• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Details
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Cel-018251
Ensembl Protein ID K12C11.2
UniProt Accession P55853; SUMO_CAEEL
Genbank Protein ID CAA67914.1; AAB67608.1; CCD72942.1
Protein Name Small ubiquitin-related modifier; Ubiquitin-like protein SMT3
Genbank Nucleotide ID X99600; U94830; FO081631
Gene Name smo-1; smt3; sumo; K12C11.2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00004888 K12C11.2 K12C11.2
Annotation
mRNA Expression
GEO
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
Post-translational Modifications (PTMs)
dbPAFdbPTMPhospho.ELMPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
ULD/UBL/SUMO SUMO 11806825
Classification
Family E-value Score Start End
ULD/UBL/SUMO 2.90e-26 92.3 11 90
ULD/UDP/UBQ/UBQ_Other 4.20e-06 26.9 24 87
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   ULD/UBL/SUMO
   S: 5    fkapvslkvagqdGsevlfklklsaqlkklmeavYvkrinldensvrfvfngqkireqetpeelevededkiellcqksGG 85
           +++++++kv gqd++ev+f++k+ +++ kl+++ Y++r+++ +ns+rf+f+g++i++++tp++le+ed+d+ie+++++ GG
   Q: 11   NAEYIKIKVVGQDSNEVHFRVKYGTSMAKLKKS-YADRTGVAVNSLRFLFDGRRINDDDTPKTLEMEDDDVIEVYQEQLGG 90
           899******************************.**********************************************9 PP
   

   ULD/UDP/UBQ/UBQ_Other
   S: 11   s.eltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiLeddktLadyglkdgstihllekk 73
           s e  ++v+  ++ a+LK+   +++g+ +++ r +++G+ + dd+t + + + d+++i +++++
   Q: 24   SnEVHFRVKYGTSMAKLKKSYADRTGVAVNSLRFLFDGRRINDDDTPKTLEMEDDDVIEVYQEQ 87
           44666778888999**********************************************9976 PP
   
Organism Caenorhabditis elegans
Functional Description
(View)

Functional Description


     Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process (PubMed:11806825). Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction (PubMed:11806825, PubMed:25475837). Covalent attachment to its substrates requires prior activation by the E1 complex aos-1-uba-2 and linkage to the E2 enzyme ubc-9, and can be promoted by an E3 ligase such as gei-17 (PubMed:15107848, PubMed:16701625). Required for embryonic development, fertility, vulval morphogenesis and inhibition of vulval cell fates (PubMed:15466489, PubMed:15689373, PubMed:15990876, PubMed:24349540). Probably by sumoylating bet-1, prevents muscle myosin depletion in aging adults probably by preventing myoblast growth factor receptor egl-15 overexpression (PubMed:24285704). Plays a role in the attenuation of the let-60/ras pathway (PubMed:24349540, PubMed:24285704).
 Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process (PubMed:11806825). Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction (PubMed:11806825, PubMed:25475837). Covalent attachment to its substrates requires prior activation by the E1 complex aos-1-uba-2 and linkage to the E2 enzyme ubc-9, and can be promoted by an E3 ligase such as gei-17 (PubMed:15107848, PubMed:16701625). Required for embryonic development, fertility, vulval morphogenesis and inhibition of vulval cell fates (PubMed:15466489, PubMed:15689373, PubMed:15990876, PubMed:24349540). Probably by sumoylating bet-1, prevents muscle myosin depletion in aging adults probably by preventing myoblast growth factor receptor egl-15 overexpression (PubMed:24285704). Plays a role in the attenuation of the let-60/ras pathway (PubMed:24349540, PubMed:24285704).
Protein Sequence
(Fasta)
MADDAAQAGD NAEYIKIKVV GQDSNEVHFR VKYGTSMAKL KKSYADRTGV AVNSLRFLFD 60
GRRINDDDTP KTLEMEDDDV IEVYQEQLGG F 91
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Cel-018251|ULD,SUMO;ULD,UBQ_Other|Caenorhabditis elegans
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTTTCAGAGA CTCCCGCTAT AAACGATGGC CGATGATGCA GCTCAAGCAG GCGACAACGC 60
CGAATACATC AAGATCAAGG TCGTTGGACA GGTAATTTGA CTGGAAATTC GCCGCGAATT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cel-018251|ULD,SUMO;ULD,UBQ_Other|Caenorhabditis elegans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0158--Chromosome
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0217--Developmental protein
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR022617--Rad60/SUMO-like_dom
IPR033950--Sumo
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom
PROSITE

PS50053--UBIQUITIN_2
Pfam

PF11976--Rad60-SLD
SMART

SM00213--UBQ
Gene Ontology

GO:0005694--C:chromosome
GO:0005737--C:cytoplasm
GO:0005815--C:microtubule organizing center
GO:0005634--C:nucleus
GO:0005819--C:spindle
GO:0042802--F:identical protein binding
GO:0031386--F:protein tag
GO:0009792--P:embryo development ending in birth or egg hatching
GO:0007080--P:mitotic metaphase plate congression
GO:0051306--P:mitotic sister chromatid separation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0002119--P:nematode larval development
GO:0034502--P:protein localization to chromosome
GO:0016925--P:protein sumoylation
GO:0070194--P:synaptonemal complex disassembly
KEGG cel:CELE_K12C11.2
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001056 Aegilops tauschii 48.61 6.00e-16 74.30
IUUC-Aml-001606 Ailuropoda melanoleuca 65.82 9.00e-29 116.00
IUUC-Atr-002794 Amborella trichopoda 50.62 4.00e-19 84.30
IUUC-Apl-003638 Anas platyrhynchos 65.82 5.00e-29 117.00
IUUC-Aca-004710 Anolis carolinensis 65.82 6.00e-29 117.00
IUUC-Aly-005765 Arabidopsis lyrata 50.62 4.00e-19 84.70
IUUC-Ath-007391 Arabidopsis thaliana 48.81 1.00e-19 85.90
IUUC-Ago-007749 Ashbya gossypii 40.66 1.00e-16 75.90
IUUC-Acl-008286 Aspergillus clavatus 44.09 4.00e-18 80.90
IUUC-Afl-008650 Aspergillus flavus 45.16 1.00e-19 85.90
IUUC-Afu-008969 Aspergillus fumigatus 42.55 3.00e-18 81.60
IUUC-Ani-009300 Aspergillus nidulans 44.09 6.00e-19 84.00
IUUC-Ang-009651 Aspergillus niger 44.83 6.00e-19 83.60
IUUC-Ate-010503 Aspergillus terreus 36.94 2.00e-15 73.20
IUUC-Ame-011662 Astyanax mexicanus 64.20 4.00e-29 117.00
IUUC-Bgr-012250 Blumeria graminis 37.08 1.00e-16 76.60
IUUC-Bta-013491 Bos taurus 65.82 9.00e-29 116.00
IUUC-Bci-013625 Botrytis cinerea 46.84 2.00e-18 82.00
IUUC-Bdi-014847 Brachypodium distachyon 50.00 1.00e-18 82.80
IUUC-Bol-015977 Brassica oleracea 47.62 5.00e-19 84.30
IUUC-Bra-017542 Brassica rapa 48.81 1.00e-19 86.70
IUUC-Cja-019109 Callithrix jacchus 65.82 9.00e-29 116.00
IUUC-Cfa-020657 Canis familiaris 65.82 9.00e-29 116.00
IUUC-Cpo-022508 Cavia porcellus 65.82 8.00e-29 116.00
IUUC-Cre-022970 Chlamydomonas reinhardtii 44.44 7.00e-18 80.10
IUUC-Csa-023026 Chlorocebus sabaeus 67.09 1.00e-20 89.70
IUUC-Cho-024767 Choloepus hoffmanni 64.71 4.00e-23 99.00
IUUC-Cin-025314 Ciona intestinalis 44.44 6.00e-19 84.00
IUUC-Csv-026212 Ciona savignyi 41.67 6.00e-20 87.40
IUUC-Cne-027072 Cryptococcus neoformans 53.03 5.00e-15 71.20
IUUC-Cme-027181 Cyanidioschyzon merolae 48.75 5.00e-17 77.40
IUUC-Dre-028383 Danio rerio 66.25 1.00e-28 116.00
IUUC-Dno-029820 Dasypus novemcinctus 65.82 9.00e-29 116.00
IUUC-Dor-030760 Dipodomys ordii 22.78 4.00e-05 40.80
IUUC-Dse-031390 Dothistroma septosporum 45.92 5.00e-21 90.90
IUUC-Dme-031967 Drosophila melanogaster 47.78 7.00e-22 93.60
IUUC-Ete-032934 Echinops telfairi 37.23 9.00e-16 73.20
IUUC-Eca-033958 Equus caballus 65.82 9.00e-29 116.00
IUUC-Eeu-034822 Erinaceus europaeus 65.82 8.00e-29 116.00
IUUC-Fca-035601 Felis catus 65.82 1.00e-28 116.00
IUUC-Fal-036740 Ficedula albicollis 65.82 8.00e-29 117.00
IUUC-Fox-037950 Fusarium oxysporum 48.81 3.00e-20 88.20
IUUC-Fso-038430 Fusarium solani 49.41 7.00e-21 90.50
IUUC-Gmo-038535 Gadus morhua 46.81 1.00e-23 99.40
IUUC-Ggr-040015 Gaeumannomyces graminis 48.05 2.00e-18 82.80
IUUC-Gga-040129 Gallus gallus 65.82 5.00e-29 117.00
IUUC-Gac-042112 Gasterosteus aculeatus 62.96 3.00e-28 114.00
IUUC-Gma-043091 Glycine max 46.59 5.00e-19 84.70
IUUC-Ggo-045413 Gorilla gorilla 65.82 9.00e-29 116.00
IUUC-Hsa-046108 Homo sapiens 65.82 9.00e-29 116.00
IUUC-Hvu-047514 Hordeum vulgare 46.07 4.00e-18 81.60
IUUC-Itr-047968 Ictidomys tridecemlineatus 65.82 1.00e-28 116.00
IUUC-Kpa-049243 Komagataella pastoris 41.98 2.00e-09 52.00
IUUC-Lch-049881 Latimeria chalumnae 59.34 1.00e-24 102.00
IUUC-Lpe-051684 Leersia perrieri 46.67 4.00e-19 84.70
IUUC-Loc-052189 Lepisosteus oculatus 64.20 8.00e-29 117.00
IUUC-Lma-052968 Leptosphaeria maculans 46.84 4.00e-19 84.70
IUUC-Laf-053478 Loxodonta africana 65.82 1.00e-28 116.00
IUUC-Mcc-054832 Macaca mulatta 48.15 5.00e-21 92.00
IUUC-Meu-056112 Macropus eugenii 66.67 8.00e-29 117.00
IUUC-Mor-057132 Magnaporthe oryzae 48.72 7.00e-19 84.00
IUUC-Mpo-057351 Magnaporthe poae 48.05 2.00e-18 82.40
IUUC-Mtr-057985 Medicago truncatula 51.95 1.00e-18 83.20
IUUC-Mla-059030 Melampsora laricipopulina 45.68 4.00e-10 55.50
IUUC-Mga-060035 Meleagris gallopavo 65.82 5.00e-29 117.00
IUUC-Mvi-060478 Microbotryum violaceum 29.69 4.00e-08 48.10
IUUC-Mmr-060903 Microcebus murinus 65.82 9.00e-29 116.00
IUUC-Mdo-062633 Monodelphis domestica 65.82 6.00e-29 117.00
IUUC-Mmu-063272 Mus musculus 65.82 9.00e-29 116.00
IUUC-Mac-064486 Musa acuminata 47.73 5.00e-21 90.50
IUUC-Mpu-066505 Mustela putorius furo 65.82 1.00e-28 117.00
IUUC-Mlu-067469 Myotis lucifugus 65.82 1.00e-28 116.00
IUUC-Nfi-068364 Neosartorya fischeri 42.39 3.00e-18 81.30
IUUC-Ncr-068663 Neurospora crassa 46.25 6.00e-19 84.00
IUUC-Nle-069344 Nomascus leucogenys 65.22 4.00e-24 100.00
IUUC-Opr-071104 Ochotona princeps 23.53 2.00e-05 42.70
IUUC-Ont-071436 Oreochromis niloticus 62.96 3.00e-28 114.00
IUUC-Oan-073080 Ornithorhynchus anatinus 48.68 4.00e-20 88.20
IUUC-Ocu-074220 Oryctolagus cuniculus 65.00 9.00e-29 116.00
IUUC-Oba-075425 Oryza barthii 51.95 4.00e-19 84.70
IUUC-Obr-076884 Oryza brachyantha 51.95 2.00e-19 85.50
IUUC-Ogl-077346 Oryza glaberrima 51.95 4.00e-19 84.70
IUUC-Ogu-078983 Oryza glumaepatula 50.65 3.00e-18 82.80
IUUC-Oin-079503 Oryza indica 51.95 4.00e-19 84.70
IUUC-Olo-080573 Oryza longistaminata 51.95 4.00e-19 84.70
IUUC-Ome-081885 Oryza meridionalis 51.95 4.00e-19 84.70
IUUC-Oni-082762 Oryza nivara 51.95 4.00e-19 84.70
IUUC-Opu-083431 Oryza punctata 51.95 1.00e-18 84.70
IUUC-Oru-084392 Oryza rufipogon 51.95 4.00e-19 84.70
IUUC-Osa-086070 Oryza sativa 51.95 4.00e-19 84.70
IUUC-Ola-086373 Oryzias latipes 62.96 5.00e-28 114.00
IUUC-Olu-087670 Ostreococcus lucimarinus 45.71 2.00e-16 75.10
IUUC-Oga-088024 Otolemur garnettii 62.50 2.00e-27 112.00
IUUC-Oar-089991 Ovis aries 65.82 1.00e-28 116.00
IUUC-Ptr-090688 Pan troglodytes 65.82 7.00e-29 117.00
IUUC-Pan-092204 Papio anubis 65.82 9.00e-29 116.00
IUUC-Psi-093396 Pelodiscus sinensis 65.82 6.00e-29 117.00
IUUC-Pno-094884 Phaeosphaeria nodorum 46.84 4.00e-19 84.70
IUUC-Ppa-095772 Physcomitrella patens 48.10 2.00e-17 79.30
IUUC-Pfo-096306 Poecilia formosa 62.96 5.00e-28 114.00
IUUC-Pab-098393 Pongo abelii 66.67 2.00e-28 117.00
IUUC-Pop-099655 Populus trichocarpa 47.73 7.00e-20 87.40
IUUC-Pca-100237 Procavia capensis 65.82 3.00e-27 112.00
IUUC-Ppe-102021 Prunus persica 49.41 8.00e-21 90.10
IUUC-Pva-102353 Pteropus vampyrus 64.41 3.00e-20 89.00
IUUC-Pgr-103683 Puccinia graminis 48.10 2.00e-17 79.30
IUUC-Ptt-103986 Puccinia triticina 46.84 7.00e-17 77.40
IUUC-Pte-104358 Pyrenophora teres 46.34 2.00e-19 85.10
IUUC-Pyt-104485 Pyrenophora triticirepentis 46.34 2.00e-19 85.10
IUUC-Rno-105286 Rattus norvegicus 65.82 9.00e-29 116.00
IUUC-Sce-106231 Saccharomyces cerevisiae 45.45 2.00e-16 75.50
IUUC-Sha-106712 Sarcophilus harrisii 64.71 1.00e-23 99.00
IUUC-Sja-107710 Schizosaccharomyces japonicus 50.52 7.00e-22 94.40
IUUC-Spo-108261 Schizosaccharomyces pombe 56.25 2.00e-21 92.80
IUUC-Smo-109051 Selaginella moellendorffii 43.75 2.00e-17 79.30
IUUC-Sit-110664 Setaria italica 33.72 5.00e-08 48.50
IUUC-Sly-111435 Solanum lycopersicum 48.86 8.00e-20 87.00
IUUC-Stu-111935 Solanum tuberosum 47.19 4.00e-19 84.70
IUUC-Sar-113550 Sorex araneus 65.82 9.00e-29 116.00
IUUC-Sbi-114801 Sorghum bicolor 49.41 9.00e-19 83.60
IUUC-Sre-115172 Sporisorium reilianum 55.56 1.00e-20 89.70
IUUC-Ssc-115837 Sus scrofa 63.29 5.00e-28 114.00
IUUC-Tgu-117064 Taeniopygia guttata 65.82 5.00e-29 117.00
IUUC-Tru-117752 Takifugu rubripes 62.96 3.00e-28 114.00
IUUC-Tsy-119358 Tarsius syrichta 63.33 2.00e-20 89.40
IUUC-Tni-120621 Tetraodon nigroviridis 62.96 4.00e-28 114.00
IUUC-Tca-120927 Theobroma cacao 47.73 2.00e-19 86.30
IUUC-Tre-121926 Trichoderma reesei 48.75 1.00e-19 86.30
IUUC-Tvi-122514 Trichoderma virens 45.98 1.00e-19 86.30
IUUC-Tae-124484 Triticum aestivum 48.31 4.00e-19 84.70
IUUC-Tur-126333 Triticum urartu 48.53 2.00e-14 70.10
IUUC-Tme-126902 Tuber melanosporum 48.10 7.00e-19 83.60
IUUC-Tbe-127363 Tupaia belangeri 44.68 6.00e-21 90.50
IUUC-Ttr-128166 Tursiops truncatus 65.82 1.00e-28 117.00
IUUC-Uma-129444 Ustilago maydis 51.69 5.00e-21 90.90
IUUC-Vda-129731 Verticillium dahliae 43.96 2.00e-19 85.90
IUUC-Vpa-130172 Vicugna pacos 65.82 1.00e-28 117.00
IUUC-Vvi-131092 Vitis vinifera 50.62 1.00e-19 86.70
IUUC-Xtr-132473 Xenopus tropicalis 58.43 8.00e-29 117.00
IUUC-Xma-133814 Xiphophorus maculatus 62.96 3.00e-28 114.00
IUUC-Yli-134507 Yarrowia lipolytica 43.33 1.00e-15 72.40
IUUC-Zma-134810 Zea mays 46.43 1.00e-18 82.80
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved