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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Dme-031608
Ensembl Protein ID FBpp0071283
UniProt Accession Q9W385; Q9GQQ7; FRDA_DROME
Genbank Protein ID CAC20098.1; AAG35732.1; AAG35733.1; AAF46449.1; AAM11002.1
Protein Name Frataxin homolog, mitochondrial
Genbank Nucleotide ID AJ002208; AF208491; AF208492; AE014298; AY094649
Gene Name fh; CG8971
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0030092 FBtr0333477 FBpp0305664
FBgn0030092 FBtr0071348 FBpp0071283
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
iRefIndexMentha
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/Other/Other 53.28 4.00e-32 135.00 IUUC-Hsa-046921
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Drosophila melanogaster
Functional Description
(View)

Functional Description


     Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+). May be able to store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization.
 Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+). May be able to store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization.
Protein Sequence
(Fasta)
MFAGRLMVRS IVGRACLATM GRWSKPQAHA SQVILPSTPA IAAVAIQCEE FTANRRLFSS 60
QIETESTLDG ATYERVCSDT LDALCDYFEE LTENASELQG TDVAYSDGVL TVNLGGQHGT 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Dme-031608|UBD,UBD/Other/Other|Drosophila melanogaster
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGTTGGCAGC CCCGCAACTG GGATTTGTAA AATATAAACA AATCGTAAAC AACTAAAAAA 60
TGTTTGCCGG TCGTTTGATG GTCCGTTCGA TCGTTGGTCG GGCATGCTTG GCCACCATGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Dme-031608|UBD,UBD/Other/Other|Drosophila melanogaster
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0350--Heme biosynthesis
KW-0406--Ion transport
KW-0408--Iron
KW-0409--Iron storage
KW-0410--Iron transport
KW-0496--Mitochondrion
KW-0560--Oxidoreductase
KW-1185--Reference proteome
KW-0809--Transit peptide
KW-0813--Transport
Interpro

IPR017789--Frataxin
IPR002908--Frataxin/CyaY
IPR020895--Frataxin_CS
PROSITE

PS01344--FRATAXIN_1
PS50810--FRATAXIN_2
Pfam

PF01491--Frataxin_Cyay
PRINTS

PR00904--FRATAXIN
SMART

SM01219--Frataxin_Cyay
Gene Ontology

GO:1904115--C:axon cytoplasm
GO:0005739--C:mitochondrion
GO:0051537--F:2 iron, 2 sulfur cluster binding
GO:0008199--F:ferric iron binding
GO:0008198--F:ferrous iron binding
GO:0004322--F:ferroxidase activity
GO:0034986--F:iron chaperone activity
GO:0008344--P:adult locomotory behavior
GO:0019896--P:axonal transport of mitochondrion
GO:0006879--P:cellular iron ion homeostasis
GO:0034599--P:cellular response to oxidative stress
GO:0008340--P:determination of adult lifespan
GO:0006783--P:heme biosynthetic process
GO:0006811--P:ion transport
GO:0018283--P:iron incorporation into metallo-sulfur cluster
GO:0016042--P:lipid catabolic process
GO:0007005--P:mitochondrion organization
GO:0045998--P:positive regulation of ecdysteroid biosynthetic process
GO:0045823--P:positive regulation of heart contraction
GO:0035073--P:pupariation
GO:0051881--P:regulation of mitochondrial membrane potential
GO:0042542--P:response to hydrogen peroxide
GO:0010039--P:response to iron ion
GO:0006979--P:response to oxidative stress
KEGG dme:Dmel_CG8971
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002122 Ailuropoda melanoleuca 52.03 1.00e-32 131.00
IUUC-Apl-003853 Anas platyrhynchos 55.26 4.00e-33 132.00
IUUC-Aca-005026 Anolis carolinensis 53.04 3.00e-33 132.00
IUUC-Aly-006200 Arabidopsis lyrata 38.66 2.00e-17 81.30
IUUC-Ath-007033 Arabidopsis thaliana 39.45 3.00e-17 80.10
IUUC-Ago-007707 Ashbya gossypii 42.00 8.00e-17 78.20
IUUC-Acl-008146 Aspergillus clavatus 36.51 3.00e-16 77.40
IUUC-Afl-008501 Aspergillus flavus 38.26 3.00e-15 73.90
IUUC-Afu-008851 Aspergillus fumigatus 36.51 3.00e-17 80.90
IUUC-Ani-009129 Aspergillus nidulans 35.04 1.00e-12 65.50
IUUC-Ang-009557 Aspergillus niger 36.51 7.00e-17 79.70
IUUC-Ate-010486 Aspergillus terreus 37.30 2.00e-17 81.60
IUUC-Bgr-012108 Blumeria graminis 41.28 1.00e-16 78.60
IUUC-Bta-013437 Bos taurus 53.45 1.00e-31 128.00
IUUC-Bci-013810 Botrytis cinerea 58.44 1.00e-18 85.50
IUUC-Bdi-014226 Brachypodium distachyon 38.74 1.00e-20 92.00
IUUC-Bol-015092 Brassica oleracea 40.00 3.00e-17 80.50
IUUC-Bra-017945 Brassica rapa 33.82 2.00e-19 87.40
IUUC-Cel-018466 Caenorhabditis elegans 47.79 4.00e-27 112.00
IUUC-Cja-019306 Callithrix jacchus 56.57 7.00e-30 122.00
IUUC-Cfa-020063 Canis familiaris 50.78 3.00e-33 133.00
IUUC-Cpo-021325 Cavia porcellus 51.15 6.00e-35 139.00
IUUC-Cre-022889 Chlamydomonas reinhardtii 51.09 4.00e-20 90.50
IUUC-Csa-023739 Chlorocebus sabaeus 53.28 1.00e-33 135.00
IUUC-Cho-024324 Choloepus hoffmanni 55.56 3.00e-28 117.00
IUUC-Cgl-026402 Colletotrichum gloeosporioides 46.96 3.00e-20 90.50
IUUC-Cne-027094 Cryptococcus neoformans 37.65 5.00e-12 63.20
IUUC-Cme-027112 Cyanidioschyzon merolae 36.27 1.00e-12 64.70
IUUC-Dre-028813 Danio rerio 46.00 1.00e-32 131.00
IUUC-Dno-029949 Dasypus novemcinctus 54.55 6.00e-30 121.00
IUUC-Dse-031482 Dothistroma septosporum 39.47 2.00e-16 78.20
IUUC-Ete-032937 Echinops telfairi 78.12 2.00e-10 57.80
IUUC-Eca-033899 Equus caballus 54.55 1.00e-29 121.00
IUUC-Fca-036579 Felis catus 56.70 2.00e-28 117.00
IUUC-Fox-037940 Fusarium oxysporum 33.33 8.00e-20 89.40
IUUC-Fso-038465 Fusarium solani 44.35 5.00e-20 90.10
IUUC-Ggr-040089 Gaeumannomyces graminis 40.77 1.00e-21 95.10
IUUC-Gga-040910 Gallus gallus 51.56 6.00e-34 135.00
IUUC-Gma-044349 Glycine max 38.74 1.00e-18 85.10
IUUC-Ggo-044854 Gorilla gorilla 56.57 5.00e-30 123.00
IUUC-Hsa-046921 Homo sapiens 56.57 5.00e-30 123.00
IUUC-Hvu-047142 Hordeum vulgare 42.34 5.00e-20 89.70
IUUC-Kpa-049187 Komagataella pastoris 37.88 5.00e-16 76.30
IUUC-Lch-050614 Latimeria chalumnae 51.59 2.00e-34 137.00
IUUC-Lpe-051184 Leersia perrieri 38.94 1.00e-20 91.70
IUUC-Loc-052083 Lepisosteus oculatus 53.51 4.00e-33 132.00
IUUC-Lma-053209 Leptosphaeria maculans 46.46 6.00e-18 82.80
IUUC-Laf-054090 Loxodonta africana 51.22 1.00e-32 131.00
IUUC-Meu-056814 Macropus eugenii 55.26 9.00e-34 134.00
IUUC-Mor-057169 Magnaporthe oryzae 41.67 8.00e-20 89.40
IUUC-Mpo-057483 Magnaporthe poae 40.77 3.00e-22 97.10
IUUC-Mtr-058166 Medicago truncatula 37.84 2.00e-16 77.80
IUUC-Mla-059015 Melampsora laricipopulina 39.09 1.00e-17 81.60
IUUC-Mvi-060356 Microbotryum violaceum 51.69 7.00e-18 82.80
IUUC-Mdo-062658 Monodelphis domestica 40.09 8.00e-34 135.00
IUUC-Mmu-063470 Mus musculus 51.18 2.00e-34 137.00
IUUC-Mac-065327 Musa acuminata 31.48 3.00e-19 87.40
IUUC-Mpu-065761 Mustela putorius furo 52.03 6.00e-30 122.00
IUUC-Mlu-067175 Myotis lucifugus 51.64 2.00e-32 130.00
IUUC-Nfi-068535 Neosartorya fischeri 37.30 9.00e-18 82.40
IUUC-Ncr-068966 Neurospora crassa 43.12 2.00e-21 94.40
IUUC-Opr-070533 Ochotona princeps 54.24 4.00e-14 69.70
IUUC-Oan-073024 Ornithorhynchus anatinus 45.86 1.00e-29 121.00
IUUC-Ocu-074451 Oryctolagus cuniculus 46.72 2.00e-30 125.00
IUUC-Oba-075540 Oryza barthii 42.06 8.00e-20 89.40
IUUC-Obr-076285 Oryza brachyantha 39.82 3.00e-20 90.90
IUUC-Ogl-077827 Oryza glaberrima 42.06 8.00e-20 89.40
IUUC-Ogu-078491 Oryza glumaepatula 42.06 6.00e-20 89.40
IUUC-Oin-080149 Oryza indica 41.67 8.00e-20 89.00
IUUC-Olo-080318 Oryza longistaminata 39.84 1.00e-18 84.70
IUUC-Oni-083037 Oryza nivara 42.06 1.00e-19 88.60
IUUC-Opu-083448 Oryza punctata 41.23 1.00e-20 92.00
IUUC-Oru-084793 Oryza rufipogon 42.06 1.00e-19 88.60
IUUC-Osa-086032 Oryza sativa 42.06 1.00e-19 88.60
IUUC-Ola-086956 Oryzias latipes 54.03 4.00e-34 136.00
IUUC-Olu-087806 Ostreococcus lucimarinus 30.67 1.00e-15 74.70
IUUC-Oga-089029 Otolemur garnettii 52.34 4.00e-30 123.00
IUUC-Oar-089471 Ovis aries 53.45 9.00e-32 129.00
IUUC-Pan-092091 Papio anubis 53.28 1.00e-33 135.00
IUUC-Psi-093193 Pelodiscus sinensis 51.97 6.00e-34 135.00
IUUC-Pma-094540 Petromyzon marinus 57.14 9.00e-33 130.00
IUUC-Pno-094873 Phaeosphaeria nodorum 40.00 1.00e-17 81.60
IUUC-Ppa-095343 Physcomitrella patens 43.52 1.00e-19 89.40
IUUC-Pfo-097093 Poecilia formosa 49.65 3.00e-35 140.00
IUUC-Pab-098781 Pongo abelii 67.21 5.00e-20 89.00
IUUC-Pop-098983 Populus trichocarpa 37.84 2.00e-17 80.90
IUUC-Pca-100872 Procavia capensis 49.47 3.00e-24 103.00
IUUC-Ppe-101711 Prunus persica 39.39 1.00e-15 75.10
IUUC-Pva-102256 Pteropus vampyrus 52.46 8.00e-32 129.00
IUUC-Pgr-103607 Puccinia graminis 47.01 1.00e-23 102.00
IUUC-Pte-104220 Pyrenophora teres 41.84 2.00e-16 77.00
IUUC-Pyt-104562 Pyrenophora triticirepentis 41.84 1.00e-16 78.60
IUUC-Rno-105021 Rattus norvegicus 44.62 3.00e-27 114.00
IUUC-Sce-106182 Saccharomyces cerevisiae 46.84 2.00e-14 71.20
IUUC-Sha-107279 Sarcophilus harrisii 51.20 2.00e-32 130.00
IUUC-Sja-107819 Schizosaccharomyces japonicus 40.91 2.00e-20 90.90
IUUC-Spo-108197 Schizosaccharomyces pombe 43.93 1.00e-19 88.20
IUUC-Smo-108810 Selaginella moellendorffii 44.32 2.00e-16 76.60
IUUC-Sit-110256 Setaria italica 42.00 8.00e-19 86.30
IUUC-Sly-111448 Solanum lycopersicum 41.44 2.00e-19 88.20
IUUC-Stu-112702 Solanum tuberosum 41.44 2.00e-19 87.80
IUUC-Sbi-113956 Sorghum bicolor 46.00 1.00e-20 92.00
IUUC-Sre-115024 Sporisorium reilianum 32.35 2.00e-16 78.20
IUUC-Ssc-116034 Sus scrofa 53.28 5.00e-34 136.00
IUUC-Tgu-117503 Taeniopygia guttata 55.14 8.00e-32 128.00
IUUC-Tsy-119166 Tarsius syrichta 32.08 3.00e-11 60.10
IUUC-Tni-120703 Tetraodon nigroviridis 41.73 7.00e-17 79.70
IUUC-Tca-121473 Theobroma cacao 41.41 2.00e-16 77.80
IUUC-Tre-122241 Trichoderma reesei 44.78 3.00e-23 99.80
IUUC-Tvi-122347 Trichoderma virens 46.09 2.00e-20 90.50
IUUC-Tae-124560 Triticum aestivum 44.00 1.00e-20 92.00
IUUC-Tur-126452 Triticum urartu 43.24 4.00e-20 90.10
IUUC-Tme-127205 Tuber melanosporum 42.00 8.00e-16 74.30
IUUC-Ttr-128186 Tursiops truncatus 52.89 6.00e-31 126.00
IUUC-Uma-129523 Ustilago maydis 33.85 7.00e-15 72.80
IUUC-Vda-129793 Verticillium dahliae 44.62 7.00e-22 96.30
IUUC-Vpa-130040 Vicugna pacos 52.76 2.00e-33 133.00
IUUC-Vvi-131588 Vitis vinifera 41.41 1.00e-16 78.60
IUUC-Yli-134631 Yarrowia lipolytica 41.67 3.00e-16 77.00
IUUC-Zma-135478 Zea mays 47.00 5.00e-21 93.20
Created Date 25-Jun-2017

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