iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Rno-105825

Ensembl Protein ID

ENSRNOP00000016608.2

UniProt Accession

Q920G0; SKAP2_RAT

Genbank Protein ID

AAK97262.1; AAH70949.1

Protein Name

Src kinase-associated phosphoprotein 2; SKAP55 homolog; Src family-associated phosphoprotein 2; Src kinase-associated phosphoprotein 55-related protein

Genbank Nucleotide ID

AF302132; BC070949

Gene Name

Skap2; Scap2; Skap55r

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000012228.2	ENSRNOT00000016608.2	ENSRNOP00000016608.2

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	miRNAMap	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	UniProt
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.00e-11	44.1	301	354

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 6    vqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
            q l+d +++ +deL++k+Gdv+++++ke +  gW++g  e +g  Gl+P+ +  +
   Q: 301  YQGLWDCTGSLSDELSFKRGDVIYILSKEYNRYGWWVG--EMQGAIGLVPKAYLME 354
           5778999999****************************..9**********99765 PP

Organism

Rattus norvegicus

Functional Description
(View)

May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway (By similarity).

Protein Sequence
(Fasta)

MPNPGSTSSP GSIPEEIRNL LADVETFVAD TLKGENLSKK AKEKRDSLIK KIKDVKSVYP 60
QEFQDKGDAE EGDEYDDPFA GPPDTISLAS ERYDKDDDGP SDGNQFPPIA AQDLSFVIKA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGCGTCCAG CGACCGCTGC CTGGACAGCC AGTGACTTCC TTGTTGTGGG TCTCGGCCAG 60
GTCGTGTCCC GAGTCGTAGC CCCGCGGTGC TTACTCGGAC CGCTTTTGCA AGTCTAGGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0075--B-cell activation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR011993--PH_dom-like
IPR001849--PH_domain
IPR001452--SH3_domain

PROSITE

PS50003--PH_DOMAIN
PS50002--SH3

Pfam

PF00169--PH
PF00018--SH3_1

PRINTS

PR00452--SH3DOMAIN

SMART

SM00233--PH
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005886--C:plasma membrane
GO:0005070--F:SH3/SH2 adaptor activity
GO:0042113--P:B cell activation
GO:0002757--P:immune response-activating signal transduction
GO:0008285--P:negative regulation of cell proliferation

KEGG

rno:155183

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001212	Ailuropoda melanoleuca	86.63	4.00e-176	610.00
IUUC-Apl-003565	Anas platyrhynchos	70.77	1.00e-99	355.00
IUUC-Aca-005159	Anolis carolinensis	70.34	3.00e-125	441.00
IUUC-Ame-011510	Astyanax mexicanus	60.12	4.00e-108	384.00
IUUC-Bta-013222	Bos taurus	86.59	1.00e-170	592.00
IUUC-Cja-019091	Callithrix jacchus	83.33	4.00e-175	607.00
IUUC-Cfa-020492	Canis familiaris	85.52	4.00e-169	587.00
IUUC-Cpo-021974	Cavia porcellus	85.51	2.00e-162	565.00
IUUC-Csa-023195	Chlorocebus sabaeus	87.45	3.00e-122	430.00
IUUC-Cho-024462	Choloepus hoffmanni	78.33	1.00e-157	548.00
IUUC-Dre-027975	Danio rerio	47.53	1.00e-56	213.00
IUUC-Dno-029759	Dasypus novemcinctus	81.94	5.00e-168	583.00
IUUC-Dor-030116	Dipodomys ordii	76.82	2.00e-148	518.00
IUUC-Eca-034293	Equus caballus	82.45	1.00e-166	578.00
IUUC-Fca-036423	Felis catus	86.03	2.00e-173	601.00
IUUC-Fal-037146	Ficedula albicollis	66.78	2.00e-109	388.00
IUUC-Gmo-039059	Gadus morhua	57.31	1.00e-85	309.00
IUUC-Gga-040385	Gallus gallus	68.97	2.00e-113	402.00
IUUC-Gac-042122	Gasterosteus aculeatus	56.86	1.00e-93	336.00
IUUC-Ggo-044961	Gorilla gorilla	87.74	3.00e-176	610.00
IUUC-Hsa-046197	Homo sapiens	87.74	6.00e-177	613.00
IUUC-Lch-049485	Latimeria chalumnae	70.36	2.00e-109	388.00
IUUC-Loc-052335	Lepisosteus oculatus	62.36	7.00e-107	380.00
IUUC-Laf-053622	Loxodonta africana	86.15	4.00e-173	600.00
IUUC-Mcc-055725	Macaca mulatta	88.02	3.00e-177	613.00
IUUC-Meu-056098	Macropus eugenii	76.72	1.00e-151	528.00
IUUC-Mga-059932	Meleagris gallopavo	74.61	2.00e-108	384.00
IUUC-Mmr-061781	Microcebus murinus	81.34	3.00e-155	540.00
IUUC-Mdo-062502	Monodelphis domestica	73.89	4.00e-143	500.00
IUUC-Mmu-063978	Mus musculus	93.85	0.00e+00	655.00
IUUC-Mpu-065930	Mustela putorius furo	85.24	1.00e-172	598.00
IUUC-Mlu-067603	Myotis lucifugus	84.82	1.00e-109	388.00
IUUC-Nle-069223	Nomascus leucogenys	87.47	2.00e-176	611.00
IUUC-Opr-070422	Ochotona princeps	65.64	2.00e-112	399.00
IUUC-Ont-072351	Oreochromis niloticus	56.20	1.00e-103	369.00
IUUC-Oan-073125	Ornithorhynchus anatinus	84.05	2.00e-120	424.00
IUUC-Ocu-074410	Oryctolagus cuniculus	84.12	3.00e-157	547.00
IUUC-Ola-087314	Oryzias latipes	50.68	1.00e-90	326.00
IUUC-Oga-087912	Otolemur garnettii	83.84	9.00e-168	582.00
IUUC-Oar-089480	Ovis aries	87.43	2.00e-171	594.00
IUUC-Ptr-091579	Pan troglodytes	87.74	6.00e-177	613.00
IUUC-Pan-092200	Papio anubis	81.62	7.00e-157	546.00
IUUC-Psi-093510	Pelodiscus sinensis	73.73	2.00e-101	361.00
IUUC-Pfo-096925	Poecilia formosa	57.18	8.00e-101	360.00
IUUC-Pab-097723	Pongo abelii	86.63	2.00e-174	605.00
IUUC-Pca-100318	Procavia capensis	84.72	1.00e-174	605.00
IUUC-Pva-102860	Pteropus vampyrus	85.52	6.00e-175	606.00
IUUC-Sha-107224	Sarcophilus harrisii	76.02	1.00e-128	452.00
IUUC-Sar-112982	Sorex araneus	78.87	3.00e-139	487.00
IUUC-Ssc-115926	Sus scrofa	86.35	5.00e-175	606.00
IUUC-Tgu-116935	Taeniopygia guttata	70.70	2.00e-103	368.00
IUUC-Tru-118152	Takifugu rubripes	49.58	5.00e-90	324.00
IUUC-Tsy-119643	Tarsius syrichta	79.94	6.00e-154	536.00
IUUC-Tni-120040	Tetraodon nigroviridis	55.43	4.00e-103	367.00
IUUC-Tbe-127242	Tupaia belangeri	84.96	2.00e-145	508.00
IUUC-Ttr-128482	Tursiops truncatus	76.88	7.00e-140	489.00
IUUC-Vpa-130355	Vicugna pacos	43.55	3.00e-70	258.00
IUUC-Xtr-132597	Xenopus tropicalis	56.20	1.00e-95	343.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence