG 60
TAGGGTCCGA GCGCAGGCAG AACTTGCCCT GGCCCTGGGT CTAGGGCGCT GGGCTCTGAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046182|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0687--Ribonucleoprotein
KW-0694--RNA-binding
KW-0779--Telomere
KW-0853--WD repeat
Interpro

IPR025139--DUF4062
IPR007111--NACHT_NTPase
IPR027417--P-loop_NTPase
IPR023302--Pept_S9A_N
IPR008850--TEP1_N
IPR008858--TROVE_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS50837--NACHT
PS51226--TEP1_N
PS50988--TROVE
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF13271--DUF4062
PF05386--TEP1_N
PF05731--TROVE
PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0071013--C:catalytic step 2 spliceosome
GO:0000781--C:chromosome, telomeric region
GO:0005737--C:cytoplasm
GO:0030529--C:intracellular ribonucleoprotein complex
GO:0016363--C:nuclear matrix
GO:0071011--C:precatalytic spliceosome
GO:0005697--C:telomerase holoenzyme complex
GO:0005682--C:U5 snRNP
GO:0005524--F:ATP binding
GO:0019899--F:enzyme binding
GO:0002039--F:p53 binding
GO:0003723--F:RNA binding
GO:0003720--F:telomerase activity
GO:0070034--F:telomerase RNA binding
GO:0008380--P:RNA splicing
GO:0000722--P:telomere maintenance via recombination
KEGG hsa:7011
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001482 Ailuropoda melanoleuca 78.50 0.00e+00 3889.00
IUUC-Aca-005102 Anolis carolinensis 42.46 0.00e+00 1653.00
IUUC-Ame-011165 Astyanax mexicanus 32.67 0.00e+00 788.00
IUUC-Bta-012323 Bos taurus 79.26 0.00e+00 3947.00
IUUC-Cja-019005 Callithrix jacchus 92.41 0.00e+00 4841.00
IUUC-Cfa-020803 Canis familiaris 71.97 0.00e+00 3439.00
IUUC-Cpo-022312 Cavia porcellus 75.08 0.00e+00 3553.00
IUUC-Csa-023287 Chlorocebus sabaeus 94.75 0.00e+00 4860.00
IUUC-Dre-028825 Danio rerio 35.38 0.00e+00 1165.00
IUUC-Dno-029455 Dasypus novemcinctus 78.70 0.00e+00 3818.00
IUUC-Dor-030328 Dipodomys ordii 74.01 0.00e+00 2621.00
IUUC-Ete-032385 Echinops telfairi 73.78 0.00e+00 1955.00
IUUC-Eca-033726 Equus caballus 82.83 0.00e+00 4167.00
IUUC-Eeu-034665 Erinaceus europaeus 62.15 0.00e+00 956.00
IUUC-Fca-035365 Felis catus 80.03 0.00e+00 3984.00
IUUC-Gmo-039584 Gadus morhua 31.72 3.00e-121 430.00
IUUC-Gac-042307 Gasterosteus aculeatus 35.79 0.00e+00 1036.00
IUUC-Ggo-045432 Gorilla gorilla 96.02 0.00e+00 4741.00
IUUC-Itr-049021 Ictidomys tridecemlineatus 80.23 0.00e+00 4041.00
IUUC-Lch-050186 Latimeria chalumnae 38.49 1.00e-78 287.00
IUUC-Laf-054524 Loxodonta africana 78.82 0.00e+00 3997.00
IUUC-Mcc-055628 Macaca mulatta 95.43 0.00e+00 4885.00
IUUC-Meu-056338 Macropus eugenii 63.47 0.00e+00 1313.00
IUUC-Mmr-060854 Microcebus murinus 83.54 0.00e+00 4186.00
IUUC-Mdo-062247 Monodelphis domestica 60.09 0.00e+00 2819.00
IUUC-Mmu-064406 Mus musculus 74.52 0.00e+00 3724.00
IUUC-Mpu-065806 Mustela putorius furo 77.88 0.00e+00 3922.00
IUUC-Mlu-068116 Myotis lucifugus 81.02 0.00e+00 3935.00
IUUC-Nle-069628 Nomascus leucogenys 95.00 0.00e+00 4348.00
IUUC-Opr-070242 Ochotona princeps 79.51 0.00e+00 2897.00
IUUC-Oan-073598 Ornithorhynchus anatinus 52.67 0.00e+00 1960.00
IUUC-Ocu-073933 Oryctolagus cuniculus 80.55 0.00e+00 3963.00
IUUC-Ola-086886 Oryzias latipes 35.31 0.00e+00 1065.00
IUUC-Oga-088609 Otolemur garnettii 80.94 0.00e+00 4022.00
IUUC-Oar-089957 Ovis aries 78.67 0.00e+00 3830.00
IUUC-Ptr-090577 Pan troglodytes 96.99 0.00e+00 4972.00
IUUC-Pan-092397 Papio anubis 94.67 0.00e+00 4841.00
IUUC-Pma-094373 Petromyzon marinus 35.31 7.00e-77 281.00
IUUC-Pfo-096497 Poecilia formosa 35.89 0.00e+00 1081.00
IUUC-Pab-098028 Pongo abelii 96.50 0.00e+00 4910.00
IUUC-Pca-101002 Procavia capensis 83.57 0.00e+00 1915.00
IUUC-Pva-102144 Pteropus vampyrus 74.19 0.00e+00 1739.00
IUUC-Rno-105828 Rattus norvegicus 74.11 0.00e+00 3759.00
IUUC-Sha-106469 Sarcophilus harrisii 60.70 0.00e+00 2921.00
IUUC-Sar-113035 Sorex araneus 77.24 0.00e+00 1465.00
IUUC-Ssc-116122 Sus scrofa 82.59 0.00e+00 3012.00
IUUC-Tru-118412 Takifugu rubripes 32.69 0.00e+00 1154.00
IUUC-Tsy-119257 Tarsius syrichta 77.26 0.00e+00 1635.00
IUUC-Tni-120032 Tetraodon nigroviridis 33.33 8.00e-39 154.00
IUUC-Tbe-127312 Tupaia belangeri 68.33 0.00e+00 1035.00
IUUC-Ttr-128335 Tursiops truncatus 80.56 0.00e+00 3468.00
IUUC-Xtr-132524 Xenopus tropicalis 39.53 0.00e+00 1405.00
Created Date 25-Jun-2017

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