iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

   S: 7    lrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlye 50
           + +ep SL hL+Rl++r++lg++rl +i+ LPLP+++k+YLly+
   Q: 221  RAEEPQSLLHLSRLCVRHALGDTRLGQISSLPLPPAMKRYLLYK 264
           6789***************************************7 PP

Organism

Rattus norvegicus

Functional Description
(View)

Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Protein Sequence
(Fasta)

MGQTALARGS SSTPSSHALY SDLSPPEGLE ELLSAPPPDL GAQRHHGWNP KDCSENIDVK 60
EGGLCFERRP VAQSTDGVRG KRGYSRGLHA WEISWPLEQR GTHAVVGVAT ALAPLQADHY 120

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Nucleotide Sequence
(Fasta)

GTTGCTGGTC AGGGGCGCTT CCACCCTTCC CTATCTGTGC TTCCACTGAG GTCTCTGAGG 60
GGTAGGGGGA GCCCAGTGAG GTGCGGGATA GGGGCCGGGC CTTAGAGACC TCAAGGGGAC 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR001870--B30.2/SPRY
IPR013320--ConA-like_dom
IPR001496--SOCS_box
IPR003877--SPRY_dom

PROSITE

PS50188--B302_SPRY
PS50225--SOCS

Pfam

PF07525--SOCS_box
PF00622--SPRY

SMART

SM00253--SOCS
SM00969--SOCS_box
SM00449--SPRY

Gene Ontology

GO:0005737--C:cytoplasm
GO:0035556--P:intracellular signal transduction
GO:0016567--P:protein ubiquitination

KEGG

rno:100911548; rno:297592

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001366	Ailuropoda melanoleuca	89.02	6.00e-124	436.00
IUUC-Cja-019350	Callithrix jacchus	89.39	2.00e-133	468.00
IUUC-Cfa-020542	Canis familiaris	89.77	8.00e-135	472.00
IUUC-Cpo-021754	Cavia porcellus	89.02	7.00e-134	469.00
IUUC-Cho-024374	Choloepus hoffmanni	85.00	7.00e-61	225.00
IUUC-Dno-029997	Dasypus novemcinctus	89.39	3.00e-110	390.00
IUUC-Eeu-034632	Erinaceus europaeus	87.12	4.00e-129	453.00
IUUC-Fca-035539	Felis catus	90.76	2.00e-123	434.00
IUUC-Ggo-044949	Gorilla gorilla	91.29	7.00e-137	479.00
IUUC-Hsa-046131	Homo sapiens	91.29	9.00e-137	479.00
IUUC-Itr-048113	Ictidomys tridecemlineatus	92.42	9.00e-141	492.00
IUUC-Laf-053755	Loxodonta africana	89.77	3.00e-128	451.00
IUUC-Mcc-055467	Macaca mulatta	81.93	6.00e-110	389.00
IUUC-Meu-056625	Macropus eugenii	80.45	1.00e-109	389.00
IUUC-Mmr-061190	Microcebus murinus	91.67	3.00e-130	457.00
IUUC-Mmu-063210	Mus musculus	97.35	7.00e-150	522.00
IUUC-Mpu-066662	Mustela putorius furo	88.64	6.00e-133	466.00
IUUC-Nle-069267	Nomascus leucogenys	90.53	7.00e-136	476.00
IUUC-Opr-070650	Ochotona princeps	80.30	2.00e-105	374.00
IUUC-Ocu-073993	Oryctolagus cuniculus	89.39	4.00e-133	466.00
IUUC-Oga-089049	Otolemur garnettii	87.88	4.00e-123	433.00
IUUC-Pab-098113	Pongo abelii	90.91	3.00e-136	477.00
IUUC-Pca-100149	Procavia capensis	91.86	8.00e-116	409.00
IUUC-Pva-102664	Pteropus vampyrus	90.15	5.00e-127	446.00
IUUC-Sha-107519	Sarcophilus harrisii	80.08	1.00e-108	385.00
IUUC-Ssc-115687	Sus scrofa	89.39	8.00e-133	466.00
IUUC-Tsy-119519	Tarsius syrichta	66.67	3.00e-80	291.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence